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Items: 1 to 50 of 110


Epidemiology and effects of fluid bolus administration in the paediatric emergency department.

Solan T, Stephens DJ, Williams A, Babl FE, Long E.

Emerg Med Australas. 2019 Dec 23. doi: 10.1111/1742-6723.13437. [Epub ahead of print]


ER-to-Golgi Transport: A Sizeable Problem.

McCaughey J, Stephens DJ.

Trends Cell Biol. 2019 Dec;29(12):940-953. doi: 10.1016/j.tcb.2019.08.007. Epub 2019 Oct 17. Review.


Developing pathways to clarify pathogenicity of unclassified variants in Osteogenesis Imperfecta genetic analysis.

Balasubramanian M, Hobson E, Skae M, McCaughey J, Stephens DJ.

Mol Genet Genomic Med. 2019 Dec;7(12):e912. doi: 10.1002/mgg3.912. Epub 2019 Sep 30.


Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Gerondopoulos A, Strutt H, Stevenson NL, Sobajima T, Levine TP, Stephens DJ, Strutt D, Barr FA.

Curr Biol. 2019 Oct 7;29(19):3323-3330.e8. doi: 10.1016/j.cub.2019.07.090. Epub 2019 Sep 26.


ER-to-Golgi trafficking of procollagen in the absence of large carriers.

McCaughey J, Stevenson NL, Cross S, Stephens DJ.

J Cell Biol. 2019 Mar 4;218(3):929-948. doi: 10.1083/jcb.201806035. Epub 2018 Dec 26.


Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.

Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ.

Elife. 2018 Oct 16;7. pii: e39655. doi: 10.7554/eLife.39655.


COPII-dependent ER export in animal cells: adaptation and control for diverse cargo.

McCaughey J, Stephens DJ.

Histochem Cell Biol. 2018 Aug;150(2):119-131. doi: 10.1007/s00418-018-1689-2. Epub 2018 Jun 18. Review.


Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.

Stevenson NL, Bergen DJM, Xu A, Wyatt E, Henry F, McCaughey J, Vuolo L, Hammond CL, Stephens DJ.

J Cell Sci. 2018 May 4;131(9). pii: jcs212258. doi: 10.1242/jcs.212258.


P4HB recurrent missense mutation causing Cole-Carpenter syndrome.

Balasubramanian M, Padidela R, Pollitt RC, Bishop NJ, Mughal MZ, Offiah AC, Wagner BE, McCaughey J, Stephens DJ.

J Med Genet. 2018 Mar;55(3):158-165. doi: 10.1136/jmedgenet-2017-104899. Epub 2017 Dec 20.


Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.

Stevenson NL, Bergen DJM, Skinner REH, Kague E, Martin-Silverstone E, Robson Brown KA, Hammond CL, Stephens DJ.

J Cell Sci. 2017 Dec 15;130(24):4132-4143. doi: 10.1242/jcs.212308. Epub 2017 Nov 1.


Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity.

Evans AJ, Gurung S, Wilkinson KA, Stephens DJ, Henley JM.

Cell Rep. 2017 Jun 20;19(12):2613-2626. doi: 10.1016/j.celrep.2017.06.001.


The Golgi matrix protein giantin is required for normal cilia function in zebrafish.

Bergen DJM, Stevenson NL, Skinner REH, Stephens DJ, Hammond CL.

Biol Open. 2017 Aug 15;6(8):1180-1189. doi: 10.1242/bio.025502.


TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion.

McCaughey J, Miller VJ, Stevenson NL, Brown AK, Budnik A, Heesom KJ, Alibhai D, Stephens DJ.

Cell Rep. 2016 May 24;15(8):1648-59. doi: 10.1016/j.celrep.2016.04.062. Epub 2016 May 12.


Identification of an Immunogenic Subset of Metastatic Uveal Melanoma.

Rothermel LD, Sabesan AC, Stephens DJ, Chandran SS, Paria BC, Srivastava AK, Somerville R, Wunderlich JR, Lee CC, Xi L, Pham TH, Raffeld M, Jailwala P, Kasoji M, Kammula US.

Clin Cancer Res. 2016 May 1;22(9):2237-49. doi: 10.1158/1078-0432.CCR-15-2294. Epub 2015 Dec 28.


Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event.

Boal F, Hodgson LR, Reed SE, Yarwood SE, Just VJ, Stephens DJ, McCaffrey MW, Tavaré JM.

Cell Signal. 2016 Jan;28(1):74-82. doi: 10.1016/j.cellsig.2015.10.014. Epub 2015 Oct 26.


Tumor-Specific Effector CD8+ T Cells That Can Establish Immunological Memory in Humans after Adoptive Transfer Are Marked by Expression of IL7 Receptor and c-myc.

Chandran SS, Paria BC, Srivastava AK, Rothermel LD, Stephens DJ, Kammula US.

Cancer Res. 2015 Aug 15;75(16):3216-26. doi: 10.1158/0008-5472.CAN-15-0584. Epub 2015 Jun 22.


Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans.

Chandran SS, Paria BC, Srivastava AK, Rothermel LD, Stephens DJ, Dudley ME, Somerville R, Wunderlich JR, Sherry RM, Yang JC, Rosenberg SA, Kammula US.

Clin Cancer Res. 2015 Feb 1;21(3):534-43. doi: 10.1158/1078-0432.CCR-14-2208. Epub 2014 Nov 25.


Subunit composition of the human cytoplasmic dynein-2 complex.

Asante D, Stevenson NL, Stephens DJ.

J Cell Sci. 2014 Nov 1;127(Pt 21):4774-87. doi: 10.1242/jcs.159038. Epub 2014 Sep 9.


Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation.

Bonavita R, Walas D, Brown AK, Luini A, Stephens DJ, Colanzi A.

Biol Cell. 2014 Aug;106(8):254-67. doi: 10.1111/boc.201300087. Epub 2014 Jul 9.


Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport.

Brown AK, Hunt SD, Stephens DJ.

Biol Open. 2014 Apr 4;3(5):307-13. doi: 10.1242/bio.20147633.


Human melanoma metastases demonstrate nonstochastic site-specific antigen heterogeneity that correlates with T-cell infiltration.

Bartlett EK, Fetsch PA, Filie AC, Abati A, Steinberg SM, Wunderlich JR, White DE, Stephens DJ, Marincola FM, Rosenberg SA, Kammula US.

Clin Cancer Res. 2014 May 15;20(10):2607-2616. doi: 10.1158/1078-0432.CCR-13-2690. Epub 2014 Mar 19.


The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

Fryer LG, Jones B, Duncan EJ, Hutchison CE, Ozkan T, Williams PA, Alder O, Nieuwdorp M, Townley AK, Mensenkamp AR, Stephens DJ, Dallinga-Thie GM, Shoulders CC.

J Biol Chem. 2014 Feb 14;289(7):4244-61. doi: 10.1074/jbc.M113.479980. Epub 2013 Dec 13.


RNA interference approaches to examine Golgi function in animal cell culture.

Miller VJ, McKinnon CM, Mellor H, Stephens DJ.

Methods Cell Biol. 2013;118:15-34. doi: 10.1016/B978-0-12-417164-0.00002-1.


A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.

Asante D, Maccarthy-Morrogh L, Townley AK, Weiss MA, Katayama K, Palmer KJ, Suzuki H, Westlake CJ, Stephens DJ.

J Cell Sci. 2013 Nov 15;126(Pt 22):5189-97. doi: 10.1242/jcs.131664. Epub 2013 Sep 17.


A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection.

Midgley R, Moffat K, Berryman S, Hawes P, Simpson J, Fullen D, Stephens DJ, Burman A, Jackson T.

J Gen Virol. 2013 Dec;94(Pt 12):2636-46. doi: 10.1099/vir.0.055442-0. Epub 2013 Aug 20.


Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis.

Satchwell TJ, Pellegrin S, Bianchi P, Hawley BR, Gampel A, Mordue KE, Budnik A, Fermo E, Barcellini W, Stephens DJ, van den Akker E, Toye AM.

Haematologica. 2013 Nov;98(11):1788-96. doi: 10.3324/haematol.2013.085522. Epub 2013 Aug 9.


Membrane contact sites--an interesting species, an interesting mix.

Miller VJ, Stephens DJ.

EMBO Rep. 2013 May;14(5):396-7. doi: 10.1038/embor.2013.43. Epub 2013 Apr 5. No abstract available.


Microtubule motors mediate endosomal sorting by maintaining functional domain organization.

Hunt SD, Townley AK, Danson CM, Cullen PJ, Stephens DJ.

J Cell Sci. 2013 Jun 1;126(Pt 11):2493-501. doi: 10.1242/jcs.122317. Epub 2013 Apr 2.


Early stages of retinal development depend on Sec13 function.

Schmidt K, Cavodeassi F, Feng Y, Stephens DJ.

Biol Open. 2013 Mar 15;2(3):256-66. doi: 10.1242/bio.20133251. Epub 2013 Jan 10.


Clostridium difficile infection in the pediatric surgery population.

Chen KT, Stephens DJ, Anderson E, Acton R, Saltzman D, Hess DJ.

J Pediatr Surg. 2012 Jul;47(7):1385-9. doi: 10.1016/j.jpedsurg.2011.12.001.


Functional coupling of microtubules to membranes - implications for membrane structure and dynamics.

Stephens DJ.

J Cell Sci. 2012 Jun 15;125(Pt 12):2795-804. doi: 10.1242/jcs.097675. Epub 2012 Jun 26.


Cell biology: Collagen secretion explained.

Stephens DJ.

Nature. 2012 Feb 22;482(7386):474-5. doi: 10.1038/482474a. No abstract available.


Characterization of human Sec16B: indications of specialized, non-redundant functions.

Budnik A, Heesom KJ, Stephens DJ.

Sci Rep. 2011;1:77. doi: 10.1038/srep00077. Epub 2011 Aug 30.


Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.

Townley AK, Schmidt K, Hodgson L, Stephens DJ.

J Cell Sci. 2012 Feb 1;125(Pt 3):673-84. doi: 10.1242/jcs.091355. Epub 2012 Feb 13.


The role of motor proteins in endosomal sorting.

Hunt SD, Stephens DJ.

Biochem Soc Trans. 2011 Oct;39(5):1179-84. doi: 10.1042/BST0391179. Review.


A role for Tctex-1 (DYNLT1) in controlling primary cilium length.

Palmer KJ, MacCarthy-Morrogh L, Smyllie N, Stephens DJ.

Eur J Cell Biol. 2011 Oct;90(10):865-71. doi: 10.1016/j.ejcb.2011.05.003. Epub 2011 Jun 22.


What will become of the general surgeon?

Stephens DJ, Wang WN, Wallack MK.

Am Surg. 2011 Mar;77(3):270-2. No abstract available.


Cargo loading at the ER.

Schmidt K, Stephens DJ.

Mol Membr Biol. 2010 Nov;27(8):398-411. doi: 10.3109/09687688.2010.506203. Review.


Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis.

Hughes H, Stephens DJ.

J Cell Sci. 2010 Dec 1;123(Pt 23):4032-8. doi: 10.1242/jcs.076000. Epub 2010 Nov 2.


LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells.

Boal F, Guetzoyan L, Sessions RB, Zeghouf M, Spooner RA, Lord JM, Cherfils J, Clarkson GJ, Roberts LM, Stephens DJ.

Traffic. 2010 Dec;11(12):1537-51. doi: 10.1111/j.1600-0854.2010.01122.x. Epub 2010 Oct 15.


Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells.

Guetzoyan LJ, Spooner RA, Boal F, Stephens DJ, Lord JM, Roberts LM, Clarkson GJ.

Mol Biosyst. 2010 Oct;6(10):2030-8. doi: 10.1039/c0mb00035c. Epub 2010 Aug 9.


Specific functions of BIG1 and BIG2 in endomembrane organization.

Boal F, Stephens DJ.

PLoS One. 2010 Mar 25;5(3):e9898. doi: 10.1371/journal.pone.0009898.


ER exit sites--localization and control of COPII vesicle formation.

Budnik A, Stephens DJ.

FEBS Lett. 2009 Dec 3;583(23):3796-803. doi: 10.1016/j.febslet.2009.10.038. Epub 2009 Oct 20. Review.


Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

Hughes H, Budnik A, Schmidt K, Palmer KJ, Mantell J, Noakes C, Johnson A, Carter DA, Verkade P, Watson P, Stephens DJ.

J Cell Sci. 2009 Aug 15;122(Pt 16):2924-34. doi: 10.1242/jcs.044032. Epub 2009 Jul 28.


The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.

Wassmer T, Attar N, Harterink M, van Weering JR, Traer CJ, Oakley J, Goud B, Stephens DJ, Verkade P, Korswagen HC, Cullen PJ.

Dev Cell. 2009 Jul;17(1):110-22. doi: 10.1016/j.devcel.2009.04.016.


Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps.

Palmer KJ, Hughes H, Stephens DJ.

Mol Biol Cell. 2009 Jun;20(12):2885-99. doi: 10.1091/mbc.E08-12-1160. Epub 2009 Apr 22.


Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport.

Gupta V, Palmer KJ, Spence P, Hudson A, Stephens DJ.

Traffic. 2008 Nov;9(11):1850-66. doi: 10.1111/j.1600-0854.2008.00811.x. Epub 2008 Aug 9.


Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.

Townley AK, Feng Y, Schmidt K, Carter DA, Porter R, Verkade P, Stephens DJ.

J Cell Sci. 2008 Sep 15;121(Pt 18):3025-34. doi: 10.1242/jcs.031070. Epub 2008 Aug 19.


The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

Spooner RA, Watson P, Smith DC, Boal F, Amessou M, Johannes L, Clarkson GJ, Lord JM, Stephens DJ, Roberts LM.

Biochem J. 2008 Sep 15;414(3):471-84. doi: 10.1042/BJ20080149.

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