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Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL.

Curran KJ, Margossian SP, Kernan NA, Silverman LB, Williams DA, Shukla N, Kobos R, Forlenza CJ, Steinherz P, Prockop S, Boulad F, Spitzer B, Cancio MI, Boelens JJ, Kung AL, Szenes V, Park JH, Sauter CS, Heller G, Wang X, Senechal B, O'Reilly RJ, Riviere I, Sadelain M, Brentjens RJ.

Blood. 2019 Dec 26;134(26):2361-2368. doi: 10.1182/blood.2019001641.


Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children's Oncology Group.

Steinherz PG, Seibel NL, Sather H, Ji L, Xu X, Devidas M, Gaynon PS.

Leukemia. 2019 Sep;33(9):2144-2154. doi: 10.1038/s41375-019-0422-z. Epub 2019 Feb 28.


A case of KMT2A-SEPT9 fusion-associated acute megakaryoblastic leukemia.

Forlenza CJ, Zhang Y, Yao J, Benayed R, Steinherz P, Ramaswamy K, Kessel R, Roshal M, Shukla N.

Cold Spring Harb Mol Case Stud. 2018 Dec 17;4(6). pii: a003426. doi: 10.1101/mcs.a003426. Print 2018 Dec.


Maintenance chemotherapy to reduce the risk of a metachronous Wilms tumor in children with bilateral nephroblastomatosis.

Ortiz MV, Fernandez-Ledon S, Ramaswamy K, Forlenza CJ, Shukla NN, Kobos R, Heaton TE, LaQuaglia MP, Steinherz PG.

Pediatr Blood Cancer. 2019 Jan;66(1):e27500. doi: 10.1002/pbc.27500. Epub 2018 Oct 18.


Outcome of children and adolescents with relapsed Hodgkin lymphoma treated with high-dose therapy and autologous stem cell transplantation: the Memorial Sloan Kettering Cancer Center experience.

Giulino-Roth L, O'Donohue T, Chen Z, Trippett TM, Klein E, Kernan NA, Kobos R, Prockop SE, Scaradavou A, Shukla N, Steinherz PG, Moskowitz AJ, Moskowitz CH, Boulad F.

Leuk Lymphoma. 2018 Aug;59(8):1861-1870. doi: 10.1080/10428194.2017.1403601. Epub 2017 Nov 29.


Allogeneic Hematopoietic Stem Cell Transplantation with Myeloablative Conditioning Is Associated with Favorable Outcomes in Mixed Phenotype Acute Leukemia.

Getta BM, Roshal M, Zheng J, Park JH, Stein EM, Levine R, Papadopoulos EB, Jakubowski AA, Kernan NA, Steinherz P, O'Reilly RJ, Perales MA, Giralt SA, Tallman MS, Shaffer BC.

Biol Blood Marrow Transplant. 2017 Nov;23(11):1879-1886. doi: 10.1016/j.bbmt.2017.06.026. Epub 2017 Jul 8.


Vincristine toxicity with co-administration of fluconazole: Long-term concerns.

Thackray J, Spatz K, Steinherz PG.

Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26652. Epub 2017 May 24. No abstract available.


Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia.

Topka S, Vijai J, Walsh MF, Jacobs L, Maria A, Villano D, Gaddam P, Wu G, McGee RB, Quinn E, Inaba H, Hartford C, Pui CH, Pappo A, Edmonson M, Zhang MY, Stepensky P, Steinherz P, Schrader K, Lincoln A, Bussel J, Lipkin SM, Goldgur Y, Harit M, Stadler ZK, Mullighan C, Weintraub M, Shimamura A, Zhang J, Downing JR, Nichols KE, Offit K.

PLoS Genet. 2015 Jun 23;11(6):e1005262. doi: 10.1371/journal.pgen.1005262. eCollection 2015 Jun.


PET-adapted sequential salvage therapy with brentuximab vedotin followed by augmented ifosamide, carboplatin, and etoposide for patients with relapsed and refractory Hodgkin's lymphoma: a non-randomised, open-label, single-centre, phase 2 study.

Moskowitz AJ, Schöder H, Yahalom J, McCall SJ, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz S, Kobos R, Kumar A, Matasar M, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Shukla N, Steinherz P, Straus D, Trippett T, Younes A, Zelenetz A, Moskowitz CH.

Lancet Oncol. 2015 Mar;16(3):284-92. doi: 10.1016/S1470-2045(15)70013-6. Epub 2015 Feb 13.


ALK-positive (2p23 rearranged) anaplastic large cell lymphoma with localization to the skin in a pediatric patient.

Pulitzer M, Ogunrinade O, Lin O, Steinherz P.

J Cutan Pathol. 2015 Mar;42(3):182-7. doi: 10.1111/cup.12446. Epub 2015 Feb 5.


High-dose cyclophosphamide for the treatment of refractory T-cell acute lymphoblastic leukemia in children.

Kobos R, Shukla N, Renaud T, Prockop SE, Boulad F, Steinherz PG.

J Pediatr Hematol Oncol. 2014 Jul;36(5):e265-70. doi: 10.1097/MPH.0000000000000080.


Phase II trial of clofarabine with topotecan, vinorelbine, and thiotepa in pediatric patients with relapsed or refractory acute leukemia.

Shukla N, Kobos R, Renaud T, Steinherz LJ, Steinherz PG.

Pediatr Blood Cancer. 2014 Mar;61(3):431-5. doi: 10.1002/pbc.24789. Epub 2013 Sep 24.


Ten-year follow-up of pediatric patients with non-Hodgkin lymphoma treated with allogeneic or autologous stem cell transplantation.

Giulino-Roth L, Ricafort R, Kernan NA, Small TN, Trippett TM, Steinherz PG, Prockop SE, Scaradavou A, Chiu M, O'Reilly RJ, Boulad F.

Pediatr Blood Cancer. 2013 Dec;60(12):2018-24. doi: 10.1002/pbc.24722. Epub 2013 Aug 30.


CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.

Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, Bartido S, Stefanski J, Taylor C, Olszewska M, Borquez-Ojeda O, Qu J, Wasielewska T, He Q, Bernal Y, Rijo IV, Hedvat C, Kobos R, Curran K, Steinherz P, Jurcic J, Rosenblat T, Maslak P, Frattini M, Sadelain M.

Sci Transl Med. 2013 Mar 20;5(177):177ra38. doi: 10.1126/scitranslmed.3005930.


Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial.

Mattano LA Jr, Devidas M, Nachman JB, Sather HN, Hunger SP, Steinherz PG, Gaynon PS, Seibel NL; Children's Oncology Group.

Lancet Oncol. 2012 Sep;13(9):906-15. Epub 2012 Aug 15.


Factors associated with relapse and survival in Wilms tumor: a multivariate analysis.

Honeyman JN, Rich BS, McEvoy MP, Knowles MA, Heller G, Riachy E, Kobos R, Shukla N, Wolden SL, Steinherz PG, La Quaglia MP.

J Pediatr Surg. 2012 Jun;47(6):1228-33. doi: 10.1016/j.jpedsurg.2012.03.030. Review.


Successful treatment of refractory metastatic histiocytic sarcoma with alemtuzumab.

Shukla N, Kobos R, Renaud T, Teruya-Feldstein J, Price A, McAllister-Lucas L, Steinherz P.

Cancer. 2012 Aug 1;118(15):3719-24. doi: 10.1002/cncr.26712. Epub 2011 Dec 13.


Allogeneic hematopoietic stem cell transplantation for pediatric patients with treatment-related myelodysplastic syndrome or acute myelogenous leukemia.

Kobos R, Steinherz PG, Kernan NA, Prockop SE, Scaradavou A, Small TN, Shukla N, Khalaf R, O'Reilly RJ, Boulad F.

Biol Blood Marrow Transplant. 2012 Mar;18(3):473-80. doi: 10.1016/j.bbmt.2011.11.009. Epub 2011 Nov 10.


Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia.

Hijiya N, Thomson B, Isakoff MS, Silverman LB, Steinherz PG, Borowitz MJ, Kadota R, Cooper T, Shen V, Dahl G, Thottassery JV, Jeha S, Maloney K, Paul JA, Barry E, Carroll WL, Gaynon PS.

Blood. 2011 Dec 1;118(23):6043-9. doi: 10.1182/blood-2011-08-374710. Epub 2011 Oct 3.


Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer.

Bonate PL, Cunningham CC, Gaynon P, Jeha S, Kadota R, Lam GN, Razzouk B, Rytting M, Steinherz P, Weitman S.

Cancer Chemother Pharmacol. 2011 Apr;67(4):875-90. doi: 10.1007/s00280-010-1376-z. Epub 2010 Jun 26.


Effect of hemodialysis on the plasma levels of clofarabine.

Steinherz PG, Shukla N, Kobos R, Latcha S.

Pediatr Blood Cancer. 2010 Jul 15;55(1):196-8. doi: 10.1002/pbc.22458.


Intraventricular meningioma after cranial irradiation for childhood leukemia.

Ney DE, Huse JT, Dunkel IJ, Steinherz PG, Haque S, Khakoo Y.

J Child Neurol. 2010 Oct;25(10):1292-5. doi: 10.1177/0883073810362267. Epub 2010 Mar 5.


Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia.

Steinherz PG, Shukla N, Kobos R, Steinherz L.

Pediatr Blood Cancer. 2010 May;54(5):687-93. doi: 10.1002/pbc.22321.


Eradication of cryptosporidium from a defunctionalized colon limb by refeeding stoma effluent.

Sidebotham EL, Sepkowitz K, Price AP, Steinherz PG, La Quaglia MP, Kayton ML.

J Pediatr Surg. 2010 Jan;45(1):E33-6. doi: 10.1016/j.jpedsurg.2009.10.091.


Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias.

Yan Y, Wieman EA, Guan X, Jakubowski AA, Steinherz PG, O'Reilly RJ.

J Hematol Oncol. 2009 Dec 29;2:51. doi: 10.1186/1756-8722-2-51.


Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children's oncology group.

Nachman JB, La MK, Hunger SP, Heerema NA, Gaynon PS, Hastings C, Mattano LA Jr, Sather H, Devidas M, Freyer DR, Steinherz PG, Seibel NL.

J Clin Oncol. 2009 Nov 1;27(31):5189-94. doi: 10.1200/JCO.2008.20.8959. Epub 2009 Oct 5.


A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia.

Hijiya N, Gaynon P, Barry E, Silverman L, Thomson B, Chu R, Cooper T, Kadota R, Rytting M, Steinherz P, Shen V, Jeha S, Abichandani R, Carroll WL.

Leukemia. 2009 Dec;23(12):2259-64. doi: 10.1038/leu.2009.185. Epub 2009 Sep 10.


Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study.

Mensah NY, Peterlongo P, Steinherz P, Pamer EG, Satagopan J, Papanicolaou GA.

Biol Blood Marrow Transplant. 2009 Sep;15(9):1130-3. doi: 10.1016/j.bbmt.2009.04.012. Epub 2009 Jun 26. Erratum in: Biol Blood Marrow Transplant. 2010 Jan;16(1):128. Yaa, Mensah Nana [corrected to Mensah, Nana Yaa]; Paolo, Peterlongo [corrected to Peterlongo, Paolo]; Peter, Steinherz [corrected to Steinherz, Peter]; Eric, Pamer G [corrected to Pamer, Eric G]; Jaya, Satagopan [corrected to Satagopan, Jaya].


Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia.

Jeha S, Razzouk B, Rytting M, Rheingold S, Albano E, Kadota R, Luchtman-Jones L, Bomgaars L, Gaynon P, Goldman S, Ritchey K, Arceci R, Altman A, Stine K, Steinherz L, Steinherz P.

J Clin Oncol. 2009 Sep 10;27(26):4392-7. doi: 10.1200/JCO.2008.18.8706. Epub 2009 Aug 3.


Two pediatric cases of primary cutaneous B-cell lymphoma and review of the literature.

Sharon V, Mecca PS, Steinherz PG, Trippett TM, Myskowski PL.

Pediatr Dermatol. 2009 Jan-Feb;26(1):34-9. doi: 10.1111/j.1525-1470.2008.00843.x. Review.


Patients with Epstein Barr virus-positive lymphomas have decreased CD4(+) T-cell responses to the viral nuclear antigen 1.

Heller KN, Arrey F, Steinherz P, Portlock C, Chadburn A, Kelly K, Münz C.

Int J Cancer. 2008 Dec 15;123(12):2824-31. doi: 10.1002/ijc.23845.


Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Trigg ME, Sather HN, Reaman GH, Tubergen DG, Steinherz PG, Gaynon PS, Uckun FM, Hammond GD; Children's Oncology Group.

Leuk Lymphoma. 2008 Jun;49(6):1142-54. doi: 10.1080/10428190802074593.


Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Seibel NL, Steinherz PG, Sather HN, Nachman JB, Delaat C, Ettinger LJ, Freyer DR, Mattano LA Jr, Hastings CA, Rubin CM, Bertolone K, Franklin JL, Heerema NA, Mitchell TL, Pyesmany AF, La MK, Edens C, Gaynon PS.

Blood. 2008 Mar 1;111(5):2548-55. Epub 2007 Nov 26.


The use of preoperative chemotherapy in Wilms' tumor with contained retroperitoneal rupture.

Rutigliano DN, Kayton ML, Steinherz P, Wolden S, La Quaglia MP.

J Pediatr Surg. 2007 Sep;42(9):1595-9.


Clofarabine induced durable complete remission in heavily pretreated adolescents with relapsed and refractory leukemia.

Steinherz PG, Meyers PA, Steinherz LJ, Jeha S.

J Pediatr Hematol Oncol. 2007 Sep;29(9):656-8.


Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia.

Jeha S, Gaynon PS, Razzouk BI, Franklin J, Kadota R, Shen V, Luchtman-Jones L, Rytting M, Bomgaars LR, Rheingold S, Ritchey K, Albano E, Arceci RJ, Goldman S, Griffin T, Altman A, Gordon B, Steinherz L, Weitman S, Steinherz P.

J Clin Oncol. 2006 Apr 20;24(12):1917-23.


Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia.

Bonate PL, Craig A, Gaynon P, Gandhi V, Jeha S, Kadota R, Lam GN, Plunkett W, Razzouk B, Rytting M, Steinherz P, Weitman S.

J Clin Pharmacol. 2004 Nov;44(11):1309-22.


Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961.

Panosyan EH, Seibel NL, Martin-Aragon S, Gaynon PS, Avramis IA, Sather H, Franklin J, Nachman J, Ettinger LJ, La M, Steinherz P, Cohen LJ, Siegel SE, Avramis VI; Children's Cancer Group Study CCG-1961.

J Pediatr Hematol Oncol. 2004 Apr;26(4):217-26.


Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group.

Heerema NA, Nachman JB, Sather HN, La MK, Hutchinson R, Lange BJ, Bostrom B, Steinherz PG, Gaynon PS, Uckun FM; Children's Cancer Group.

Leukemia. 2004 May;18(5):939-47.


Imatinib mesylate in Philadelphia chromosome-positive leukemia of childhood.

Kolb EA, Pan Q, Ladanyi M, Steinherz PG.

Cancer. 2003 Dec 15;98(12):2643-50. Review.


Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study.

Levy AS, Sather HN, Steinherz PG, Sowers R, La M, Moscow JA, Gaynon PS, Uckun FM, Bertino JR, Gorlick R; Children's Cancer Group Study.

J Pediatr Hematol Oncol. 2003 Sep;25(9):688-95.


Human granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia: a Children's Cancer Group Study.

Heath JA, Steinherz PG, Altman A, Sather H, Jhanwar S, Halpern S, Pieters R, Shah N, Steinherz L, Tannous R, Terry W, Trigg ME; Children's Cancer Group.

J Clin Oncol. 2003 Apr 15;21(8):1612-7.


Late cardiotoxicity after bolus versus infusion anthracycline therapy for childhood cancers.

Gupta M, Steinherz PG, Cheung NK, Steinherz L.

Med Pediatr Oncol. 2003 Jun;40(6):343-7.


Phase I study of gemcitabine (difluorodeoxycytidine) in children with relapsed or refractory leukemia (CCG-0955): a report from the Children's Cancer Group.

Steinherz PG, Seibel NL, Ames MM, Avramis VI, Krailo MD, Liu-Mares W, Reid JM, Safgren SL, Reaman GH.

Leuk Lymphoma. 2002 Oct;43(10):1945-50.


Pediatric AML: past, present, and future.

Onel K, Steinherz PG.

Cancer Invest. 2002;20(7-8):1117. No abstract available.


Pythium insidiosum pleuropericarditis complicating pneumonia in a child with leukemia.

Heath JA, Kiehn TE, Brown AE, LaQuaglia MP, Steinherz LJ, Bearman G, Wong M, Steinherz PG.

Clin Infect Dis. 2002 Sep 15;35(6):E60-4. Epub 2002 Aug 23.


Radiation myelitis in a 5-year-old girl.

Antunes NL, Wolden S, Souweidane MM, Lis E, Rosenblum M, Steinherz PG.

J Child Neurol. 2002 Mar;17(3):217-9.


Methotrexate leukoencephalopathy presenting as Klüver-Bucy syndrome and uncinate seizures.

Antunes NL, Souweidane MM, Lis E, Rosenblum MK, Steinherz PG.

Pediatr Neurol. 2002 Apr;26(4):305-8.


Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia.

Heerema NA, Sather HN, Sensel MG, La MK, Hutchinson RJ, Nachman JB, Reaman GH, Lange BJ, Steinherz PG, Bostrom BC, Gaynon PS, Uckun FM.

Cancer. 2002 Feb 15;94(4):1102-10.

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