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Items: 1 to 50 of 54

1.

Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.

Koppitz M, Bräuer N, Ter Laak A, Irlbacher H, Rotgeri A, Coelho AM, Walter D, Steinmeyer A, Zollner TM, Peters M, Nagel J.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2700-2705. doi: 10.1016/j.bmcl.2019.07.007. Epub 2019 Jul 24.

PMID:
31362919
2.

Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis.

Bäurle S, Nagel J, Peters O, Bräuer N, Ter Laak A, Preusse C, Rottmann A, Heldmann D, Bothe U, Blume T, Zorn L, Walter D, Zollner TM, Steinmeyer A, Langer G.

J Med Chem. 2019 Mar 14;62(5):2541-2563. doi: 10.1021/acs.jmedchem.8b01862. Epub 2019 Feb 22.

PMID:
30707023
3.

An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds?

Follmann M, Briem H, Steinmeyer A, Hillisch A, Schmitt MH, Haning H, Meier H.

Drug Discov Today. 2019 Mar;24(3):668-672. doi: 10.1016/j.drudis.2018.12.003. Epub 2018 Dec 15. Review.

4.

Sharing pharma compounds with academia: experiences with providing vitamin D receptor ligands.

Schmitz AA, Hackethal S, Schulz A, May E, Steinmeyer A, Zügel U, Asadullah K.

Nat Rev Drug Discov. 2015 Apr;14(4):294. doi: 10.1038/nrd4008-c1. Epub 2015 Mar 6. No abstract available.

PMID:
25743082
5.

Role of vitamin D derivatives in intestinal tissue of patients with inflammatory bowel diseases.

Martinesi M, Ambrosini S, Treves C, Zuegel U, Steinmeyer A, Vito A, Milla M, Bonanomi AG, Stio M.

J Crohns Colitis. 2014 Sep;8(9):1062-71. doi: 10.1016/j.crohns.2014.02.005. Epub 2014 Mar 12.

PMID:
24630484
6.

Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo.

Blomberg Jensen M, Jørgensen A, Nielsen JE, Steinmeyer A, Leffers H, Juul A, Rajpert-De Meyts E.

Neoplasia. 2012 Oct;14(10):952-63.

7.

The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.

van der Eerden BC, Fratzl-Zelman N, Nijenhuis T, Roschger P, Zügel U, Steinmeyer A, Hoenderop JG, Bindels RJ, Klaushofer K, van Leeuwen JP.

J Cell Physiol. 2013 Feb;228(2):402-7. doi: 10.1002/jcp.24144.

PMID:
22740316
8.

The novel vitamin D analog ZK191784 inhibits prostate cancer cell invasion.

Stio M, Martinesi M, Simoni A, Zuegel U, Steinmeyer A, Santi R, Treves C, Nesi G.

Anticancer Res. 2011 Dec;31(12):4091-8.

PMID:
22199266
9.

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.

Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL.

Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

10.

Vitamin D receptor activation improves allergen-triggered eczema in mice.

Hartmann B, Riedel R, Jörss K, Loddenkemper C, Steinmeyer A, Zügel U, Babina M, Radbruch A, Worm M.

J Invest Dermatol. 2012 Feb;132(2):330-6. doi: 10.1038/jid.2011.296. Epub 2011 Sep 22.

11.

Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production.

Khoo AL, Chai LY, Koenen HJ, Oosting M, Steinmeyer A, Zuegel U, Joosten I, Netea MG, van der Ven AJ.

Cytokine. 2011 Aug;55(2):294-300. doi: 10.1016/j.cyto.2011.04.016. Epub 2011 May 17.

PMID:
21592820
12.

Rendezvous in chemical space? Comparing the small molecule compound libraries of Bayer and Schering.

Schamberger J, Grimm M, Steinmeyer A, Hillisch A.

Drug Discov Today. 2011 Jul;16(13-14):636-41. doi: 10.1016/j.drudis.2011.04.005. Epub 2011 Apr 30.

PMID:
21554978
13.

Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response.

Hartmann B, Heine G, Babina M, Steinmeyer A, Zügel U, Radbruch A, Worm M.

Allergy. 2011 Apr;66(4):540-8. doi: 10.1111/j.1398-9995.2010.02513.x. Epub 2010 Dec 1.

PMID:
21121929
14.

Calcitriol down-regulates human ether a go-go 1 potassium channel expression in cervical cancer cells.

Avila E, García-Becerra R, Rodríguez-Rasgado JA, Díaz L, Ordaz-Rosado D, Zügel U, Steinmeyer A, Barrera D, Halhali A, Larrea F, Camacho J.

Anticancer Res. 2010 Jul;30(7):2667-72.

PMID:
20682996
15.

Down-regulation of adhesion molecules and matrix metalloproteinases by ZK 156979 in inflammatory bowel diseases.

Martinesi M, Treves C, Bonanomi AG, Milla M, Bagnoli S, Zuegel U, Steinmeyer A, Stio M.

Clin Immunol. 2010 Jul;136(1):51-60. doi: 10.1016/j.clim.2010.03.004. Epub 2010 Apr 15.

PMID:
20399147
16.

Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells.

Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J.

J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):142-50. doi: 10.1016/j.jsbmb.2009.11.004. Epub 2009 Nov 17.

17.

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis.

Peric M, Koglin S, Dombrowski Y, Gross K, Bradac E, Büchau A, Steinmeyer A, Zügel U, Ruzicka T, Schauber J.

PLoS One. 2009 Jul 22;4(7):e6340. doi: 10.1371/journal.pone.0006340.

18.

Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.

Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL.

PLoS One. 2009 Jun 5;4(6):e5810. doi: 10.1371/journal.pone.0005810.

19.

Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host.

Szalay G, Sauter M, Haberland M, Zuegel U, Steinmeyer A, Kandolf R, Klingel K.

Circ Res. 2009 Apr 10;104(7):851-9. doi: 10.1161/CIRCRESAHA.109.193805. Epub 2009 Feb 26.

PMID:
19246678
20.

Immunomodulation by a novel, dissociated Vitamin D analogue.

Zügel U, Steinmeyer A, May E, Lehmann M, Asadullah K.

Exp Dermatol. 2009 Jul;18(7):619-27. doi: 10.1111/j.1600-0625.2009.00845.x. Epub 2009 Feb 23.

PMID:
19239489
21.

1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.

Széles L, Keresztes G, Töröcsik D, Balajthy Z, Krenács L, Póliska S, Steinmeyer A, Zuegel U, Pruenster M, Rot A, Nagy L.

J Immunol. 2009 Feb 15;182(4):2074-83. doi: 10.4049/jimmunol.0803345.

22.

1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells.

Heine G, Niesner U, Chang HD, Steinmeyer A, Zügel U, Zuberbier T, Radbruch A, Worm M.

Eur J Immunol. 2008 Aug;38(8):2210-8. doi: 10.1002/eji.200838216.

23.

Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype.

Strauch UG, Obermeier F, Grunwald N, Dunger N, Rath HC, Schölmerich J, Steinmeyer A, Zügel U, Herfarth HH.

World J Gastroenterol. 2007 Dec 28;13(48):6529-37.

24.

Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.

Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL.

J Invest Dermatol. 2008 Apr;128(4):816-24. Epub 2007 Oct 18.

25.

Lactational state modifies alcohol pharmacokinetics in women.

Pepino MY, Steinmeyer AL, Mennella JA.

Alcohol Clin Exp Res. 2007 Jun;31(6):909-18. Epub 2007 Apr 13.

26.

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.

Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL.

J Clin Invest. 2007 Mar;117(3):803-11. Epub 2007 Feb 8.

27.

Vitamin D regulates the phenotype of human breast cancer cells.

Pendás-Franco N, González-Sancho JM, Suárez Y, Aguilera O, Steinmeyer A, Gamallo C, Berciano MT, Lafarga M, Muñoz A.

Differentiation. 2007 Mar;75(3):193-207. Epub 2006 Dec 11.

PMID:
17288543
28.

Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts.

Avila E, Díaz L, Barrera D, Halhali A, Méndez I, González L, Zuegel U, Steinmeyer A, Larrea F.

J Steroid Biochem Mol Biol. 2007 Jan;103(1):90-6. Epub 2006 Oct 31.

PMID:
17079137
29.

The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.

Nijenhuis T, van der Eerden BC, Zügel U, Steinmeyer A, Weinans H, Hoenderop JG, van Leeuwen JP, Bindels RJ.

FASEB J. 2006 Oct;20(12):2171-3.

PMID:
17012263
30.

The retinoid X receptor ligand restores defective signalling by the vitamin D receptor.

Sánchez-Martínez R, Castillo AI, Steinmeyer A, Aranda A.

EMBO Rep. 2006 Oct;7(10):1030-4. Epub 2006 Aug 25.

31.

The new low calcemic vitamin D analog 22-ene-25-oxa-vitamin D prominently ameliorates T helper cell type 1-mediated colitis in mice.

Daniel C, Radeke HH, Sartory NA, Zahn N, Zuegel U, Steinmeyer A, Stein J.

J Pharmacol Exp Ther. 2006 Nov;319(2):622-31. Epub 2006 Aug 16.

PMID:
16914561
32.

Characterization of vitamin D receptor ligands with cell-specific and dissociated activity.

Castillo AI, Sánchez-Martínez R, Jiménez-Lara AM, Steinmeyer A, Zügel U, Aranda A.

Mol Endocrinol. 2006 Dec;20(12):3093-104. Epub 2006 Aug 10.

33.

The hit-to-lead process at Schering AG: strategic aspects.

Steinmeyer A.

ChemMedChem. 2006 Jan;1(1):31-6.

PMID:
16892330
34.

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL.

Science. 2006 Mar 24;311(5768):1770-3. Epub 2006 Feb 23.

35.

Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.

Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J, Zügel U, Steinmeyer A, Pollak A, Roth E, Boltz-Nitulescu G, Spittler A.

Eur J Immunol. 2006 Feb;36(2):361-70.

36.

Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3.

Wehmeier K, Beers A, Haas MJ, Wong NC, Steinmeyer A, Zugel U, Mooradian AD.

Biochim Biophys Acta. 2005 Oct 15;1737(1):16-26. Epub 2005 Sep 26.

PMID:
16236546
37.

Calbindin-D28k (CaBP28k) identification and regulation by 1,25-dihydroxyvitamin D3 in human choriocarcinoma cell line JEG-3.

Belkacemi L, Züegel U, Steinmeyer A, Dion JP, Lafond J.

Mol Cell Endocrinol. 2005 May 31;236(1-2):31-41. Epub 2005 Apr 12.

PMID:
15922086
38.

22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities.

Daniel C, Schlauch T, Zügel U, Steinmeyer A, Radeke HH, Steinhilber D, Stein J.

Eur J Clin Invest. 2005 May;35(5):343-9.

PMID:
15860047
39.
40.

A novel immunosuppressive 1alpha,25-dihydroxyvitamin D3 analog with reduced hypercalcemic activity.

Zügel U, Steinmeyer A, Giesen C, Asadullah K.

J Invest Dermatol. 2002 Dec;119(6):1434-42.

41.

Critical role of helix 12 of the vitamin D(3) receptor for the partial agonism of carboxylic ester antagonists.

Väisänen S, Peräkylä M, Kärkkäinen JI, Steinmeyer A, Carlberg C.

J Mol Biol. 2002 Jan 11;315(2):229-38.

PMID:
11779241
42.

ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog.

Gaschott T, Steinmeyer A, Steinhilber D, Stein J.

Biochem Biophys Res Commun. 2002 Jan 11;290(1):504-9.

PMID:
11779200
43.

Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor.

Gaschott T, Werz O, Steinmeyer A, Steinhilber D, Stein J.

Biochem Biophys Res Commun. 2001 Nov 2;288(3):690-6.

PMID:
11676498
44.

Different molecular mechanisms of vitamin D(3) receptor antagonists.

Toell A, Gonzalez MM, Ruf D, Steinmeyer A, Ishizuka S, Carlberg C.

Mol Pharmacol. 2001 Jun;59(6):1478-85.

PMID:
11353809
45.

Metabolism of a 20-methyl substituted series of vitamin D analogs by cultured human cells: apparent reduction of 23-hydroxylation of the side chain by the 20-methyl group.

Shankar VN, Byford V, Prosser DE, Schroeder NJ, Makin HL, Wiesinger H, Neef G, Steinmeyer A, Jones G.

Biochem Pharmacol. 2001 Apr 1;61(7):893-902.

PMID:
11274975
46.

Synthesis and biological activities of a new series of secosteroids: vitamin D phosphonate hybrids.

Steinmeyer A, Schwarz K, Haberey M, Langer G, Wiesinger H.

Steroids. 2001 Mar-May;66(3-5):257-66.

PMID:
11179733
47.

Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.

Marczak S, Przezdziecka A, Wicha J, Steinmeyer A, Zügel U.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):63-6.

PMID:
11140735
48.

Carboxylic ester antagonists of 1alpha,25-dihydroxyvitamin D(3) show cell-specific actions.

Herdick M, Steinmeyer A, Carlberg C.

Chem Biol. 2000 Nov;7(11):885-94.

49.

Structure activity relationship of carboxylic ester antagonists of the vitamin D(3) receptor.

Bury Y, Steinmeyer A, Carlberg C.

Mol Pharmacol. 2000 Nov;58(5):1067-74.

PMID:
11040055
50.

New synthetic vitamin D analogs with antiproliferative activities.

Steinmeyer A, Kirsch G, Neef G, Schwarz K.

Curr Pharm Des. 2000 May;6(7):767-89. Review.

PMID:
10828307

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