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Structural Basis for Target-Directed MicroRNA Degradation.

Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ.

Mol Cell. 2019 Jul 13. pii: S1097-2765(19)30475-7. doi: 10.1016/j.molcel.2019.06.019. [Epub ahead of print]


Size-Tailored Biocompatible FePt Nanoparticles for Dual T1/T2 Magnetic Resonance Imaging Contrast Enhancement.

Slabu I, Wiemer K, Steitz J, Liffmann R, Mues B, Eisold S, Caumanns T, Mayer J, Kuhl CK, Schmitz-Rode T, Simon U.

Langmuir. 2019 Aug 13;35(32):10424-10434. doi: 10.1021/acs.langmuir.9b00337. Epub 2019 Jul 29.


In vivo endothelialization and neointimal hyperplasia assessment after angioplasty of sheep carotid artery with a novel polycarbonate polyurethane patch.

Jalaie H, Steitz J, Afify M, Barbati ME, Hoeft K, Assar MAM, Hermanns-Sachweh B, Tolba RH, Jacobs MJ, Schleimer K.

J Biomater Appl. 2019 Aug;34(2):208-218. doi: 10.1177/0885328219849368. Epub 2019 May 14. No abstract available.


Idiosyncrasies of Viral Noncoding RNAs Provide Insights into Host Cell Biology.

Withers JB, Mondol V, Pawlica P, Rosa-Mercado NA, Tycowski KT, Ghasempur S, Torabi SF, Steitz JA.

Annu Rev Virol. 2019 Apr 30. doi: 10.1146/annurev-virology-092818-015811. [Epub ahead of print]


The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia⁻Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats.

Iwasaki J, Afify M, Bleilevens C, Klinge U, Weiskirchen R, Steitz J, Vogt M, Yagi S, Nagai K, Uemoto S, Tolba RH.

Int J Mol Sci. 2019 Apr 29;20(9). pii: E2114. doi: 10.3390/ijms20092114.


Two herpesviral noncoding PAN RNAs are functionally homologous but do not associate with common chromatin loci.

Withers JB, Li ES, Vallery TK, Yario TA, Steitz JA.

PLoS Pathog. 2018 Nov 1;14(11):e1007389. doi: 10.1371/journal.ppat.1007389. eCollection 2018 Nov.


Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens.

Hampel S, Steitz JP, Baierl A, Lehwald P, Wiesli L, Richter M, Fries A, Pohl M, Schneider G, Dobritzsch D, Müller M.

Chembiochem. 2018 Nov 2;19(21):2283-2292. doi: 10.1002/cbic.201800325. Epub 2018 Oct 11.


Surgical Management of Nasal Valve Collapse.

Samra S, Steitz JT, Hajnas N, Toriumi DM.

Otolaryngol Clin North Am. 2018 Oct;51(5):929-944. doi: 10.1016/j.otc.2018.05.009. Epub 2018 Jul 13. Review.


Sheep models for evaluation of novel patch and prosthesis material in vascular surgery: tips and tricks to avoid possible pitfalls.

Schleimer K, Jalaie H, Afify M, Woitok A, Barbati ME, Hoeft K, Jacobs M, Tolba RH, Steitz J.

Acta Vet Scand. 2018 Jul 5;60(1):42. doi: 10.1186/s13028-018-0397-1.


Caution needs to be taken when assigning transcription start sites to ends of protein-coding genes: a rebuttal.

Sabath N, Vilborg A, Steitz JA, Shalgi R.

Hum Genomics. 2018 Jun 27;12(1):32. doi: 10.1186/s40246-018-0164-4.


Kaposi's Sarcoma-Associated Herpesvirus mRNA Accumulation in Nuclear Foci Is Influenced by Viral DNA Replication and Viral Noncoding Polyadenylated Nuclear RNA.

Vallery TK, Withers JB, Andoh JA, Steitz JA.

J Virol. 2018 Jun 13;92(13). pii: e00220-18. doi: 10.1128/JVI.00220-18. Print 2018 Jul 1.


Immunoprecipitation of Tri-methylated Capped RNA.

Hayes KE, Barr JA, Xie M, Steitz JA, Martinez I.

Bio Protoc. 2018 Feb 5;8(3). pii: e2717. doi: 10.21769/BioProtoc.2717.


Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation.

Brehs M, Pötgens AJG, Steitz J, Thewes K, Schwarz J, Conibear AC, Bartneck M, Tacke F, Becker CFW.

Sci Rep. 2017 Dec 14;7(1):17592. doi: 10.1038/s41598-017-17627-0.


Comparative analysis reveals genomic features of stress-induced transcriptional readthrough.

Vilborg A, Sabath N, Wiesel Y, Nathans J, Levy-Adam F, Yario TA, Steitz JA, Shalgi R.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8362-E8371. doi: 10.1073/pnas.1711120114. Epub 2017 Sep 19.


Not just Salk.

Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V.

Science. 2017 Sep 15;357(6356):1105-1106. doi: 10.1126/science.aao6221. No abstract available.


Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL-PEGACLONE.

Angerer V, Mogler L, Steitz JP, Bisel P, Hess C, Schoeder CT, Müller CE, Huppertz LM, Westphal F, Schäper J, Auwärter V.

Drug Test Anal. 2018 Mar;10(3):597-603. doi: 10.1002/dta.2237. Epub 2017 Aug 9.


Settling the m6A debate: methylation of mature mRNA is not dynamic but accelerates turnover.

Rosa-Mercado NA, Withers JB, Steitz JA.

Genes Dev. 2017 May 15;31(10):957-958. doi: 10.1101/gad.302695.117. Review.


An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence.

Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4961-E4970. doi: 10.1073/pnas.1618732114. Epub 2017 Jun 5.


The Aachen Minipig: Phenotype, Genotype, Hematological and Biochemical Characterization, and Comparison to the Göttingen Minipig.

Pawlowsky K, Ernst L, Steitz J, Stopinski T, Kögel B, Henger A, Kluge R, Tolba R.

Eur Surg Res. 2017;58(5-6):193-203. doi: 10.1159/000471483. Epub 2017 Apr 22.


ITIH5 mediates epigenetic reprogramming of breast cancer cells.

Rose M, Kloten V, Noetzel E, Gola L, Ehling J, Heide T, Meurer SK, Gaiko-Shcherbak A, Sechi AS, Huth S, Weiskirchen R, Klaas O, Antonopoulos W, Lin Q, Wagner W, Veeck J, Gremse F, Steitz J, Knüchel R, Dahl E.

Mol Cancer. 2017 Feb 23;16(1):44. doi: 10.1186/s12943-017-0610-2.


Detection and Specific Elimination of EGFR+ Ovarian Cancer Cells Using a Near Infrared Photoimmunotheranostic Approach.

Bauerschlag D, Meinhold-Heerlein I, Maass N, Bleilevens A, Bräutigam K, Al Rawashdeh W, Di Fiore S, Haugg AM, Gremse F, Steitz J, Fischer R, Stickeler E, Barth S, Hussain AF.

Pharm Res. 2017 Apr;34(4):696-703. doi: 10.1007/s11095-017-2096-4. Epub 2017 Jan 10.


Fluorescence Amplification Method for Forward Genetic Discovery of Factors in Human mRNA Degradation.

Alexandrov A, Shu MD, Steitz JA.

Mol Cell. 2017 Jan 5;65(1):191-201. doi: 10.1016/j.molcel.2016.11.032. Epub 2016 Dec 22.


Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.

Brown JA, Kinzig CG, DeGregorio SJ, Steitz JA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14013-14018. Epub 2016 Nov 21.


Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling.

Broda J, Küster A, Westhues S, Fahrenkamp D, Vogg AT, Steitz J, Mottaghy FM, Müller-Newen G, Simon U.

Adv Healthc Mater. 2016 Dec;5(24):3118-3128. doi: 10.1002/adhm.201600892. Epub 2016 Nov 18.


Cyclooxygenase Inhibitors as a New Therapeutic Strategy in Small Bowel Transplantation.

Schildberg FA, Liu B, Afify M, Steitz J, Paschenda P, Schäfer N, Kalff JC, Minor T, Tolba RH.

Transplantation. 2016 Nov;100(11):2324-2331.


Advantages of laparoscopic compared to conventional surgery are not related to an innate immune response of peritoneal immune activation: an animal study in rats.

Lingohr P, Dohmen J, Matthaei H, Schwandt T, Stein K, Hong GS, Steitz J, Longerich T, Bölke E, Wehner S, Kalff JC.

Langenbecks Arch Surg. 2017 Jun;402(4):625-636. doi: 10.1007/s00423-016-1521-1. Epub 2016 Oct 19.


Worst case optimization for interfractional motion mitigation in carbon ion therapy of pancreatic cancer.

Steitz J, Naumann P, Ulrich S, Haefner MF, Sterzing F, Oelfke U, Bangert M.

Radiat Oncol. 2016 Oct 7;11(1):134.


A proximity-dependent assay for specific RNA-protein interactions in intact cells.

Zhang W, Xie M, Shu MD, Steitz JA, DiMaio D.

RNA. 2016 Nov;22(11):1785-1792. Epub 2016 Sep 22.


Host miRNA degradation by Herpesvirus saimiri small nuclear RNA requires an unstructured interacting region.

Pawlica P, Moss WN, Steitz JA.

RNA. 2016 Aug;22(8):1181-9. doi: 10.1261/rna.054817.115. Epub 2016 Jun 22.


Intronless β-Globin Reporter: A Tool for Studying Nuclear RNA Stability Elements.

Brown JA, Steitz JA.

Methods Mol Biol. 2016;1428:77-92. doi: 10.1007/978-1-4939-3625-0_5.


Myriad Triple-Helix-Forming Structures in the Transposable Element RNAs of Plants and Fungi.

Tycowski KT, Shu MD, Steitz JA.

Cell Rep. 2016 May 10;15(6):1266-76. doi: 10.1016/j.celrep.2016.04.010. Epub 2016 Apr 28.


Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix.

Brown JA, Kinzig CG, DeGregorio SJ, Steitz JA.

RNA. 2016 May;22(5):743-9. doi: 10.1261/rna.055707.115. Epub 2016 Mar 7.


EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression.

Lee N, Yario TA, Gao JS, Steitz JA.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3221-6. doi: 10.1073/pnas.1601773113. Epub 2016 Mar 7.


Sonoporation enhances liposome accumulation and penetration in tumors with low EPR.

Theek B, Baues M, Ojha T, Möckel D, Veettil SK, Steitz J, van Bloois L, Storm G, Kiessling F, Lammers T.

J Control Release. 2016 Jun 10;231:77-85. doi: 10.1016/j.jconrel.2016.02.021. Epub 2016 Feb 12.


Readthrough transcription: How are DoGs made and what do they do?

Vilborg A, Steitz JA.

RNA Biol. 2017 May 4;14(5):632-636. doi: 10.1080/15476286.2016.1149680. Epub 2016 Feb 9. Review.


Ligand-lipid and ligand-core affinity control the interaction of gold nanoparticles with artificial lipid bilayers and cell membranes.

Broda J, Setzler J, Leifert A, Steitz J, Benz R, Simon U, Wenzel W.

Nanomedicine. 2016 Jul;12(5):1409-19. doi: 10.1016/j.nano.2015.12.384. Epub 2016 Jan 7.


Calcium signaling and transcription: elongation, DoGs, and eRNAs.

Vilborg A, Passarelli MC, Steitz JA.

Receptors Clin Investig. 2016;3(1). pii: e1169. doi: 10.14800/rci.1169. Epub 2016 Feb 1.


Surgical Management of Recurrent Tracheocarotid Fistula following Endovascular Stent Placement.

Steitz JT, Cappello ZJ, Katrib Z, Tennant PA.

Case Rep Otolaryngol. 2015;2015:547248. doi: 10.1155/2015/547248. Epub 2015 Nov 29.


A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.

Herbert KM, Sarkar SK, Mills M, Delgado De la Herran HC, Neuman KC, Steitz JA.

RNA. 2016 Feb;22(2):175-83. doi: 10.1261/rna.054684.115. Epub 2015 Dec 18.


Herpesvirus saimiri MicroRNAs Preferentially Target Host Cell Cycle Regulators.

Guo YE, Oei T, Steitz JA.

J Virol. 2015 Nov;89(21):10901-11. doi: 10.1128/JVI.01884-15. Epub 2015 Aug 19.


The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3' ends.

Xie M, Zhang W, Shu MD, Xu A, Lenis DA, DiMaio D, Steitz JA.

Genes Dev. 2015 Jul 15;29(14):1552-64. doi: 10.1101/gad.266973.115.


Noncoding RNA-guided recruitment of transcription factors: A prevalent but undocumented mechanism?

Lee N, Steitz JA.

Bioessays. 2015 Sep;37(9):936-41. doi: 10.1002/bies.201500060. Epub 2015 Jul 22.


Widespread Inducible Transcription Downstream of Human Genes.

Vilborg A, Passarelli MC, Yario TA, Tycowski KT, Steitz JA.

Mol Cell. 2015 Aug 6;59(3):449-61. doi: 10.1016/j.molcel.2015.06.016. Epub 2015 Jul 16.


Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2.

Pimienta G, Fok V, Haslip M, Nagy M, Takyar S, Steitz JA.

PLoS One. 2015 Jun 29;10(6):e0124638. doi: 10.1371/journal.pone.0124638. eCollection 2015.


In silico discovery and modeling of non-coding RNA structure in viruses.

Moss WN, Steitz JA.

Methods. 2015 Dec;91:48-56. doi: 10.1016/j.ymeth.2015.06.015. Epub 2015 Jun 23. Review.


Correction for Kim et al., development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model.

Kim E, Okada K, Beeler JA, Crim RL, Steitz J, Piedra PA, Gilbert BE, Gambotto A.

J Virol. 2015 May;89(9):5193. doi: 10.1128/JVI.03669-14. No abstract available.


Viral noncoding RNAs: more surprises.

Tycowski KT, Guo YE, Lee N, Moss WN, Vallery TK, Xie M, Steitz JA.

Genes Dev. 2015 Mar 15;29(6):567-84. doi: 10.1101/gad.259077.115. Review.


RNA-RNA base-pairing: theme and variations.

Steitz J.

RNA. 2015 Apr;21(4):476-7. doi: 10.1261/rna.050427.115. No abstract available.


EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA.

Lee N, Moss WN, Yario TA, Steitz JA.

Cell. 2015 Feb 12;160(4):607-618. doi: 10.1016/j.cell.2015.01.015. Epub 2015 Feb 5.


RNA editing, epitranscriptomics, and processing in cancer progression.

Witkin KL, Hanlon SE, Strasburger JA, Coffin JM, Jaffrey SR, Howcroft TK, Dedon PC, Steitz JA, Daschner PJ, Read-Connole E.

Cancer Biol Ther. 2015;16(1):21-7. doi: 10.4161/15384047.2014.987555.

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