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Items: 1 to 50 of 168

1.

Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System.

Miedel MT, Gavlock DC, Jia S, Gough A, Taylor DL, Stern AM.

Sci Rep. 2019 Jun 6;9(1):8341. doi: 10.1038/s41598-019-44756-5.

2.

Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision.

Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE.

J Neurotrauma. 2019 Feb 1. doi: 10.1089/neu.2018.6203. [Epub ahead of print]

PMID:
30520681
3.

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2018 Sep;561(7723):420. doi: 10.1038/s41586-018-0284-y.

4.

A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.

Schurdak ME, Pei F, Lezon TR, Carlisle D, Friedlander R, Taylor DL, Stern AM.

Methods Mol Biol. 2018;1787:207-222. doi: 10.1007/978-1-4939-7847-2_16.

PMID:
29736721
5.

Disproportionate Sterilization of Latinos Under California's Eugenic Sterilization Program, 1920-1945.

Novak NL, Lira N, O'Connor KE, Harlow SD, Kardia SLR, Stern AM.

Am J Public Health. 2018 May;108(5):611-613. doi: 10.2105/AJPH.2018.304369. Epub 2018 Mar 22.

6.

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.

Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM.

Oncology. 2018;94(3):176-189. doi: 10.1159/000485510. Epub 2018 Jan 6.

7.

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Pei F, Li H, Henderson MJ, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME.

Sci Rep. 2017 Dec 19;7(1):17803. doi: 10.1038/s41598-017-17378-y.

8.

Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.

Spagnolo DM, Al-Kofahi Y, Zhu P, Lezon TR, Gough A, Stern AM, Lee AV, Ginty F, Sarachan B, Taylor DL, Chennubhotla SC.

Cancer Res. 2017 Nov 1;77(21):e71-e74. doi: 10.1158/0008-5472.CAN-17-0676.

9.

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.

Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S.

Breast Cancer Res. 2017 May 23;19(1):60. doi: 10.1186/s13058-017-0851-4.

10.

Shadows of doubt: the uneasy incorporation of identification science into legal determination of paternity in Brazil.

Caulfield S, Stern AM.

Cad Saude Publica. 2017 May 8;33Suppl 1(Suppl 1):e00110016. doi: 10.1590/0102-311X00110016.

11.

Race, health, and discrimination: historical and contemporary perspectives from Brazil and the United States.

Chor D, Stern AM, Santos RV.

Cad Saude Publica. 2017 May 8;33Suppl 1(Suppl 1):e00044817. doi: 10.1590/0102-311X00044817. English, Portuguese, Spanish. No abstract available.

12.

Biologically Relevant Heterogeneity: Metrics and Practical Insights.

Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL.

SLAS Discov. 2017 Mar;22(3):213-237. doi: 10.1177/2472555216682725. Epub 2017 Jan 6. Review.

13.

Eugenics, sterilization, and historical memory in the United States.

Stern AM.

Hist Cienc Saude Manguinhos. 2016 Dec;23Suppl 1(Suppl 1):195-212. doi: 10.1590/S0104-59702016000500011.

14.

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.

Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL, Chennubhotla SC.

J Pathol Inform. 2016 Nov 29;7:47. eCollection 2016.

15.

California's Sterilization Survivors: An Estimate and Call for Redress.

Stern AM, Novak NL, Lira N, O'Connor K, Harlow S, Kardia S.

Am J Public Health. 2017 Jan;107(1):50-54. Epub 2016 Nov 17.

16.

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

Law JM, Stark SC, Liu K, Liang NE, Hussain MM, Leiendecker M, Ito D, Verho O, Stern AM, Johnston SE, Zhang YL, Dunn GP, Shamji AF, Schreiber SL.

ACS Med Chem Lett. 2016 Aug 18;7(10):944-949. eCollection 2016 Oct 13.

17.

Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system.

Yadavalli SS, Carey JN, Leibman RS, Chen AI, Stern AM, Roggiani M, Lippa AM, Goulian M.

Nat Commun. 2016 Jul 29;7:12340. doi: 10.1038/ncomms12340.

18.

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.

Stern AM, Schurdak ME, Bahar I, Berg JM, Taylor DL.

J Biomol Screen. 2016 Jul;21(6):521-34. doi: 10.1177/1087057116635818. Epub 2016 Mar 8.

19.

Human Visual Cortex Responses to Rapid Cone and Melanopsin-Directed Flicker.

Spitschan M, Datta R, Stern AM, Brainard DH, Aguirre GK.

J Neurosci. 2016 Feb 3;36(5):1471-82. doi: 10.1523/JNEUROSCI.1932-15.2016.

20.

Spatial Stigma and Health in Postindustrial Detroit.

Graham LF, Padilla MB, Lopez WD, Stern AM, Peterson J, Keene DE.

Int Q Community Health Educ. 2016;36(2):105-13. doi: 10.1177/0272684X15627800. Epub 2016 Jan 31.

PMID:
26833796
21.

Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients.

Wang P, Bahreini A, Gyanchandani R, Lucas PC, Hartmaier RJ, Watters RJ, Jonnalagadda AR, Trejo Bittar HE, Berg A, Hamilton RL, Kurland BF, Weiss KR, Mathew A, Leone JP, Davidson NE, Nikiforova MN, Brufsky AM, Ambros TF, Stern AM, Puhalla SL, Lee AV, Oesterreich S.

Clin Cancer Res. 2016 Mar 1;22(5):1130-7. doi: 10.1158/1078-0432.CCR-15-1534. Epub 2015 Oct 23.

22.

Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2015 Oct 22;526(7574):596. doi: 10.1038/nature15370. Epub 2015 Sep 16. No abstract available.

PMID:
26375002
23.

Treating gynecologic malignancies with selective estrogen receptor downregulators (SERDs): promise and challenges.

Boisen MM, Andersen CL, Sreekumar S, Stern AM, Oesterreich S.

Mol Cell Endocrinol. 2015 Dec 15;418 Pt 3:322-33. doi: 10.1016/j.mce.2015.04.035. Epub 2015 Aug 11.

PMID:
26276546
24.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dančík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL.

Cell Rep. 2015 Feb 10;10(5):755-770. doi: 10.1016/j.celrep.2015.01.017. Epub 2015 Feb 5.

25.

Financial costs and personal consequences of research misconduct resulting in retracted publications.

Stern AM, Casadevall A, Steen RG, Fang FC.

Elife. 2014 Aug 14;3:e02956. doi: 10.7554/eLife.02956.

26.

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL.

PLoS One. 2014 Jul 18;9(7):e102678. doi: 10.1371/journal.pone.0102678. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0120468.

27.

An introduction to nitric oxide sensing and response in bacteria.

Stern AM, Zhu J.

Adv Appl Microbiol. 2014;87:187-220. doi: 10.1016/B978-0-12-800261-2.00005-0. Review.

PMID:
24581392
28.

A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities.

Joy ME, Vollmer LL, Hulkower K, Stern AM, Peterson CK, Boltz RC, Roy P, Vogt A.

PLoS One. 2014 Feb 10;9(2):e88350. doi: 10.1371/journal.pone.0088350. eCollection 2014.

29.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.

Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS, Scadden DT, Schreiber SL, Ebert BL, Golub TR.

Nat Chem Biol. 2013 Dec;9(12):840-848. doi: 10.1038/nchembio.1367. Epub 2013 Oct 27.

30.

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, Stransky N, Kryukov GV, Dancik V, Barretina J, Garraway LA, Hon CS, Munoz B, Bittker JA, Stockwell BR, Khabele D, Stern AM, Clemons PA, Shamji AF, Schreiber SL.

Cell. 2013 Aug 29;154(5):1151-1161. doi: 10.1016/j.cell.2013.08.003.

31.

A novel protein protects bacterial iron-dependent metabolism from nitric oxide.

Stern AM, Liu B, Bakken LR, Shapleigh JP, Zhu J.

J Bacteriol. 2013 Oct;195(20):4702-8. doi: 10.1128/JB.00836-13. Epub 2013 Aug 9.

32.

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.

Adams DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, Schreiber SL.

ACS Chem Biol. 2013 May 17;8(5):923-9. doi: 10.1021/cb300653v. Epub 2013 Mar 25.

33.

Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence.

Yang M, Liu Z, Hughes C, Stern AM, Wang H, Zhong Z, Kan B, Fenical W, Zhu J.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2348-53. doi: 10.1073/pnas.1218039110. Epub 2013 Jan 22.

34.

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.

Weïwer M, Spoonamore J, Wei J, Guichard B, Ross NT, Masson K, Silkworth W, Dandapani S, Palmer M, Scherer CA, Stern AM, Schreiber SL, Munoz B.

ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub 2012 Oct 22.

35.

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.

Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15115-20. Epub 2012 Sep 4.

36.

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.

Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD.

Cell. 2012 Aug 3;150(3):575-89. doi: 10.1016/j.cell.2012.06.032.

37.

The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines.

Stern AM, Hay AJ, Liu Z, Desland FA, Zhang J, Zhong Z, Zhu J.

MBio. 2012 Apr 17;3(2):e00013-12. doi: 10.1128/mBio.00013-12. Print 2012.

38.

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability.

Luo T, Masson K, Jaffe JD, Silkworth W, Ross NT, Scherer CA, Scholl C, Fröhling S, Carr SA, Stern AM, Schreiber SL, Golub TR.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5. doi: 10.1073/pnas.1120589109. Epub 2012 Feb 9.

39.

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Mali RS, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, Stern AM, Wen Q, Crispino JD, Boswell HS, Kapur R.

Cancer Cell. 2011 Sep 13;20(3):357-69. doi: 10.1016/j.ccr.2011.07.016.

40.

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW.

Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. Erratum in: Nature. 2012 Jan 26;481(7382):534. Nature. 2015 Oct 22;526(7574):596. Retraction in: Nature. 2018 Sep;561(7723):420.

41.

Generation and evaluation of A2-expressing Lactococcus lactis live vaccines against Leishmania donovani in BALB/c mice.

Yam KK, Hugentobler F, Pouliot P, Stern AM, Lalande JD, Matlashewski G, Olivier M, Cousineau B.

J Med Microbiol. 2011 Sep;60(Pt 9):1248-60. doi: 10.1099/jmm.0.029959-0. Epub 2011 Apr 28.

PMID:
21527547
42.
43.

Towards patient-based cancer therapeutics.

Cancer Target Discovery and Development Network, Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA.

Nat Biotechnol. 2010 Sep;28(9):904-6. doi: 10.1038/nbt0910-904. No abstract available.

44.

Lucien Howe, hereditary blindness, and the eugenics movement.

Ravin JG, Stern AM.

Arch Ophthalmol. 2010 Jul;128(7):924-30. doi: 10.1001/archophthalmol.2010.137.

PMID:
20625057
45.
46.

The 1918-1919 influenza pandemic in the United States: lessons learned and challenges exposed.

Stern AM, Cetron MS, Markel H.

Public Health Rep. 2010 Apr;125 Suppl 3:6-8. No abstract available.

47.

Findings, gaps, and future direction for research in nonpharmaceutical interventions for pandemic influenza.

Vukotich CJ Jr, Coulborn RM, Aragon TJ, Baker MG, Burrus BB, Aiello AE, Cowling BJ, Duncan A, Enanoria W, Fabian MP, Ferng YH, Larson EL, Leung GM, Markel H, Milton DK, Monto AS, Morse SS, Navarro JA, Park SY, Priest P, Stebbins S, Stern AM, Uddin M, Wetterhall SF.

Emerg Infect Dis. 2010 Apr;16(4):e2. No abstract available.

48.

Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research.

Aiello AE, Coulborn RM, Aragon TJ, Baker MG, Burrus BB, Cowling BJ, Duncan A, Enanoria W, Fabian MP, Ferng YH, Larson EL, Leung GM, Markel H, Milton DK, Monto AS, Morse SS, Navarro JA, Park SY, Priest P, Stebbins S, Stern AM, Uddin M, Wetterhall SF, Vukotich CJ Jr.

Am J Infect Control. 2010 May;38(4):251-8. doi: 10.1016/j.ajic.2009.12.007. Epub 2010 Mar 12. Review.

49.

Virulence regulator AphB enhances toxR transcription in Vibrio cholerae.

Xu X, Stern AM, Liu Z, Kan B, Zhu J.

BMC Microbiol. 2010 Jan 6;10:3. doi: 10.1186/1471-2180-10-3.

50.

Closing the schools: lessons from the 1918-19 U.S. influenza pandemic.

Stern AM, Cetron MS, Markel H.

Health Aff (Millwood). 2009 Nov-Dec;28(6):w1066-78. doi: 10.1377/hlthaff.28.6.w1066. Epub 2009 Sep 28.

PMID:
19797251

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