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Items: 14


An improved platform for functional assessment of large protein libraries in mammalian cells.

Matreyek KA, Stephany JJ, Chiasson MA, Hasle N, Fowler DM.

Nucleic Acids Res. 2019 Oct 15. pii: gkz910. doi: 10.1093/nar/gkz910. [Epub ahead of print]


Elucidating the Molecular Determinants of Αβ Aggregation with Deep Mutational Scanning.

Gray VE, Sitko K, Kameni FZN, Williamson M, Stephany JJ, Hasle N, Fowler DM.

G3 (Bethesda). 2019 Sep 26. pii: g3.400535.2019. doi: 10.1534/g3.119.400535. [Epub ahead of print]


A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions.

Ahler E, Register AC, Chakraborty S, Fang L, Dieter EM, Sitko KA, Vidadala RSR, Trevillian BM, Golkowski M, Gelman H, Stephany JJ, Rubin AF, Merritt EA, Fowler DM, Maly DJ.

Mol Cell. 2019 Apr 18;74(2):393-408.e20. doi: 10.1016/j.molcel.2019.02.003. Epub 2019 Apr 4.


Multiplex assessment of protein variant abundance by massively parallel sequencing.

Matreyek KA, Starita LM, Stephany JJ, Martin B, Chiasson MA, Gray VE, Kircher M, Khechaduri A, Dines JN, Hause RJ, Bhatia S, Evans WE, Relling MV, Yang W, Shendure J, Fowler DM.

Nat Genet. 2018 Jun;50(6):874-882. doi: 10.1038/s41588-018-0122-z. Epub 2018 May 21.


Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing.

Rose JC, Stephany JJ, Wei CT, Fowler DM, Maly DJ.

ACS Chem Biol. 2018 Feb 16;13(2):438-442. doi: 10.1021/acschembio.7b00652. Epub 2017 Sep 15.


Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

Rose JC, Stephany JJ, Valente WJ, Trevillian BM, Dang HV, Bielas JH, Maly DJ, Fowler DM.

Nat Methods. 2017 Sep;14(9):891-896. doi: 10.1038/nmeth.4368. Epub 2017 Jul 24.


A platform for functional assessment of large variant libraries in mammalian cells.

Matreyek KA, Stephany JJ, Fowler DM.

Nucleic Acids Res. 2017 Jun 20;45(11):e102. doi: 10.1093/nar/gkx183.


Measuring the activity of protein variants on a large scale using deep mutational scanning.

Fowler DM, Stephany JJ, Fields S.

Nat Protoc. 2014 Sep;9(9):2267-84. doi: 10.1038/nprot.2014.153. Epub 2014 Aug 28.


Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection.

Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD.

J Biol Chem. 2013 Jun 14;288(24):17111-21. doi: 10.1074/jbc.M112.447326. Epub 2013 Apr 26.


Suppression of statin effectiveness by copper and zinc in yeast and human cells.

Fowler DM, Cooper SJ, Stephany JJ, Hendon N, Nelson S, Fields S.

Mol Biosyst. 2011 Feb;7(2):533-44. doi: 10.1039/c0mb00166j. Epub 2010 Nov 17.


High-resolution mapping of protein sequence-function relationships.

Fowler DM, Araya CL, Fleishman SJ, Kellogg EH, Stephany JJ, Baker D, Fields S.

Nat Methods. 2010 Sep;7(9):741-6. doi: 10.1038/nmeth.1492. Epub 2010 Aug 15.


CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.

Loffredo JT, Friedrich TC, León EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontkivska H, Hughes AL, Sette A, Watkins DI.

PLoS One. 2007 Nov 14;2(11):e1152.


Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.

Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz BJ, Stephany JJ, Loffredo JT, Allison DB, Adnan S, Hoji A, Wilson NA, Friedrich TC, Lifson JD, Yang OO, Watkins DI.

J Immunol. 2007 Mar 1;178(5):2746-54.


The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.

Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Vela JP, Martin SR, Reed J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoé G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI.

J Virol. 2007 Mar;81(6):2624-34. Epub 2006 Dec 27.

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