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Items: 1 to 50 of 118

1.

Steric Accessibility of the Cleavage Sites Dictates the Proteolytic Vulnerability of the Anti-HIV-1 Antibodies 2F5, 2G12, and PG9 in Plants.

Puchol Tarazona AA, Lobner E, Taubenschmid Y, Paireder M, Torres Acosta JA, Göritzer K, Steinkellner H, Mach L.

Biotechnol J. 2019 Oct 28:e1900308. doi: 10.1002/biot.201900308. [Epub ahead of print]

PMID:
31657528
2.

In Planta Glycan Engineering and Functional Activities of IgE Antibodies.

Montero-Morales L, Maresch D, Crescioli S, Castilho A, Ilieva KM, Mele S, Karagiannis SN, Altmann F, Steinkellner H.

Front Bioeng Biotechnol. 2019 Sep 25;7:242. doi: 10.3389/fbioe.2019.00242. eCollection 2019.

3.

Combined hazard assessment of mycotoxins and their modified forms applying relative potency factors: Zearalenone and T2/HT2 toxin.

Steinkellner H, Binaglia M, Dall'Asta C, Gutleb AC, Metzler M, Oswald IP, Parent-Massin D, Alexander J.

Food Chem Toxicol. 2019 Sep;131:110599. doi: 10.1016/j.fct.2019.110599. Epub 2019 Jun 24. Review.

PMID:
31247258
4.

In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants.

Hurtado J, Acharya D, Lai H, Sun H, Kallolimath S, Steinkellner H, Bai F, Chen Q.

Plant Biotechnol J. 2019 Jun 17. doi: 10.1111/pbi.13194. [Epub ahead of print]

5.

An electrochemiluminescence based assay for quantitative detection of endogenous and exogenously applied MeCP2 protein variants.

Steinkellner H, Schönegger A, Etzler J, Kempaiah P, Huber A, Hahn K, Rose K, Duerr M, Christodoulou J, Beribisky AV, Neuhaus W, Laccone F.

Sci Rep. 2019 May 28;9(1):7929. doi: 10.1038/s41598-019-44372-3.

6.

AllergoOncology: Expression platform development and functional profiling of an anti-HER2 IgE antibody.

Ilieva KM, Fazekas-Singer J, Bax HJ, Crescioli S, Montero-Morales L, Mele S, Sow HS, Stavraka C, Josephs DH, Spicer JF, Steinkellner H, Jensen-Jarolim E, Tutt ANJ, Karagiannis SN.

Allergy. 2019 Oct;74(10):1985-1989. doi: 10.1111/all.13818. Epub 2019 May 27. No abstract available.

7.

Advanced Plant-Based Glycan Engineering.

Montero-Morales L, Steinkellner H.

Front Bioeng Biotechnol. 2018 Jun 14;6:81. doi: 10.3389/fbioe.2018.00081. eCollection 2018. Review.

8.

An oligosaccharyltransferase from Leishmania major increases the N-glycan occupancy on recombinant glycoproteins produced in Nicotiana benthamiana.

Castilho A, Beihammer G, Pfeiffer C, Göritzer K, Montero-Morales L, Vavra U, Maresch D, Grünwald-Gruber C, Altmann F, Steinkellner H, Strasser R.

Plant Biotechnol J. 2018 Oct;16(10):1700-1709. doi: 10.1111/pbi.12906. Epub 2018 Mar 25.

9.

Promoter Choice Impacts the Efficiency of Plant Glyco-Engineering.

Kallolimath S, Gruber C, Steinkellner H, Castilho A.

Biotechnol J. 2018 Jan;13(1). doi: 10.1002/biot.201700380. Epub 2017 Aug 29.

PMID:
28755501
10.

No changes in heme synthesis in human Friedreich´s ataxia erythroid progenitor cells.

Steinkellner H, Singh HN, Muckenthaler MU, Goldenberg H, Moganty RR, Scheiber-Mojdehkar B, Sturm B.

Gene. 2017 Jul 20;621:5-11. doi: 10.1016/j.gene.2017.04.014. Epub 2017 Apr 12.

PMID:
28412459
11.

Recombinant plant-derived human IgE glycoproteomics.

Montero-Morales L, Maresch D, Castilho A, Turupcu A, Ilieva KM, Crescioli S, Karagiannis SN, Lupinek C, Oostenbrink C, Altmann F, Steinkellner H.

J Proteomics. 2017 May 24;161:81-87. doi: 10.1016/j.jprot.2017.04.002. Epub 2017 Apr 8.

PMID:
28400175
12.

Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.

Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, Deer DJ, Steinkellner H, Bohorov O, Bohorova N, Goodman C, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Crowe JE Jr, Zeitlin L, Geisbert TW.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8711. doi: 10.1126/scitranslmed.aai8711.

13.

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity.

Dent M, Hurtado J, Paul AM, Sun H, Lai H, Yang M, Esqueda A, Bai F, Steinkellner H, Chen Q.

J Gen Virol. 2016 Dec;97(12):3280-3290. doi: 10.1099/jgv.0.000635. Epub 2016 Oct 20.

14.

Glycosylation of plant produced human antibodies.

Kallolimath S, Steinkellner H.

Hum Antibodies. 2015 Dec 23;23(3-4):45-8. doi: 10.3233/HAB-150283. Review.

PMID:
27472861
15.

Engineering of complex protein sialylation in plants.

Kallolimath S, Castilho A, Strasser R, Grünwald-Gruber C, Altmann F, Strubl S, Galuska CE, Zlatina K, Galuska SP, Werner S, Thiesler H, Werneburg S, Hildebrandt H, Gerardy-Schahn R, Steinkellner H.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9498-503. doi: 10.1073/pnas.1604371113. Epub 2016 Jul 21. Erratum in: Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3870.

16.

Efficient In Vitro and In Vivo Activity of Glyco-Engineered Plant-Produced Rabies Monoclonal Antibodies E559 and 62-71-3.

Tsekoa TL, Lotter-Stark T, Buthelezi S, Chakauya E, Stoychev SH, Sabeta C, Shumba W, Phahladira B, Hume S, Morton J, Rupprecht CE, Steinkellner H, Pauly M, Zeitlin L, Whaley K, Chikwamba R.

PLoS One. 2016 Jul 18;11(7):e0159313. doi: 10.1371/journal.pone.0159313. eCollection 2016.

17.

Reduced paucimannosidic N-glycan formation by suppression of a specific β-hexosaminidase from Nicotiana benthamiana.

Shin YJ, Castilho A, Dicker M, Sádio F, Vavra U, Grünwald-Gruber C, Kwon TH, Altmann F, Steinkellner H, Strasser R.

Plant Biotechnol J. 2017 Feb;15(2):197-206. doi: 10.1111/pbi.12602. Epub 2016 Aug 11.

18.

Production of a tumour-targeting antibody with a human-compatible glycosylation profile in N. benthamiana hairy root cultures.

Lonoce C, Salem R, Marusic C, Jutras PV, Scaloni A, Salzano AM, Lucretti S, Steinkellner H, Benvenuto E, Donini M.

Biotechnol J. 2016 Sep;11(9):1209-20. doi: 10.1002/biot.201500628. Epub 2016 Jun 30.

PMID:
27313150
19.

Vacuolar targeting of recombinant antibodies in Nicotiana benthamiana.

Ocampo CG, Lareu JF, Marin Viegas VS, Mangano S, Loos A, Steinkellner H, Petruccelli S.

Plant Biotechnol J. 2016 Dec;14(12):2265-2275. doi: 10.1111/pbi.12580. Epub 2016 Jun 14.

20.

Monoclonal antibody therapy for Junin virus infection.

Zeitlin L, Geisbert JB, Deer DJ, Fenton KA, Bohorov O, Bohorova N, Goodman C, Kim D, Hiatt A, Pauly MH, Velasco J, Whaley KJ, Altmann F, Gruber C, Steinkellner H, Honko AN, Kuehne AI, Aman MJ, Sahandi S, Enterlein S, Zhan X, Enria D, Geisbert TW.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4458-63. doi: 10.1073/pnas.1600996113. Epub 2016 Apr 4.

21.

Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants.

Dicker M, Tschofen M, Maresch D, König J, Juarez P, Orzaez D, Altmann F, Steinkellner H, Strasser R.

Front Plant Sci. 2016 Jan 29;7:18. doi: 10.3389/fpls.2016.00018. eCollection 2016.

22.

Transient Expression of Mammalian Genes in N. benthamiana to Modulate N-Glycosylation.

Castilho A, Steinkellner H.

Methods Mol Biol. 2016;1385:99-113. doi: 10.1007/978-1-4939-3289-4_7.

PMID:
26614284
23.

Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.

Loos A, Gach JS, Hackl T, Maresch D, Henkel T, Porodko A, Bui-Minh D, Sommeregger W, Wozniak-Knopp G, Forthal DN, Altmann F, Steinkellner H, Mach L.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12675-80. doi: 10.1073/pnas.1509090112. Epub 2015 Sep 28.

24.

N-Glyco-Engineering in Plants: Update on Strategies and Major Achievements.

Steinkellner H, Castilho A.

Methods Mol Biol. 2015;1321:195-212. doi: 10.1007/978-1-4939-2760-9_14. Review.

PMID:
26082224
25.

Processing of complex N-glycans in IgG Fc-region is affected by core fucosylation.

Castilho A, Gruber C, Thader A, Oostenbrink C, Pechlaner M, Steinkellner H, Altmann F.

MAbs. 2015;7(5):863-70. doi: 10.1080/19420862.2015.1053683.

26.

Characterization of plants expressing the human β1,4-galactosyltrasferase gene.

Schneider J, Castilho A, Pabst M, Altmann F, Gruber C, Strasser R, Gattinger P, Seifert GJ, Steinkellner H.

Plant Physiol Biochem. 2015 Jul;92:39-47. doi: 10.1016/j.plaphy.2015.04.010. Epub 2015 Apr 13.

27.

Detection of survival motor neuron protein in buccal cells through electrochemiluminescence-based assay.

Steinkellner H, Etzler J, Gmeiner BM, Laccone F.

Assay Drug Dev Technol. 2015 Apr;13(3):167-73. doi: 10.1089/adt.2015.635. Epub 2015 Apr 7.

PMID:
25848917
28.

Identification and molecular characterisation of a homozygous missense mutation in the ADAMTS10 gene in a patient with Weill-Marchesani syndrome.

Steinkellner H, Etzler J, Gogoll L, Neesen J, Stifter E, Brandau O, Laccone F.

Eur J Hum Genet. 2015 Sep;23(9):1186-91. doi: 10.1038/ejhg.2014.264. Epub 2014 Dec 3.

29.

Proteolytic and N-glycan processing of human α1-antitrypsin expressed in Nicotiana benthamiana.

Castilho A, Windwarder M, Gattinger P, Mach L, Strasser R, Altmann F, Steinkellner H.

Plant Physiol. 2014 Dec;166(4):1839-51. doi: 10.1104/pp.114.250720. Epub 2014 Oct 29.

30.

Plant glyco-biotechnology on the way to synthetic biology.

Loos A, Steinkellner H.

Front Plant Sci. 2014 Oct 8;5:523. doi: 10.3389/fpls.2014.00523. eCollection 2014. Review.

31.

Controlled glycosylation of plant-produced recombinant proteins.

Strasser R, Altmann F, Steinkellner H.

Curr Opin Biotechnol. 2014 Dec;30:95-100. doi: 10.1016/j.copbio.2014.06.008. Epub 2014 Jul 5. Review.

PMID:
25000187
32.

In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites.

Woisetschläger M, Antes B, Borrowdale R, Wiederkum S, Kainer M, Steinkellner H, Wozniak-Knopp G, Moulder K, Rüker F, Mudde GC.

Biotechnol J. 2014 Jun;9(6):844-51. doi: 10.1002/biot.201300387. Epub 2014 May 8.

PMID:
24806546
33.

Expression and glycoengineering of functionally active heteromultimeric IgM in plants.

Loos A, Gruber C, Altmann F, Mehofer U, Hensel F, Grandits M, Oostenbrink C, Stadlmayr G, Furtmüller PG, Steinkellner H.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6263-8. doi: 10.1073/pnas.1320544111. Epub 2014 Mar 31.

34.

Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus.

He J, Lai H, Engle M, Gorlatov S, Gruber C, Steinkellner H, Diamond MS, Chen Q.

PLoS One. 2014 Mar 27;9(3):e93541. doi: 10.1371/journal.pone.0093541. eCollection 2014.

35.

Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana.

Schneider JD, Marillonnet S, Castilho A, Gruber C, Werner S, Mach L, Klimyuk V, Mor TS, Steinkellner H.

Plant Biotechnol J. 2014 Sep;12(7):832-9. doi: 10.1111/pbi.12184. Epub 2014 Mar 11.

36.

The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms.

Niemer M, Mehofer U, Torres Acosta JA, Verdianz M, Henkel T, Loos A, Strasser R, Maresch D, Rademacher T, Steinkellner H, Mach L.

Biotechnol J. 2014 Apr;9(4):493-500. doi: 10.1002/biot.201300207.

37.

Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue.

Schneider JD, Castilho A, Neumann L, Altmann F, Loos A, Kannan L, Mor TS, Steinkellner H.

Biotechnol J. 2014 Apr;9(4):501-10. doi: 10.1002/biot.201300229. Epub 2013 Nov 8.

38.

N-glycosylation of plant-produced recombinant proteins.

Bosch D, Castilho A, Loos A, Schots A, Steinkellner H.

Curr Pharm Des. 2013;19(31):5503-12. Review.

PMID:
23394562
39.

Generation of biologically active multi-sialylated recombinant human EPOFc in plants.

Castilho A, Neumann L, Gattinger P, Strasser R, Vorauer-Uhl K, Sterovsky T, Altmann F, Steinkellner H.

PLoS One. 2013;8(1):e54836. doi: 10.1371/journal.pone.0054836. Epub 2013 Jan 25.

40.

Expression of functionally active sialylated human erythropoietin in plants.

Jez J, Castilho A, Grass J, Vorauer-Uhl K, Sterovsky T, Altmann F, Steinkellner H.

Biotechnol J. 2013 Mar;8(3):371-82. doi: 10.1002/biot.201200363.

41.

Engineering of sialylated mucin-type O-glycosylation in plants.

Castilho A, Neumann L, Daskalova S, Mason HS, Steinkellner H, Altmann F, Strasser R.

J Biol Chem. 2012 Oct 19;287(43):36518-26. doi: 10.1074/jbc.M112.402685. Epub 2012 Sep 4.

42.

Glyco-engineering in plants to produce human-like N-glycan structures.

Castilho A, Steinkellner H.

Biotechnol J. 2012 Sep;7(9):1088-98. doi: 10.1002/biot.201200032. Epub 2012 Aug 14. Review.

PMID:
22890723
43.

IgG-Fc glycoengineering in non-mammalian expression hosts.

Loos A, Steinkellner H.

Arch Biochem Biophys. 2012 Oct 15;526(2):167-73. doi: 10.1016/j.abb.2012.05.011. Epub 2012 May 23. Review.

44.

Significant impact of single N-glycan residues on the biological activity of Fc-based antibody-like fragments.

Jez J, Antes B, Castilho A, Kainer M, Wiederkum S, Grass J, Rüker F, Woisetschläger M, Steinkellner H.

J Biol Chem. 2012 Jul 13;287(29):24313-9. doi: 10.1074/jbc.M112.360701. Epub 2012 May 15.

45.

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant.

Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, Hiatt A, Ngo L, Steinkellner H, Whaley KJ, Olinger GG.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20690-4. doi: 10.1073/pnas.1108360108. Epub 2011 Dec 5.

46.

Rapid high yield production of different glycoforms of Ebola virus monoclonal antibody.

Castilho A, Bohorova N, Grass J, Bohorov O, Zeitlin L, Whaley K, Altmann F, Steinkellner H.

PLoS One. 2011;6(10):e26040. doi: 10.1371/journal.pone.0026040. Epub 2011 Oct 24.

47.

Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia.

Nachbauer W, Wanschitz J, Steinkellner H, Eigentler A, Sturm B, Hufler K, Scheiber-Mojdehkar B, Poewe W, Reindl M, Boesch S.

Mov Disord. 2011 Aug 15;26(10):1935-8. doi: 10.1002/mds.23789. Epub 2011 Jun 20.

PMID:
21692115
48.

Use of computational tools in the field of food safety.

Lo Piparo E, Worth A, Manibusan M, Yang C, Schilter B, Mazzatorta P, Jacobs MN, Steinkellner H, Mohimont L.

Regul Toxicol Pharmacol. 2011 Aug;60(3):354-62. doi: 10.1016/j.yrtph.2011.05.003. Epub 2011 May 12. Review.

PMID:
21600952
49.

Effects of erythropoietin on frataxin levels and mitochondrial function in Friedreich ataxia--a dose-response trial.

Nachbauer W, Hering S, Seifert M, Steinkellner H, Sturm B, Scheiber-Mojdehkar B, Reindl M, Strasak A, Poewe W, Weiss G, Boesch S.

Cerebellum. 2011 Dec;10(4):763-9. doi: 10.1007/s12311-011-0287-9.

PMID:
21597884
50.

Expression of antibody fragments with a controlled N-glycosylation pattern and induction of endoplasmic reticulum-derived vesicles in seeds of Arabidopsis.

Loos A, Van Droogenbroeck B, Hillmer S, Grass J, Pabst M, Castilho A, Kunert R, Liang M, Arcalis E, Robinson DG, Depicker A, Steinkellner H.

Plant Physiol. 2011 Apr;155(4):2036-48. doi: 10.1104/pp.110.171330. Epub 2011 Feb 16.

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