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Items: 32

1.

Immunosuppression withdrawal in liver transplant recipients on sirolimus.

Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian S, Sanchez-Fueyo A, Lozano JJ, Demetris A, Lesniak A, Kirk AD, Stempora L, Yang GY, Mathew JM.

Hepatology. 2019 Nov 13. doi: 10.1002/hep.31036. [Epub ahead of print]

PMID:
31721246
2.

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.

Espinosa JR, Mou D, Adams BW, DiBernardo LR, MacDonald AL, McRae M, Miller AN, Song M, Stempora LL, Wang J, Iwakoshi NN, Kirk AD.

Front Immunol. 2018 Jun 15;9:1371. doi: 10.3389/fimmu.2018.01371. eCollection 2018.

3.

Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers.

Weinhold KJ, Bukowski JF, Brennan TV, Noveck RJ, Staats JS, Lin L, Stempora L, Hammond C, Wouters A, Mojcik CF, Cheng J, Collinge M, Jesson MI, Hazra A, Biswas P, Lan S, Clark JD, Hodge JA.

Clin Immunol. 2018 Jun;191:10-20. doi: 10.1016/j.clim.2018.03.002. Epub 2018 Mar 5.

4.

Premature T Cell Senescence in Pediatric CKD.

George RP, Mehta AK, Perez SD, Winterberg P, Cheeseman J, Johnson B, Kwun J, Monday S, Stempora L, Warshaw B, Kirk AD.

J Am Soc Nephrol. 2017 Jan;28(1):359-367. doi: 10.1681/ASN.2016010053. Epub 2016 Jul 13.

5.

Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.

Furlan SN, Watkins B, Tkachev V, Flynn R, Cooley S, Ramakrishnan S, Singh K, Giver C, Hamby K, Stempora L, Garrett A, Chen J, Betz KM, Ziegler CG, Tharp GK, Bosinger SE, Promislow DE, Miller JS, Waller EK, Blazar BR, Kean LS.

Sci Transl Med. 2015 Nov 25;7(315):315ra191. doi: 10.1126/scitranslmed.aad3231.

6.

CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection.

Espinosa J, Herr F, Tharp G, Bosinger S, Song M, Farris AB 3rd, George R, Cheeseman J, Stempora L, Townsend R, Durrbach A, Kirk AD.

Am J Transplant. 2016 Apr;16(4):1102-12. doi: 10.1111/ajt.13613. Epub 2016 Jan 14.

7.

Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients.

Xu H, Samy KP, Guasch A, Mead SI, Ghali A, Mehta A, Stempora L, Kirk AD.

Am J Transplant. 2016 Feb;16(2):550-64. doi: 10.1111/ajt.13469. Epub 2015 Oct 5.

8.

Studies Introducing Costimulation Blockade for Vascularized Composite Allografts in Nonhuman Primates.

Freitas AM, Samy KP, Farris AB, Leopardi FV, Song M, Stempora L, Strobert EA, Jenkins JA, Kirk AD, Cendales LC.

Am J Transplant. 2015 Aug;15(8):2240-9. doi: 10.1111/ajt.13379. Epub 2015 Jul 2.

9.

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCR╬▓ repertoire.

Suessmuth Y, Mukherjee R, Watkins B, Koura DT, Finstermeier K, Desmarais C, Stempora L, Horan JT, Langston A, Qayed M, Khoury HJ, Grizzle A, Cheeseman JA, Conger JA, Robertson J, Garrett A, Kirk AD, Waller EK, Blazar BR, Mehta AK, Robins HS, Kean LS.

Blood. 2015 Jun 18;125(25):3835-50. doi: 10.1182/blood-2015-03-631853. Epub 2015 Apr 7.

10.

Viral-induced CD28 loss evokes costimulation independent alloimmunity.

Mou D, Espinosa JE, Stempora L, Iwakoshi NN, Kirk AD.

J Surg Res. 2015 Jun 15;196(2):241-6. doi: 10.1016/j.jss.2015.02.033. Epub 2015 Feb 21.

11.

Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.

Singh K, Stempora L, Harvey RD, Kirk AD, Larsen CP, Blazar BR, Kean LS.

Am J Transplant. 2014 Dec;14(12):2691-703. doi: 10.1111/ajt.12934. Epub 2014 Oct 30.

12.

In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial.

Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS.

Biol Blood Marrow Transplant. 2013 Nov;19(11):1638-49. doi: 10.1016/j.bbmt.2013.09.003. Epub 2013 Sep 15.

13.

Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection.

Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS.

PLoS One. 2013 Aug 5;8(8):e71221. doi: 10.1371/journal.pone.0071221. Print 2013.

14.

CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules.

Ferrer IR, Liu D, Pinelli DF, Koehn BH, Stempora LL, Ford ML.

J Immunol. 2012 Nov 1;189(9):4387-95. doi: 10.4049/jimmunol.1201757. Epub 2012 Sep 21.

15.

Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.

Ramakrishnan SK, Page A, Farris AB 3rd, Singh K, Leopardi F, Hamby K, Sen S, Polnett A, Deane T, Song M, Stempora L, Strobert E, Kirk AD, Larsen CP, Kean LS.

Am J Transplant. 2012 Jul;12(7):1755-64. doi: 10.1111/j.1600-6143.2012.04045.x. Epub 2012 May 29.

16.

Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.

Singh K, Kozyr N, Stempora L, Kirk AD, Larsen CP, Blazar BR, Kean LS.

Am J Transplant. 2012 Jun;12(6):1441-57. doi: 10.1111/j.1600-6143.2011.03963.x. Epub 2012 Feb 2.

17.

Significant mobilization of both conventional and regulatory T cells with AMD3100.

Kean LS, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, Bonifacino AC, Metzger ME, Promislow DE, Mattapallil JJ, Donahue RE.

Blood. 2011 Dec 15;118(25):6580-90. doi: 10.1182/blood-2011-06-359331. Epub 2011 Oct 11.

18.

CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.

Page A, Srinivasan S, Singh K, Russell M, Hamby K, Deane T, Sen S, Stempora L, Leopardi F, Price AA, Strobert E, Reimann KA, Kirk AD, Larsen CP, Kean LS.

Am J Transplant. 2012 Jan;12(1):115-25. doi: 10.1111/j.1600-6143.2011.03737.x. Epub 2011 Sep 19.

19.

Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall.

Floyd TL, Koehn BH, Kitchens WH, Robertson JM, Cheeseman JA, Stempora L, Larsen CP, Ford ML.

J Immunol. 2011 Feb 15;186(4):2033-41. doi: 10.4049/jimmunol.1003015. Epub 2011 Jan 21.

20.

CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha.

Ford ML, Stempora LL, Larsen CP.

Transpl Immunol. 2011 Jan 15;24(2):94-9. doi: 10.1016/j.trim.2010.11.002. Epub 2010 Nov 10.

21.

Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.

Lo DJ, Weaver TA, Stempora L, Mehta AK, Ford ML, Larsen CP, Kirk AD.

Am J Transplant. 2011 Jan;11(1):22-33. doi: 10.1111/j.1600-6143.2010.03317.x. Epub 2010 Nov 10.

22.

An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.

Larsen CP, Page A, Linzie KH, Russell M, Deane T, Stempora L, Strobert E, Penedo MC, Ward T, Wiseman R, O'Connor D, Miller W, Sen S, Singh K, Kean LS.

Am J Transplant. 2010 Nov;10(11):2396-409. doi: 10.1111/j.1600-6143.2010.03272.x. Epub 2010 Sep 17.

23.

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression.

Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, Wheeler C, Anderson DC, Sharma P, Garcia A, Strobert E, Elder E, Crocker I, Crenshaw T, Penedo MC, Ward T, Song M, Horan J, Larsen CP, Blazar BR, Kean LS.

Blood. 2010 Dec 9;116(24):5403-18. doi: 10.1182/blood-2010-06-289272. Epub 2010 Sep 10.

24.

Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.

Weaver TA, Charafeddine AH, Agarwal A, Turner AP, Russell M, Leopardi FV, Kampen RL, Stempora L, Song M, Larsen CP, Kirk AD.

Nat Med. 2009 Jul;15(7):746-9. doi: 10.1038/nm.1993. Epub 2009 Jul 5.

25.

Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.

Anderson A, Martens CL, Hendrix R, Stempora LL, Miller WP, Hamby K, Russell M, Strobert E, Blazar BR, Pearson TC, Larsen CP, Kean LS.

Am J Transplant. 2008 Nov;8(11):2252-64. doi: 10.1111/j.1600-6143.2008.02376.x. Epub 2008 Sep 17.

26.

NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.

Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP.

Am J Transplant. 2006 Feb;6(2):292-304.

27.

Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003.

Learned LA, Reynolds MG, Wassa DW, Li Y, Olson VA, Karem K, Stempora LL, Braden ZH, Kline R, Likos A, Libama F, Moudzeo H, Bolanda JD, Tarangonia P, Boumandoki P, Formenty P, Harvey JM, Damon IK.

Am J Trop Med Hyg. 2005 Aug;73(2):428-34.

PMID:
16103616
28.

CD117/CD34 expression in leukemic blasts.

Wells SJ, Bray RA, Stempora LL, Farhi DC.

Am J Clin Pathol. 1996 Aug;106(2):192-5.

PMID:
8712172
29.

Lymphoid-associated antigen expression by acute myeloid leukemia.

Launder TM, Bray RA, Stempora L, Chenggis ML, Farhi DC.

Am J Clin Pathol. 1996 Aug;106(2):185-91.

PMID:
8712171
30.

DNA index and ploidy distinguish normal human parathyroids from parathyroid adenomas and primary hyperplastic parathyroids.

Chryssochoos JT, Weber CJ, Cohen C, Moore J, DeRose PB, Hagler M, Bray R, Stempora L, Mainiero M, McGarity WC.

Surgery. 1995 Dec;118(6):1041-9; discussion 1049-50.

PMID:
7491521
31.

Characterization of Thy-1 (CDw90) expression in CD34+ acute leukemia.

Holden JT, Geller RB, Farhi DC, Holland HK, Stempora LL, Phillips CN, Bray RA.

Blood. 1995 Jul 1;86(1):60-5.

PMID:
7540889
32.

CD34+ progenitors and colony-forming units-granulocyte macrophage are recruited during large-volume leukapheresis and concentrated by counterflow centrifugal elutriation.

Hillyer CD, Lackey DA 3rd, Hart KK, Stempora LL, Bray RA, Bender JG, Donnenberg AD.

Transfusion. 1993 Apr;33(4):316-21.

PMID:
7683152

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