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Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.

Suire S, Baltanas FC, Segonds-Pichon A, Davidson K, Santos E, Hawkins PT, Stephens LR.

J Leukoc Biol. 2019 Oct;106(4):815-822. doi: 10.1002/JLB.2HI0918-359RR. Epub 2019 Feb 5.


Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.

Gyori D, Lim EL, Grant FM, Spensberger D, Roychoudhuri R, Shuttleworth SJ, Okkenhaug K, Stephens LR, Hawkins PT.

JCI Insight. 2018 Jun 7;3(11). pii: 120631. doi: 10.1172/jci.insight.120631. eCollection 2018 Jun 7.


In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF, Hers I.

Blood Adv. 2017 Jun 13;1(14):918-932. doi: 10.1182/bloodadvances.2017005173.


PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Novère N, Sasaki T, Clark J, Hawkins PT, Stephens LR.

Mol Cell. 2017 Nov 2;68(3):566-580.e10. doi: 10.1016/j.molcel.2017.09.024. Epub 2017 Oct 19.


Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.

Gyori D, Chessa T, Hawkins PT, Stephens LR.

Cancers (Basel). 2017 Mar 4;9(3). pii: E24. doi: 10.3390/cancers9030024. Review.


cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR, Hawkins PT, Sebo P.

J Immunol. 2017 Feb 1;198(3):1285-1296. doi: 10.4049/jimmunol.1601309. Epub 2016 Dec 30.


In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH, Anderson KE, Stephens LR, Hawkins PT, Irvine RF.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10571-6. doi: 10.1073/pnas.1522478113. Epub 2016 Sep 6.


Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.

Ross SH, Rollings C, Anderson KE, Hawkins PT, Stephens LR, Cantrell DA.

Immunity. 2016 Sep 20;45(3):685-700. doi: 10.1016/j.immuni.2016.07.022. Epub 2016 Aug 23.


Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.

Houslay DM, Anderson KE, Chessa T, Kulkarni S, Fritsch R, Downward J, Backer JM, Stephens LR, Hawkins PT.

Sci Signal. 2016 Aug 16;9(441):ra82. doi: 10.1126/scisignal.aae0453.


Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.

Hawkins PT, Stephens LR.

Biochem Soc Trans. 2016 Feb;44(1):307-14. doi: 10.1042/BST20150248. Review.


Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.

Anderson KE, Juvin V, Clark J, Stephens LR, Hawkins PT.

Adv Biol Regul. 2016 Sep;62:18-24. doi: 10.1016/j.jbior.2015.11.002. Epub 2015 Nov 14.


The cytotoxic T cell proteome and its shaping by the kinase mTOR.

Hukelmann JL, Anderson KE, Sinclair LV, Grzes KM, Murillo AB, Hawkins PT, Stephens LR, Lamond AI, Cantrell DA.

Nat Immunol. 2016 Jan;17(1):104-12. doi: 10.1038/ni.3314. Epub 2015 Nov 9.


The regulatory subunits of PI3Kγ control distinct neutrophil responses.

Deladeriere A, Gambardella L, Pan D, Anderson KE, Hawkins PT, Stephens LR.

Sci Signal. 2015 Jan 20;8(360):ra8. doi: 10.1126/scisignal.2005564.


PI3K signalling in inflammation.

Hawkins PT, Stephens LR.

Biochim Biophys Acta. 2015 Jun;1851(6):882-97. doi: 10.1016/j.bbalip.2014.12.006. Epub 2014 Dec 13. Review.


Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.

Clark J, Kay RR, Kielkowska A, Niewczas I, Fets L, Oxley D, Stephens LR, Hawkins PT.

EMBO J. 2014 Oct 1;33(19):2188-200. doi: 10.15252/embj.201488677. Epub 2014 Sep 1.


The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation.

Jones DR, Keune WJ, Anderson KE, Stephens LR, Hawkins PT, Divecha N.

FEBS J. 2014 Aug;281(16):3591-608. doi: 10.1111/febs.12879. Epub 2014 Jul 14.


BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.

Potter DS, Kelly P, Denneny O, Juvin V, Stephens LR, Dive C, Morrow CJ.

Neoplasia. 2014 Feb;16(2):147-57. doi: 10.1593/neo.131376.


P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.

Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT.

J Cell Sci. 2014 Jun 1;127(Pt 11):2589-600. doi: 10.1242/jcs.153049. Epub 2014 Mar 21.


Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.

Hodakoski C, Hopkins BD, Barrows D, Mense SM, Keniry M, Anderson KE, Kern PA, Hawkins PT, Stephens LR, Parsons R.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):155-60. doi: 10.1073/pnas.1213773111. Epub 2013 Dec 23.


Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines.

Juvin V, Malek M, Anderson KE, Dion C, Chessa T, Lecureuil C, Ferguson GJ, Cosulich S, Hawkins PT, Stephens LR.

PLoS One. 2013 Oct 4;8(10):e75045. doi: 10.1371/journal.pone.0075045. eCollection 2013.


A new approach to measuring phosphoinositides in cells by mass spectrometry.

Kielkowska A, Niewczas I, Anderson KE, Durrant TN, Clark J, Stephens LR, Hawkins PT.

Adv Biol Regul. 2014 Jan;54:131-41. doi: 10.1016/j.jbior.2013.09.001. Epub 2013 Sep 17. Review.


3D time series analysis of cell shape using Laplacian approaches.

Du CJ, Hawkins PT, Stephens LR, Bretschneider T.

BMC Bioinformatics. 2013 Oct 4;14:296. doi: 10.1186/1471-2105-14-296.


Two distinct functions for PI3-kinases in macropinocytosis.

Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR.

J Cell Sci. 2013 Sep 15;126(Pt 18):4296-307. doi: 10.1242/jcs.134015. Epub 2013 Jul 10.


Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.

Anderson KE, Kielkowska A, Durrant TN, Juvin V, Clark J, Stephens LR, Hawkins PT.

PLoS One. 2013;8(3):e58425. doi: 10.1371/journal.pone.0058425. Epub 2013 Mar 5.


Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus.

Boyle KB, Stephens LR, Hawkins PT.

Ann N Y Acad Sci. 2012 Dec;1273:68-73. doi: 10.1111/j.1749-6632.2012.06821.x.


Radiological versus clinical evidence of malrotation, a tortuous tale--10-year review.

Stephens LR, Donoghue V, Gillick J.

Eur J Pediatr Surg. 2012 Jun;22(3):238-42. doi: 10.1055/s-0032-1308707. Epub 2012 May 8.


PI3Kβ plays a critical role in neutrophil activation by immune complexes.

Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F, Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT.

Sci Signal. 2011 Apr 12;4(168):ra23. doi: 10.1126/scisignal.2001617.


Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Zhang X, Vadas O, Perisic O, Anderson KE, Clark J, Hawkins PT, Stephens LR, Williams RL.

Mol Cell. 2011 Mar 4;41(5):567-78. doi: 10.1016/j.molcel.2011.01.026.


Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

Clark J, Anderson KE, Juvin V, Smith TS, Karpe F, Wakelam MJ, Stephens LR, Hawkins PT.

Nat Methods. 2011 Mar;8(3):267-72. doi: 10.1038/nmeth.1564. Epub 2011 Jan 30.


Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.

Boyle KB, Gyori D, Sindrilaru A, Scharffetter-Kochanek K, Taylor PR, Mócsai A, Stephens LR, Hawkins PT.

J Immunol. 2011 Mar 1;186(5):2978-89. doi: 10.4049/jimmunol.1002268. Epub 2011 Jan 21.


Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.

Chessa TA, Anderson KE, Hu Y, Xu Q, Rausch O, Stephens LR, Hawkins PT.

Blood. 2010 Dec 23;116(26):6027-36. doi: 10.1182/blood-2010-08-300889. Epub 2010 Sep 22.


PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.

Anderson KE, Chessa TA, Davidson K, Henderson RB, Walker S, Tolmachova T, Grys K, Rausch O, Seabra MC, Tybulewicz VL, Stephens LR, Hawkins PT.

Blood. 2010 Dec 2;116(23):4978-89. doi: 10.1182/blood-2010-03-275602. Epub 2010 Sep 2.


PI3K signaling in neutrophils.

Hawkins PT, Stephens LR, Suire S, Wilson M.

Curr Top Microbiol Immunol. 2010;346:183-202. doi: 10.1007/82_2010_40. Review.


Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.

Conway SJ, Gardiner J, Grove SJ, Johns MK, Lim ZY, Painter GF, Robinson DE, Schieber C, Thuring JW, Wong LS, Yin MX, Burgess AW, Catimel B, Hawkins PT, Ktistakis NT, Stephens LR, Holmes AB.

Org Biomol Chem. 2010 Jan 7;8(1):66-76. doi: 10.1039/b913399b. Epub 2009 Nov 9.


CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.

Anderson KE, Boyle KB, Davidson K, Chessa TA, Kulkarni S, Jarvis GE, Sindrilaru A, Scharffetter-Kochanek K, Rausch O, Stephens LR, Hawkins PT.

Blood. 2008 Dec 15;112(13):5202-11. doi: 10.1182/blood-2008-04-149450. Epub 2008 Aug 28.


Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate.

Guillou H, Stephens LR, Hawkins PT.

Methods Enzymol. 2007;434:117-30.


PI3K class IB pathway in neutrophils.

Andrews S, Stephens LR, Hawkins PT.

Sci STKE. 2007 Oct 9;2007(407):cm3. Review.


PI3K class IB pathway.

Andrews S, Stephens LR, Hawkins PT.

Sci STKE. 2007 Oct 9;2007(407):cm2. Review.


PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis.

Hawkins PT, Stephens LR.

Science. 2007 Oct 5;318(5847):64-6.


The role of PI3Ks in the regulation of the neutrophil NADPH oxidase.

Hawkins PT, Davidson K, Stephens LR.

Biochem Soc Symp. 2007;(74):59-67. Review.


Structural determinants of LL5beta subcellular localisation and association with filamin C.

Paranavitane V, Stephens LR, Hawkins PT.

Cell Signal. 2007 Apr;19(4):817-24. Epub 2006 Dec 14.


Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach.

Guillou H, Lécureuil C, Anderson KE, Suire S, Ferguson GJ, Ellson CD, Gray A, Divecha N, Hawkins PT, Stephens LR.

J Lipid Res. 2007 Mar;48(3):726-32. Epub 2006 Nov 27.


Signalling through Class I PI3Ks in mammalian cells.

Hawkins PT, Anderson KE, Davidson K, Stephens LR.

Biochem Soc Trans. 2006 Nov;34(Pt 5):647-62. Review.


PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation.

Ellson C, Davidson K, Anderson K, Stephens LR, Hawkins PT.

EMBO J. 2006 Oct 4;25(19):4468-78. Epub 2006 Sep 21.


Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.

Ellson CD, Davidson K, Ferguson GJ, O'Connor R, Stephens LR, Hawkins PT.

J Exp Med. 2006 Aug 7;203(8):1927-37. Epub 2006 Jul 31.


RhoG regulates the neutrophil NADPH oxidase.

Condliffe AM, Webb LM, Ferguson GJ, Davidson K, Turner M, Vigorito E, Manifava M, Chilvers ER, Stephens LR, Hawkins PT.

J Immunol. 2006 May 1;176(9):5314-20.


P-Rex1 regulates neutrophil function.

Welch HC, Condliffe AM, Milne LJ, Ferguson GJ, Hill K, Webb LM, Okkenhaug K, Coadwell WJ, Andrews SR, Thelen M, Jones GE, Hawkins PT, Stephens LR.

Curr Biol. 2005 Oct 25;15(20):1867-73.


Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.

Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT.

Blood. 2005 Aug 15;106(4):1432-40. Epub 2005 May 5.


Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.

Hill K, Krugmann S, Andrews SR, Coadwell WJ, Finan P, Welch HC, Hawkins PT, Stephens LR.

J Biol Chem. 2005 Feb 11;280(6):4166-73. Epub 2004 Nov 15.


P-Rex2, a new guanine-nucleotide exchange factor for Rac.

Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, Andrews SR, Walker SA, Hawkins PT, Stephens LR, Welch HC.

FEBS Lett. 2004 Aug 13;572(1-3):172-6.

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