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Items: 1 to 50 of 134

1.

NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells.

Becker-Kettern J, Paczia N, Conrotte JF, Zhu C, Fiehn O, Jung PP, Steinmetz LM, Linster CL.

FEBS J. 2018 Aug 11. doi: 10.1111/febs.14631. [Epub ahead of print]

PMID:
30098110
2.

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R.

Cell Metab. 2018 Jul 23. pii: S1550-4131(18)30450-9. doi: 10.1016/j.cmet.2018.07.007. [Epub ahead of print]

PMID:
30078552
3.

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.

Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18.

PMID:
30022164
4.

Cluster analysis describes constellations of cardiac anomalies presenting in spinal anomaly patients.

Passias PG, Poorman GW, Vasquez-Montes D, Wang C, Jalai C, Horn SR, Steinmetz LM, Bortz CA, Segreto FA, Moon J, Zhou PL, Diebo BG, Vira S.

Acta Neurochir (Wien). 2018 Aug;160(8):1613-1619. doi: 10.1007/s00701-018-3596-7. Epub 2018 Jun 28.

PMID:
29956035
5.

Clinical Impact and Economic Burden of Hospital-Acquired Conditions Following Common Surgical Procedures.

Horn SR, Liu TC, Horowitz JA, Oh C, Bortz CA, Segreto FA, Vasquez-Montes D, Steinmetz LM, Deflorimonte C, Vira S, Diebo BG, Neuman BJ, Raad M, Sciubba DM, Lafage R, Lafage V, Hassanzadeh H, Passias PG.

Spine (Phila Pa 1976). 2018 May 22. doi: 10.1097/BRS.0000000000002713. [Epub ahead of print]

PMID:
29794588
6.

Multiplexed precision genome editing with trackable genomic barcodes in yeast.

Roy KR, Smith JD, Vonesch SC, Lin G, Tu CS, Lederer AR, Chu A, Suresh S, Nguyen M, Horecka J, Tripathi A, Burnett WT, Morgan MA, Schulz J, Orsley KM, Wei W, Aiyar RS, Davis RW, Bankaitis VA, Haber JE, Salit ML, St Onge RP, Steinmetz LM.

Nat Biotechnol. 2018 Jul;36(6):512-520. doi: 10.1038/nbt.4137. Epub 2018 May 7.

PMID:
29734294
7.

HEx: A heterologous expression platform for the discovery of fungal natural products.

Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, Aiyar RS, Steinmetz LM, Davis RW, Medema MH, Sattely E, Khosla C, St Onge RP, Tang Y, Hillenmeyer ME.

Sci Adv. 2018 Apr 11;4(4):eaar5459. doi: 10.1126/sciadv.aar5459. eCollection 2018 Apr.

8.

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR.

ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25.

9.

Erratum: Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway.

Kim JH, Lee BB, Oh YM, Zhu C, Steinmetz LM, Lee Y, Kim WK, Lee SB, Buratowski S, Kim T.

Nat Commun. 2017 Nov 29;8:16122. doi: 10.1038/ncomms16122.

10.

Large-Scale Low-Cost NGS Library Preparation Using a Robust Tn5 Purification and Tagmentation Protocol.

Hennig BP, Velten L, Racke I, Tu CS, Thoms M, Rybin V, Besir H, Remans K, Steinmetz LM.

G3 (Bethesda). 2018 Jan 4;8(1):79-89. doi: 10.1534/g3.117.300257.

11.

Multiplexed ChIP-Seq Using Direct Nucleosome Barcoding: A Tool for High-Throughput Chromatin Analysis.

Chabbert CD, Adjalley SH, Steinmetz LM, Pelechano V.

Methods Mol Biol. 2018;1689:177-194. doi: 10.1007/978-1-4939-7380-4_16.

PMID:
29027175
12.

Genome Dynamics of Hybrid Saccharomyces cerevisiae During Vegetative and Meiotic Divisions.

Dutta A, Lin G, Pankajam AV, Chakraborty P, Bhat N, Steinmetz LM, Nishant KT.

G3 (Bethesda). 2017 Nov 6;7(11):3669-3679. doi: 10.1534/g3.117.1135.

13.

Assembly of functionally integrated human forebrain spheroids.

Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Paşca SP.

Nature. 2017 May 4;545(7652):54-59. doi: 10.1038/nature22330. Epub 2017 Apr 26.

14.

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.

Tay TL, Mai D, Dautzenberg J, Fernández-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Grün D, Ronneberger O, Prinz M.

Nat Neurosci. 2017 Jun;20(6):793-803. doi: 10.1038/nn.4547. Epub 2017 Apr 17.

PMID:
28414331
15.

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates.

Mall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Euong Ang C, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, Jolma A, Steinmetz LM, Taipale J, Südhof TC, Wernig M.

Nature. 2017 Apr 13;544(7649):245-249. doi: 10.1038/nature21722. Epub 2017 Apr 5.

PMID:
28379941
16.

Human haematopoietic stem cell lineage commitment is a continuous process.

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM.

Nat Cell Biol. 2017 Apr;19(4):271-281. doi: 10.1038/ncb3493. Epub 2017 Mar 20.

17.

Modulating Crossover Frequency and Interference for Obligate Crossovers in Saccharomyces cerevisiae Meiosis.

Chakraborty P, Pankajam AV, Lin G, Dutta A, Krishnaprasad GN, Tekkedil MM, Shinohara A, Steinmetz LM, Nishant KT.

G3 (Bethesda). 2017 May 5;7(5):1511-1524. doi: 10.1534/g3.117.040071.

18.

A method for high-throughput production of sequence-verified DNA libraries and strain collections.

Smith JD, Schlecht U, Xu W, Suresh S, Horecka J, Proctor MJ, Aiyar RS, Bennett RA, Chu A, Li YF, Roy K, Davis RW, Steinmetz LM, Hyman RW, Levy SF, St Onge RP.

Mol Syst Biol. 2017 Feb 13;13(2):913. doi: 10.15252/msb.20167233.

19.

The State of Systems Genetics in 2017.

Baliga NS, Björkegren JL, Boeke JD, Boutros M, Crawford NP, Dudley AM, Farber CR, Jones A, Levey AI, Lusis AJ, Mak HC, Nadeau JH, Noyes MB, Petretto E, Seyfried NT, Steinmetz LM, Vonesch SC.

Cell Syst. 2017 Jan 25;4(1):7-15. doi: 10.1016/j.cels.2017.01.005.

20.

INO80 represses osmostress induced gene expression by resetting promoter proximal nucleosomes.

Klopf E, Schmidt HA, Clauder-Münster S, Steinmetz LM, Schüller C.

Nucleic Acids Res. 2017 Apr 20;45(7):3752-3766. doi: 10.1093/nar/gkw1292.

21.

Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway.

Kim JH, Lee BB, Oh YM, Zhu C, Steinmetz LM, Lee Y, Kim WK, Lee SB, Buratowski S, Kim T.

Nat Commun. 2016 Nov 28;7:13534. doi: 10.1038/ncomms13534. Erratum in: Nat Commun. 2017 Nov 29;8:16122.

22.

A privacy-preserving solution for compressed storage and selective retrieval of genomic data.

Huang Z, Ayday E, Lin H, Aiyar RS, Molyneaux A, Xu Z, Fellay J, Steinmetz LM, Hubaux JP.

Genome Res. 2016 Dec;26(12):1687-1696. Epub 2016 Oct 27.

23.

A global genetic interaction network maps a wiring diagram of cellular function.

Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C.

Science. 2016 Sep 23;353(6306). pii: aaf1420.

24.

SYGNALing a Red Light for Glioblastoma.

Brooks AN, Mueller WF, Steinmetz LM.

Cell Syst. 2016 Aug;3(2):118-120. doi: 10.1016/j.cels.2016.08.002.

25.

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters.

Chen Y, Pai AA, Herudek J, Lubas M, Meola N, Järvelin AI, Andersson R, Pelechano V, Steinmetz LM, Jensen TH, Sandelin A.

Nat Genet. 2016 Sep;48(9):984-94. doi: 10.1038/ng.3616. Epub 2016 Jul 25.

26.

Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.

Gupta S, Radhakrishnan A, Nitin R, Raharja-Liu P, Lin G, Steinmetz LM, Gagneur J, Sinha H.

G3 (Bethesda). 2016 Aug 9;6(8):2255-63. doi: 10.1534/g3.116.029900.

27.

Protein Abundance Control by Non-coding Antisense Transcription.

Huber F, Bunina D, Gupta I, Khmelinskii A, Meurer M, Theer P, Steinmetz LM, Knop M.

Cell Rep. 2016 Jun 21;15(12):2625-36. doi: 10.1016/j.celrep.2016.05.043. Epub 2016 Jun 9.

28.

Translational Capacity of a Cell Is Determined during Transcription Elongation via the Ccr4-Not Complex.

Gupta I, Villanyi Z, Kassem S, Hughes C, Panasenko OO, Steinmetz LM, Collart MA.

Cell Rep. 2016 May 24;15(8):1782-94. doi: 10.1016/j.celrep.2016.04.055. Epub 2016 May 12.

29.

Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, Dündar F, Dasmeh P, Mittler G, Cadete FT, Ramírez F, Conrad T, Wei W, Raja S, Manke T, Luscombe NM, Steinmetz LM, Akhtar A.

Nat Struct Mol Biol. 2016 Jun;23(6):580-9. doi: 10.1038/nsmb.3233. Epub 2016 May 16.

PMID:
27183194
30.

DChIPRep, an R/Bioconductor package for differential enrichment analysis in chromatin studies.

Chabbert CD, Steinmetz LM, Klaus B.

PeerJ. 2016 Apr 26;4:e1981. doi: 10.7717/peerj.1981. eCollection 2016.

31.

Sensing a revolution.

Steinmetz LM, Jones A.

Mol Syst Biol. 2016 Apr 26;12(4):867. doi: 10.15252/msb.20166873. No abstract available.

32.

Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP.

Genome Biol. 2016 Mar 8;17:45. doi: 10.1186/s13059-016-0900-9.

33.

Landscape and Dynamics of Transcription Initiation in the Malaria Parasite Plasmodium falciparum.

Adjalley SH, Chabbert CD, Klaus B, Pelechano V, Steinmetz LM.

Cell Rep. 2016 Mar 15;14(10):2463-75. doi: 10.1016/j.celrep.2016.02.025. Epub 2016 Mar 3.

34.

Genome-wide quantification of 5'-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics.

Pelechano V, Wei W, Steinmetz LM.

Nat Protoc. 2016 Feb;11(2):359-76. doi: 10.1038/nprot.2016.026. Epub 2016 Jan 28.

35.

Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.

Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D.

PLoS Genet. 2015 Dec 22;11(12):e1005735. doi: 10.1371/journal.pgen.1005735. eCollection 2015 Dec.

36.

Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis.

Rege M, Subramanian V, Zhu C, Hsieh TH, Weiner A, Friedman N, Clauder-Münster S, Steinmetz LM, Rando OJ, Boyer LA, Peterson CL.

Cell Rep. 2015 Nov 24;13(8):1610-22. doi: 10.1016/j.celrep.2015.10.030. Epub 2015 Nov 12.

37.

Integrating Cell Phone Imaging with Magnetic Levitation (i-LEV) for Label-Free Blood Analysis at the Point-of-Living.

Baday M, Calamak S, Durmus NG, Davis RW, Steinmetz LM, Demirci U.

Small. 2016 Mar 2;12(9):1222-1229. doi: 10.1002/smll.201501845. Epub 2015 Nov 2.

38.

Genome-Wide Identification of Alternative Polyadenylation Events Using 3'T-Fill.

Wilkening S, Pelechano V, Steinmetz LM.

Methods Mol Biol. 2016;1358:295-302. doi: 10.1007/978-1-4939-3067-8_18.

PMID:
26463391
39.

Comprehensive Identification of RNA-Binding Proteins by RNA Interactome Capture.

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW.

Methods Mol Biol. 2016;1358:131-9. doi: 10.1007/978-1-4939-3067-8_8.

PMID:
26463381
40.

Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions.

Grubert F, Zaugg JB, Kasowski M, Ursu O, Spacek DV, Martin AR, Greenside P, Srivas R, Phanstiel DH, Pekowska A, Heidari N, Euskirchen G, Huber W, Pritchard JK, Bustamante CD, Steinmetz LM, Kundaje A, Snyder M.

Cell. 2015 Aug 27;162(5):1051-65. doi: 10.1016/j.cell.2015.07.048. Epub 2015 Aug 20.

41.

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA.

Cell Stem Cell. 2015 Oct 1;17(4):422-34. doi: 10.1016/j.stem.2015.07.007. Epub 2015 Aug 20.

42.

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells.

Brennecke P, Reyes A, Pinto S, Rattay K, Nguyen M, Küchler R, Huber W, Kyewski B, Steinmetz LM.

Nat Immunol. 2015 Sep;16(9):933-41. doi: 10.1038/ni.3246. Epub 2015 Aug 3.

43.

Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics.

Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4354-63. doi: 10.1073/pnas.1510824112. Epub 2015 Jul 20.

44.

Magnetic levitation of single cells.

Durmus NG, Tekin HC, Guven S, Sridhar K, Arslan Yildiz A, Calibasi G, Ghiran I, Davis RW, Steinmetz LM, Demirci U.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3661-8. doi: 10.1073/pnas.1509250112. Epub 2015 Jun 29.

45.

The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production.

Schmid M, Olszewski P, Pelechano V, Gupta I, Steinmetz LM, Jensen TH.

Cell Rep. 2015 Jul 7;12(1):128-139. doi: 10.1016/j.celrep.2015.06.008. Epub 2015 Jun 25.

46.

Widespread Co-translational RNA Decay Reveals Ribosome Dynamics.

Pelechano V, Wei W, Steinmetz LM.

Cell. 2015 Jun 4;161(6):1400-12. doi: 10.1016/j.cell.2015.05.008.

47.

Single-cell polyadenylation site mapping reveals 3' isoform choice variability.

Velten L, Anders S, Pekowska A, Järvelin AI, Huber W, Pelechano V, Steinmetz LM.

Mol Syst Biol. 2015 Jun 3;11(6):812. doi: 10.15252/msb.20156198.

48.

Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype.

Gupta S, Radhakrishnan A, Raharja-Liu P, Lin G, Steinmetz LM, Gagneur J, Sinha H.

PLoS Genet. 2015 Jun 3;11(6):e1005195. doi: 10.1371/journal.pgen.1005195. eCollection 2015 Jun.

49.

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies.

Lasserre JP, Dautant A, Aiyar RS, Kucharczyk R, Glatigny A, Tribouillard-Tanvier D, Rytka J, Blondel M, Skoczen N, Reynier P, Pitayu L, Rötig A, Delahodde A, Steinmetz LM, Dujardin G, Procaccio V, di Rago JP.

Dis Model Mech. 2015 Jun;8(6):509-26. doi: 10.1242/dmm.020438. Review.

50.

Negative feedback buffers effects of regulatory variants.

Bader DM, Wilkening S, Lin G, Tekkedil MM, Dietrich K, Steinmetz LM, Gagneur J.

Mol Syst Biol. 2015 Jan 29;11(1):785. doi: 10.15252/msb.20145844.

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