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Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies.

Bar-Or A, Pender MP, Khanna R, Steinman L, Hartung HP, Maniar T, Croze E, Aftab BT, Giovannoni G, Joshi MJ.

Trends Mol Med. 2019 Dec 17. pii: S1471-4914(19)30294-1. doi: 10.1016/j.molmed.2019.11.003. [Epub ahead of print] Review.


To help aging populations, classify organismal senescence.

Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G.

Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319. No abstract available.


Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial.

Cohen JA, Comi G, Selmaj KW, Bar-Or A, Arnold DL, Steinman L, Hartung HP, Montalban X, Kubala Havrdová E, Cree BAC, Sheffield JK, Minton N, Raghupathi K, Huang V, Kappos L; RADIANCE Trial Investigators.

Lancet Neurol. 2019 Nov;18(11):1021-1033. doi: 10.1016/S1474-4422(19)30238-8. Epub 2019 Sep 3.


Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.

Comi G, Kappos L, Selmaj KW, Bar-Or A, Arnold DL, Steinman L, Hartung HP, Montalban X, Kubala Havrdová E, Cree BAC, Sheffield JK, Minton N, Raghupathi K, Ding N, Cohen JA; SUNBEAM Study Investigators.

Lancet Neurol. 2019 Nov;18(11):1009-1020. doi: 10.1016/S1474-4422(19)30239-X. Epub 2019 Sep 3.


Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.

Steinman L, Ho PP, Robinson WH, Utz PJ, Villoslada P.

Curr Opin Immunol. 2019 Dec;61:46-53. doi: 10.1016/j.coi.2019.07.011. Epub 2019 Aug 30. Review.


Partnerships for Blood Pressure Control in Washington State, December 2016-July 2017.

Vogel MT, Petrescu-Prahova M, Steinman L, Clegg-Thorp C, Farmer C, Sarliker SE, Baldwin LM.

Health Promot Pract. 2019 Jun 11:1524839919853819. doi: 10.1177/1524839919853819. [Epub ahead of print]


Building community-clinical linkages to increase older adult physical activity: The PT-REFER trial protocol and participant baseline characteristics.

Petrescu-Prahova M, Kohn M, Leroux B, Steinman L, Fishleder S, Pike M, Kava CM, Belza B, Schrodt L, Hannon PA, Harris JR.

Contemp Clin Trials Commun. 2019 May 1;15:100373. doi: 10.1016/j.conctc.2019.100373. eCollection 2019 Sep.


Provider-Patient Communication and Involvement in Physical Activity Programs Among Patients Receiving Physical Therapy Services: A Qualitative Study.

Kava CM, Fishleder S, Steinman L, Petrescu-Prahova M, Schrodt L, Harris JR.

J Appl Gerontol. 2019 May 2:733464819847402. doi: 10.1177/0733464819847402. [Epub ahead of print]


DNA threads released by activated CD4+ T lymphocytes provide autocrine costimulation.

Costanza M, Poliani PL, Portararo P, Cappetti B, Musio S, Pagani F, Steinman L, Colombo MP, Pedotti R, Sangaletti S.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8985-8994. doi: 10.1073/pnas.1822013116. Epub 2019 Apr 15.


Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial.

Zubizarreta I, Flórez-Grau G, Vila G, Cabezón R, España C, Andorra M, Saiz A, Llufriu S, Sepulveda M, Sola-Valls N, Martinez-Lapiscina EH, Pulido-Valdeolivas I, Casanova B, Martinez Gines M, Tellez N, Oreja-Guevara C, Español M, Trias E, Cid J, Juan M, Lozano M, Blanco Y, Steinman L, Benitez-Ribas D, Villoslada P.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8463-8470. doi: 10.1073/pnas.1820039116. Epub 2019 Apr 8.


Using Targeted mHealth Messages to Address Hypertension and Diabetes Self-Management in Cambodia: Protocol for a Clustered Randomized Controlled Trial.

Fitzpatrick AL, van Pelt M, Heang H, Steinman L, Ide N, Chhea C, LoGerfo JP.

JMIR Res Protoc. 2019 Mar 19;8(3):e11614. doi: 10.2196/11614.


Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation.

Villoslada P, Vila G, Colafrancesco V, Moreno B, Fernandez-Diez B, Vazquez R, Pertsovskaya I, Zubizarreta I, Pulido-Valdeolivas I, Messeguer J, Vendrell-Navarro G, Frade JM, López-Sánchez N, Teixido M, Giralt E, Masso M, Dugas JC, Leonoudakis D, Lariosa-Willingham KD, Steinman L, Messeguer A.

Neurotherapeutics. 2019 Jul;16(3):808-827. doi: 10.1007/s13311-019-00717-4.


Bridging the Gap After Physical Therapy: Clinical-Community Linkages With Older Adult Physical Activity Programs.

Fishleder S, Petrescu-Prahova M, Harris JR, Steinman L, Kohn M, Bennett K, Helfrich CD.

Innov Aging. 2018 Apr 10;2(1):igy006. doi: 10.1093/geroni/igy006. eCollection 2018 Jan.


Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies.

Rothbard JB, Kurnellas MP, Ousman SS, Brownell S, Rothbard JJ, Steinman L.

Cold Spring Harb Perspect Med. 2019 Jul 1;9(7). pii: a034223. doi: 10.1101/cshperspect.a034223. Review.


Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9182-E9191. doi: 10.1073/pnas.1808648115. Epub 2018 Sep 4.


Efficacy and safety of ozanimod in multiple sclerosis: Dose-blinded extension of a randomized phase II study.

Cohen JA, Comi G, Arnold DL, Bar-Or A, Selmaj KW, Steinman L, Havrdová EK, Cree BA, Montalbán X, Hartung HP, Huang V, Frohna P, Skolnick BE, Kappos L; RADIANCE Trial Investigators.

Mult Scler. 2019 Aug;25(9):1255-1262. doi: 10.1177/1352458518789884. Epub 2018 Jul 25.


An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.

Mahapatra S, Ying L, Ho PP, Kurnellas M, Rothbard J, Steinman L, Cornfield DN.

PLoS One. 2018 Jul 10;13(7):e0199206. doi: 10.1371/journal.pone.0199206. eCollection 2018.


Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine.

Rothbard JB, Rothbard JJ, Soares L, Fathman CG, Steinman L.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7081-7086. doi: 10.1073/pnas.1804599115. Epub 2018 Jun 18.


Molecular signature of Epstein-Barr virus infection in MS brain lesions.

Moreno MA, Or-Geva N, Aftab BT, Khanna R, Croze E, Steinman L, Han MH.

Neurol Neuroimmunol Neuroinflamm. 2018 Jun 7;5(4):e466. doi: 10.1212/NXI.0000000000000466. eCollection 2018 Jul.


CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications.

Kaneko K, Sato DK, Nakashima I, Ogawa R, Akaishi T, Takai Y, Nishiyama S, Takahashi T, Misu T, Kuroda H, Tanaka S, Nomura K, Hashimoto Y, Callegaro D, Steinman L, Fujihara K, Aoki M.

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):927-936. doi: 10.1136/jnnp-2018-317969. Epub 2018 Jun 6. Erratum in: J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):e4.


Correction: Peroxisome proliferator-activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.

Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L.

J Exp Med. 2018 Jun 4;215(6):1765. doi: 10.1084/jem.2006183905142018c. Epub 2018 May 17. No abstract available.


Blocking immune intrusion into the brain suppresses epilepsy in Rasmussen's encephalitis model.

Steinman L.

J Clin Invest. 2018 May 1;128(5):1724-1726. doi: 10.1172/JCI120444. Epub 2018 Apr 9.


Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models.

Ajami B, Samusik N, Wieghofer P, Ho PP, Crotti A, Bjornson Z, Prinz M, Fantl WJ, Nolan GP, Steinman L.

Nat Neurosci. 2018 Apr;21(4):541-551. doi: 10.1038/s41593-018-0100-x. Epub 2018 Mar 5.


Nonclassical monocytes: are they the next therapeutic targets in multiple sclerosis?

Ajami B, Steinman L.

Immunol Cell Biol. 2018 Feb;96(2):125-127. doi: 10.1111/imcb.12004. Epub 2018 Jan 20. No abstract available.


Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS.

Bruinsma IB, van Dijk M, Bridel C, van de Lisdonk T, Haverkort SQ, Runia TF, Steinman L, Hintzen RQ, Killestein J, Verbeek MM, Teunissen CE, de Jong BA.

J Neuroinflammation. 2017 Dec 4;14(1):235. doi: 10.1186/s12974-017-1006-3.


Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine.

Bhat R, Mahapatra S, Axtell RC, Steinman L.

J Neuroimmunol. 2017 Dec 15;313:77-81. doi: 10.1016/j.jneuroim.2017.10.012. Epub 2017 Oct 21.


Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens.

DeFalco J, Harbell M, Manning-Bog A, Baia G, Scholz A, Millare B, Sumi M, Zhang D, Chu F, Dowd C, Zuno-Mitchell P, Kim D, Leung Y, Jiang S, Tang X, Williamson KS, Chen X, Carroll SM, Espiritu Santo G, Haaser N, Nguyen N, Giladi E, Minor D, Tan YC, Sokolove JB, Steinman L, Serafini TA, Cavet G, Greenberg NM, Glanville J, Volkmuth W, Emerling DE, Robinson WH.

Clin Immunol. 2018 Feb;187:37-45. doi: 10.1016/j.clim.2017.10.002. Epub 2017 Oct 12.


Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.

Sagan SA, Cruz-Herranz A, Spencer CM, Ho PP, Steinman L, Green AJ, Sobel RA, Zamvil SS.

J Vis Exp. 2017 Aug 21;(126). doi: 10.3791/56185.


Creating Environments to Support Breastfeeding: The Challenges and Facilitators of Policy Development in Hospitals, Clinics, Early Care and Education, and Worksites.

Bradford VA, Walkinshaw LP, Steinman L, Otten JJ, Fisher K, Ellings A, O'Leary J, Johnson DB.

Matern Child Health J. 2017 Dec;21(12):2188-2198. doi: 10.1007/s10995-017-2338-4.


Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.

Lepka K, Volbracht K, Bill E, Schneider R, Rios N, Hildebrandt T, Ingwersen J, Prozorovski T, Lillig CH, van Horssen J, Steinman L, Hartung HP, Radi R, Holmgren A, Aktas O, Berndt C.

Glia. 2017 Sep;65(9):1521-1534. doi: 10.1002/glia.23178. Epub 2017 Jun 15.


Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin.

Musio S, Costanza M, Poliani PL, Fontana E, Cominelli M, Abolafio G, Steinman L, Pedotti R.

Neurol Neuroimmunol Neuroinflamm. 2017 Apr 14;4(3):e342. doi: 10.1212/NXI.0000000000000342. eCollection 2017 May.


Induction of New Autoimmune Diseases After Alemtuzumab Therapy for Multiple Sclerosis: Learning From Adversity.

Steinman L.

JAMA Neurol. 2017 Aug 1;74(8):907-908. doi: 10.1001/jamaneurol.2017.0325. No abstract available.


Adrenocorticotropic hormone versus methylprednisolone added to interferon β in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial.

Berkovich R, Bakshi R, Amezcua L, Axtell RC, Cen SY, Tauhid S, Neema M, Steinman L.

Ther Adv Neurol Disord. 2017 Jan;10(1):3-17. doi: 10.1177/1756285616670060. Epub 2016 Oct 19.


T Cell-Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity.

Hohlfeld R, Steinman L.

J Immunol. 2017 May 1;198(9):3381-3383. doi: 10.4049/jimmunol.1700346. No abstract available.


PH20 is not expressed in murine CNS and oligodendrocyte precursor cells.

Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ.

Ann Clin Transl Neurol. 2017 Feb 23;4(3):191-211. doi: 10.1002/acn3.393. eCollection 2017 Mar.


Time correlation between mononucleosis and initial symptoms of MS.

Endriz J, Ho PP, Steinman L.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 27;4(3):e308. doi: 10.1212/NXI.0000000000000308. eCollection 2017 May.


Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.

Kuipers HF, Yoon J, van Horssen J, Han MH, Bollyky PL, Palmer TD, Steinman L.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1745-E1754. doi: 10.1073/pnas.1621314114. Epub 2017 Feb 14.


Narcolepsy and influenza vaccination-induced autoimmunity.

Ahmed SS, Steinman L.

Ann Transl Med. 2017 Jan;5(1):25. doi: 10.21037/atm.2016.12.63. No abstract available.


Dementia and co-occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?

Snowden MB, Steinman LE, Bryant LL, Cherrier MM, Greenlund KJ, Leith KH, Levy C, Logsdon RG, Copeland C, Vogel M, Anderson LA, Atkins DC, Bell JF, Fitzpatrick AL.

Int J Geriatr Psychiatry. 2017 Apr;32(4):357-371. doi: 10.1002/gps.4652. Epub 2017 Feb 1. Review.


Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14781-14786. doi: 10.1073/pnas.1617859114. Epub 2016 Dec 8.


An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.

Inoue M, Chen PH, Siecinski S, Li QJ, Liu C, Steinman L, Gregory SG, Benner E, Shinohara ML.

Nat Neurosci. 2016 Dec;19(12):1599-1609. doi: 10.1038/nn.4421. Epub 2016 Nov 7.


The emergence of neuroepidemiology, neurovirology and neuroimmunology: the legacies of John F. Kurtzke and Richard 'Dick' T. Johnson.

Kildebeck EJ, Narayan R, Nath A, Weiner H, Beh S, Calabresi PA, Steinman L, Major EO, Frohman TC, Frohman EM.

J Neurol. 2017 Apr;264(4):817-828. doi: 10.1007/s00415-016-8293-y. Epub 2016 Oct 12. No abstract available.


A Journey in Science: The Privilege of Exploring the Brain and the Immune System.

Steinman L.

Mol Med. 2016 Jun 2;22. doi: 10.2119/molmed.2015.00263.


Restoring immune tolerance in neuromyelitis optica: Part II.

Bar-Or A, Steinman L, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Smith TJ, Yeaman MR.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e277. doi: 10.1212/NXI.0000000000000277. eCollection 2016 Oct. Review.


Restoring immune tolerance in neuromyelitis optica: Part I.

Steinman L, Bar-Or A, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Yeaman MR, Smith TJ.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e276. doi: 10.1212/NXI.0000000000000276. eCollection 2016 Oct. Review.


Genetic background modulates outcome of therapeutic amyloid peptides in treatment of neuroinflammation.

Kraus A, Race B, Phillips K, Winkler C, Saturday G, Kurnellas M, Rothbard JB, Groveman BR, Steinman L, Caughey B.

J Neuroimmunol. 2016 Sep 15;298:42-50. doi: 10.1016/j.jneuroim.2016.06.010. Epub 2016 Jun 27.


Examining the Washington State Breastfeeding-Friendly Policy Development Process Using the Advocacy Coalition Framework.

Steinman LE, Bradford V, Quinn E, Otten JJ, McNamara J, Fisher K, Johnson DB.

Matern Child Health J. 2017 Mar;21(3):659-669. doi: 10.1007/s10995-016-2154-2.


CEACAM1 mediates B cell aggregation in central nervous system autoimmunity.

Rovituso DM, Scheffler L, Wunsch M, Kleinschnitz C, Dörck S, Ulzheimer J, Bayas A, Steinman L, Ergün S, Kuerten S.

Sci Rep. 2016 Jul 20;6:29847. doi: 10.1038/srep29847.


The Safety of Adjuvanted Vaccines Revisited: Vaccine-Induced Narcolepsy.

Ahmed SS, Montomoli E, Pasini FL, Steinman L.

Isr Med Assoc J. 2016 Mar-Apr;18(3-4):216-20. Review.


The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice.

Kuipers HF, Nagy N, Ruppert SM, Sunkari VG, Marshall PL, Gebe JA, Ishak HD, Keswani SG, Bollyky J, Frymoyer AR, Wight TN, Steinman L, Bollyky PL.

Clin Exp Immunol. 2016 Sep;185(3):372-81. doi: 10.1111/cei.12815.

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