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Mechanical Ventilation in the Prehospital and Emergency Department Environment.

Stephens RJ, Siegler JE, Fuller BM.

Respir Care. 2019 May;64(5):595-603. doi: 10.4187/respcare.06888. Review.


The Accuracy of Clinical Staging of Stage I-IIIa Non-Small Cell Lung Cancer: An Analysis Based on Individual Participant Data.

Navani N, Fisher DJ, Tierney JF, Stephens RJ, Burdett S; NSCLC Meta-analysis Collaborative Group.

Chest. 2019 Mar;155(3):502-509. doi: 10.1016/j.chest.2018.10.020. Epub 2018 Oct 26.


Practice Patterns and Outcomes Associated With Early Sedation Depth in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis.

Stephens RJ, Dettmer MR, Roberts BW, Ablordeppey E, Fowler SA, Kollef MH, Fuller BM.

Crit Care Med. 2018 Mar;46(3):471-479. doi: 10.1097/CCM.0000000000002885.


Pulmonary Mechanics and Mortality in Mechanically Ventilated Patients Without Acute Respiratory Distress Syndrome: A Cohort Study.

Fuller BM, Page D, Stephens RJ, Roberts BW, Drewry AM, Ablordeppey E, Mohr NM, Kollef MH.

Shock. 2018 Mar;49(3):311-316. doi: 10.1097/SHK.0000000000000977.


Analgosedation Practices and the Impact of Sedation Depth on Clinical Outcomes Among Patients Requiring Mechanical Ventilation in the ED: A Cohort Study.

Stephens RJ, Ablordeppey E, Drewry AM, Palmer C, Wessman BT, Mohr NM, Roberts BW, Liang SY, Kollef MH, Fuller BM.

Chest. 2017 Nov;152(5):963-971. doi: 10.1016/j.chest.2017.05.041. Epub 2017 Jun 21.


Practice patterns and outcomes associated with early sedation depth in mechanically ventilated patients: a systematic review protocol.

Stephens RJ, Dettmer MR, Roberts BW, Fowler SA, Fuller BM.

BMJ Open. 2017 Jun 9;7(6):e016437. doi: 10.1136/bmjopen-2017-016437.


Effects of Diaphragmatic Breathing Patterns on Balance: A Preliminary Clinical Trial.

Stephens RJ, Haas M, Moore WL 3rd, Emmil JR, Sipress JA, Williams A.

J Manipulative Physiol Ther. 2017 Mar - Apr;40(3):169-175. doi: 10.1016/j.jmpt.2017.01.005. Epub 2017 Mar 1.


Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Ann Emerg Med. 2017 Sep;70(3):406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013. Epub 2017 Mar 2.


A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Crit Care Med. 2017 Apr;45(4):645-652. doi: 10.1097/CCM.0000000000002268.


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

BMJ Open. 2016 Apr 11;6(4):e010991. doi: 10.1136/bmjopen-2015-010991.


Research priorities in mesothelioma: A James Lind Alliance Priority Setting Partnership.

Stephens RJ, Whiting C, Cowan K; James Lind Alliance Mesothelioma Priority Setting Partnership Steering Committee.

Lung Cancer. 2015 Aug;89(2):175-80. doi: 10.1016/j.lungcan.2015.05.021. Epub 2015 Jun 4.


Adjuvant chemotherapy for resected early-stage non-small cell lung cancer.

Burdett S, Pignon JP, Tierney J, Tribodet H, Stewart L, Le Pechoux C, Aupérin A, Le Chevalier T, Stephens RJ, Arriagada R, Higgins JP, Johnson DH, Van Meerbeeck J, Parmar MK, Souhami RL, Bergman B, Douillard JY, Dunant A, Endo C, Girling D, Kato H, Keller SM, Kimura H, Knuuttila A, Kodama K, Komaki R, Kris MG, Lad T, Mineo T, Piantadosi S, Rosell R, Scagliotti G, Seymour LK, Shepherd FA, Sylvester R, Tada H, Tanaka F, Torri V, Waller D, Liang Y; Non‐Small Cell Lung Cancer Collaborative Group.

Cochrane Database Syst Rev. 2015 Mar 2;(3):CD011430. doi: 10.1002/14651858.CD011430. Review.


Lung cancer diagnosis and staging with endobronchial ultrasound-guided transbronchial needle aspiration compared with conventional approaches: an open-label, pragmatic, randomised controlled trial.

Navani N, Nankivell M, Lawrence DR, Lock S, Makker H, Baldwin DR, Stephens RJ, Parmar MK, Spiro SG, Morris S, Janes SM; Lung-BOOST trial investigators.

Lancet Respir Med. 2015 Apr;3(4):282-9. doi: 10.1016/S2213-2600(15)00029-6. Epub 2015 Feb 4.


Factors associated with longer length of stay for mental health emergency department patients.

Stephens RJ, White SE, Cudnik M, Patterson ES.

J Emerg Med. 2014 Oct;47(4):412-9. doi: 10.1016/j.jemermed.2014.04.040. Epub 2014 Jul 26.


Interim results in clinical trials: do we need to keep all interim randomised clinical trial results confidential?

Stephens RJ, Langley RE, Mulvenna P, Nankivell M, Vail A, Parmar MK.

Lung Cancer. 2014 Aug;85(2):116-8. doi: 10.1016/j.lungcan.2014.05.012. Epub 2014 May 22. Review.


Relationship between polysomnographic sleep architecture and behavior in medication-free children with TS, ADHD, TS and ADHD, and controls.

Stephens RJ, Chung SA, Jovanovic D, Guerra R, Stephens B, Sandor P, Shapiro CM.

J Dev Behav Pediatr. 2013 Nov-Dec;34(9):688-96. doi: 10.1097/DBP.0000000000000012.


Interim data from the Medical Research Council QUARTZ Trial: does whole brain radiotherapy affect the survival and quality of life of patients with brain metastases from non-small cell lung cancer?

Langley RE, Stephens RJ, Nankivell M, Pugh C, Moore B, Navani N, Wilson P, Faivre-Finn C, Barton R, Parmar MK, Mulvenna PM; QUARTZ Investigators.

Clin Oncol (R Coll Radiol). 2013 Mar;25(3):e23-30. doi: 10.1016/j.clon.2012.11.002. Epub 2012 Dec 2.


Humans and multitask performance: let's give credit where credit is due.

Stephens RJ, Fairbanks RJ.

Acad Emerg Med. 2012 Feb;19(2):232-4. doi: 10.1111/j.1553-2712.2011.01264.x. No abstract available.


Chemotherapy dose reductions in obese patients with colorectal cancer.

Chambers P, Daniels SH, Thompson LC, Stephens RJ.

Ann Oncol. 2012 Mar;23(3):748-53. doi: 10.1093/annonc/mdr277. Epub 2011 Jun 6.


Impact of short-course preoperative radiotherapy for rectal cancer on patients' quality of life: data from the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial.

Stephens RJ, Thompson LC, Quirke P, Steele R, Grieve R, Couture J, Griffiths GO, Sebag-Montefiore D.

J Clin Oncol. 2010 Sep 20;28(27):4233-9. doi: 10.1200/JCO.2009.26.5264. Epub 2010 Jun 28.


Inaccurate clinical nodal staging of non-small cell lung cancer: evidence from the MRC LU22 multicentre randomised trial.

Navani N, Nankivell M, Stephens RJ, Parmar MK, Gilligan D, Nicolson M, Groen HJ, van Meerbeeck JP.

Thorax. 2010 May;65(5):463. doi: 10.1136/thx.2009.118471. No abstract available.


Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data.

NSCLC Meta-analyses Collaborative Group, Arriagada R, Auperin A, Burdett S, Higgins JP, Johnson DH, Le Chevalier T, Le Pechoux C, Parmar MK, Pignon JP, Souhami RL, Stephens RJ, Stewart LA, Tierney JF, Tribodet H, van Meerbeeck J.

Lancet. 2010 Apr 10;375(9722):1267-77. doi: 10.1016/S0140-6736(10)60059-1. Epub 2010 Mar 24.


The strength of female sex as a prognostic factor in small-cell lung cancer: a pooled analysis of chemotherapy trials from the Manchester Lung Group and Medical Research Council Clinical Trials Unit.

Wheatley-Price P, Ma C, Ashcroft LF, Nankivell M, Stephens RJ, White SC, Lorigan P, Thatcher N, Blackhall FH, Shepherd FA.

Ann Oncol. 2010 Feb;21(2):232-7. doi: 10.1093/annonc/mdp300. Epub 2009 Aug 12.


Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial.

Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J, O'Callaghan C, Myint AS, Bessell E, Thompson LC, Parmar M, Stephens RJ, Sebag-Montefiore D; MRC CR07/NCIC-CTG CO16 Trial Investigators; NCRI Colorectal Cancer Study Group.

Lancet. 2009 Mar 7;373(9666):821-8. doi: 10.1016/S0140-6736(09)60485-2.


Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial.

Sebag-Montefiore D, Stephens RJ, Steele R, Monson J, Grieve R, Khanna S, Quirke P, Couture J, de Metz C, Myint AS, Bessell E, Griffiths G, Thompson LC, Parmar M.

Lancet. 2009 Mar 7;373(9666):811-20. doi: 10.1016/S0140-6736(09)60484-0.


Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer.

Sargent DJ, Köhne CH, Sanoff HK, Bot BM, Seymour MT, de Gramont A, Porschen R, Saltz LB, Rougier P, Tournigand C, Douillard JY, Stephens RJ, Grothey A, Goldberg RM.

J Clin Oncol. 2009 Apr 20;27(12):1948-55. doi: 10.1200/JCO.2008.20.2879. Epub 2009 Mar 2. Erratum in: J Clin Oncol. 2009 Jul 10;27(20):3410-1.


Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.

Braun MS, Richman SD, Quirke P, Daly C, Adlard JW, Elliott F, Barrett JH, Selby P, Meade AM, Stephens RJ, Parmar MK, Seymour MT.

J Clin Oncol. 2008 Jun 1;26(16):2690-8. doi: 10.1200/JCO.2007.15.5580. Erratum in: J Clin Oncol. 2008 Sep 10;26(26):4363.


Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group.

Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ, Dunant A, Torri V, Rosell R, Seymour L, Spiro SG, Rolland E, Fossati R, Aubert D, Ding K, Waller D, Le Chevalier T; LACE Collaborative Group.

J Clin Oncol. 2008 Jul 20;26(21):3552-9. doi: 10.1200/JCO.2007.13.9030. Epub 2008 May 27.


Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial.

Muers MF, Stephens RJ, Fisher P, Darlison L, Higgs CM, Lowry E, Nicholson AG, O'Brien M, Peake M, Rudd R, Snee M, Steele J, Girling DJ, Nankivell M, Pugh C, Parmar MK; MS01 Trial Management Group.

Lancet. 2008 May 17;371(9625):1685-94. doi: 10.1016/S0140-6736(08)60727-8.


Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials.

Folprecht G, Seymour MT, Saltz L, Douillard JY, Hecker H, Stephens RJ, Maughan TS, Van Cutsem E, Rougier P, Mitry E, Schubert U, Köhne CH.

J Clin Oncol. 2008 Mar 20;26(9):1443-51. doi: 10.1200/JCO.2007.14.0509.


Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial.

Seymour MT, Maughan TS, Ledermann JA, Topham C, James R, Gwyther SJ, Smith DB, Shepherd S, Maraveyas A, Ferry DR, Meade AM, Thompson L, Griffiths GO, Parmar MK, Stephens RJ; FOCUS Trial Investigators; National Cancer Research Institute Colorectal Clinical Studies Group.

Lancet. 2007 Jul 14;370(9582):143-152. doi: 10.1016/S0140-6736(07)61087-3. Erratum in: Lancet. 2007 Aug 18;370(9587):566.


Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial.

Dearnaley DP, Sydes MR, Graham JD, Aird EG, Bottomley D, Cowan RA, Huddart RA, Jose CC, Matthews JH, Millar J, Moore AR, Morgan RC, Russell JM, Scrase CD, Stephens RJ, Syndikus I, Parmar MK; RT01 collaborators.

Lancet Oncol. 2007 Jun;8(6):475-87.


The early toxicity of escalated versus standard dose conformal radiotherapy with neo-adjuvant androgen suppression for patients with localised prostate cancer: results from the MRC RT01 trial (ISRCTN47772397).

Dearnaley DP, Sydes MR, Langley RE, Graham JD, Huddart RA, Syndikus I, Matthews JH, Scrase CD, Jose CC, Logue J, Stephens RJ; RT01 Collaborators.

Radiother Oncol. 2007 Apr;83(1):31-41. Epub 2007 Mar 27.


Lung cancer management in limited resource settings: guidelines for appropriate good care.

Macbeth FR, Abratt RP, Cho KH, Stephens RJ, Jeremic B; International Atomic Energy Agency.

Radiother Oncol. 2007 Feb;82(2):123-31. Epub 2007 Jan 19.


A comparison of statistical tests for detecting differential expression using Affymetrix oligonucleotide microarrays.

Vardhanabhuti S, Blakemore SJ, Clark SM, Ghosh S, Stephens RJ, Rajagopalan D.

OMICS. 2006 Winter;10(4):555-66.


The quality of life of men with locally advanced prostate cancer during neoadjuvant hormone therapy: data from the Medical Research Council RT01 trial (ISRCTN 47772397).

Stephens RJ, Dearnaley DP, Cowan R, Sydes M, Naylor S, Fallowfield L; RT01 collaborators.

BJU Int. 2007 Feb;99(2):301-10. Epub 2006 Nov 28.


Assessment of quality of life in the supportive care setting of the big lung trial in non-small-cell lung cancer.

Brown J, Thorpe H, Napp V, Fairlamb DJ, Gower NH, Milroy R, Parmar MK, Rudd RM, Spiro SG, Stephens RJ, Waller D, West P, Peake MD.

J Clin Oncol. 2005 Oct 20;23(30):7417-27. Epub 2005 Sep 12.


A randomised controlled trial of pre-operative chemotherapy followed, if feasible, by resection versus radiotherapy in patients with inoperable stage T3, N1, M0 or T1-3, N2, M0 non-small cell lung cancer.

Stephens RJ, Girling DJ, Hopwood P, Thatcher N; Medical Research Council Lung Cancer Working Party.

Lung Cancer. 2005 Sep;49(3):395-400.


Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life.

Spiro SG, Rudd RM, Souhami RL, Brown J, Fairlamb DJ, Gower NH, Maslove L, Milroy R, Napp V, Parmar MK, Peake MD, Stephens RJ, Thorpe H, Waller DA, West P; Big Lung Trial participants.

Thorax. 2004 Oct;59(10):828-36.


Olanzapine in the treatment of aggression and tics in children with Tourette's syndrome--a pilot study.

Stephens RJ, Bassel C, Sandor P.

J Child Adolesc Psychopharmacol. 2004 Summer;14(2):255-66.


Implementing the UK Medical Research Council (MRC) RT01 trial (ISRCTN 47772397): methods and practicalities of a randomised controlled trial of conformal radiotherapy in men with localised prostate cancer.

Sydes MR, Stephens RJ, Moore AR, Aird EG, Bidmead AM, Fallowfield LJ, Graham J, Griffiths S, Mayles WP, McGuire A, Stanley S, Warrington AP, Dearnaley DP; RT01 collaborators.

Radiother Oncol. 2004 Aug;72(2):199-211.


Chemotherapy for patients with non-small cell lung cancer: the surgical setting of the Big Lung Trial.

Waller D, Peake MD, Stephens RJ, Gower NH, Milroy R, Parmar MK, Rudd RM, Spiro SG.

Eur J Cardiothorac Surg. 2004 Jul;26(1):173-82.


Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation.

Sherwin JR, Freeman TC, Stephens RJ, Kimber S, Smith AG, Chambers I, Smith SK, Sharkey AM.

Mol Endocrinol. 2004 Sep;18(9):2185-95. Epub 2004 Jun 3.


Comparison of intermittent and continuous palliative chemotherapy for advanced colorectal cancer: a multicentre randomised trial.

Maughan TS, James RD, Kerr DJ, Ledermann JA, Seymour MT, Topham C, McArdle C, Cain D, Stephens RJ; Medical Research Council Colorectal Cancer Group.

Lancet. 2003 Feb 8;361(9356):457-64.


Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial.

Kerr DJ, McArdle CS, Ledermann J, Taylor I, Sherlock DJ, Schlag PM, Buckels J, Mayer D, Cain D, Stephens RJ; Medical Research Council's colorectal cancer study group; European Organisation for Research and Treatment of Cancer colorectal cancer study group.

Lancet. 2003 Feb 1;361(9355):368-73.


Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms: randomised controlled trial.

Falk SJ, Girling DJ, White RJ, Hopwood P, Harvey A, Qian W, Stephens RJ; Medical Research Council Lung Cancer Working Party.

BMJ. 2002 Aug 31;325(7362):465.


Costs and consequences of different chemotherapy regimens in metastatic colorectal cancer.

Hale JP, Cohen DR, Maughan TS, Stephens RJ.

Br J Cancer. 2002 Jun 5;86(11):1684-90.


Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial.

Maughan TS, James RD, Kerr DJ, Ledermann JA, McArdle C, Seymour MT, Cohen D, Hopwood P, Johnston C, Stephens RJ; British MRC Colorectal Cancer Working Party.

Lancet. 2002 May 4;359(9317):1555-63.


Comparative mapping of the human 9q34 region in Fugu rubripes.

Bouchireb N, Grützner F, Haaf T, Stephens RJ, Elgar G, Green AJ, Clark MS.

Cytogenet Cell Genet. 2001;94(3-4):173-9.


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