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Items: 1 to 50 of 145


Epac1 protects the retina against ischemia/reperfusion-induced neuronal and vascular damage.

Liu L, Jiang Y, Steinle JJ.

PLoS One. 2018 Sep 20;13(9):e0204346. doi: 10.1371/journal.pone.0204346. eCollection 2018.


Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines.

Curtiss E, Jiang Y, Liu L, Hawthorne C, Zhang J, Steinle JJ.

Mediators Inflamm. 2018 Jul 19;2018:3809092. doi: 10.1155/2018/3809092. eCollection 2018.


miR15a regulates NLRP3 inflammasome proteins in the retinal vasculature.

Curtiss E, Liu L, Steinle JJ.

Exp Eye Res. 2018 Jul 4;176:98-102. doi: 10.1016/j.exer.2018.07.005. [Epub ahead of print]


Toll-like receptor 4 regulates insulin signal transduction in retinal Müller cells.

Liu L, Steinle JJ.

Growth Factors. 2017 Dec;35(6):234-238. doi: 10.1080/08977194.2018.1442833. Epub 2018 Feb 28.


miRNA15a regulates insulin signal transduction in the retinal vasculature.

Jiang Y, Liu L, Steinle JJ.

Cell Signal. 2018 Apr;44:28-32. doi: 10.1016/j.cellsig.2018.01.016. Epub 2018 Jan 12.


Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and -independent signaling.

Liu L, Steinle JJ.

PLoS One. 2017 Dec 29;12(12):e0190253. doi: 10.1371/journal.pone.0190253. eCollection 2017.


Toll-Like Receptor 4 Reduces Occludin and Zonula Occludens 1 to Increase Retinal Permeability Both in vitro and in vivo.

Liu L, Jiang Y, Steinle JJ.

J Vasc Res. 2017;54(6):367-375. doi: 10.1159/000480455. Epub 2017 Nov 15.


A regulatory role for β-adrenergic receptors regarding the resolvin D1 (RvD1) pathway in the diabetic retina.

Shi H, Carion TW, Jiang Y, Chahine A, Steinle JJ, Berger EA.

PLoS One. 2017 Nov 2;12(11):e0185383. doi: 10.1371/journal.pone.0185383. eCollection 2017.


The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism.

He H, Weir RL, Toutounchian JJ, Pagadala J, Steinle JJ, Baudry J, Miller DD, Yates CR.

PLoS One. 2017 Aug 10;12(8):e0180808. doi: 10.1371/journal.pone.0180808. eCollection 2017.


miR-15a/16 inhibits TGF-beta3/VEGF signaling and increases retinal endothelial cell barrier proteins.

Ye EA, Liu L, Steinle JJ.

Vision Res. 2017 Oct;139:23-29. doi: 10.1016/j.visres.2017.07.007. Epub 2017 Aug 7.


TLR4 regulates insulin-resistant proteins to increase apoptosis in the mouse retina.

Liu L, Jiang Y, Curtiss E, Fukuchi KI, Steinle JJ.

Inflamm Res. 2017 Nov;66(11):993-997. doi: 10.1007/s00011-017-1080-0. Epub 2017 Jul 5.


Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma.

Webb AH, Gao BT, Goldsmith ZK, Irvine AS, Saleh N, Lee RP, Lendermon JB, Bheemreddy R, Zhang Q, Brennan RC, Johnson D, Steinle JJ, Wilson MW, Morales-Tirado VM.

BMC Cancer. 2017 Jun 20;17(1):434. doi: 10.1186/s12885-017-3418-y.


Regulatory role of microRNA on inflammatory responses of diabetic retinopathy.

Ye EA, Steinle JJ.

Neural Regen Res. 2017 Apr;12(4):580-581. doi: 10.4103/1673-5374.205095. No abstract available.


Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins.

Liu L, Jiang Y, Steinle JJ.

PLoS One. 2017 May 23;12(5):e0178236. doi: 10.1371/journal.pone.0178236. eCollection 2017.


Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature.

Jiang Y, Liu L, Curtiss E, Steinle JJ.

Mediators Inflamm. 2017;2017:2860956. doi: 10.1155/2017/2860956. Epub 2017 Feb 28.


Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature.

Jiang Y, Liu L, Steinle JJ.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):185-189. doi: 10.1167/iovs.16-20412.


miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling.

Ye EA, Liu L, Jiang Y, Jan J, Gaddipati S, Suvas S, Steinle JJ.

J Neuroinflammation. 2016 Dec 8;13(1):305.


Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion.

Liu L, Jiang Y, Steinle JJ.

PLoS One. 2016 Jul 20;11(7):e0159532. doi: 10.1371/journal.pone.0159532. eCollection 2016.


Isolation and Molecular Profiling of Primary Mouse Retinal Ganglion Cells: Comparison of Phenotypes from Healthy and Glaucomatous Retinas.

Chintalapudi SR, Djenderedjian L, Stiemke AB, Steinle JJ, Jablonski MM, Morales-Tirado VM.

Front Aging Neurosci. 2016 May 18;8:93. doi: 10.3389/fnagi.2016.00093. eCollection 2016.


VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1.

Shi H, Carion TW, Jiang Y, Steinle JJ, Berger EA.

Prostaglandins Other Lipid Mediat. 2016 Mar;123:28-32. doi: 10.1016/j.prostaglandins.2016.03.001. Epub 2016 Mar 26.


β-Adrenergic receptor agonist, compound 49b, inhibits TLR4 signaling pathway in diabetic retina.

Berger EA, Carion TW, Jiang Y, Liu L, Chahine A, Walker RJ, Steinle JJ.

Immunol Cell Biol. 2016 Aug;94(7):656-61. doi: 10.1038/icb.2016.21. Epub 2016 Feb 18.


A runner's high depends on cannabinoid receptors in mice.

Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, Gass P.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13105-8. doi: 10.1073/pnas.1514996112. Epub 2015 Oct 5.


Pioglitazone alters monocyte populations and stimulates recent thymic emigrants in the BBDZR/Wor type 2 diabetes rat model.

Gao BT, Lee RP, Jiang Y, Steinle JJ, Morales-Tirado VM.

Diabetol Metab Syndr. 2015 Sep 2;7:72. doi: 10.1186/s13098-015-0068-6. eCollection 2015.


Beta-adrenergic receptor agonist decreases VEGF levels through altered eNOS and PKC signaling in diabetic retina.

Jiang Y, Zhang Q, Steinle JJ.

Growth Factors. 2015;33(3):192-9. doi: 10.3109/08977194.2015.1054990. Epub 2015 Jun 26.


IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels.

Zhang Q, Jiang Y, Steinle JJ.

Mol Vis. 2015 May 22;21:604-11. eCollection 2015.


Sodium salicylate reduced insulin resistance in the retina of a type 2 diabetic rat model.

Jiang Y, Thakran S, Bheemreddy R, Coppess W, Walker RJ, Steinle JJ.

PLoS One. 2015 Apr 14;10(4):e0125505. doi: 10.1371/journal.pone.0125505. eCollection 2015.


Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study.

Auer MK, Sack M, Lenz JN, Jakovcevski M, Biedermann SV, Falfán-Melgoza C, Deussing J, Steinle J, Bielohuby M, Bidlingmaier M, Pfister F, Stalla GK, Ende G, Weber-Fahr W, Fuss J, Gass P.

J Cereb Blood Flow Metab. 2015 Mar 31;35(4):554-64. doi: 10.1038/jcbfm.2014.231.


The hippocampus and exercise: histological correlates of MR-detected volume changes.

Biedermann SV, Fuss J, Steinle J, Auer MK, Dormann C, Falfán-Melgoza C, Ende G, Gass P, Weber-Fahr W.

Brain Struct Funct. 2016 Apr;221(3):1353-63. doi: 10.1007/s00429-014-0976-5. Epub 2014 Dec 31.


Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions.

Thakran S, Zhang Q, Morales-Tirado V, Steinle JJ.

Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):177-84. doi: 10.1167/iovs.14-15550.


Consideration of vocal fold position in unilateral vocal fold paralyses.

Olthoff A, Steinle J, Asendorf T, Kruse E.

Eur Arch Otorhinolaryngol. 2015 Apr;272(4):923-928. doi: 10.1007/s00405-014-3442-3. Epub 2014 Dec 18.


Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line.

Jiang Y, Biswas SK, Steinle JJ.

Mol Vis. 2014 Oct 23;20:1463-70. eCollection 2014.


Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice.

Jiang Y, Zhang Q, Ye EA, Steinle JJ.

J Neuroinflammation. 2014 Aug 20;11:137. doi: 10.1186/s12974-014-0137-z.


IGFBP-3 inhibits TNF-α production and TNFR-2 signaling to protect against retinal endothelial cell apoptosis.

Zhang Q, Steinle JJ.

Microvasc Res. 2014 Sep;95:76-81. doi: 10.1016/j.mvr.2014.07.009. Epub 2014 Jul 30.


Pioglitazone normalizes insulin signaling in the diabetic rat retina through reduction in tumor necrosis factor α and suppressor of cytokine signaling 3.

Jiang Y, Thakran S, Bheemreddy R, Ye EA, He H, Walker RJ, Steinle JJ.

J Biol Chem. 2014 Sep 19;289(38):26395-405. doi: 10.1074/jbc.M114.583880. Epub 2014 Aug 1.


Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina.

Jiang Y, Pagadala J, Miller DD, Steinle JJ.

Cytokine. 2014 Dec;70(2):115-9. doi: 10.1016/j.cyto.2014.07.004. Epub 2014 Jul 28.


TNFα inhibits IGFBP-3 through activation of p38α and casein kinase 2 in human retinal endothelial cells.

Zhang Q, Soderland D, Steinle JJ.

PLoS One. 2014 Jul 29;9(7):e103578. doi: 10.1371/journal.pone.0103578. eCollection 2014.


β1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo.

Jiang Y, Zhang Q, Ye EA, Steinle JJ.

Mol Vis. 2014 Jun 21;20:872-80. eCollection 2014.


Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK.

Toutounchian JJ, Steinle JJ, Makena PS, Waters CM, Wilson MW, Haik BG, Miller DD, Yates CR.

PLoS One. 2014 Jun 23;9(6):e100210. doi: 10.1371/journal.pone.0100210. eCollection 2014.


Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina.

Jiang Y, Zhang Q, Steinle JJ.

PLoS One. 2014 Apr 2;9(4):e93788. doi: 10.1371/journal.pone.0093788. eCollection 2014.


A sensitive and fast LC-MS/MS method for determination of β-receptor agonist JP-49b: application to a pharmacokinetic study in rats.

He H, Williams-Guy K, Pagadala J, Presley CS, Miller DD, Steinle JJ, Yates CR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:86-91. doi: 10.1016/j.jchromb.2014.01.031. Epub 2014 Feb 8.


Exercise boosts hippocampal volume by preventing early age-related gray matter loss.

Fuss J, Biedermann SV, Falfán-Melgoza C, Auer MK, Zheng L, Steinle J, Hörner F, Sartorius A, Ende G, Weber-Fahr W, Gass P.

Hippocampus. 2014 Feb;24(2):131-4. doi: 10.1002/hipo.22227. Epub 2013 Nov 26.


Novel quinic acid derivative KZ-41 prevents retinal endothelial cell apoptosis without inhibiting retinoblastoma cell death through p38 signaling.

Zhang Q, Jiang Y, Toutounchian J, Wilson MW, Morales-Tirado V, Miller DD, Yates CR, Steinle JJ.

Invest Ophthalmol Vis Sci. 2013 Sep 3;54(9):5937-43. doi: 10.1167/iovs.13-12326.


Compound 49b protects against blast-induced retinal injury.

Jiang Y, Liu L, Pagadala J, Miller DD, Steinle JJ.

J Neuroinflammation. 2013 Jul 30;10:96. doi: 10.1186/1742-2094-10-96.


β2-adrenergic receptor knockout mice exhibit A diabetic retinopathy phenotype.

Jiang Y, Zhang Q, Liu L, Tang J, Kern TS, Steinle JJ.

PLoS One. 2013 Jul 24;8(7):e70555. doi: 10.1371/journal.pone.0070555. Print 2013.


IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis.

Zhang Q, Jiang Y, Miller MJ, Peng B, Liu L, Soderland C, Tang J, Kern TS, Pintar J, Steinle JJ.

Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5376-84. doi: 10.1167/iovs.13-12497.


Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings.

Tse BC, Steinle JJ, Johnson D, Haik BG, Wilson MW.

JAMA Ophthalmol. 2013 Jul;131(7):903-11. doi: 10.1001/jamaophthalmol.2013.2065.

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