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Antigenic Pressure on H3N2 Influenza Virus Drift Strains Imposes Constraints on Binding to Sialylated Receptors but Not Phosphorylated Glycans.

Byrd-Leotis L, Gao C, Jia N, Mehta AY, Trost J, Cummings SF, Heimburg-Molinaro J, Cummings RD, Steinhauer DA.

J Virol. 2019 Oct 29;93(22). pii: e01178-19. doi: 10.1128/JVI.01178-19. Print 2019 Nov 15.


A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity.

Trost JF, Wang W, Liang B, Galloway SE, Agbogu E, Byrd-Leotis L, Steinhauer DA.

Virology. 2019 Oct;536:78-90. doi: 10.1016/j.virol.2019.08.005. Epub 2019 Aug 6.


Influenza binds phosphorylated glycans from human lung.

Byrd-Leotis L, Jia N, Dutta S, Trost JF, Gao C, Cummings SF, Braulke T, Müller-Loennies S, Heimburg-Molinaro J, Steinhauer DA, Cummings RD.

Sci Adv. 2019 Feb 13;5(2):eaav2554. doi: 10.1126/sciadv.aav2554. eCollection 2019 Feb.


Unique Binding Specificities of Proteins toward Isomeric Asparagine-Linked Glycans.

Gao C, Hanes MS, Byrd-Leotis LA, Wei M, Jia N, Kardish RJ, McKitrick TR, Steinhauer DA, Cummings RD.

Cell Chem Biol. 2019 Apr 18;26(4):535-547.e4. doi: 10.1016/j.chembiol.2019.01.002. Epub 2019 Feb 7.


Development of a high-throughput assay to detect antibody inhibition of low pH induced conformational changes of influenza virus hemagglutinin.

Trost JF, LeMasters EH, Liu F, Carney P, Lu X, Sugawara K, Hongo S, Stevens J, Steinhauer DA, Tumpey T, Katz JM, Levine MZ, Li ZN.

PLoS One. 2018 Jun 27;13(6):e0199683. doi: 10.1371/journal.pone.0199683. eCollection 2018.


The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase.

Byrd-Leotis L, Cummings RD, Steinhauer DA.

Int J Mol Sci. 2017 Jul 17;18(7). pii: E1541. doi: 10.3390/ijms18071541. Review.


Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes.

Wu Z, Liu Y, Ma C, Li L, Bai J, Byrd-Leotis L, Lasanajak Y, Guo Y, Wen L, Zhu H, Song J, Li Y, Steinhauer DA, Smith DF, Zhao B, Chen X, Guan W, Wang PG.

Org Biomol Chem. 2016 Nov 29;14(47):11106-11116.


Amino acid substitution D222N from fatal influenza infection affects receptor-binding properties of the influenza A(H1N1)pdm09 virus.

Matos-Patrón A, Byrd-Leotis L, Steinhauer DA, Barclay WS, Ayora-Talavera G.

Virology. 2015 Oct;484:15-21. doi: 10.1016/j.virol.2015.05.012. Epub 2015 Jun 5.


Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes.

Byrd-Leotis L, Galloway SE, Agbogu E, Steinhauer DA.

J Virol. 2015 Apr;89(8):4504-16. doi: 10.1128/JVI.00057-15. Epub 2015 Feb 4.


Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range.

Xiong X, McCauley JW, Steinhauer DA.

Curr Top Microbiol Immunol. 2014;385:63-91. doi: 10.1007/82_2014_423. Review.


Shotgun glycomics of pig lung identifies natural endogenous receptors for influenza viruses.

Byrd-Leotis L, Liu R, Bradley KC, Lasanajak Y, Cummings SF, Song X, Heimburg-Molinaro J, Galloway SE, Culhane MR, Smith DF, Steinhauer DA, Cummings RD.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2241-50. doi: 10.1073/pnas.1323162111. Epub 2014 May 19.


Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications.

Kiss G, Chen X, Brindley MA, Campbell P, Afonso CL, Ke Z, Holl JM, Guerrero-Ferreira RC, Byrd-Leotis LA, Steel J, Steinhauer DA, Plemper RK, Kelly DF, Spearman PW, Wright ER.

Microsc Microanal. 2014 Feb;20(1):164-74. doi: 10.1017/S1431927613013937. Epub 2013 Nov 26.


Novel H7N9 influenza virus shows low infectious dose, high growth rate, and efficient contact transmission in the guinea pig model.

Gabbard JD, Dlugolenski D, Van Riel D, Marshall N, Galloway SE, Howerth EW, Campbell PJ, Jones C, Johnson S, Byrd-Leotis L, Steinhauer DA, Kuiken T, Tompkins SM, Tripp R, Lowen AC, Steel J.

J Virol. 2014 Feb;88(3):1502-12. doi: 10.1128/JVI.02959-13. Epub 2013 Nov 13.


Mutation tryptophan to leucine at position 222 of haemagglutinin could facilitate H3N2 influenza A virus infection in dogs.

Yang G, Li S, Blackmon S, Ye J, Bradley KC, Cooley J, Smith D, Hanson L, Cardona C, Steinhauer DA, Webby R, Liao M, Wan XF.

J Gen Virol. 2013 Dec;94(Pt 12):2599-608. doi: 10.1099/vir.0.054692-0. Epub 2013 Sep 1.


Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response.

Yan D, Krumm SA, Sun A, Steinhauer DA, Luo M, Moore ML, Plemper RK.

J Virol. 2013 Oct;87(20):11076-87. doi: 10.1128/JVI.01425-13. Epub 2013 Aug 7.


Influenza: Pathways to human adaptation.

Steinhauer DA.

Nature. 2013 Jul 25;499(7459):412-3. doi: 10.1038/nature12455. Epub 2013 Jul 17. No abstract available.


Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation.

Galloway SE, Reed ML, Russell CJ, Steinhauer DA.

PLoS Pathog. 2013 Feb;9(2):e1003151. doi: 10.1371/journal.ppat.1003151. Epub 2013 Feb 14.


Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers.

Yu Y, Mishra S, Song X, Lasanajak Y, Bradley KC, Tappert MM, Air GM, Steinhauer DA, Halder S, Cotmore S, Tattersall P, Agbandje-McKenna M, Cummings RD, Smith DF.

J Biol Chem. 2012 Dec 28;287(53):44784-99. doi: 10.1074/jbc.M112.425819. Epub 2012 Oct 31.


Structure of the primed paramyxovirus fusion protein.

Steinhauer DA, Plemper RK.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16404-5. doi: 10.1073/pnas.1214903109. Epub 2012 Oct 1. No abstract available.


Low pathogenic avian influenza isolates from wild birds replicate and transmit via contact in ferrets without prior adaptation.

Driskell EA, Pickens JA, Humberd-Smith J, Gordy JT, Bradley KC, Steinhauer DA, Berghaus RD, Stallknecht DE, Howerth EW, Tompkins SM.

PLoS One. 2012;7(6):e38067. doi: 10.1371/journal.pone.0038067. Epub 2012 Jun 1.


Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics.

Bradley KC, Galloway SE, Lasanajak Y, Song X, Heimburg-Molinaro J, Yu H, Chen X, Talekar GR, Smith DF, Cummings RD, Steinhauer DA.

J Virol. 2011 Dec;85(23):12387-98. doi: 10.1128/JVI.05570-11. Epub 2011 Sep 14.


Avian influenza viruses infect primary human bronchial epithelial cells unconstrained by sialic acid α2,3 residues.

Oshansky CM, Pickens JA, Bradley KC, Jones LP, Saavedra-Ebner GM, Barber JP, Crabtree JM, Steinhauer DA, Tompkins SM, Tripp RA.

PLoS One. 2011;6(6):e21183. doi: 10.1371/journal.pone.0021183. Epub 2011 Jun 23.


Immunogenicity of low-pH treated whole viral influenza vaccine.

Quan FS, Li ZN, Kim MC, Yang D, Compans RW, Steinhauer DA, Kang SM.

Virology. 2011 Aug 15;417(1):196-202. doi: 10.1016/j.virol.2011.05.014. Epub 2011 Jun 30.


Comparison of the receptor binding properties of contemporary swine isolates and early human pandemic H1N1 isolates (Novel 2009 H1N1).

Bradley KC, Jones CA, Tompkins SM, Tripp RA, Russell RJ, Gramer MR, Heimburg-Molinaro J, Smith DF, Cummings RD, Steinhauer DA.

Virology. 2011 May 10;413(2):169-82. doi: 10.1016/j.virol.2011.01.027. Epub 2011 Feb 24.


The effects of preexisting immunity to influenza on responses to influenza vectors in mice.

Langley WA, Bradley KC, Li ZN, Talekar GR, Galloway SE, Steinhauer DA.

Vaccine. 2010 Aug 31;28(38):6305-13. doi: 10.1016/j.vaccine.2010.06.112. Epub 2010 Jul 23.


Induction of neutralizing antibody responses to anthrax protective antigen by using influenza virus vectors: implications for disparate immune system priming pathways.

Langley WA, Bradley KC, Li ZN, Smith ME, Schnell MJ, Steinhauer DA.

J Virol. 2010 Aug;84(16):8300-7. doi: 10.1128/JVI.00183-10. Epub 2010 May 26.


Single residue deletions along the length of the influenza HA fusion peptide lead to inhibition of membrane fusion function.

Langley WA, Thoennes S, Bradley KC, Galloway SE, Talekar GR, Cummings SF, Varecková E, Russell RJ, Steinhauer DA.

Virology. 2009 Nov 25;394(2):321-30. doi: 10.1016/j.virol.2009.08.031. Epub 2009 Sep 15.


Composition and functions of the influenza fusion peptide.

Cross KJ, Langley WA, Russell RJ, Skehel JJ, Steinhauer DA.

Protein Pept Lett. 2009;16(7):766-78. Review.


Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion.

Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. doi: 10.1073/pnas.0807142105. Epub 2008 Nov 12.


Length requirements for membrane fusion of influenza virus hemagglutinin peptide linkers to transmembrane or fusion peptide domains.

Li ZN, Lee BJ, Langley WA, Bradley KC, Russell RJ, Steinhauer DA.

J Virol. 2008 Jul;82(13):6337-48. doi: 10.1128/JVI.02576-07. Epub 2008 Apr 16.


Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in mice.

Meisner J, Szretter KJ, Bradley KC, Langley WA, Li ZN, Lee BJ, Thoennes S, Martin J, Skehel JJ, Russell RJ, Katz JM, Steinhauer DA.

J Virol. 2008 May;82(10):5079-83. doi: 10.1128/JVI.01958-07. Epub 2008 Mar 19.


Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion.

Thoennes S, Li ZN, Lee BJ, Langley WA, Skehel JJ, Russell RJ, Steinhauer DA.

Virology. 2008 Jan 20;370(2):403-14. Epub 2007 Oct 23.


The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection.

Kemball CC, Pack CD, Guay HM, Li ZN, Steinhauer DA, Szomolanyi-Tsuda E, Lukacher AE.

J Immunol. 2007 Jul 15;179(2):1113-21.


Functional and antigenic analyses of the 1918 influenza virus haemagglutinin using a recombinant vaccinia virus expression system.

Elliot AJ, Steinhauer DA, Daniels RS, Oxford JS.

Virus Res. 2006 Dec;122(1-2):11-9. Epub 2006 Aug 9.


Murine leukemia virus R Peptide inhibits influenza virus hemagglutinin-induced membrane fusion.

Li M, Li ZN, Yao Q, Yang C, Steinhauer DA, Compans RW.

J Virol. 2006 Jun;80(12):6106-14.


Antigenic properties of a transport-competent influenza HA/HIV Env chimeric protein.

Ye L, Sun Y, Lin J, Bu Z, Wu Q, Jiang S, Steinhauer DA, Compans RW, Yang C.

Virology. 2006 Aug 15;352(1):74-85. Epub 2006 May 24.


Influenza a viruses with mutations in the m1 helix six domain display a wide variety of morphological phenotypes.

Burleigh LM, Calder LJ, Skehel JJ, Steinhauer DA.

J Virol. 2005 Jan;79(2):1262-70.


The structure and receptor binding properties of the 1918 influenza hemagglutinin.

Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ.

Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5.


Mechanisms of cell entry by influenza virus.

Cross KJ, Burleigh LM, Steinhauer DA.

Expert Rev Mol Med. 2001 Aug 6;3(21):1-18. doi: 10.1017/S1462399401003453.


Genetics of influenza viruses.

Steinhauer DA, Skehel JJ.

Annu Rev Genet. 2002;36:305-32. Epub 2002 Jun 11. Review.


Studies on influenza haemagglutinin fusion peptide mutants generated by reverse genetics.

Cross KJ, Wharton SA, Skehel JJ, Wiley DC, Steinhauer DA.

EMBO J. 2001 Aug 15;20(16):4432-42.


Role of hemagglutinin cleavage for the pathogenicity of influenza virus.

Steinhauer DA.

Virology. 1999 May 25;258(1):1-20. Review.


Studies of the binding properties of influenza hemagglutinin receptor-site mutants.

Martín J, Wharton SA, Lin YP, Takemoto DK, Skehel JJ, Wiley DC, Steinhauer DA.

Virology. 1998 Feb 1;241(1):101-11.


Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity.

Steinhauer DA, Martín J, Lin YP, Wharton SA, Oldstone MB, Skehel JJ, Wiley DC.

Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12873-8.

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