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Items: 1 to 50 of 155

1.

Taxanes convert regions of perturbed microtubule growth into rescue sites.

Rai A, Liu T, Glauser S, Katrukha EA, Estévez-Gallego J, Rodríguez-García R, Fang WS, Díaz JF, Steinmetz MO, Altmann KH, Kapitein LC, Moores CA, Akhmanova A.

Nat Mater. 2019 Dec 9. doi: 10.1038/s41563-019-0546-6. [Epub ahead of print]

PMID:
31819210
2.

Structural determinants of microtubule minus end preference in CAMSAP CKK domains.

Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores CA.

Nat Commun. 2019 Nov 20;10(1):5236. doi: 10.1038/s41467-019-13247-6.

3.

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.

Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, Barasoain I, Song C, Sun D, Dovat S, Yunes RA, Prota AE, Steinmetz MO, Díaz JF, Yunes JA.

iScience. 2019 Nov 22;21:95-109. doi: 10.1016/j.isci.2019.10.003. Epub 2019 Oct 2.

4.

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses.

Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, Martin K, Sharma A, Olieric N, Shah P, Stanczak M, Kirchhammer N, Park SM, Wieckowski S, Laubli H, Zagani R, Kasenda B, Steinmetz MO, Reinecker HC, Zippelius A.

Cell Rep. 2019 Sep 24;28(13):3367-3380.e8. doi: 10.1016/j.celrep.2019.08.057.

5.

Remote control of microtubule plus-end dynamics and function from the minus-end.

Chen X, Widmer LA, Stangier MM, Steinmetz MO, Stelling J, Barral Y.

Elife. 2019 Sep 6;8. pii: e48627. doi: 10.7554/eLife.48627.

6.

Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex.

Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, Kammerer RA.

Structure. 2019 Sep 3;27(9):1375-1383.e3. doi: 10.1016/j.str.2019.07.002. Epub 2019 Jul 25.

PMID:
31353241
7.

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Jul 24;9(1):74-92.e8. doi: 10.1016/j.cels.2019.05.009. Epub 2019 Jul 10.

8.

Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.

Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, Bao H, Krichen F, Chen L, Andrieux A, Olieric V, Moutin MJ, Steinmetz MO, Huang H.

Nat Struct Mol Biol. 2019 Jul;26(7):571-582. doi: 10.1038/s41594-019-0241-y. Epub 2019 Jun 24.

PMID:
31235911
9.

Microtubule minus-end regulation at a glance.

Akhmanova A, Steinmetz MO.

J Cell Sci. 2019 Jun 7;132(11). pii: jcs227850. doi: 10.1242/jcs.227850. Review.

10.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1392. doi: 10.3390/ijms20061392.

11.

Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data.

Dolenc J, van Gunsteren WF, Prota AE, Steinmetz MO, Missimer JH.

J Chem Inf Model. 2019 May 28;59(5):2218-2230. doi: 10.1021/acs.jcim.9b00171. Epub 2019 Mar 25.

PMID:
30855963
12.

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL.

ACS Omega. 2019 Jan 31;4(1):755-764. doi: 10.1021/acsomega.8b02879. Epub 2019 Jan 9.

13.

MAP7 family proteins regulate kinesin-1 recruitment and activation.

Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A.

J Cell Biol. 2019 Apr 1;218(4):1298-1318. doi: 10.1083/jcb.201808065. Epub 2019 Feb 15.

14.

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, O'Sullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S.

Eur J Med Chem. 2019 Jan 15;162:290-320. doi: 10.1016/j.ejmech.2018.11.004. Epub 2018 Nov 3.

PMID:
30448418
15.

Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils.

Kraatz SHW, Bianchi S, Steinmetz MO.

Biosci Rep. 2018 Sep 19;38(5). pii: BSR20181073. doi: 10.1042/BSR20181073. Print 2018 Oct 31.

16.

Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim KH, Kam TS, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, Moses JE.

Sci Rep. 2018 Jul 13;8(1):10617. doi: 10.1038/s41598-018-28880-2.

17.

CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.

Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A.

Dev Cell. 2018 Jul 2;46(1):40-58.e8. doi: 10.1016/j.devcel.2018.05.032. Epub 2018 Jun 21.

18.

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton.

Steinmetz MO, Prota AE.

Trends Cell Biol. 2018 Oct;28(10):776-792. doi: 10.1016/j.tcb.2018.05.001. Epub 2018 Jun 2. Review.

PMID:
29871823
19.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Müller R, Paterson I, Díaz JF, Altmann KH, Steinmetz MO.

Nat Commun. 2018 May 29;9(1):2106. doi: 10.1038/s41467-018-04535-8.

20.

Structure-Function Relationship of the Bik1-Bim1 Complex.

Stangier MM, Kumar A, Chen X, Farcas AM, Barral Y, Steinmetz MO.

Structure. 2018 Apr 3;26(4):607-618.e4. doi: 10.1016/j.str.2018.03.003. Epub 2018 Mar 22.

21.

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.

Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM.

Sci Rep. 2018 Mar 9;8(1):4242. doi: 10.1038/s41598-018-22382-x.

22.

Cep120 promotes microtubule formation through a unique tubulin binding C2 domain.

Sharma A, Gerard SF, Olieric N, Steinmetz MO.

J Struct Biol. 2018 Jul;203(1):62-70. doi: 10.1016/j.jsb.2018.01.009. Epub 2018 Feb 1.

PMID:
29398280
23.

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Jiang K, Faltova L, Hua S, Capitani G, Prota AE, Landgraf C, Volkmer R, Kammerer RA, Steinmetz MO, Akhmanova A.

Structure. 2018 Mar 6;26(3):375-382.e4. doi: 10.1016/j.str.2017.12.017. Epub 2018 Jan 26.

24.

Interaction between the Caenorhabditis elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly.

Bianchi S, Rogala KB, Dynes NJ, Hilbert M, Leidel SA, Steinmetz MO, Gönczy P, Vakonakis I.

Mol Biol Cell. 2018 Mar 15;29(6):722-735. doi: 10.1091/mbc.E17-06-0412. Epub 2018 Jan 24.

25.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, Hamel E, Thomas MP, Kasprzyk PG, Ferrandis E, Steinmetz MO, Leese MP, Potter BVL.

J Med Chem. 2018 Feb 8;61(3):1031-1044. doi: 10.1021/acs.jmedchem.7b01474. Epub 2018 Jan 8.

PMID:
29227648
26.

Structural basis of katanin p60:p80 complex formation.

Rezabkova L, Jiang K, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, Kammerer RA.

Sci Rep. 2017 Nov 2;7(1):14893. doi: 10.1038/s41598-017-14194-2.

27.

A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.

Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A.

Nat Struct Mol Biol. 2017 Nov;24(11):931-943. doi: 10.1038/nsmb.3483. Epub 2017 Oct 9.

28.

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS.

Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012.

29.

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.

Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J.

Nat Commun. 2017 Sep 14;8(1):542. doi: 10.1038/s41467-017-00630-4.

30.

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.

Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P, Gönczy P.

Curr Biol. 2017 Aug 21;27(16):2486-2498.e6. doi: 10.1016/j.cub.2017.07.011. Epub 2017 Aug 3.

31.

Erratum: Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A.

Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3557.

PMID:
28659643
32.

Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.

Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz JF, Steinmetz MO.

Int J Mol Sci. 2017 Jun 22;18(7). pii: E1336. doi: 10.3390/ijms18071336.

33.

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.

Sáez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodríguez-Salarichs J, Olieric N, Muñoz-Hernández H, Berbís MÁ, Wendeborn S, Peñalva MA, Matesanz R, Canales Á, Prota AE, Jímenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Díaz JF.

Cell Chem Biol. 2017 Jun 22;24(6):737-750.e6. doi: 10.1016/j.chembiol.2017.05.016. Epub 2017 Jun 1.

34.

Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.

Kumar A, Manatschal C, Rai A, Grigoriev I, Degen MS, Jaussi R, Kretzschmar I, Prota AE, Volkmer R, Kammerer RA, Akhmanova A, Steinmetz MO.

Structure. 2017 Jun 6;25(6):924-932.e4. doi: 10.1016/j.str.2017.04.010. Epub 2017 May 25.

35.

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A.

Nat Cell Biol. 2017 May;19(5):480-492. doi: 10.1038/ncb3511. Epub 2017 Apr 24. Erratum in: Nat Cell Biol. 2017 Jun 29;19(7):873.

36.

Kinesin-4 KIF21B is a potent microtubule pausing factor.

van Riel WE, Rai A, Bianchi S, Katrukha EA, Liu Q, Heck AJ, Hoogenraad CC, Steinmetz MO, Kapitein LC, Akhmanova A.

Elife. 2017 Mar 14;6. pii: e24746. doi: 10.7554/eLife.24746.

37.

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP.

Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683.

38.

Structural Basis of Microtubule Stabilization by Discodermolide.

Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB 3rd, Yang CH, McDaid HM, Paterson I, Horwitz SB, Fernando Díaz J, Steinmetz MO.

Chembiochem. 2017 May 18;18(10):905-909. doi: 10.1002/cbic.201600696. Epub 2017 Mar 27.

39.

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Trigili C, Barasoain I, Sánchez-Murcia PA, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner NM, Meyer A, Naylor GJ, Gómez-Rubio E, Gago F, Steinmetz MO, Paterson I, Prota AE, Díaz JF.

ACS Omega. 2016 Dec 31;1(6):1192-1204. doi: 10.1021/acsomega.6b00317. Epub 2016 Dec 13.

40.

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.

Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A.

Sci Transl Med. 2016 Nov 16;8(365):365ra159. Erratum in: Sci Transl Med. 2017 Dec 20;9(421):.

41.

Molecular basis of Kar9-Bim1 complex function during mating and spindle positioning.

Manatschal C, Farcas AM, Degen MS, Bayer M, Kumar A, Landgraf C, Volkmer R, Barral Y, Steinmetz MO.

Mol Biol Cell. 2016 Sep 28. pii: mbc.E16-07-0552. [Epub ahead of print]

42.

EB1 interacts with outwardly curved and straight regions of the microtubule lattice.

Guesdon A, Bazile F, Buey RM, Mohan R, Monier S, García RR, Angevin M, Heichette C, Wieneke R, Tampé R, Duchesne L, Akhmanova A, Steinmetz MO, Chrétien D.

Nat Cell Biol. 2016 Oct;18(10):1102-8. doi: 10.1038/ncb3412. Epub 2016 Sep 12.

PMID:
27617931
43.

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE.

PLoS One. 2016 Aug 12;11(8):e0160890. doi: 10.1371/journal.pone.0160890. eCollection 2016.

44.

Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations.

Bianchi S, van Riel WE, Kraatz SH, Olieric N, Frey D, Katrukha EA, Jaussi R, Missimer J, Grigoriev I, Olieric V, Benoit RM, Steinmetz MO, Akhmanova A, Kammerer RA.

Sci Rep. 2016 Aug 3;6:30668. doi: 10.1038/srep30668.

45.

The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.

Kraatz S, Guichard P, Obbineni JM, Olieric N, Hatzopoulos GN, Hilbert M, Sen I, Missimer J, Gönczy P, Steinmetz MO.

Structure. 2016 Aug 2;24(8):1358-1371. doi: 10.1016/j.str.2016.06.011. Epub 2016 Jul 28.

46.

Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.

Rezabkova L, Kraatz SH, Akhmanova A, Steinmetz MO, Kammerer RA.

J Biol Chem. 2016 Aug 26;291(35):18496-504. doi: 10.1074/jbc.M116.739771. Epub 2016 Jul 8.

47.

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation.

Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, Steinmetz MO.

J Mol Biol. 2016 Jul 31;428(15):2981-8. doi: 10.1016/j.jmb.2016.06.023. Epub 2016 Jul 6.

48.

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.

Doodhi H, Prota AE, Rodríguez-García R, Xiao H, Custar DW, Bargsten K, Katrukha EA, Hilbert M, Hua S, Jiang K, Grigoriev I, Yang CH, Cox D, Horwitz SB, Kapitein LC, Akhmanova A, Steinmetz MO.

Curr Biol. 2016 Jul 11;26(13):1713-1721. doi: 10.1016/j.cub.2016.04.053. Epub 2016 Jun 16.

49.

Corrigendum: SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P, Hirono M, Steinmetz MO.

Nat Cell Biol. 2016 May 27;18(6):709. doi: 10.1038/ncb3362. No abstract available.

PMID:
27230531
50.

Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.

Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A.

J Biol Chem. 2016 Jul 29;291(31):16292-306. doi: 10.1074/jbc.M116.726547. Epub 2016 May 10.

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