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Items: 32

1.

Stricturing and Fistulizing Crohn's Disease Is Associated with Anti-tumor Necrosis Factor-Induced Psoriasis in Patients with Inflammatory Bowel Disease.

Weizman AV, Sharma R, Afzal NM, Xu W, Walsh S, Stempak JM, Nguyen GC, Croitoru K, Steinhart AH, Silverberg MS.

Dig Dis Sci. 2018 Sep;63(9):2430-2438. doi: 10.1007/s10620-018-5096-2. Epub 2018 May 8.

PMID:
29736839
2.

Therapeutic Drug Monitoring to Guide Infliximab Dose Adjustment is Associated with Better Endoscopic Outcomes than Clinical Decision Making Alone in Active Inflammatory Bowel Disease.

Kelly OB, Donnell SO, Stempak JM, Steinhart AH, Silverberg MS.

Inflamm Bowel Dis. 2017 Jul;23(7):1202-1209. doi: 10.1097/MIB.0000000000001126.

PMID:
28498155
3.

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ, Barrett J, de Lane K, Edwards C, Hart A, Hawkey C, Jostins L, Kennedy N, Lamb C, Lee J, Lees C, Mansfield J, Mathew C, Mowatt C, Newman B, Nimmo E, Parkes M, Pollard M, Prescott N, Randall J, Rice D, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson D, Abraham C, Achkar JP, Bitton A, Boucher G, Croitoru K, Fleshner P, Glas J, Kugathasan S, Limbergen JV, Milgrom R, Proctor D, Regueiro M, Schumm PL, Sharma Y, Stempak JM, Targan SR, Wang MH.

Nat Commun. 2016 Aug 9;7:12342. doi: 10.1038/ncomms12342. Erratum in: Nat Commun. 2016 Sep 13;7:12869.

4.

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.

Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH.

Gastroenterology. 2016 Oct;151(4):724-32. doi: 10.1053/j.gastro.2016.06.051. Epub 2016 Aug 1.

5.

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Evelyn Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH.

Gastroenterology. 2016 Oct;151(4):710-723.e2. doi: 10.1053/j.gastro.2016.06.045. Epub 2016 Jul 1.

6.

TNFRSF1B Is Associated with ANCA in IBD.

Li D, Silverberg MS, Haritunians T, Dubinsky MC, Landers C, Stempak JM, Milgrom R, Guo X, Chen YD, Rotter JI, Taylor KD, McGovern DP, Targan SR.

Inflamm Bowel Dis. 2016 Jun;22(6):1346-52. doi: 10.1097/MIB.0000000000000771.

PMID:
27104820
7.

Microbiome Heterogeneity Characterizing Intestinal Tissue and Inflammatory Bowel Disease Phenotype.

Tyler AD, Kirsch R, Milgrom R, Stempak JM, Kabakchiev B, Silverberg MS.

Inflamm Bowel Dis. 2016 Apr;22(4):807-16. doi: 10.1097/MIB.0000000000000674.

8.

Infliximab to Treat Refractory Inflammation After Pelvic Pouch Surgery for Ulcerative Colitis.

Kelly OB, Rosenberg M, Tyler AD, Stempak JM, Steinhart AH, Cohen Z, Greenberg GR, Silverberg MS.

J Crohns Colitis. 2016 Apr;10(4):410-7. doi: 10.1093/ecco-jcc/jjv225. Epub 2015 Dec 30.

9.

A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables.

Siegel CA, Horton H, Siegel LS, Thompson KD, Mackenzie T, Stewart SK, Rice PW, Stempak JM, Dezfoli S, Haritunians T, Levy A, Baek M, Milgrom R, Dulai PS, Targan SR, Silverberg MS, Dubinsky MC, McGovern DP.

Aliment Pharmacol Ther. 2016 Jan;43(2):262-71. doi: 10.1111/apt.13460. Epub 2015 Nov 15.

10.

Predictors of Outcome in Ulcerative Colitis.

Waterman M, Knight J, Dinani A, Xu W, Stempak JM, Croitoru K, Nguyen GC, Cohen Z, McLeod RS, Greenberg GR, Steinhart AH, Silverberg MS.

Inflamm Bowel Dis. 2015 Sep;21(9):2097-105. doi: 10.1097/MIB.0000000000000466.

PMID:
26177304
11.

Higher Rates of Dose Optimisation for Infliximab Responders in Ulcerative Colitis than in Crohn's disease.

O'Donnell S, Stempak JM, Steinhart AH, Silverberg MS.

J Crohns Colitis. 2015 Oct;9(10):830-6. doi: 10.1093/ecco-jcc/jjv115. Epub 2015 Jun 26.

PMID:
26116556
12.

Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.

Morgan XC, Kabakchiev B, Waldron L, Tyler AD, Tickle TL, Milgrom R, Stempak JM, Gevers D, Xavier RJ, Silverberg MS, Huttenhower C.

Genome Biol. 2015 Apr 8;16:67. doi: 10.1186/s13059-015-0637-x.

13.

Complex host genetics influence the microbiome in inflammatory bowel disease.

Knights D, Silverberg MS, Weersma RK, Gevers D, Dijkstra G, Huang H, Tyler AD, van Sommeren S, Imhann F, Stempak JM, Huang H, Vangay P, Al-Ghalith GA, Russell C, Sauk J, Knight J, Daly MJ, Huttenhower C, Xavier RJ.

Genome Med. 2014 Dec 2;6(12):107. doi: 10.1186/s13073-014-0107-1. eCollection 2014.

14.

Downregulation of expression of xenobiotic efflux genes is associated with pelvic pouch inflammation in ulcerative colitis.

Kabakchiev B, Tyler A, Stempak JM, Milgrom R, Silverberg MS.

Inflamm Bowel Dis. 2014 Jul;20(7):1157-64. doi: 10.1097/MIB.0000000000000078.

PMID:
24874456
15.

Attachment, childhood abuse, and IBD-related quality of life and disease activity outcomes.

Caplan RA, Maunder RG, Stempak JM, Silverberg MS, Hart TL.

Inflamm Bowel Dis. 2014 May;20(5):909-15. doi: 10.1097/MIB.0000000000000015.

PMID:
24651585
16.

Effect of inflammatory bowel disease therapies on immunogenicity of Mycobacterium paratuberculosis proteins.

Xia A, Stempak JM, Grist J, Bressler B, Silverberg MS, Bach H.

Scand J Gastroenterol. 2014 Feb;49(2):157-63. doi: 10.3109/00365521.2013.857713. Epub 2013 Nov 21.

PMID:
24256081
17.

Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease.

Gathungu G, Kim MO, Ferguson JP, Sharma Y, Zhang W, Ng SM, Bonkowski E, Ning K, Simms LA, Croft AR, Stempak JM, Walker N, Huang N, Xiao Y, Silverberg MS, Trapnell B, Cho JH, Radford-Smith GL, Denson LA.

Inflamm Bowel Dis. 2013 Jul;19(8):1671-80. doi: 10.1097/MIB.0b013e318281f506.

18.

Serum antibodies associated with complex inflammatory bowel disease.

Elkadri AA, Stempak JM, Walters TD, Lal S, Griffiths AM, Steinhart AH, Silverberg MS.

Inflamm Bowel Dis. 2013 Jun;19(7):1499-505. doi: 10.1097/MIB.0b013e318281f2a1.

PMID:
23702714
19.

The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis.

Tyler AD, Milgrom R, Stempak JM, Xu W, Brumell JH, Muise AM, Sehgal R, Cohen Z, Koltun W, Shen B, Silverberg MS.

Gut. 2013 Oct;62(10):1433-9. doi: 10.1136/gutjnl-2011-301957. Epub 2012 Aug 9.

PMID:
22879519
20.

Hypothesis-free analysis of ATG16L1 demonstrates gene-wide extent of association with Crohn's disease susceptibility.

Van Limbergen J, Kabakchiev B, Stempak JM, Schumm P, Xu W, Henderson P, Girardin S, Griffiths AM, Philpott D, Silverberg M.

Gut. 2013 Feb;62(2):331-3. doi: 10.1136/gutjnl-2012-303165. Epub 2012 Jul 24. No abstract available.

PMID:
22833393
21.

Prevalence of genetic variants associated with inflammatory bowel disease in a healthy First Nations cohort.

Murdoch TB, Bernstein CN, El-Gabalawy H, Stempak JM, Sargent M, Elias B, Xu W, Pathan S, Silverberg MS.

CMAJ. 2012 May 15;184(8):E435-41. doi: 10.1503/cmaj.110613. Epub 2012 Apr 10. Erratum in: CMAJ. 2012 Jul 10;184(10):1176.

22.

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease.

Murdoch TB, Xu W, Stempak JM, Landers C, Targan SR, Rotter JI, Silverberg MS.

Inflamm Bowel Dis. 2012 Sep;18(9):1743-8. doi: 10.1002/ibd.22884. Epub 2012 Jan 24.

23.

Antimicrobial antibodies are associated with a Crohn's disease-like phenotype after ileal pouch-anal anastomosis.

Tyler AD, Milgrom R, Xu W, Stempak JM, Steinhart AH, McLeod RS, Greenberg GR, Cohen Z, Silverberg MS.

Clin Gastroenterol Hepatol. 2012 May;10(5):507-12.e1. doi: 10.1016/j.cgh.2011.09.016. Epub 2011 Oct 1.

PMID:
21963956
24.

Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis.

Waterman M, Xu W, Stempak JM, Milgrom R, Bernstein CN, Griffiths AM, Greenberg GR, Steinhart AH, Silverberg MS.

Inflamm Bowel Dis. 2011 Sep;17(9):1936-42. doi: 10.1002/ibd.21579. Epub 2010 Dec 10.

25.

Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior.

Lichtenstein GR, Targan SR, Dubinsky MC, Rotter JI, Barken DM, Princen F, Carroll S, Brown M, Stachelski J, Chuang E, Landers CJ, Stempak JM, Singh S, Silverberg MS.

Inflamm Bowel Dis. 2011 Dec;17(12):2488-96. doi: 10.1002/ibd.21661. Epub 2011 Mar 9.

26.

Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype.

Seow CH, Stempak JM, Xu W, Lan H, Griffiths AM, Greenberg GR, Steinhart AH, Dotan N, Silverberg MS.

Am J Gastroenterol. 2009 Jun;104(6):1426-34. doi: 10.1038/ajg.2009.79. Epub 2009 Apr 21.

PMID:
19491856
27.

Attitudes toward genetic testing in patients with inflammatory bowel disease.

Lal S, Appelton J, Mascarenhas J, Stempak JM, Esplen MJ, Silverberg MS.

Eur J Gastroenterol Hepatol. 2007 Apr;19(4):321-7.

PMID:
17353697
29.

Association between the C3435T polymorphism of the MDR1 gene and Crohn's disease.

Lal S, Stempak JM, Law C, Elkadri AA, Steinhart AH, Silverberg MS.

Inflamm Bowel Dis. 2006 Oct;12(10):1006-7. No abstract available.

PMID:
17012973
30.

Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.

Novakovic P, Stempak JM, Sohn KJ, Kim YI.

Carcinogenesis. 2006 May;27(5):916-24. Epub 2005 Dec 16.

PMID:
16361273
31.

Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model.

Stempak JM, Sohn KJ, Chiang EP, Shane B, Kim YI.

Carcinogenesis. 2005 May;26(5):981-90. Epub 2005 Feb 3.

PMID:
15695236
32.

The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon.

Sohn KJ, Stempak JM, Reid S, Shirwadkar S, Mason JB, Kim YI.

Carcinogenesis. 2003 Jan;24(1):81-90.

PMID:
12538352

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