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Items: 1 to 50 of 103

1.

Common and distinct transcriptional signatures of mammalian embryonic lethality.

Collins JE, White RJ, Staudt N, Sealy IM, Packham I, Wali N, Tudor C, Mazzeo C, Green A, Siragher E, Ryder E, White JK, Papatheodoru I, Tang A, Füllgrabe A, Billis K, Geyer SH, Weninger WJ, Galli A, Hemberger M, Stemple DL, Robertson E, Smith JC, Mohun T, Adams DJ, Busch-Nentwich EM.

Nat Commun. 2019 Jun 26;10(1):2792. doi: 10.1038/s41467-019-10642-x.

2.

The gene regulatory basis of genetic compensation during neural crest induction.

Dooley CM, Wali N, Sealy IM, White RJ, Stemple DL, Collins JE, Busch-Nentwich EM.

PLoS Genet. 2019 Jun 14;15(6):e1008213. doi: 10.1371/journal.pgen.1008213. eCollection 2019 Jun.

3.

The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish.

Scahill CM, Digby Z, Sealy IM, White RJ, Wali N, Collins JE, Stemple DL, Busch-Nentwich EM.

Wellcome Open Res. 2017 Sep 4;2:77. doi: 10.12688/wellcomeopenres.12530.2. eCollection 2017.

4.

A high-resolution mRNA expression time course of embryonic development in zebrafish.

White RJ, Collins JE, Sealy IM, Wali N, Dooley CM, Digby Z, Stemple DL, Murphy DN, Billis K, Hourlier T, Füllgrabe A, Davis MP, Enright AJ, Busch-Nentwich EM.

Elife. 2017 Nov 16;6. pii: e30860. doi: 10.7554/eLife.30860.

5.

Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form.

Henke K, Daane JM, Hawkins MB, Dooley CM, Busch-Nentwich EM, Stemple DL, Harris MP.

Genetics. 2017 Oct;207(2):609-623. doi: 10.1534/genetics.117.300187. Epub 2017 Aug 23.

6.

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish.

Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE, Busch-Nentwich EM.

PLoS Genet. 2017 Aug 14;13(8):e1006959. doi: 10.1371/journal.pgen.1006959. eCollection 2017 Aug.

7.

In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors.

Nelson AC, Cutty SJ, Gasiunas SN, Deplae I, Stemple DL, Wardle FC.

Cell Rep. 2017 Jun 27;19(13):2782-2795. doi: 10.1016/j.celrep.2017.06.011.

8.

Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution.

McConnell SC, Hernandez KM, Wcisel DJ, Kettleborough RN, Stemple DL, Yoder JA, Andrade J, de Jong JL.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5014-23. doi: 10.1073/pnas.1607602113. Epub 2016 Aug 4.

9.

The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.

Praissman JL, Willer T, Sheikh MO, Toi A, Chitayat D, Lin YY, Lee H, Stalnaker SH, Wang S, Prabhakar PK, Nelson SF, Stemple DL, Moore SA, Moremen KW, Campbell KP, Wells L.

Elife. 2016 Apr 29;5. pii: e14473. doi: 10.7554/eLife.14473.

10.

Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish.

Brocal I, White RJ, Dooley CM, Carruthers SN, Clark R, Hall A, Busch-Nentwich EM, Stemple DL, Kettleborough RN.

BMC Genomics. 2016 Mar 24;17:259. doi: 10.1186/s12864-016-2563-z.

11.

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish.

Bielczyk-Maczyńska E, Lam Hung L, Ferreira L, Fleischmann T, Weis F, Fernández-Pevida A, Harvey SA, Wali N, Warren AJ, Barroso I, Stemple DL, Cvejic A.

PLoS Genet. 2015 Dec 1;11(12):e1005677. doi: 10.1371/journal.pgen.1005677. eCollection 2015 Dec.

12.

High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping.

Collins JE, Wali N, Sealy IM, Morris JA, White RJ, Leonard SR, Jackson DK, Jones MC, Smerdon NC, Zamora J, Dooley CM, Carruthers SN, Barrett JC, Stemple DL, Busch-Nentwich EM.

BMC Genomics. 2015 Aug 5;16:578. doi: 10.1186/s12864-015-1788-6.

13.

Identification of a plant isoflavonoid that causes biliary atresia.

Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, Pack M.

Sci Transl Med. 2015 May 6;7(286):286ra67. doi: 10.1126/scitranslmed.aaa1652.

14.

Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function.

Sztal TE, Zhao M, Williams C, Oorschot V, Parslow AC, Giousoh A, Yuen M, Hall TE, Costin A, Ramm G, Bird PI, Busch-Nentwich EM, Stemple DL, Currie PD, Cooper ST, Laing NG, Nowak KJ, Bryson-Richardson RJ.

Acta Neuropathol. 2015 Sep;130(3):389-406. doi: 10.1007/s00401-015-1430-3. Epub 2015 May 1.

15.

Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling.

Kenyon EJ, Campos I, Bull JC, Williams PH, Stemple DL, Clark MD.

Dev Biol. 2015 Jan 15;397(2):212-24. doi: 10.1016/j.ydbio.2014.11.007. Epub 2014 Dec 3.

16.

New insights into the maternal to zygotic transition.

Langley AR, Smith JC, Stemple DL, Harvey SA.

Development. 2014 Oct;141(20):3834-41. doi: 10.1242/dev.102368. Review.

17.
18.

Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character.

Fish MB, Nakayama T, Fisher M, Hirsch N, Cox A, Reeder R, Carruthers S, Hall A, Stemple DL, Grainger RM.

Dev Biol. 2014 Nov 15;395(2):317-330. doi: 10.1016/j.ydbio.2014.09.004. Epub 2014 Sep 16.

19.

A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.

Bielczyk-Maczyńska E, Serbanovic-Canic J, Ferreira L, Soranzo N, Stemple DL, Ouwehand WH, Cvejic A.

PLoS Genet. 2014 Jul 10;10(7):e1004450. doi: 10.1371/journal.pgen.1004450. eCollection 2014 Jul.

20.

Zebrafish models of cancer: progress and future challenges.

Yen J, White RM, Stemple DL.

Curr Opin Genet Dev. 2014 Feb;24:38-45. doi: 10.1016/j.gde.2013.11.003. Epub 2013 Dec 27. Review.

21.

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson IR, Wu CJ, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O'Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, Futreal PA.

Genome Biol. 2013;14(10):R113.

22.

The emerging use of zebrafish to model metabolic disease.

Seth A, Stemple DL, Barroso I.

Dis Model Mech. 2013 Sep;6(5):1080-8. doi: 10.1242/dmm.011346. Review.

23.

So, you want to sequence a genome...

Stemple DL.

Genome Biol. 2013 Jul 30;14(7):128. doi: 10.1186/gb-2013-14-7-128. No abstract available.

24.

Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan.

Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL, Hurles ME, van Bokhoven H, Campbell KP, Lefeber DJ; UK10K Consortium, Lin YY, Muntoni F.

Am J Hum Genet. 2013 Jul 11;93(1):29-41. doi: 10.1016/j.ajhg.2013.05.009. Epub 2013 Jun 13.

25.

Multi-allelic phenotyping--a systematic approach for the simultaneous analysis of multiple induced mutations.

Dooley CM, Scahill C, Fényes F, Kettleborough RN, Stemple DL, Busch-Nentwich EM.

Methods. 2013 Aug 15;62(3):197-206. doi: 10.1016/j.ymeth.2013.04.013. Epub 2013 Apr 23.

26.

The zebrafish reference genome sequence and its relationship to the human genome.

Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, Collins JE, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett JC, Koch R, Rauch GJ, White S, Chow W, Kilian B, Quintais LT, Guerra-Assunção JA, Zhou Y, Gu Y, Yen J, Vogel JH, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire SF, Laird GK, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliot D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley CM, Ersan-Ürün Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberländer M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster SC, Carter NP, Harrow J, Ning Z, Herrero J, Searle SM, Enright A, Geisler R, Plasterk RH, Lee C, Westerfield M, de Jong PJ, Zon LI, Postlethwait JH, Nüsslein-Volhard C, Hubbard TJ, Roest Crollius H, Rogers J, Stemple DL.

Nature. 2013 Apr 25;496(7446):498-503. doi: 10.1038/nature12111. Epub 2013 Apr 17. Erratum in: Nature. 2014 Jan 9;505(7482):248. Cooper, James [corrected to Cooper, James D]; Eliott, David [corrected to Elliot, David]; Mortimer, Beverly [corrected to Mortimore, Beverley]; Begum, Sharmin [added]; Lloyd, Christine [added]; Lanz, Christa [added]; Raddatz, Günter [added]; Schuster, Ste.

27.

A systematic genome-wide analysis of zebrafish protein-coding gene function.

Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ, Fényes F, Mehroke S, Scahill C, Gibbons R, Wali N, Carruthers S, Hall A, Yen J, Cuppen E, Stemple DL.

Nature. 2013 Apr 25;496(7446):494-7. doi: 10.1038/nature11992. Epub 2013 Apr 17.

28.

A sequence-based variation map of zebrafish.

Patowary A, Purkanti R, Singh M, Chauhan R, Singh AR, Swarnkar M, Singh N, Pandey V, Torroja C, Clark MD, Kocher JP, Clark KJ, Stemple DL, Klee EW, Ekker SC, Scaria V, Sivasubbu S.

Zebrafish. 2013 Mar;10(1):15-20. doi: 10.1089/zeb.2012.0848.

29.

Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism.

Grønskov K, Dooley CM, Østergaard E, Kelsh RN, Hansen L, Levesque MP, Vilhelmsen K, Møllgård K, Stemple DL, Rosenberg T.

Am J Hum Genet. 2013 Mar 7;92(3):415-21. doi: 10.1016/j.ajhg.2013.01.006. Epub 2013 Feb 7.

30.

Missense mutations in β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.

Buysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg EJ, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin YY, Lefeber DJ, van Bokhoven H.

Hum Mol Genet. 2013 May 1;22(9):1746-54. doi: 10.1093/hmg/ddt021. Epub 2013 Jan 28.

31.

Genetic analysis of Xenopus tropicalis.

Geach TJ, Stemple DL, Zimmerman LB.

Methods Mol Biol. 2012;917:69-110. doi: 10.1007/978-1-61779-992-1_5.

32.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

J Pathol. 2012 Nov;228(3):274-85. doi: 10.1002/path.4082. Epub 2012 Sep 26.

33.

Incorporating RNA-seq data into the zebrafish Ensembl genebuild.

Collins JE, White S, Searle SM, Stemple DL.

Genome Res. 2012 Oct;22(10):2067-78. doi: 10.1101/gr.137901.112. Epub 2012 Jul 12.

34.

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA.

Nature. 2012 Apr 29;486(7402):266-70. doi: 10.1038/nature11114. Erratum in: Nature. 2013 Feb 21;494(7437):390. Scarlett, Christopher J [added]; Kaplan, Warren [added]; Scarpa, Aldo [added], Das, Amithabad [corrected to Das, Amitabha].

35.

Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan.

Roscioli T, Kamsteeg EJ, Buysse K, Maystadt I, van Reeuwijk J, van den Elzen C, van Beusekom E, Riemersma M, Pfundt R, Vissers LE, Schraders M, Altunoglu U, Buckley MF, Brunner HG, Grisart B, Zhou H, Veltman JA, Gilissen C, Mancini GM, Delrée P, Willemsen MA, Ramadža DP, Chitayat D, Bennett C, Sheridan E, Peeters EA, Tan-Sindhunata GM, de Die-Smulders CE, Devriendt K, Kayserili H, El-Hashash OA, Stemple DL, Lefeber DJ, Lin YY, van Bokhoven H.

Nat Genet. 2012 May;44(5):581-5. doi: 10.1038/ng.2253.

36.

Image-based characterization of thrombus formation in time-lapse DIC microscopy.

Brieu N, Navab N, Serbanovic-Canic J, Ouwehand WH, Stemple DL, Cvejic A, Groher M.

Med Image Anal. 2012 May;16(4):915-31. doi: 10.1016/j.media.2012.02.002. Epub 2012 Feb 11.

37.

Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome.

Albers CA, Paul DS, Schulze H, Freson K, Stephens JC, Smethurst PA, Jolley JD, Cvejic A, Kostadima M, Bertone P, Breuning MH, Debili N, Deloukas P, Favier R, Fiedler J, Hobbs CM, Huang N, Hurles ME, Kiddle G, Krapels I, Nurden P, Ruivenkamp CA, Sambrook JG, Smith K, Stemple DL, Strauss G, Thys C, van Geet C, Newbury-Ecob R, Ouwehand WH, Ghevaert C.

Nat Genet. 2012 Feb 26;44(4):435-9, S1-2. doi: 10.1038/ng.1083.

38.

Characterization of a novel Xenopus tropicalis cell line as a model for in vitro studies.

Sinzelle L, Thuret R, Hwang HY, Herszberg B, Paillard E, Bronchain OJ, Stemple DL, Dhorne-Pollet S, Pollet N.

Genesis. 2012 Mar;50(3):316-24. doi: 10.1002/dvg.20822. Epub 2011 Dec 27.

39.

Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish.

Clark MD, Guryev V, Bruijn Ed, Nijman IJ, Tada M, Wilson C, Deloukas P, Postlethwait JH, Cuppen E, Stemple DL.

Methods Cell Biol. 2011;104:219-35. doi: 10.1016/B978-0-12-374814-0.00013-6.

PMID:
21924166
40.

High-throughput target-selected gene inactivation in zebrafish.

Kettleborough RN, Bruijn Ed, Eeden Fv, Cuppen E, Stemple DL.

Methods Cell Biol. 2011;104:121-7. doi: 10.1016/B978-0-12-374814-0.00006-9.

PMID:
21924159
41.

The future of model organisms in human disease research.

Aitman TJ, Boone C, Churchill GA, Hengartner MO, Mackay TF, Stemple DL.

Nat Rev Genet. 2011 Jul 18;12(8):575-82. doi: 10.1038/nrg3047. Review.

PMID:
21765459
42.

Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.

Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH, Freson K.

Blood. 2011 Nov 3;118(18):4967-76. doi: 10.1182/blood-2011-02-337295. Epub 2011 Jun 28.

43.

Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.

Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, Wang X, Ottersbach K, Stemple DL, Green AR, Ouwehand WH, Göttgens B.

Dev Cell. 2011 May 17;20(5):597-609. doi: 10.1016/j.devcel.2011.04.008.

44.

A genetic map of Xenopus tropicalis.

Wells DE, Gutierrez L, Xu Z, Krylov V, Macha J, Blankenburg KP, Hitchens M, Bellot LJ, Spivey M, Stemple DL, Kowis A, Ye Y, Pasternak S, Owen J, Tran T, Slavikova R, Tumova L, Tlapakova T, Seifertova E, Scherer SE, Sater AK.

Dev Biol. 2011 Jun 1;354(1):1-8. doi: 10.1016/j.ydbio.2011.03.022. Epub 2011 Mar 31.

45.

Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies.

Lin YY, White RJ, Torelli S, Cirak S, Muntoni F, Stemple DL.

Hum Mol Genet. 2011 May 1;20(9):1763-75. doi: 10.1093/hmg/ddr059. Epub 2011 Feb 11.

46.

Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.

Ferrante MI, Kiff RM, Goulding DA, Stemple DL.

J Cell Sci. 2011 Feb 15;124(Pt 4):565-77. doi: 10.1242/jcs.071274. Epub 2011 Jan 18.

47.

The role of meis1 in primitive and definitive hematopoiesis during zebrafish development.

Cvejic A, Serbanovic-Canic J, Stemple DL, Ouwehand WH.

Haematologica. 2011 Feb;96(2):190-8. doi: 10.3324/haematol.2010.027698. Epub 2010 Nov 3.

48.

The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment.

Jacoby AS, Busch-Nentwich E, Bryson-Richardson RJ, Hall TE, Berger J, Berger S, Sonntag C, Sachs C, Geisler R, Stemple DL, Currie PD.

Development. 2009 Oct;136(19):3367-76. doi: 10.1242/dev.034561.

49.

Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.

O'Connor MN, Salles II, Cvejic A, Watkins NA, Walker A, Garner SF, Jones CI, Macaulay IC, Steward M, Zwaginga JJ, Bray SL, Dudbridge F, de Bono B, Goodall AH, Deckmyn H, Stemple DL, Ouwehand WH; Bloodomics Consortium.

Blood. 2009 May 7;113(19):4754-62. doi: 10.1182/blood-2008-06-162693. Epub 2008 Dec 24.

50.

Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene.

Ferrante MI, Romio L, Castro S, Collins JE, Goulding DA, Stemple DL, Woolf AS, Wilson SW.

Hum Mol Genet. 2009 Jan 15;18(2):289-303. doi: 10.1093/hmg/ddn356. Epub 2008 Oct 29.

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