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Items: 1 to 50 of 69

1.

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies.

Law SC, Haigh OL, Walpole CM, Keane C, Miles JJ, Gandhi MK, Radford KJ, Steptoe RJ.

J Immunol Methods. 2019 Feb;465:72-76. doi: 10.1016/j.jim.2018.12.002. Epub 2018 Dec 8.

PMID:
30537479
2.

Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous Squamous Cell Carcinoma.

Jung JW, Veitch M, Bridge JA, Overgaard NH, Cruz JL, Linedale R, Franklin ME, Saunders NA, Simpson F, Frazer IH, Steptoe RJ, Wells JW.

Oncoimmunology. 2018 Jul 30;7(9):e1479627. doi: 10.1080/2162402X.2018.1479627. eCollection 2018.

3.

Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling.

Kling JC, Jordan MA, Pitt LA, Meiners J, Thanh-Tran T, Tran LS, Nguyen TTK, Mittal D, Villani R, Steptoe RJ, Khosrotehrani K, Berzins SP, Baxter AG, Godfrey DI, Blumenthal A.

Front Immunol. 2018 Mar 16;9:483. doi: 10.3389/fimmu.2018.00483. eCollection 2018.

4.

Tetramer-based identification of naïve antigen-specific B cells within a polyclonal repertoire.

Brooks JF, Liu X, Davies JM, Wells JW, Steptoe RJ.

Eur J Immunol. 2018 Jul;48(7):1251-1254. doi: 10.1002/eji.201747447. Epub 2018 Apr 17.

5.

Flt-3L Expansion of Recipient CD8α+ Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD.

Markey KA, Kuns RD, Browne DJ, Gartlan KH, Robb RJ, Martins JP, Henden AS, Minnie SA, Cheong M, Koyama M, Smyth MJ, Steptoe RJ, Belz GT, Brocker T, Degli-Esposti MA, Lane SW, Hill GR.

Clin Cancer Res. 2018 Apr 1;24(7):1604-1616. doi: 10.1158/1078-0432.CCR-17-2148. Epub 2018 Jan 24.

6.

Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy.

Brooks JF, Davies JM, Wells JW, Steptoe RJ.

J Mol Med (Berl). 2018 Jan;96(1):21-30. doi: 10.1007/s00109-017-1611-8. Epub 2017 Nov 17. Review.

PMID:
29150718
7.

The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse.

Borg DJ, Wang R, Murray L, Tong H, Steptoe RJ, McGuckin MA, Hasnain SZ.

Diabetologia. 2017 Nov;60(11):2256-2261. doi: 10.1007/s00125-017-4392-2. Epub 2017 Aug 4.

8.

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice.

Reeves PLS, Rudraraju R, Wong FS, Hamilton-Williams EE, Steptoe RJ.

Eur J Immunol. 2017 Sep;47(9):1550-1561. doi: 10.1002/eji.201747089. Epub 2017 Jul 18.

9.

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin.

Overgaard NH, Cruz JL, Bridge JA, Nel HJ, Frazer IH, La Gruta NL, Blumenthal A, Steptoe RJ, Wells JW.

J Leukoc Biol. 2017 Sep;102(3):837-844. doi: 10.1189/jlb.1AB0217-065R. Epub 2017 Jun 21.

PMID:
28637895
10.

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.

Reeves PL, Rudraraju R, Liu X, Wong FS, Hamilton-Williams EE, Steptoe RJ.

Immunol Cell Biol. 2017 Oct;95(9):765-774. doi: 10.1038/icb.2017.48. Epub 2017 Jun 14.

PMID:
28611473
11.

Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation.

Al-Kouba J, Wilkinson AN, Starkey MR, Rudraraju R, Werder RB, Liu X, Law SC, Horvat JC, Brooks JF, Hill GR, Davies JM, Phipps S, Hansbro PM, Steptoe RJ.

JCI Insight. 2017 Jun 2;2(11). pii: 85742. doi: 10.1172/jci.insight.85742. eCollection 2017 Jun 2.

12.

Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance.

Bhatt KH, Rudraraju R, Brooks JF, Jung JW, Galea R, Wells JW, Steptoe RJ.

Stem Cell Res Ther. 2017 Mar 9;8(1):57. doi: 10.1186/s13287-017-0508-3.

13.

The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma.

Keane C, Gould C, Jones K, Hamm D, Talaulikar D, Ellis J, Vari F, Birch S, Han E, Wood P, Le-Cao KA, Green MR, Crooks P, Jain S, Tobin J, Steptoe RJ, Gandhi MK.

Clin Cancer Res. 2017 Apr 1;23(7):1820-1828. doi: 10.1158/1078-0432.CCR-16-1576. Epub 2016 Sep 20.

14.

Maintenance of peripheral tolerance to islet antigens.

Hamilton-Williams EE, Bergot AS, Reeves PL, Steptoe RJ.

J Autoimmun. 2016 Aug;72:118-25. doi: 10.1016/j.jaut.2016.05.009. Epub 2016 May 30. Review.

PMID:
27255733
15.

Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection.

Coleman MA, Jessup CF, Bridge JA, Overgaard NH, Penko D, Walters S, Borg DJ, Galea R, Forbes JM, Thomas R, Coates PT, Grey ST, Wells JW, Steptoe RJ.

Diabetes. 2016 May;65(5):1328-1340. doi: 10.2337/db15-1418. Epub 2016 Mar 9.

16.

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice.

James CR, Buckle I, Muscate F, Otsuka M, Nakao M, Oon JSh, Steptoe RJ, Thomas R, Hamilton-Williams EE.

Immunol Cell Biol. 2016 May;94(5):509-19. doi: 10.1038/icb.2016.7. Epub 2016 Jan 14.

PMID:
26763864
17.

Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?

Nassef Kadry Naguib Roufaiel M, Wells JW, Steptoe RJ.

Front Immunol. 2015 Jun 2;6:258. doi: 10.3389/fimmu.2015.00258. eCollection 2015. Review.

18.

Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation.

Foo SY, Zhang V, Lalwani A, Lynch JP, Zhuang A, Lam CE, Foster PS, King C, Steptoe RJ, Mazzone SB, Sly PD, Phipps S.

J Immunol. 2015 May 1;194(9):4567-76. doi: 10.4049/jimmunol.1400909. Epub 2015 Mar 25.

19.

Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment.

Blake SJ, Ching AL, Kenna TJ, Galea R, Large J, Yagita H, Steptoe RJ.

PLoS One. 2015 Mar 5;10(3):e0119483. doi: 10.1371/journal.pone.0119483. eCollection 2015.

20.

HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions.

Bergot AS, Monnet N, Le Tran S, Mittal D, Al-Kouba J, Steptoe RJ, Grimbaldeston MA, Frazer IH, Wells JW.

Immunol Cell Biol. 2015 Jul;93(6):540-7. doi: 10.1038/icb.2014.123. Epub 2015 Jan 20.

21.

CD4+/CD8+ double-positive T cells: more than just a developmental stage?

Overgaard NH, Jung JW, Steptoe RJ, Wells JW.

J Leukoc Biol. 2015 Jan;97(1):31-8. doi: 10.1189/jlb.1RU0814-382. Epub 2014 Oct 30. Review.

PMID:
25360000
22.

Asymmetric peptide dendrimers are effective linkers for antibody-mediated delivery of diverse payloads to b cells in vitro and in vivo.

Shah ND, Parekh HS, Steptoe RJ.

Pharm Res. 2014 Nov;31(11):3150-60. doi: 10.1007/s11095-014-1408-1. Epub 2014 May 22.

PMID:
24848340
23.

Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation.

McNally A, McNally M, Galea R, Thomas R, Steptoe RJ.

PLoS One. 2014 Jan 13;9(1):e85455. doi: 10.1371/journal.pone.0085455. eCollection 2014.

24.

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours.

Khairuddin N, Blake SJ, Firdaus F, Steptoe RJ, Behlke MA, Hertzog PJ, McMillan NA.

Immunol Cell Biol. 2014 Feb;92(2):156-63. doi: 10.1038/icb.2013.75. Epub 2013 Nov 12.

PMID:
24217808
25.

Cell-based therapies for ocular inflammation.

Forrester JV, Steptoe RJ, Klaska IP, Martin-Granados C, Dua HS, Degli-Esposti MA, Wikstrom ME.

Prog Retin Eye Res. 2013 Jul;35:82-101. doi: 10.1016/j.preteyeres.2013.02.002. Epub 2013 Mar 29. Review.

PMID:
23542232
26.

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy.

Coleman MA, Bridge JA, Lane SW, Dixon CM, Hill GR, Wells JW, Thomas R, Steptoe RJ.

Blood. 2013 Feb 7;121(6):1049-58. doi: 10.1182/blood-2012-06-434100. Epub 2012 Dec 11.

27.

A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin.

Fiorenza S, Kenna TJ, Comerford I, McColl S, Steptoe RJ, Leggatt GR, Frazer IH.

J Immunol. 2012 Dec 15;189(12):5622-31. doi: 10.4049/jimmunol.1200709. Epub 2012 Nov 9.

28.

Induction of antigen-specific tolerance through hematopoietic stem cell-mediated gene therapy: the future for therapy of autoimmune disease?

Coleman MA, Steptoe RJ.

Autoimmun Rev. 2012 Dec;12(2):195-203. doi: 10.1016/j.autrev.2011.08.012. Epub 2012 Oct 6. Review.

PMID:
23047179
29.

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.

Markey KA, Koyama M, Kuns RD, Lineburg KE, Wilson YA, Olver SD, Raffelt NC, Don AL, Varelias A, Robb RJ, Cheong M, Engwerda CR, Steptoe RJ, Ramshaw HS, Lopez AF, Vega-Ramos J, Lew AM, Villadangos JA, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5918-30. doi: 10.1182/blood-2011-12-398164. Epub 2012 Mar 13.

30.

γδ T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen.

Rahimpour A, Mattarollo SR, Yong M, Leggatt GR, Steptoe RJ, Frazer IH.

J Invest Dermatol. 2012 Jun;132(6):1656-64. doi: 10.1038/jid.2012.16. Epub 2012 Feb 23.

31.

Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation.

O'Sullivan BJ, Pai S, Street S, An X, MacDonald KP, Wong M, Strutton G, Gerondakis S, Steptoe RJ, de St Groth BF, Hill GR, Thomas R.

J Immunol. 2011 Oct 15;187(8):4018-30. doi: 10.4049/jimmunol.1101727. Epub 2011 Sep 7.

32.

CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.

McNally A, Hill GR, Sparwasser T, Thomas R, Steptoe RJ.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7529-34. doi: 10.1073/pnas.1103782108. Epub 2011 Apr 18.

33.

Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA.

Shah N, Steptoe RJ, Parekh HS.

J Pept Sci. 2011 Jun;17(6):470-8. doi: 10.1002/psc.1347. Epub 2011 Feb 24.

PMID:
21351322
34.

Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses.

Nasreen M, Waldie TM, Dixon CM, Steptoe RJ.

Eur J Immunol. 2010 Jul;40(7):2016-25. doi: 10.1002/eji.200940085.

35.

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.

Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S.

J Exp Med. 2009 Dec 21;206(13):3001-14. doi: 10.1084/jem.20091411. Epub 2009 Dec 7. Erratum in: J Exp Med.2010 Apr 12;207(4):899. Li, Wu [corrected to Wu, Li].

36.

Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function.

Kenna TJ, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, Steptoe RJ.

J Immunol. 2010 Jan 15;184(2):598-606. doi: 10.4049/jimmunol.0900032. Epub 2009 Dec 7.

37.

Steady-state dendritic cells continuously inactivate T cells that escape thymic negative selection.

Doan T, McNally A, Thomas R, Steptoe RJ.

Immunol Cell Biol. 2009 Nov-Dec;87(8):615-22. doi: 10.1038/icb.2009.46. Epub 2009 Jul 7.

PMID:
19581919
38.

Dendritic cells in the thymus contribute to T-regulatory cell induction.

Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K, Wu L.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19869-74. doi: 10.1073/pnas.0810268105. Epub 2008 Dec 10. Erratum in: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1679.

39.

Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses.

Kenna TJ, Thomas R, Steptoe RJ.

Blood. 2008 Feb 15;111(4):2091-100. Epub 2007 Nov 14.

40.

Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells.

Steptoe RJ, Ritchie JM, Wilson NS, Villadangos JA, Lew AM, Harrison LC.

J Immunol. 2007 Feb 15;178(4):2094-103.

41.

Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.

Narendran P, Neale AM, Lee BH, Ngui K, Steptoe RJ, Morahan G, Madsen O, Dromey JA, Jensen KP, Harrison LC.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16430-5. Epub 2006 Oct 19.

42.

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

O'Sullivan BJ, Thomas HE, Pai S, Santamaria P, Iwakura Y, Steptoe RJ, Kay TW, Thomas R.

J Immunol. 2006 Jun 15;176(12):7278-87.

43.

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity.

Wilson NS, Behrens GM, Lundie RJ, Smith CM, Waithman J, Young L, Forehan SP, Mount A, Steptoe RJ, Shortman KD, de Koning-Ward TF, Belz GT, Carbone FR, Crabb BS, Heath WR, Villadangos JA.

Nat Immunol. 2006 Feb;7(2):165-72. Epub 2006 Jan 15.

PMID:
16415871
45.

Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation.

Steptoe RJ, Stankovic S, Lopaticki S, Jones LK, Harrison LC, Morahan G.

J Autoimmun. 2004 Mar;22(2):131-8.

PMID:
14987741
46.

The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation.

El-Sukkari D, Wilson NS, Hakansson K, Steptoe RJ, Grubb A, Shortman K, Villadangos JA.

J Immunol. 2003 Nov 15;171(10):5003-11.

47.

Most lymphoid organ dendritic cell types are phenotypically and functionally immature.

Wilson NS, El-Sukkari D, Belz GT, Smith CM, Steptoe RJ, Heath WR, Shortman K, Villadangos JA.

Blood. 2003 Sep 15;102(6):2187-94. Epub 2003 Jun 5.

48.

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes.

Steptoe RJ, Ritchie JM, Harrison LC.

J Clin Invest. 2003 May;111(9):1357-63.

49.

Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice.

Steptoe RJ, Ritchie JM, Harrison LC.

J Immunol. 2002 May 15;168(10):5032-41.

50.

Immunobiology of liver dendritic cells.

Thomson AW, O'Connell PJ, Steptoe RJ, Lu L.

Immunol Cell Biol. 2002 Feb;80(1):65-73. Review.

PMID:
11881616

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