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Items: 1 to 50 of 293


Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P, Liu X.

J Med Chem. 2019 Feb 14;62(3):1484-1501. doi: 10.1021/acs.jmedchem.8b01656. Epub 2019 Jan 18.


Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation.

Lomakin IB, Dmitriev SE, Steitz TA.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):528-533. doi: 10.1073/pnas.1809688116. Epub 2018 Dec 24.


Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.

Yang Y, Kang D, Nguyen LA, Smithline ZB, Pannecouque C, Zhan P, Liu X, Steitz TA.

Elife. 2018 Jul 25;7. pii: e36340. doi: 10.7554/eLife.36340.


Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.

Lin J, Zhou D, Steitz TA, Polikanov YS, Gagnon MG.

Annu Rev Biochem. 2018 Jun 20;87:451-478. doi: 10.1146/annurev-biochem-062917-011942. Epub 2018 Mar 23. Review.


Structural basis of bacterial transcription activation.

Liu B, Hong C, Huang RK, Yu Z, Steitz TA.

Science. 2017 Nov 17;358(6365):947-951. doi: 10.1126/science.aao1923.


Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.

Vaidya AT, Lomakin IB, Joseph NN, Dmitriev SE, Steitz TA.

J Mol Biol. 2017 Sep 1;429(18):2765-2771. doi: 10.1016/j.jmb.2017.07.015. Epub 2017 Jul 21.


Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.

Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA.

Cell Rep. 2017 Jul 18;20(3):521-528. doi: 10.1016/j.celrep.2017.06.025.


Perspectives on the ribosome.

Steitz TA, Moore PB.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160537. doi: 10.1098/rstb.2016.0537. No abstract available.


Crystal structure of Pistol, a class of self-cleaving ribozyme.

Nguyen LA, Wang J, Steitz TA.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1021-1026. doi: 10.1073/pnas.1611191114. Epub 2017 Jan 17.


Structural insights into NusG regulating transcription elongation.

Liu B, Steitz TA.

Nucleic Acids Res. 2017 Jan 25;45(2):968-974. doi: 10.1093/nar/gkw1159. Epub 2016 Nov 29.


A structure-based kinetic model of transcription.

Zuo Y, Steitz TA.

Transcription. 2017 Jan;8(1):1-8. doi: 10.1080/21541264.2016.1234821. Epub 2016 Sep 22.


Elongation factor 4 remodels the A-site tRNA on the ribosome.

Gagnon MG, Lin J, Steitz TA.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4994-9. doi: 10.1073/pnas.1522932113. Epub 2016 Apr 18.


Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.

Melnikov SV, Söll D, Steitz TA, Polikanov YS.

Nucleic Acids Res. 2016 Jun 2;44(10):4978-87. doi: 10.1093/nar/gkw246. Epub 2016 Apr 13.


Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism.

Liu B, Zuo Y, Steitz TA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4051-6. doi: 10.1073/pnas.1520555113. Epub 2016 Mar 28.


Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.

Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA.

Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi: 10.1093/nar/gkw018. Epub 2016 Jan 24.


Antimicrobial peptides targeting bacterial ribosome.

Lomakin IB, Gagnon MG, Steitz TA.

Oncotarget. 2015 Aug 7;6(22):18744-5. No abstract available.


Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.


The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin.

Roy RN, Lomakin IB, Gagnon MG, Steitz TA.

Nat Struct Mol Biol. 2015 Jun;22(6):466-9. doi: 10.1038/nsmb.3031. Epub 2015 May 18.


Crystal structures of the E. coli transcription initiation complexes with a complete bubble.

Zuo Y, Steitz TA.

Mol Cell. 2015 May 7;58(3):534-40. doi: 10.1016/j.molcel.2015.03.010. Epub 2015 Apr 9.


Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.

Polikanov YS, Melnikov SV, Söll D, Steitz TA.

Nat Struct Mol Biol. 2015 Apr;22(4):342-344. doi: 10.1038/nsmb.2992. Epub 2015 Mar 16.


Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27.

Bunick CG, Presland RB, Lawrence OT, Pearton DJ, Milstone LM, Steitz TA.

J Invest Dermatol. 2015 Jul;135(7):1801-1809. doi: 10.1038/jid.2015.102. Epub 2015 Mar 11.


Structural basis for transcription reactivation by RapA.

Liu B, Zuo Y, Steitz TA.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2006-10. doi: 10.1073/pnas.1417152112. Epub 2015 Feb 2.


Conformational changes of elongation factor G on the ribosome during tRNA translocation.

Lin J, Gagnon MG, Bulkley D, Steitz TA.

Cell. 2015 Jan 15;160(1-2):219-27. doi: 10.1016/j.cell.2014.11.049.


Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.

Guo LT, Wang YS, Nakamura A, Eiler D, Kavran JM, Wong M, Kiessling LL, Steitz TA, O'Donoghue P, Söll D.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16724-9. doi: 10.1073/pnas.1419737111. Epub 2014 Nov 10.


Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.

Polikanov YS, Szal T, Jiang F, Gupta P, Matsuda R, Shiozuka M, Steitz TA, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2014 Nov 20;56(4):541-50. doi: 10.1016/j.molcel.2014.09.021. Epub 2014 Oct 9.


Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.

Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV.

Mol Cell. 2014 Nov 20;56(4):531-40. doi: 10.1016/j.molcel.2014.09.020. Epub 2014 Oct 9.


Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme.

Eiler D, Wang J, Steitz TA.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13028-33. doi: 10.1073/pnas.1414571111. Epub 2014 Aug 25.


A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.

Polikanov YS, Steitz TA, Innis CA.

Nat Struct Mol Biol. 2014 Sep;21(9):787-93. doi: 10.1038/nsmb.2871. Epub 2014 Aug 17.


Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome.

Gagnon MG, Lin J, Bulkley D, Steitz TA.

Science. 2014 Aug 8;345(6197):684-7. doi: 10.1126/science.1253525.


Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix.

Brown JA, Bulkley D, Wang J, Valenstein ML, Yario TA, Steitz TA, Steitz JA.

Nat Struct Mol Biol. 2014 Jul;21(7):633-40. doi: 10.1038/nsmb.2844. Epub 2014 Jun 22.


Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex.

Ritacco CJ, Steitz TA, Wang J.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):685-93. doi: 10.1107/S1399004713032392. Epub 2014 Feb 15.


A new system for naming ribosomal proteins.

Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M.

Curr Opin Struct Biol. 2014 Feb;24:165-9. doi: 10.1016/ Epub 2014 Feb 10. Review.


The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.

Bulkley D, Brandi L, Polikanov YS, Fabbretti A, O'Connor M, Gualerzi CO, Steitz TA.

Cell Rep. 2014 Jan 30;6(2):357-65. doi: 10.1016/j.celrep.2013.12.024. Epub 2014 Jan 9.


Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases.

Eiler D, Lin J, Simonetti A, Klaholz BP, Steitz TA.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15662-7. doi: 10.1073/pnas.1309360110. Epub 2013 Sep 12.


Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.

Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15656-61. doi: 10.1073/pnas.1309578110. Epub 2013 Sep 12.


The initiation of mammalian protein synthesis and mRNA scanning mechanism.

Lomakin IB, Steitz TA.

Nature. 2013 Aug 15;500(7462):307-11. doi: 10.1038/nature12355. Epub 2013 Jul 21.


The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.

Zuo Y, Wang Y, Steitz TA.

Mol Cell. 2013 May 9;50(3):430-6. doi: 10.1016/j.molcel.2013.03.020. Epub 2013 Apr 25.


Structure of the PolIIIα-τc-DNA complex suggests an atomic model of the replisome.

Liu B, Lin J, Steitz TA.

Structure. 2013 Apr 2;21(4):658-64. doi: 10.1016/j.str.2013.02.002. Epub 2013 Mar 7.


Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase.

Ritacco CJ, Kamtekar S, Wang J, Steitz TA.

Nucleic Acids Res. 2013 Feb 1;41(4):2673-82. doi: 10.1093/nar/gks1303. Epub 2012 Dec 28.


The hexameric helicase DnaB adopts a nonplanar conformation during translocation.

Itsathitphaisarn O, Wing RA, Eliason WK, Wang J, Steitz TA.

Cell. 2012 Oct 12;151(2):267-77. doi: 10.1016/j.cell.2012.09.014. Epub 2012 Sep 27.


Elements of ribosomal drug resistance and specificity.

Blaha GM, Polikanov YS, Steitz TA.

Curr Opin Struct Biol. 2012 Dec;22(6):750-8. doi: 10.1016/ Epub 2012 Sep 13. Review.


How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.

Polikanov YS, Blaha GM, Steitz TA.

Science. 2012 May 18;336(6083):915-8. doi: 10.1126/science.1218538.


Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.

Gagnon MG, Seetharaman SV, Bulkley D, Steitz TA.

Science. 2012 Mar 16;335(6074):1370-2. doi: 10.1126/science.1217443.


The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome.

Bulkley D, Johnson F, Steitz TA.

J Mol Biol. 2012 Mar 2;416(4):571-8. doi: 10.1016/j.jmb.2011.12.055. Epub 2012 Jan 2.


Lunchtime science.

Steitz TA.

Nature. 2011 Oct 12;478(7368):S2-3. doi: 10.1038/478S2a. No abstract available.


Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex.

Wang M, Xia S, Blaha G, Steitz TA, Konigsberg WH, Wang J.

Biochemistry. 2011 Feb 1;50(4):581-90. doi: 10.1021/bi101192f. Epub 2010 Dec 30.


Poly(A) tail recognition by a viral RNA element through assembly of a triple helix.

Mitton-Fry RM, DeGregorio SJ, Wang J, Steitz TA, Steitz JA.

Science. 2010 Nov 26;330(6008):1244-7. doi: 10.1126/science.1195858.


How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA.

Pan B, Xiong Y, Steitz TA.

Science. 2010 Nov 12;330(6006):937-40. doi: 10.1126/science.1194985.


The roles of RNA in the synthesis of protein.

Moore PB, Steitz TA.

Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a003780. doi: 10.1101/cshperspect.a003780. Review.

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