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Items: 47


Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover.

Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML.

J Cell Biol. 2019 Nov 12. pii: jcb.201901097. doi: 10.1083/jcb.201901097. [Epub ahead of print]


Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment.

Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML, Kühn B.

Sci Transl Med. 2019 Oct 9;11(513). pii: eaaw6419. doi: 10.1126/scitranslmed.aaw6419.


Aging Is a Powerful Risk Factor for Type 2 Diabetes Mellitus Independent of Body Mass Index.

Fazeli PK, Lee H, Steinhauser ML.

Gerontology. 2019 Sep 10:1-2. doi: 10.1159/000501745. [Epub ahead of print] No abstract available.


Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis.

Guillermier C, Doherty SP, Whitney AG, Babaev VR, Linton MF, Steinhauser ML, Brown JD.

JCI Insight. 2019 Jun 6;4(11). pii: 128528. doi: 10.1172/jci.insight.128528. eCollection 2019 Jun 6.


Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.

Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W.

EMBO J. 2018 Nov 15;37(22). pii: e100294. doi: 10.15252/embj.2018100294. Epub 2018 Oct 22.


Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity.

Zhang Y, Federation AJ, Kim S, O'Keefe JP, Lun M, Xiang D, Brown JD, Steinhauser ML.

J Clin Invest. 2018 Nov 1;128(11):4898-4911. doi: 10.1172/JCI98353. Epub 2018 Oct 2.


The circulating metabolome of human starvation.

Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK.

JCI Insight. 2018 Aug 23;3(16). pii: 121434. doi: 10.1172/jci.insight.121434. eCollection 2018 Aug 23.


Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Vujic A, Lerchenmüller C, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT, Rosenzweig A.

Nat Commun. 2018 Apr 25;9(1):1659. doi: 10.1038/s41467-018-04083-1.


Amyloid-β Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity.

Wildburger NC, Gyngard F, Guillermier C, Patterson BW, Elbert D, Mawuenyega KG, Schneider T, Green K, Roth R, Schmidt RE, Cairns NJ, Benzinger TLS, Steinhauser ML, Bateman RJ.

Front Neurol. 2018 Mar 22;9:169. doi: 10.3389/fneur.2018.00169. eCollection 2018.


Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm.

Lu J, Baccei A, Lummertz da Rocha E, Guillermier C, McManus S, Finney LA, Zhang C, Steinhauser ML, Li H, Lerou PH.

Stem Cell Res. 2018 Apr;28:48-55. doi: 10.1016/j.scr.2018.01.015. Epub 2018 Jan 31.


Quantitative imaging of deuterated metabolic tracers in biological tissues with nanoscale secondary ion mass spectrometry.

Guillermier C, Poczatek JC, Taylor WR, Steinhauser ML.

Int J Mass Spectrom. 2017 Nov;422:42-50. doi: 10.1016/j.ijms.2017.08.004. Epub 2017 Aug 24.


Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.

Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML.

JCI Insight. 2017 Mar 9;2(5):e90349. doi: 10.1172/jci.insight.90349.


Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.

Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH Jr, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS.

Nat Genet. 2017 Jan;49(1):125-130. doi: 10.1038/ng.3738. Epub 2016 Dec 5.


Zinc-Induced Polymerization of Killer-Cell Ig-like Receptor into Filaments Promotes Its Inhibitory Function at Cytotoxic Immunological Synapses.

Kumar S, Rajagopalan S, Sarkar P, Dorward DW, Peterson ME, Liao HS, Guillermier C, Steinhauser ML, Vogel SS, Long EO.

Mol Cell. 2016 Apr 7;62(1):21-33. doi: 10.1016/j.molcel.2016.03.009.


Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG.

Dev Cell. 2016 Mar 7;36(5):540-9. doi: 10.1016/j.devcel.2016.02.012.


FGF21 and the late adaptive response to starvation in humans.

Fazeli PK, Lun M, Kim SM, Bredella MA, Wright S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML.

J Clin Invest. 2015 Nov 3;125(12):4601-11. doi: 10.1172/JCI83349.


Approaches to increasing analytical throughput of human samples with multi-isotope imaging mass spectrometry.

Steinhauser ML, Guillermier C, Wang M, Lechene CP.

Surf Interface Anal. 2014 Nov 1;46(Suppl 1):165-168.


Quantifying cell division with deuterated water and multi-isotope imaging mass spectrometry (MIMS).

Steinhauser ML, Guillermier C, Wang M, Lechene CP.

Surf Interface Anal. 2014 Nov 1;46(Suppl 1):161-164.


Loss of white adipose hyperplastic potential is associated with enhanced susceptibility to insulin resistance.

Kim SM, Lun M, Wang M, Senyo SE, Guillermier C, Patwari P, Steinhauser ML.

Cell Metab. 2014 Dec 2;20(6):1049-58. doi: 10.1016/j.cmet.2014.10.010. Epub 2014 Nov 20.


Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples.

Guillermier C, Steinhauser ML, Lechene CP.

Surf Interface Anal. 2014 Nov;46(Suppl 1):150-153. doi: 10.1002/sia.5496. Epub 2014 May 7.


An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential.

Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT.

Circulation. 2013 Jul 9;128(2):152-61. doi: 10.1161/CIRCULATIONAHA.113.002203. Epub 2013 Jun 11.


Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.

Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT.

Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015.


Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry.

Steinhauser ML, Lechene CP.

Semin Cell Dev Biol. 2013 Aug-Sep;24(8-9):661-7. doi: 10.1016/j.semcdb.2013.05.001. Epub 2013 May 7. Review.


Braveheart, a long noncoding RNA required for cardiovascular lineage commitment.

Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA.

Cell. 2013 Jan 31;152(3):570-83. doi: 10.1016/j.cell.2013.01.003. Epub 2013 Jan 24.


Pericyte progenitors at the crossroads between fibrosis and regeneration.

Steinhauser ML, Lee RT.

Circ Res. 2013 Jan 18;112(2):230-2. doi: 10.1161/CIRCRESAHA.111.300287.


Mammalian heart renewal by pre-existing cardiomyocytes.

Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu TD, Guerquin-Kern JL, Lechene CP, Lee RT.

Nature. 2013 Jan 17;493(7432):433-6. doi: 10.1038/nature11682. Epub 2012 Dec 5.


Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism.

Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP.

Nature. 2012 Jan 15;481(7382):516-9. doi: 10.1038/nature10734.


Regeneration of the heart.

Steinhauser ML, Lee RT.

EMBO Mol Med. 2011 Dec;3(12):701-12. doi: 10.1002/emmm.201100175. Epub 2011 Sep 23. Review.


Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair.

Loffredo FS, Steinhauser ML, Gannon J, Lee RT.

Cell Stem Cell. 2011 Apr 8;8(4):389-98. doi: 10.1016/j.stem.2011.02.002. Erratum in: Cell Stem Cell. 2015 Jul 2;17(1):125.


A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment.

Amadi OC, Steinhauser ML, Nishi Y, Chung S, Kamm RD, McMahon AP, Lee RT.

Biomed Microdevices. 2010 Dec;12(6):1027-41. doi: 10.1007/s10544-010-9457-7.


Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling.

Seki K, Sanada S, Kudinova AY, Steinhauser ML, Handa V, Gannon J, Lee RT.

Circ Heart Fail. 2009 Nov;2(6):684-91. doi: 10.1161/CIRCHEARTFAILURE.109.873240. Epub 2009 Sep 22.


Cardiovascular regeneration: pushing and pulling on progenitors.

Steinhauser ML, Lee RT.

Cell Stem Cell. 2009 Apr 3;4(4):277-8. doi: 10.1016/j.stem.2009.03.008.


Risk stratification and management of aortic stenosis with concomitant left ventricular dysfunction.

Steinhauser ML, Stone PH.

Curr Treat Options Cardiovasc Med. 2007 Dec;9(6):490-500.


New Frontiers in Cytokine Involvement during Experimental Sepsis.

Steinhauser ML, Kunkel SL, Hogaboam CM.

ILAR J. 1999 Sep;40(4):142-150.


Chemokine C10 promotes disease resolution and survival in an experimental model of bacterial sepsis.

Steinhauser ML, Hogaboam CM, Matsukawa A, Lukacs NW, Strieter RM, Kunkel SL.

Infect Immun. 2000 Nov;68(11):6108-14.


Novel protective effects of stem cell factor in a murine model of acute septic peritonitis. Dependence on MCP-1.

Bone-Larson CL, Hogaboam CM, Steinhauser ML, Oliveira SH, Lukacs NW, Strieter RM, Kunkel SL.

Am J Pathol. 2000 Oct;157(4):1177-86.


Therapeutic use of chemokines.

Hogaboam CM, Bone-Larson C, Matsukawa A, Steinhauser ML, Blease K, Lukacs NW, Kunkel SL.

Curr Pharm Des. 2000 Apr;6(6):651-63. Review.


Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.

Hogaboam CM, Bone-Larson CL, Steinhauser ML, Matsukawa A, Gosling J, Boring L, Charo IF, Simpson KJ, Lukacs NW, Kunkel SL.

Am J Pathol. 2000 Apr;156(4):1245-52.


Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus.

Hogaboam CM, Blease K, Mehrad B, Steinhauser ML, Standiford TJ, Kunkel SL, Lukacs NW.

Am J Pathol. 2000 Feb;156(2):723-32.


Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury.

Hogaboam CM, Simpson KJ, Chensue SW, Steinhauser ML, Lukacs NW, Gauldie J, Strieter RM, Kunkel SL.

Gene Ther. 1999 Apr;6(4):573-84.


Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines.

Hogaboam CM, Bone-Larson CL, Steinhauser ML, Lukacs NW, Colletti LM, Simpson KJ, Strieter RM, Kunkel SL.

FASEB J. 1999 Sep;13(12):1565-74.


Multiple roles for IL-12 in a model of acute septic peritonitis.

Steinhauser ML, Hogaboam CM, Lukacs NW, Strieter RM, Kunkel SL.

J Immunol. 1999 May 1;162(9):5437-43.


IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense.

Steinhauser ML, Hogaboam CM, Kunkel SL, Lukacs NW, Strieter RM, Standiford TJ.

J Immunol. 1999 Jan 1;162(1):392-9.


Novel roles for chemokines and fibroblasts in interstitial fibrosis.

Hogaboam CM, Steinhauser ML, Chensue SW, Kunkel SL.

Kidney Int. 1998 Dec;54(6):2152-9. Review.


Macrophage/fibroblast coculture induces macrophage inflammatory protein-1alpha production mediated by intercellular adhesion molecule-1 and oxygen radicals.

Steinhauser ML, Kunkel SL, Hogaboam CM, Evanoff H, Strieter RM, Lukacs NW.

J Leukoc Biol. 1998 Nov;64(5):636-41.


Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide.

Hogaboam CM, Chensue SW, Steinhauser ML, Huffnagle GB, Lukacs NW, Strieter RM, Kunkel SL.

J Immunol. 1997 Dec 1;159(11):5585-93.


Therapeutic effects of nitric oxide inhibition during experimental fecal peritonitis: role of interleukin-10 and monocyte chemoattractant protein 1.

Hogaboam CM, Steinhauser ML, Schock H, Lukacs N, Strieter RM, Standiford T, Kunkel SL.

Infect Immun. 1998 Feb;66(2):650-5.

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