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Items: 1 to 50 of 83

1.

Chip-based sensing of membrane release of unprocessed cell surface proteins in vitro and in serum and its (patho)physiological relevance.

Müller GA, Herling AW, Stemmer K, Lechner A, Tschöp MH.

Am J Physiol Endocrinol Metab. 2019 Apr 30. doi: 10.1152/ajpendo.00079.2019. [Epub ahead of print]

PMID:
31039006
2.

Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models.

Bastek H, Zubel T, Stemmer K, Mangerich A, Beneke S, Dietrich DR.

Toxicology. 2019 May 15;420:29-38. doi: 10.1016/j.tox.2019.03.013. Epub 2019 Mar 30.

PMID:
30940547
3.

Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Niu L, Geyer PE, Wewer Albrechtsen NJ, Gluud LL, Santos A, Doll S, Treit PV, Holst JJ, Knop FK, Vilsbøll T, Junker A, Sachs S, Stemmer K, Müller TD, Tschöp MH, Hofmann SM, Mann M.

Mol Syst Biol. 2019 Mar 1;15(3):e8793. doi: 10.15252/msb.20188793.

4.

Peptide-based multi-agonists: a new paradigm in metabolic pharmacology.

Brandt SJ, Müller TD, DiMarchi RD, Tschöp MH, Stemmer K.

J Intern Med. 2018 Dec;284(6):581-602. doi: 10.1111/joim.12837. Epub 2018 Oct 23.

PMID:
30230640
5.

Computer-assisted 3D bowel length measurement for quantitative laparoscopy.

Wagner M, Mayer BFB, Bodenstedt S, Stemmer K, Fereydooni A, Speidel S, Dillmann R, Nickel F, Fischer L, Kenngott HG.

Surg Endosc. 2018 Sep;32(9):4052-4061. doi: 10.1007/s00464-018-6135-y. Epub 2018 Mar 5.

PMID:
29508142
6.

Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.

Rahn S, Zimmermann V, Viol F, Knaack H, Stemmer K, Peters L, Lenk L, Ungefroren H, Saur D, Schäfer H, Helm O, Sebens S.

Cancer Lett. 2018 Feb 28;415:129-150. doi: 10.1016/j.canlet.2017.12.004. Epub 2017 Dec 6.

PMID:
29222037
7.

Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.

Ryan KK, Packard AEB, Larson KR, Stout J, Fourman SM, Thompson AMK, Ludwick K, Habegger KM, Stemmer K, Itoh N, Perez-Tilve D, Tschöp MH, Seeley RJ, Ulrich-Lai YM.

Endocrinology. 2018 Jan 1;159(1):400-413. doi: 10.1210/en.2017-00486.

8.

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241c.

PMID:
28985207
9.

Emerging Poly-Agonists for Obesity and Type 2 Diabetes.

Kleinert M, Clemmensen C, Stemmer K, Müller TD, DiMarchi RD, Tschöp MH.

Obesity (Silver Spring). 2017 Oct;25(10):1647-1649. doi: 10.1002/oby.21932. No abstract available.

10.

Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice.

Pfuhlmann K, Pfluger PT, Schriever SC, Müller TD, Tschöp MH, Stemmer K.

PLoS One. 2017 Sep 5;12(9):e0183488. doi: 10.1371/journal.pone.0183488. eCollection 2017.

11.

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. Erratum in: Nat Med. 2017 Oct 6;23 (10 ):1241.

12.

Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.

Klaus V, Bastek H, Damme K, Collins LB, Frötschl R, Benda N, Lutter D, Ellinger-Ziegelbauer H, Swenberg JA, Dietrich DR, Stemmer K.

Arch Toxicol. 2017 Oct;91(10):3427-3438. doi: 10.1007/s00204-017-1953-6. Epub 2017 Mar 27.

13.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.

Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. Epub 2016 Oct 6.

14.

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.

Maida A, Zota A, Sjøberg KA, Schumacher J, Sijmonsma TP, Pfenninger A, Christensen MM, Gantert T, Fuhrmeister J, Rothermel U, Schmoll D, Heikenwälder M, Iovanna JL, Stemmer K, Kiens B, Herzig S, Rose AJ.

J Clin Invest. 2016 Sep 1;126(9):3263-78. doi: 10.1172/JCI85946. Epub 2016 Aug 22.

15.

Hypothalamic leptin action is mediated by histone deacetylase 5.

Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT.

Nat Commun. 2016 Feb 29;7:10782. doi: 10.1038/ncomms10782.

16.

Image-based laparoscopic bowel measurement.

Bodenstedt S, Wagner M, Mayer B, Stemmer K, Kenngott H, Müller-Stich B, Dillmann R, Speidel S.

Int J Comput Assist Radiol Surg. 2016 Mar;11(3):407-19. doi: 10.1007/s11548-015-1291-1. Epub 2015 Sep 26.

PMID:
26410840
17.

FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice.

Stemmer K, Zani F, Habegger KM, Neff C, Kotzbeck P, Bauer M, Yalamanchilli S, Azad A, Lehti M, Martins PJ, Müller TD, Pfluger PT, Seeley RJ.

Diabetologia. 2015 Oct;58(10):2414-23. doi: 10.1007/s00125-015-3668-7. Epub 2015 Jun 23.

18.

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.

Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U.

Gastroenterology. 2015 Oct;149(4):1042-52. doi: 10.1053/j.gastro.2015.05.055. Epub 2015 Jun 5.

PMID:
26052074
19.

Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice.

Stemmer K, Kotzbeck P, Zani F, Bauer M, Neff C, Müller TD, Pfluger PT, Seeley RJ, Divanovic S.

Int J Obes (Lond). 2015 May;39(5):791-7. doi: 10.1038/ijo.2014.187. Epub 2014 Oct 28.

20.

Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M.

Cancer Cell. 2014 Oct 13;26(4):549-64. doi: 10.1016/j.ccell.2014.09.003.

21.

Structure-function relationship of thiazolide-induced apoptosis in colorectal tumor cells.

Brockmann A, Strittmatter T, May S, Stemmer K, Marx A, Brunner T.

ACS Chem Biol. 2014 Jul 18;9(7):1520-7. doi: 10.1021/cb500209a. Epub 2014 May 20.

PMID:
24810314
22.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, Aulock SV, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A, Barile FA.

Toxicon. 2013 Dec 15;76:A1-A2. doi: 10.1016/j.toxicon.2013.10.020. Epub 2013 Oct 24. No abstract available.

PMID:
24512766
23.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A, Barile FA.

Toxicon. 2013 Dec 15;76:A1-A2. No abstract available.

PMID:
24409469
24.

Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets.

Bielohuby M, Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Wanke R, Tschöp MH, Seeley RJ, Bidlingmaier M.

Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1059-70. doi: 10.1152/ajpendo.00208.2013. Epub 2013 Aug 27.

25.

Open letter to the European Commission: scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles.

Dietrich D, von Aulock S, Marquardt HW, Blaauboer BJ, Dekant W, Kehrer J, Hengstler JG, Collier AC, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Arch Toxicol. 2013 Sep;87(9):1739-41. doi: 10.1007/s00204-013-1117-2. Epub 2013 Aug 27. No abstract available.

PMID:
23979651
26.

Elevated CO₂ levels do not affect the shell structure of the bivalve Arctica islandica from the Western Baltic.

Stemmer K, Nehrke G, Brey T.

PLoS One. 2013 Jul 29;8(7):e70106. doi: 10.1371/journal.pone.0070106. Print 2013.

27.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Batta Gori G, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Wallace Hayes A, Gooderham N, Harvey A.

ALTEX. 2013;30(3):381-5. doi: 10.14573/altex.2013.3.381. No abstract available.

28.

Editorial.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Regul Toxicol Pharmacol. 2013 Dec;67(3):317-20. doi: 10.1016/j.yrtph.2013.07.001. Epub 2013 Jul 9. No abstract available.

PMID:
23850959
29.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen OP, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes A, Gooderham N, Harvey A.

Toxicol In Vitro. 2013 Oct;27(7):2110-4. doi: 10.1016/j.tiv.2013.07.001. Epub 2013 Jul 9. No abstract available.

PMID:
23850741
30.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Food Chem Toxicol. 2013 Dec;62:A1-4. doi: 10.1016/j.fct.2013.07.005. Epub 2013 Jul 5. No abstract available.

PMID:
23835284
31.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, Aulock Sv, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Barile FA, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Chem Biol Interact. 2013 Sep 5;205(1):A1-5. doi: 10.1016/j.cbi.2013.07.001. Epub 2013 Jul 4. No abstract available.

PMID:
23832050
32.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.

Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968.

33.

Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats.

Stemmer K, Bielohuby M, Grayson BE, Begg DP, Chambers AP, Neff C, Woods SC, Erben RG, Tschöp MH, Bidlingmaier M, Clemens TL, Seeley RJ.

Endocrinology. 2013 Jun;154(6):2015-24. doi: 10.1210/en.2012-2130. Epub 2013 Apr 3. Erratum in: Endocrinology. 2016 May;157(5):2196.

34.

Fibroblast growth factor 21 mediates specific glucagon actions.

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.

Diabetes. 2013 May;62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10.

35.

p62 links β-adrenergic input to mitochondrial function and thermogenesis.

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH.

J Clin Invest. 2013 Jan;123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21.

36.

Targeted estrogen delivery reverses the metabolic syndrome.

Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, de Angelis MH, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH.

Nat Med. 2012 Dec;18(12):1847-56. doi: 10.1038/nm.3009. Epub 2012 Nov 11.

37.

L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations.

Okle O, Stemmer K, Deschl U, Dietrich DR.

Toxicol Sci. 2013 Jan;131(1):217-24. doi: 10.1093/toxsci/kfs291. Epub 2012 Oct 9.

PMID:
23047912
38.

High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney.

Stemmer K, Perez-Tilve D, Ananthakrishnan G, Bort A, Seeley RJ, Tschöp MH, Dietrich DR, Pfluger PT.

Dis Model Mech. 2012 Sep;5(5):627-35. doi: 10.1242/dmm.009407. Epub 2012 Mar 15.

39.

Evaluation of a nurse practitioner disease management model for chronic heart failure: a multi-site implementation study.

Lowery J, Hopp F, Subramanian U, Wiitala W, Welsh DE, Larkin A, Stemmer K, Zak C, Vaitkevicius P.

Congest Heart Fail. 2012 Jan-Feb;18(1):64-71. doi: 10.1111/j.1751-7133.2011.00228.x. Epub 2011 Jun 27.

40.

Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats.

Bielohuby M, Stemmer K, Berger J, Ramisch J, Smith K, Holland J, Parks K, Pfluger PT, Habegger KM, Tschöp MH, Seeley RJ, Bidlingmaier M.

Obes Surg. 2012 Jan;22(1):140-51. doi: 10.1007/s11695-011-0528-5.

PMID:
21971629
41.

Microcystin congener- and concentration-dependent induction of murine neuron apoptosis and neurite degeneration.

Feurstein D, Stemmer K, Kleinteich J, Speicher T, Dietrich DR.

Toxicol Sci. 2011 Dec;124(2):424-31. doi: 10.1093/toxsci/kfr243. Epub 2011 Sep 20.

PMID:
21934130
42.

Application of laser-capture microdissection to study renal carcinogenesis.

Stemmer K, Dietrich DR.

Methods Mol Biol. 2011;755:279-90. doi: 10.1007/978-1-61779-163-5_23.

PMID:
21761312
43.

Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein.

Bielohuby M, Menhofer D, Kirchner H, Stoehr BJ, Müller TD, Stock P, Hempel M, Stemmer K, Pfluger PT, Kienzle E, Christ B, Tschöp MH, Bidlingmaier M.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E65-76. doi: 10.1152/ajpendo.00478.2010. Epub 2010 Oct 13.

44.

Investigation of microcystin congener-dependent uptake into primary murine neurons.

Feurstein D, Kleinteich J, Heussner AH, Stemmer K, Dietrich DR.

Environ Health Perspect. 2010 Oct;118(10):1370-5. doi: 10.1289/ehp.0901289. Epub 2010 May 15. Erratum in: Environ Health Perspect. 2013 Mar;121(3):A73.

45.

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells.

Fischer A, Hoeger SJ, Stemmer K, Feurstein DJ, Knobeloch D, Nussler A, Dietrich DR.

Toxicol Appl Pharmacol. 2010 May 15;245(1):9-20. doi: 10.1016/j.taap.2010.02.006. Epub 2010 Feb 17.

PMID:
20171238
46.

Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors.

Stemmer K, Ellinger-Ziegelbauer H, Ahr HJ, Dietrich DR.

Am J Pathol. 2009 Oct;175(4):1686-98. doi: 10.2353/ajpath.2009.081071. Epub 2009 Aug 28.

47.
48.

Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips.

Stemmer K, Ellinger-Ziegelbauer H, Lotz K, Ahr HJ, Dietrich DR.

Toxicol Appl Pharmacol. 2006 Nov 15;217(1):134-42. Epub 2006 Aug 8.

PMID:
16962625
49.

Animal models for transdermal drug delivery.

Panchagnula R, Stemmer K, Ritschel WA.

Methods Find Exp Clin Pharmacol. 1997 Jun;19(5):335-41.

PMID:
9379782
50.

Development of an intracutaneous depot for drugs. Binding, drug accumulation and retention studies, and mechanism of depot.

Ritschel WA, Panchagnula R, Stemmer K, Ashraf M.

Skin Pharmacol. 1991;4(4):235-45.

PMID:
1789985

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