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Items: 1 to 50 of 339

1.

Critical Roles of the Pentose Phosphate Pathway and GLN3 in Isobutanol-Specific Tolerance in Yeast.

Kuroda K, Hammer SK, Watanabe Y, Montaño López J, Fink GR, Stephanopoulos G, Ueda M, Avalos JL.

Cell Syst. 2019 Nov 11. pii: S2405-4712(19)30382-5. doi: 10.1016/j.cels.2019.10.006. [Epub ahead of print]

PMID:
31734159
2.

Engineering Yarrowia lipolytica for the utilization of acid whey.

Mano J, Liu N, Hammond JH, Currie DH, Stephanopoulos G.

Metab Eng. 2019 Sep 25;57:43-50. doi: 10.1016/j.ymben.2019.09.010. [Epub ahead of print]

PMID:
31562926
3.

Mixed carbon substrates: a necessary nuisance or a missed opportunity?

Liu N, Santala S, Stephanopoulos G.

Curr Opin Biotechnol. 2019 Sep 9;62:15-21. doi: 10.1016/j.copbio.2019.07.003. [Epub ahead of print] Review.

PMID:
31513988
4.

Cell free biosynthesis of isoprenoids from isopentenol.

Ward VCA, Chatzivasileiou AO, Stephanopoulos G.

Biotechnol Bioeng. 2019 Dec;116(12):3269-3281. doi: 10.1002/bit.27146. Epub 2019 Sep 3.

PMID:
31429926
5.

Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid.

Cheng F, Yu H, Stephanopoulos G.

Metab Eng. 2019 Sep;55:276-289. doi: 10.1016/j.ymben.2019.07.003. Epub 2019 Jul 10.

PMID:
31301358
6.

Limitations in converting waste gases to fuels and chemicals.

Emerson DF, Stephanopoulos G.

Curr Opin Biotechnol. 2019 Oct;59:39-45. doi: 10.1016/j.copbio.2019.02.004. Epub 2019 Mar 8. Review.

PMID:
30856509
7.

Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2.

Roth TB, Woolston BM, Stephanopoulos G, Liu DR.

ACS Synth Biol. 2019 Apr 19;8(4):796-806. doi: 10.1021/acssynbio.8b00481. Epub 2019 Mar 20.

8.

Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging.

Vasdekis AE, Alanazi H, Silverman AM, Williams CJ, Canul AJ, Cliff JB, Dohnalkova AC, Stephanopoulos G.

Nat Commun. 2019 Feb 19;10(1):848. doi: 10.1038/s41467-019-08717-w.

9.

Two-step pathway for isoprenoid synthesis.

Chatzivasileiou AO, Ward V, Edgar SM, Stephanopoulos G.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):506-511. doi: 10.1073/pnas.1812935116. Epub 2018 Dec 24.

10.

Biosynthesis of monoethylene glycol in Saccharomyces cerevisiae utilizing native glycolytic enzymes.

Uranukul B, Woolston BM, Fink GR, Stephanopoulos G.

Metab Eng. 2019 Jan;51:20-31. doi: 10.1016/j.ymben.2018.09.012. Epub 2018 Sep 27.

PMID:
30268818
11.

Enhancing hydrogen-dependent growth of and carbon dioxide fixation by Clostridium ljungdahlii through nitrate supplementation.

Emerson DF, Woolston BM, Liu N, Donnelly M, Currie DH, Stephanopoulos G.

Biotechnol Bioeng. 2019 Feb;116(2):294-306. doi: 10.1002/bit.26847. Epub 2018 Dec 9.

PMID:
30267586
12.

Metabolic engineering in the host Yarrowia lipolytica.

Abdel-Mawgoud AM, Markham KA, Palmer CM, Liu N, Stephanopoulos G, Alper HS.

Metab Eng. 2018 Nov;50:192-208. doi: 10.1016/j.ymben.2018.07.016. Epub 2018 Jul 26. Review.

PMID:
30056205
13.

Holistic Approaches in Lipid Production by Yarrowia lipolytica.

Lazar Z, Liu N, Stephanopoulos G.

Trends Biotechnol. 2018 Nov;36(11):1157-1170. doi: 10.1016/j.tibtech.2018.06.007. Epub 2018 Jul 11. Review.

PMID:
30006239
14.

Improving formaldehyde consumption drives methanol assimilation in engineered E. coli.

Woolston BM, King JR, Reiter M, Van Hove B, Stephanopoulos G.

Nat Commun. 2018 Jun 19;9(1):2387. doi: 10.1038/s41467-018-04795-4.

15.

Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering.

Abdel-Mawgoud AM, Stephanopoulos G.

Synth Syst Biotechnol. 2017 Dec 15;3(1):3-19. doi: 10.1016/j.synbio.2017.12.001. eCollection 2018 Mar. Review.

16.

Rediverting carbon flux in Clostridium ljungdahlii using CRISPR interference (CRISPRi).

Woolston BM, Emerson DF, Currie DH, Stephanopoulos G.

Metab Eng. 2018 Jul;48:243-253. doi: 10.1016/j.ymben.2018.06.006. Epub 2018 Jun 15.

PMID:
29906505
17.

Metabolic engineering of Escherichia coli for the production of L-malate from xylose.

Li ZJ, Hong PH, Da YY, Li LK, Stephanopoulos G.

Metab Eng. 2018 Jul;48:25-32. doi: 10.1016/j.ymben.2018.05.010. Epub 2018 May 22.

PMID:
29800611
18.

Metabolic engineering of Escherichia coli for the production of isoprenoids.

Ward VCA, Chatzivasileiou AO, Stephanopoulos G.

FEMS Microbiol Lett. 2018 May 1;365(10). doi: 10.1093/femsle/fny079. Review.

PMID:
29718190
19.

Harnessing a methane-fueled, sediment-free mixed microbial community for utilization of distributed sources of natural gas.

Marlow JJ, Kumar A, Enalls BC, Reynard LM, Tuross N, Stephanopoulos G, Girguis P.

Biotechnol Bioeng. 2018 Jun;115(6):1450-1464. doi: 10.1002/bit.26576. Epub 2018 Mar 24.

20.

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.

Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG.

Elife. 2017 Dec 14;6. pii: e27293. doi: 10.7554/eLife.27293.

21.

Development of a formaldehyde biosensor with application to synthetic methylotrophy.

Woolston BM, Roth T, Kohale I, Liu DR, Stephanopoulos G.

Biotechnol Bioeng. 2018 Jan;115(1):206-215. doi: 10.1002/bit.26455. Epub 2017 Nov 3.

22.

Metabolic engineering of Escherichia coli for the synthesis of the quadripolymer poly(glycolate-co-lactate-co-3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose.

Li ZJ, Qiao K, Che XM, Stephanopoulos G.

Metab Eng. 2017 Nov;44:38-44. doi: 10.1016/j.ymben.2017.09.003. Epub 2017 Sep 13.

PMID:
28916461
23.

Enhanced Biosynthesis of Hyaluronic Acid Using Engineered Corynebacterium glutamicum Via Metabolic Pathway Regulation.

Cheng F, Luozhong S, Guo Z, Yu H, Stephanopoulos G.

Biotechnol J. 2017 Oct;12(10). doi: 10.1002/biot.201700191. Epub 2017 Sep 28.

PMID:
28869338
24.

Application of metabolic controls for the maximization of lipid production in semicontinuous fermentation.

Xu J, Liu N, Qiao K, Vogg S, Stephanopoulos G.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5308-E5316. doi: 10.1073/pnas.1703321114. Epub 2017 Jun 19.

25.

In Vitro Metabolic Engineering of Amorpha-4,11-diene Biosynthesis at Enhanced Rate and Specific Yield of Production.

Chen X, Zhang C, Zou R, Stephanopoulos G, Too HP.

ACS Synth Biol. 2017 Sep 15;6(9):1691-1700. doi: 10.1021/acssynbio.6b00377. Epub 2017 May 25.

PMID:
28520394
26.

Exploring biochemical pathways for mono-ethylene glycol (MEG) synthesis from synthesis gas.

Islam MA, Hadadi N, Ataman M, Hatzimanikatis V, Stephanopoulos G.

Metab Eng. 2017 May;41:173-181. doi: 10.1016/j.ymben.2017.04.005. Epub 2017 Apr 19.

PMID:
28433737
27.

Designing a New Entry Point into Isoprenoid Metabolism by Exploiting Fructose-6-Phosphate Aldolase Side Reactivity of Escherichia coli.

King JR, Woolston BM, Stephanopoulos G.

ACS Synth Biol. 2017 Jul 21;6(7):1416-1426. doi: 10.1021/acssynbio.7b00072. Epub 2017 Apr 13.

PMID:
28375628
28.

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.

Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, Iliopoulos O.

J Clin Invest. 2017 May 1;127(5):1631-1645. doi: 10.1172/JCI87800. Epub 2017 Mar 27.

29.

Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica.

Xu P, Qiao K, Stephanopoulos G.

Biotechnol Bioeng. 2017 Jul;114(7):1521-1530. doi: 10.1002/bit.26285. Epub 2017 Apr 18.

PMID:
28295166
30.

Key Role of the Carboxyl Terminus of Hyaluronan Synthase in Processive Synthesis and Size Control of Hyaluronic Acid Polymers.

Yang J, Cheng F, Yu H, Wang J, Guo Z, Stephanopoulos G.

Biomacromolecules. 2017 Apr 10;18(4):1064-1073. doi: 10.1021/acs.biomac.6b01239. Epub 2017 Mar 8.

PMID:
28192668
31.

Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis.

Dong W, Keibler MA, Stephanopoulos G.

Metab Eng. 2017 Sep;43(Pt B):113-124. doi: 10.1016/j.ymben.2017.02.002. Epub 2017 Feb 10. Review.

32.

Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism.

Qiao K, Wasylenko TM, Zhou K, Xu P, Stephanopoulos G.

Nat Biotechnol. 2017 Feb;35(2):173-177. doi: 10.1038/nbt.3763. Epub 2017 Jan 16.

PMID:
28092657
33.

Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica.

Vasdekis AE, Silverman AM, Stephanopoulos G.

PLoS One. 2017 Jan 4;12(1):e0168889. doi: 10.1371/journal.pone.0168889. eCollection 2017.

34.

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG.

Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26.

35.

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.

Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA.

PLoS Pathog. 2016 Nov 23;12(11):e1006020. doi: 10.1371/journal.ppat.1006020. eCollection 2016 Nov.

36.

Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production.

Li ZJ, Qiao K, Liu N, Stephanopoulos G.

J Ind Microbiol Biotechnol. 2017 May;44(4-5):605-612. doi: 10.1007/s10295-016-1864-1. Epub 2016 Nov 8.

PMID:
27826725
37.

Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate.

Edgar S, Li FS, Qiao K, Weng JK, Stephanopoulos G.

ACS Synth Biol. 2017 Feb 17;6(2):201-205. doi: 10.1021/acssynbio.6b00206. Epub 2016 Nov 4.

PMID:
27794603
38.

13C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica.

Liu N, Qiao K, Stephanopoulos G.

Metab Eng. 2016 Nov;38:86-97. doi: 10.1016/j.ymben.2016.06.006. Epub 2016 Jul 5.

PMID:
27387605
39.

Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals.

Xu P, Qiao K, Ahn WS, Stephanopoulos G.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10848-53. doi: 10.1073/pnas.1607295113. Epub 2016 Sep 12.

40.

Metabolic requirements for cancer cell proliferation.

Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G.

Cancer Metab. 2016 Aug 18;4:16. doi: 10.1186/s40170-016-0156-6. eCollection 2016.

41.

Metabolic engineering of microbial competitive advantage for industrial fermentation processes.

Shaw AJ, Lam FH, Hamilton M, Consiglio A, MacEwen K, Brevnova EE, Greenhagen E, LaTouf WG, South CR, van Dijken H, Stephanopoulos G.

Science. 2016 Aug 5;353(6299):583-6. doi: 10.1126/science.aaf6159.

42.

Improving Metabolic Pathway Efficiency by Statistical Model-Based Multivariate Regulatory Metabolic Engineering.

Xu P, Rizzoni EA, Sul SY, Stephanopoulos G.

ACS Synth Biol. 2017 Jan 20;6(1):148-158. doi: 10.1021/acssynbio.6b00187. Epub 2016 Aug 15.

PMID:
27490704
43.

Engineering Microbes to Synthesize Plant Isoprenoids.

Zhou K, Edgar S, Stephanopoulos G.

Methods Enzymol. 2016;575:225-45. doi: 10.1016/bs.mie.2016.03.007. Epub 2016 Mar 30.

PMID:
27417931
44.

Letter from AIChE President.

Stephanopoulos G.

Bioeng Transl Med. 2016 May 27;1(1):3. doi: 10.1002/btm2.10006. eCollection 2016 Mar. No abstract available.

45.

Co-culture engineering for microbial biosynthesis of 3-amino-benzoic acid in Escherichia coli.

Zhang H, Stephanopoulos G.

Biotechnol J. 2016 Jul;11(7):981-7. doi: 10.1002/biot.201600013. Epub 2016 Jun 17.

PMID:
27168529
46.

Accessing Nature's diversity through metabolic engineering and synthetic biology.

King JR, Edgar S, Qiao K, Stephanopoulos G.

F1000Res. 2016 Mar 24;5. pii: F1000 Faculty Rev-397. doi: 10.12688/f1000research.7311.1. eCollection 2016. Review.

47.

Engineering of a high lipid producing Yarrowia lipolytica strain.

Friedlander J, Tsakraklides V, Kamineni A, Greenhagen EH, Consiglio AL, MacEwen K, Crabtree DV, Afshar J, Nugent RL, Hamilton MA, Joe Shaw A, South CR, Stephanopoulos G, Brevnova EE.

Biotechnol Biofuels. 2016 Mar 31;9:77. doi: 10.1186/s13068-016-0492-3. eCollection 2016.

48.

Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli.

Biggs BW, Lim CG, Sagliani K, Shankar S, Stephanopoulos G, De Mey M, Ajikumar PK.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3209-14. doi: 10.1073/pnas.1515826113. Epub 2016 Mar 7.

49.

Integrated bioprocess for conversion of gaseous substrates to liquids.

Hu P, Chakraborty S, Kumar A, Woolston B, Liu H, Emerson D, Stephanopoulos G.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3773-8. doi: 10.1073/pnas.1516867113. Epub 2016 Mar 7.

50.

Functional overexpression and characterization of lipogenesis-related genes in the oleaginous yeast Yarrowia lipolytica.

Silverman AM, Qiao K, Xu P, Stephanopoulos G.

Appl Microbiol Biotechnol. 2016 Apr;100(8):3781-98. doi: 10.1007/s00253-016-7376-0. Epub 2016 Feb 26.

PMID:
26915993

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