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Items: 1 to 50 of 57

1.

Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.

Weinman EJ, Steplock D, Shenolikar S, Biswas R.

J Biol Chem. 2011 Oct 28;286(43):37216-21. doi: 10.1074/jbc.M111.288357. Epub 2011 Sep 9.

2.

Increased renal dopamine and acute renal adaptation to a high-phosphate diet.

Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S.

Am J Physiol Renal Physiol. 2011 May;300(5):F1123-9. doi: 10.1152/ajprenal.00744.2010. Epub 2011 Feb 16.

3.

Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells.

Weinman EJ, Steplock D, Shenolikar S, Blanpied TA.

Am J Physiol Renal Physiol. 2011 Jan;300(1):F231-5. doi: 10.1152/ajprenal.00532.2010. Epub 2010 Nov 3.

4.

Role of NHERF and scaffolding proteins in proximal tubule transport.

Cunningham R, Biswas R, Steplock D, Shenolikar S, Weinman E.

Urol Res. 2010 Aug;38(4):257-62. doi: 10.1007/s00240-010-0294-1. Epub 2010 Jul 15. Review.

PMID:
20632170
5.

Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport.

Weinman EJ, Steplock D, Zhang Y, Biswas R, Bloch RJ, Shenolikar S.

J Biol Chem. 2010 Aug 13;285(33):25134-8. doi: 10.1074/jbc.M110.132423. Epub 2010 Jun 22.

6.

Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.

Weinman EJ, Biswas R, Steplock D, Douglass TS, Cunningham R, Shenolikar S.

J Biol Chem. 2010 Apr 30;285(18):13454-60. doi: 10.1074/jbc.M109.094359. Epub 2010 Mar 3.

7.

PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.

Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1560-5. doi: 10.1152/ajprenal.90657.2008. Epub 2009 Sep 30.

8.

Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells.

Cunningham R, Biswas R, Brazie M, Steplock D, Shenolikar S, Weinman EJ.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F355-61. doi: 10.1152/ajprenal.90426.2008. Epub 2008 Nov 5.

9.

The ROMK potassium channel is present in mammalian urinary tract epithelia and muscle.

Spector DA, Yang Q, Klopouh L, Deng J, Weinman EJ, Steplock DA, Biswas R, Brazie MF, Liu J, Wade JB.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1658-65. doi: 10.1152/ajprenal.00022.2008. Epub 2008 Sep 17.

10.

Novel regulatory function for NHERF-1 in Npt2a transcription.

Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F840-9. doi: 10.1152/ajprenal.00180.2007. Epub 2008 Jan 23.

11.

Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.

Weinman EJ, Biswas RS, Peng G, Shen L, Turner CL, E X, Steplock D, Shenolikar S, Cunningham R.

J Clin Invest. 2007 Nov;117(11):3412-20. Erratum in: J Clin Invest. 2008 Jan;118(1):387. Peng, Quihong [corrected to Peng, Guihong]. J Clin Invest. 2013 Jun;123(6):2752.

12.

Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.

Voltz JW, Brush M, Sikes S, Steplock D, Weinman EJ, Shenolikar S.

J Biol Chem. 2007 Nov 16;282(46):33879-87. Epub 2007 Sep 25. Erratum in: J Biol Chem. 2008 Feb 15;283(7):4459.

13.

Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.

Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M.

J Biol Chem. 2007 Aug 24;282(34):25141-51. Epub 2007 Jun 19.

14.

Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.

Cunningham R, Brazie M, Kanumuru S, E X, Biswas R, Wang F, Steplock D, Wade JB, Anzai N, Endou H, Shenolikar S, Weinman EJ.

J Am Soc Nephrol. 2007 May;18(5):1419-25. Epub 2007 Apr 4.

15.

Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.

Cunningham R, Steplock D, E X, Biswas RS, Wang F, Shenolikar S, Weinman EJ.

Am J Physiol Renal Physiol. 2006 Oct;291(4):F896-901. Epub 2006 May 16.

16.

Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.

Weinman EJ, Mohanlal V, Stoycheff N, Wang F, Steplock D, Shenolikar S, Cunningham R.

Am J Physiol Renal Physiol. 2006 Apr;290(4):F838-43. Epub 2005 Oct 25. Erratum in: Am J Physiol Renal Physiol. 2006 Jul;291(1):F254-5.

17.

Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells.

Khundmiri SJ, Weinman EJ, Steplock D, Cole J, Ahmad A, Baumann PD, Barati M, Rane MJ, Lederer E.

J Am Soc Nephrol. 2005 Sep;16(9):2598-607. Epub 2005 Jul 6.

18.

Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.

Cunningham R, E X, Steplock D, Shenolikar S, Weinman EJ.

Am J Physiol Renal Physiol. 2005 Oct;289(4):F933-8. Epub 2005 Jun 7.

19.

Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells.

Cunningham R, Steplock D, Wang F, Huang H, E X, Shenolikar S, Weinman EJ.

J Biol Chem. 2004 Sep 3;279(36):37815-21. Epub 2004 Jun 24.

20.
21.

A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange.

Weinman EJ, Wang Y, Wang F, Greer C, Steplock D, Shenolikar S.

Biochemistry. 2003 Nov 4;42(43):12662-8.

PMID:
14580213
22.

NHERF-1 is required for renal adaptation to a low-phosphate diet.

Weinman EJ, Boddeti A, Cunningham R, Akom M, Wang F, Wang Y, Liu J, Steplock D, Shenolikar S, Wade JB.

Am J Physiol Renal Physiol. 2003 Dec;285(6):F1225-32. Epub 2003 Sep 2.

23.

Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.

Wade JB, Liu J, Coleman RA, Cunningham R, Steplock DA, Lee-Kwon W, Pallone TL, Shenolikar S, Weinman EJ.

Am J Physiol Cell Physiol. 2003 Dec;285(6):C1494-503. Epub 2003 Aug 13.

24.
25.

Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia.

Spector DA, Wade JB, Dillow R, Steplock DA, Weinman EJ.

Am J Physiol Renal Physiol. 2002 Jun;282(6):F1034-42.

26.

Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells.

Weinman EJ, Evangelista CM, Steplock D, Liu MZ, Shenolikar S, Bernardo A.

J Biol Chem. 2001 Nov 9;276(45):42339-46. Epub 2001 Sep 4.

27.

Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex.

Weinman EJ, Steplock D, Shenolikar S.

Kidney Int. 2001 Aug;60(2):450-4. Review.

28.

Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells.

Weinman EJ, Steplock D, Wade JB, Shenolikar S.

Am J Physiol Renal Physiol. 2001 Aug;281(2):F374-80.

29.

N-terminal PDZ domain is required for NHERF dimerization.

Shenolikar S, Minkoff CM, Steplock DA, Evangelista C, Liu M, Weinman EJ.

FEBS Lett. 2001 Feb 2;489(2-3):233-6.

30.
31.

Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor.

Weinman EJ, Steplock D, Zhang X, Akhter S, Shenolikar S.

Biochim Biophys Acta. 1999 Oct 6;1447(1):71-6.

PMID:
10500246
32.

cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.

Zizak M, Lamprecht G, Steplock D, Tariq N, Shenolikar S, Donowitz M, Yun CH, Weinman EJ.

J Biol Chem. 1999 Aug 27;274(35):24753-8.

33.

Regulation of the Na/H exchanger regulatory factor in OK cells.

Weinman EJ, Steplock D, Lamprecht G, Yun CH, Shenolikar S.

Miner Electrolyte Metab. 1999 May-Jun;25(3):135-42.

PMID:
10436398
34.

Basolateral Na(+)/HCO(3)(-) cotransport activity is regulated by the dissociable Na(+)/H(+) exchanger regulatory factor.

Bernardo AA, Kear FT, Santos AV, Ma J, Steplock D, Robey RB, Weinman EJ.

J Clin Invest. 1999 Jul;104(2):195-201.

35.

Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).

Weinman EJ, Steplock D, Tate K, Hall RA, Spurney RF, Shenolikar S.

J Clin Invest. 1998 May 15;101(10):2199-206.

36.

cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.

Yun CH, Oh S, Zizak M, Steplock D, Tsao S, Tse CM, Weinman EJ, Donowitz M.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3010-5. Erratum in: Proc Natl Acad Sci U S A 1997 Sep 2;94(18):10006.

37.
38.
39.

Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes.

Weinman EJ, Steplock D, Corry D, Shenolikar S.

J Clin Invest. 1993 May;91(5):2097-102.

40.

Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane.

Weinman EJ, Steplock DA, Shenolikar S.

Miner Electrolyte Metab. 1993;19(1):47-50.

PMID:
8393961
41.

Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II.

Weinman E, Hanley R, Morell G, Yuan N, Steplock D, Bui G, Shenolikar S.

Miner Electrolyte Metab. 1992;18(1):35-9.

PMID:
1328833
42.

Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM.

Morell G, Steplock D, Shenolikar S, Weinman EJ.

Am J Physiol. 1990 Dec;259(6 Pt 2):F867-71.

PMID:
2175560
43.

Identification of calcium-calmodulin multifunctional protein kinase II in rabbit kidney.

Hanley RM, Shenolikar S, Pollack J, Steplock D, Weinman EJ.

Kidney Int. 1990 Jul;38(1):63-6.

44.

Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase.

Weinman EJ, Steplock D, Bui G, Yuan N, Shenolikar S.

Am J Physiol. 1990 May;258(5 Pt 2):F1254-8.

PMID:
2159717
45.

Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase.

Weinman EJ, Dubinsky WP, Dinh Q, Steplock D, Shenolikar S.

J Membr Biol. 1989 Aug;109(3):233-41.

PMID:
2552124
46.

Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases.

Weinman EJ, Dubinsky WP, Fisher K, Steplock D, Dinh Q, Chang L, Shenolikar S.

J Membr Biol. 1988 Aug;103(3):237-44.

PMID:
2846848
47.

Lipid methylation, sodium transport and the response to PTH in renal tubules.

Hise MK, Steplock DA, Weinman EJ.

Life Sci. 1986 Sep 1;39(9):831-5.

PMID:
3747733
48.

Effect of dibutyryl cyclic AMP on glucose transport in isolated brush border membrane vesicles from the rat kidney.

Kahn AM, Steplock D, Weinman EJ.

Pflugers Arch. 1984 Jan;400(1):109-11. No abstract available.

PMID:
6324065
49.

The transport of urate in the small intestine of the rat.

Dukes CE, Steplock DA, Kahn AM, Weinman EJ.

Proc Soc Exp Biol Med. 1982 Oct;171(1):19-23. No abstract available.

PMID:
7145934
50.

Determination of the apparent transport constants for urate absorption in the rat proximal tubule.

Sansom SC, Senekjian HO, Knight TF, Babino H, Steplock D, Weinman EJ.

Am J Physiol. 1981 May;240(5):F406-10.

PMID:
7235015

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