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Items: 1 to 50 of 73

1.

A neurotoxin that specifically targets Anopheles mosquitoes.

Contreras E, Masuyer G, Qureshi N, Chawla S, Dhillon HS, Lee HL, Chen J, Stenmark P, Gill SS.

Nat Commun. 2019 Jun 28;10(1):2869. doi: 10.1038/s41467-019-10732-w.

2.

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.

Scaletti E, Jemth AS, Helleday T, Stenmark P.

FEBS Lett. 2019 Jul;593(14):1863-1873. doi: 10.1002/1873-3468.13455. Epub 2019 Jun 10.

PMID:
31127856
3.

Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin.

Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P.

FEBS Lett. 2019 Jun;593(12):1403-1410. doi: 10.1002/1873-3468.13446. Epub 2019 May 31.

PMID:
31111466
4.

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.

Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp J.

Sci Adv. 2019 Jan 16;5(1):eaau7196. doi: 10.1126/sciadv.aau7196. eCollection 2019 Jan.

5.

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.

Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P.

Biochemistry. 2019 Feb 19;58(7):887-899. doi: 10.1021/acs.biochem.8b00950. Epub 2019 Jan 16.

PMID:
30614695
6.

Cotranslational Folding of a Pentarepeat β-Helix Protein.

Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G.

J Mol Biol. 2018 Dec 7;430(24):5196-5206. doi: 10.1016/j.jmb.2018.10.016. Epub 2018 Oct 27.

PMID:
30539762
7.

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, Wallner O, Masuyer G, Loseva O, Mortusewicz O, Wiita E, Sarno A, Manoilov A, Astorga-Wells J, Jemth AS, Pan L, Sanjiv K, Karsten S, Gokturk C, Grube M, Homan EJ, Hanna BMF, Paulin CBJ, Pham T, Rasti A, Berglund UW, von Nicolai C, Benitez-Buelga C, Koolmeister T, Ivanic D, Iliev P, Scobie M, Krokan HE, Baranczewski P, Artursson P, Altun M, Jensen AJ, Kalderén C, Ba X, Zubarev RA, Stenmark P, Boldogh I, Helleday T.

Science. 2018 Nov 16;362(6416):834-839. doi: 10.1126/science.aar8048.

8.

Botulinum and Tetanus Neurotoxins.

Dong M, Masuyer G, Stenmark P.

Annu Rev Biochem. 2019 Jun 20;88:811-837. doi: 10.1146/annurev-biochem-013118-111654. Epub 2018 Nov 2.

PMID:
30388027
9.

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.

Jemth AS, Gustafsson R, Bräutigam L, Henriksson L, Vallin KSA, Sarno A, Almlöf I, Homan E, Rasti A, Warpman Berglund U, Stenmark P, Helleday T.

Nucleic Acids Res. 2018 Nov 16;46(20):10888-10904. doi: 10.1093/nar/gky896.

10.

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.

Mur P, Jemth AS, Bevc L, Amaral N, Navarro M, Valdés-Mas R, Pons T, Aiza G, Urioste M, Valencia A, Lázaro C, Moreno V, Puente XS, Stenmark P, Warpman-Berglund U, Capellá G, Helleday T, Valle L.

Hum Mutat. 2018 Sep;39(9):1214-1225. doi: 10.1002/humu.23564. Epub 2018 Jul 4.

PMID:
29900613
11.

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.

Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P.

Toxins (Basel). 2018 Apr 12;10(4). pii: E153. doi: 10.3390/toxins10040153.

12.

Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.

Masuyer G, Zhang S, Barkho S, Shen Y, Henriksson L, Košenina S, Dong M, Stenmark P.

Sci Rep. 2018 Mar 14;8(1):4518. doi: 10.1038/s41598-018-22842-4.

13.

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.

Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P.

Structure. 2018 Feb 6;26(2):295-303.e6. doi: 10.1016/j.str.2018.01.004.

14.

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.

Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M.

Cell Host Microbe. 2018 Feb 14;23(2):169-176.e6. doi: 10.1016/j.chom.2017.12.018. Epub 2018 Jan 27.

15.

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, Wallner O, Isaksson R, Carter M, Rudd SG, Loseva O, Jemth AS, Almlöf I, Font-Mateu J, Llona-Minguez S, Baranczewski P, Jeppsson F, Homan E, Almqvist H, Axelsson H, Regmi S, Gustavsson AL, Lundbäck T, Scobie M, Strömberg K, Stenmark P, Beato M, Helleday T.

Nat Commun. 2018 Jan 17;9(1):250. doi: 10.1038/s41467-017-02293-7.

16.

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.

Narwal M, Jemth AS, Gustafsson R, Almlöf I, Warpman Berglund U, Helleday T, Stenmark P.

Biochemistry. 2018 Feb 6;57(5):593-603. doi: 10.1021/acs.biochem.7b01163. Epub 2018 Jan 16.

PMID:
29281266
17.

Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.

Teixeira PF, Masuyer G, Pinho CM, Branca RMM, Kmiec B, Wallin C, Wärmländer SKTS, Berntsson RP, Ankarcrona M, Gräslund A, Lehtiö J, Stenmark P, Glaser E.

J Mol Biol. 2018 Feb 2;430(3):348-362. doi: 10.1016/j.jmb.2017.11.011. Epub 2017 Nov 26.

PMID:
29183787
18.

Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.

Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong M.

Nat Commun. 2017 Nov 21;8(1):1637. doi: 10.1038/s41467-017-01534-z.

19.

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.

Carreras-Puigvert J, Zitnik M, Jemth AS, Carter M, Unterlass JE, Hallström B, Loseva O, Karem Z, Calderón-Montaño JM, Lindskog C, Edqvist PH, Matuszewski DJ, Ait Blal H, Berntsson RPA, Häggblad M, Martens U, Studham M, Lundgren B, Wählby C, Sonnhammer ELL, Lundberg E, Stenmark P, Zupan B, Helleday T.

Nat Commun. 2017 Nov 16;8(1):1541. doi: 10.1038/s41467-017-01642-w.

20.

Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.

Gustafsson R, Berntsson RP, Martínez-Carranza M, El Tekle G, Odegrip R, Johnson EA, Stenmark P.

FEBS Lett. 2017 Nov;591(22):3781-3792. doi: 10.1002/1873-3468.12889. Epub 2017 Nov 5.

21.

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.

Rudling A, Gustafsson R, Almlöf I, Homan E, Scobie M, Warpman Berglund U, Helleday T, Stenmark P, Carlsson J.

J Med Chem. 2017 Oct 12;60(19):8160-8169. doi: 10.1021/acs.jmedchem.7b01006. Epub 2017 Oct 3.

PMID:
28929756
22.

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.

Llona-Minguez S, Throup A, Steiner E, Lightowler M, Van der Haegen S, Homan E, Eriksson L, Stenmark P, Jenmalm-Jensen A, Helleday T.

Org Biomol Chem. 2017 Sep 26;15(37):7758-7764. doi: 10.1039/c7ob02069d.

PMID:
28891572
23.

Identification and characterization of a novel botulinum neurotoxin.

Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P.

Nat Commun. 2017 Aug 3;8:14130. doi: 10.1038/ncomms14130.

24.

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors.

Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong M.

Nat Commun. 2017 Jul 3;8(1):53. doi: 10.1038/s41467-017-00064-y.

25.

The structure of the tetanus toxin reveals pH-mediated domain dynamics.

Masuyer G, Conrad J, Stenmark P.

EMBO Rep. 2017 Aug;18(8):1306-1317. doi: 10.15252/embr.201744198. Epub 2017 Jun 23.

26.

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KSA, Wallner OA, Hammarström LGJ, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Carreras Puigvert J, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jenmalm Jensen A, Artursson P, Nilsson JA, Stenmark P, Scobie M; Ulrika Warpman Berglund &Thomas Helleday.

Nature. 2017 Apr 26;544(7651):508. doi: 10.1038/nature22083. No abstract available.

PMID:
28447629
27.

Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A.

Hamark C, Berntsson RP, Masuyer G, Henriksson LM, Gustafsson R, Stenmark P, Widmalm G.

J Am Chem Soc. 2017 Jan 11;139(1):218-230. doi: 10.1021/jacs.6b09534. Epub 2016 Dec 27.

PMID:
27958736
28.

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.

Gustafsson R, Jemth AS, Gustafsson NM, Färnegårdh K, Loseva O, Wiita E, Bonagas N, Dahllund L, Llona-Minguez S, Häggblad M, Henriksson M, Andersson Y, Homan E, Helleday T, Stenmark P.

Cancer Res. 2017 Feb 15;77(4):937-948. doi: 10.1158/0008-5472.CAN-16-1476. Epub 2016 Nov 29.

29.

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.

Valerie NC, Hagenkort A, Page BD, Masuyer G, Rehling D, Carter M, Bevc L, Herr P, Homan E, Sheppard NG, Stenmark P, Jemth AS, Helleday T.

Cancer Res. 2016 Sep 15;76(18):5501-11. doi: 10.1158/0008-5472.CAN-16-0584. Epub 2016 Aug 16.

30.

A comparison of X-ray and calculated structures of the enzyme MTH1.

Ryan H, Carter M, Stenmark P, Stewart JJ, Braun-Sand SB.

J Mol Model. 2016 Jul;22(7):168. doi: 10.1007/s00894-016-3025-x. Epub 2016 Jun 27.

31.

DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels.

Frykholm K, Berntsson RP, Claesson M, de Battice L, Odegrip R, Stenmark P, Westerlund F.

Nucleic Acids Res. 2016 Sep 6;44(15):7219-27. doi: 10.1093/nar/gkw352. Epub 2016 Apr 29.

32.

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.

Bräutigam L, Pudelko L, Jemth AS, Gad H, Narwal M, Gustafsson R, Karsten S, Carreras Puigvert J, Homan E, Berndt C, Berglund UW, Stenmark P, Helleday T.

Cancer Res. 2016 Apr 15;76(8):2366-75. doi: 10.1158/0008-5472.CAN-15-2380. Epub 2016 Feb 9.

33.

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.

Llona-Minguez S, Höglund A, Jacques SA, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie NCK, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Morón EB, Baranczewski P, Hagbjörk AL, Svensson R, Wiita E, Almlöf I, Visnes T, Jeppsson F, Sigmundsson K, Jensen AJ, Artursson P, Jemth AS, Stenmark P, Berglund UW, Scobie M, Helleday T.

J Med Chem. 2016 Feb 11;59(3):1140-1148. doi: 10.1021/acs.jmedchem.5b01741. Epub 2016 Jan 27.

34.

The C repressor of the P2 bacteriophage.

Massad T, Papadopolos E, Stenmark P, Damberg P.

J Biomol NMR. 2016 Feb;64(2):175-80. doi: 10.1007/s10858-015-9999-3. Epub 2015 Dec 22. No abstract available.

35.

Crystal structure of the bacteriophage P2 integrase catalytic domain.

Skaar K, Claesson M, Odegrip R, Högbom M, Haggård-Ljungquist E, Stenmark P.

FEBS Lett. 2015 Nov 30;589(23):3556-63. doi: 10.1016/j.febslet.2015.09.026. Epub 2015 Oct 8.

36.

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T, Stenmark P.

Nat Commun. 2015 Aug 4;6:7871. doi: 10.1038/ncomms8871.

37.

Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.

Llona-Minguez S, Desroses M, Ghassemian A, Jacques SA, Eriksson L, Isacksson R, Koolmeister T, Stenmark P, Scobie M, Helleday T.

Chemistry. 2015 May 11;21(20):7394-8. doi: 10.1002/chem.201406549. Epub 2015 Mar 25.

PMID:
25809883
38.

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T.

Nature. 2014 Apr 10;508(7495):215-21. doi: 10.1038/nature13181. Epub 2014 Apr 2. Erratum in: Nature. 2017 Apr 26;544(7651):508.

PMID:
24695224
39.

Structural insight into DNA binding and oligomerization of the multifunctional Cox protein of bacteriophage P2.

Berntsson RP, Odegrip R, Sehlén W, Skaar K, Svensson LM, Massad T, Högbom M, Haggård-Ljungquist E, Stenmark P.

Nucleic Acids Res. 2014 Feb;42(4):2725-35. doi: 10.1093/nar/gkt1119. Epub 2013 Nov 19.

40.

Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts.

Kmiec B, Teixeira PF, Berntsson RP, Murcha MW, Branca RM, Radomiljac JD, Regberg J, Svensson LM, Bakali A, Langel U, Lehtiö J, Whelan J, Stenmark P, Glaser E.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3761-9. doi: 10.1073/pnas.1307637110. Epub 2013 Sep 16.

41.

Crystal structures of botulinum neurotoxin DC in complex with its protein receptors synaptotagmin I and II.

Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P.

Structure. 2013 Sep 3;21(9):1602-11. doi: 10.1016/j.str.2013.06.026. Epub 2013 Aug 8.

42.

Structure of dual receptor binding to botulinum neurotoxin B.

Berntsson RP, Peng L, Dong M, Stenmark P.

Nat Commun. 2013;4:2058. doi: 10.1038/ncomms3058.

43.

Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.

Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M.

J Cell Sci. 2012 Jul 1;125(Pt 13):3233-42. doi: 10.1242/jcs.103564. Epub 2012 Mar 27.

44.

The manganese ion of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase R2c is located at metal position 1.

Andersson CS, Öhrström M, Popović-Bijelić A, Gräslund A, Stenmark P, Högbom M.

J Am Chem Soc. 2012 Jan 11;134(1):123-5. doi: 10.1021/ja209678x. Epub 2011 Dec 8.

PMID:
22133609
45.

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.

Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L.

Nat Chem Biol. 2011 Oct 30;7(12):950-8. doi: 10.1038/nchembio.693.

46.

Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.

Ohrström M, Popović-Bijelić A, Luo J, Stenmark P, Högbom M, Gräslund A.

J Pept Sci. 2011 Nov;17(11):756-62. doi: 10.1002/psc.1399. Epub 2011 Oct 4.

PMID:
21976435
47.

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.

Svensson LM, Jemth AS, Desroses M, Loseva O, Helleday T, Högbom M, Stenmark P.

FEBS Lett. 2011 Aug 19;585(16):2617-21. doi: 10.1016/j.febslet.2011.07.017. Epub 2011 Jul 23.

48.

Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222.

Jacobson MJ, Lin G, Tepp W, Dupuy J, Stenmark P, Stevens RC, Johnson EA.

Appl Environ Microbiol. 2011 Jun;77(12):4217-22. doi: 10.1128/AEM.00201-11. Epub 2011 Apr 22.

49.

Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.

Welin M, Egeblad L, Johansson A, Stenmark P, Wang L, Flodin S, Nyman T, Trésaugues L, Kotenyova T, Johansson I, Eriksson S, Eklund H, Nordlund P.

FEBS J. 2010 Dec;277(23):4920-30. doi: 10.1111/j.1742-4658.2010.07897.x. Epub 2010 Nov 5.

50.

Crystal structure of the P2 C-repressor: a binder of non-palindromic direct DNA repeats.

Massad T, Skaar K, Nilsson H, Damberg P, Henriksson-Peltola P, Haggård-Ljungquist E, Högbom M, Stenmark P.

Nucleic Acids Res. 2010 Nov;38(21):7778-90. doi: 10.1093/nar/gkq626. Epub 2010 Jul 17.

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