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Items: 25

1.

Attaining in vivo selectivity of positive modulation of α3βγ2 GABAA receptors in rats: A hard task!

Batinić B, Stanković T, Stephen MR, Kodali R, Tiruveedhula VV, Li G, Scholze P, Marković BD, Obradović AL, Ernst M, Cook JM, Savić MM.

Eur Neuropsychopharmacol. 2018 Aug;28(8):903-914. doi: 10.1016/j.euroneuro.2018.05.014. Epub 2018 Jun 19.

PMID:
29891214
2.

Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys.

Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK.

J Pharmacol Exp Ther. 2018 Jul;366(1):145-157. doi: 10.1124/jpet.118.249250. Epub 2018 May 2.

PMID:
29720564
3.

A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.

Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2018 May 7;15(5):1766-1777. doi: 10.1021/acs.molpharmaceut.7b01013. Epub 2018 Apr 2.

PMID:
29578347
4.

Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.

Knutson DE, Kodali R, Divović B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, Mihovilovic MD, Savić MM, Sieghart W, Cook JM.

J Med Chem. 2018 Mar 22;61(6):2422-2446. doi: 10.1021/acs.jmedchem.7b01664. Epub 2018 Mar 6.

PMID:
29481759
5.

Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents.

Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, Cook J, Garman RH, Jortner B, Bolon B, Radin D, Lippa A.

Toxicol Sci. 2018 Apr 1;162(2):383-395. doi: 10.1093/toxsci/kfx277.

PMID:
29253237
6.

Concise Total Synthesis of (-)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (-)-Macrogentine, (+)-Na -Demethylalstonisine, (-)-Alstonoxine A, and (+)-Alstonisine.

Stephen MR, Rahman MT, Tiruveedhula VVNPB, Fonseca GO, Deschamps JR, Cook JM.

Chemistry. 2017 Nov 7;23(62):15805-15819. doi: 10.1002/chem.201703572. Epub 2017 Oct 18.

7.

Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators.

Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2017 Jun 5;14(6):2088-2098. doi: 10.1021/acs.molpharmaceut.7b00183. Epub 2017 May 1.

8.

Optimization of substituted imidazobenzodiazepines as novel asthma treatments.

Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, Arnold LA.

Eur J Med Chem. 2017 Jan 27;126:550-560. doi: 10.1016/j.ejmech.2016.11.045. Epub 2016 Nov 24.

9.

Effects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons.

Holtyn AF, Tiruveedhula VV, Stephen MR, Cook JM, Weerts EM.

Drug Alcohol Depend. 2017 Jan 1;170:25-31. doi: 10.1016/j.drugalcdep.2016.10.036. Epub 2016 Nov 4.

10.

Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.

Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2016 Jun 6;13(6):2026-38. doi: 10.1021/acs.molpharmaceut.6b00159. Epub 2016 May 10.

11.

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.

Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen MR, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K, Sala C.

Cereb Cortex. 2017 Mar 1;27(3):2226-2248. doi: 10.1093/cercor/bhw075.

12.

Targeting the γ-Aminobutyric Acid A Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction.

Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):546-53. doi: 10.1165/rcmb.2015-0176OC.

13.

A facile synthesis and discovery of highly functionalized tetrahydro-pyridines and pyridines as antimycobacterial agents.

Raju SK, Stephen MR, Subbu P, Debjani B, Perumal Y, Dharmarajan S.

Chem Pharm Bull (Tokyo). 2010 May;58(5):602-10.

14.

Pseudomalignancy in a hydrocele fluid.

Stephen MR, Downie I, McLellan D.

Cytopathology. 1999 Aug;10(4):283-7. No abstract available.

PMID:
10458507
15.

Xanthogranulomatous sialadenitis following diagnosis of Warthin's tumour: a possible complication of fine needle aspiration (FNA).

Stephen MR, Matalka I, Stewart CJ, Mackenzie K.

Cytopathology. 1999 Aug;10(4):276-9. No abstract available.

PMID:
10458505
16.

The cytology of bronchial brushings from a malignant paraganglioma metastasizing to the lung.

Stephen MR, Moffat D, Burnett RA.

Cytopathology. 1999 Jun;10(3):211-5. No abstract available.

PMID:
10390071
17.
18.

Hepatocellular carcinoma diagnosis in bile duct brush cytology.

Stewart CJ, Stephen MR, Ferrier RK.

Diagn Cytopathol. 1998 Aug;19(2):149-50. No abstract available.

PMID:
9702497
19.

Myxoid malignant fibrous histiocytoma mimicking papular mucinosis.

Stephen MR, Morton R.

Am J Dermatopathol. 1998 Jun;20(3):290-5.

PMID:
9650705
20.

Malignant eccrine poroma of the vulva.

Stephen MR, Matalka I, Hanretty K.

Br J Obstet Gynaecol. 1998 Apr;105(4):471-2. No abstract available.

PMID:
9609280
21.

Sequential malt lymphomas of the stomach, small intestine, and gall bladder.

Stephen MR, Farquharson MA, Sharp RA, Jackson R.

J Clin Pathol. 1998 Jan;51(1):77-9.

22.
23.

Effusion cytology of hepatocellular carcinoma with in situ hybridisation for human albumin.

Stephen MR, Oien K, Ferrier RK, Burnett RA.

J Clin Pathol. 1997 May;50(5):442-4.

24.

Osteochondroma of the tongue.

Watson C, Crowther JA, Stephen MR.

J Laryngol Otol. 1990 Feb;104(2):138-40.

PMID:
2324621
25.

Hypernatraemic dehydration in patients in a large hospital for the mentally handicapped.

Macdonald NJ, McConnell KN, Stephen MR, Dunnigan MG.

BMJ. 1989 Dec 9;299(6713):1426-9.

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