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Items: 18

1.

Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.

Hegde SS, Pulido-Rios MT, Luttmann MA, Foley JJ, Hunsberger GE, Steinfeld T, Lee T, Ji Y, Mammen MM, Jasper JR.

Pharmacol Res Perspect. 2018 Apr 30;6(3):e00400. doi: 10.1002/prp2.400. eCollection 2018 Jun.

2.

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):293-297. doi: 10.1016/j.bmcl.2017.12.051. Epub 2017 Dec 24.

PMID:
29292223
3.

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):757-760. doi: 10.1016/j.bmcl.2015.12.102. Epub 2015 Dec 30.

PMID:
26778255
5.

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.

Hegde SS, Hughes AD, Chen Y, Steinfeld T, Jasper JR, Lee TW, McNamara A, Martin WJ, Pulido-Rios MT, Mammen M.

J Pharmacol Exp Ther. 2014 Oct;351(1):190-9. doi: 10.1124/jpet.114.216861. Epub 2014 Aug 6.

PMID:
25100753
6.

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma.

Long DD, Frieman B, Hegde SS, Hill CM, Jiang L, Kintz S, Marquess DG, Purkey H, Shaw JP, Steinfeld T, Wilson MS, Wrench K.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):939-43. doi: 10.1016/j.bmcl.2012.12.058. Epub 2012 Dec 22.

PMID:
23317571
7.

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA).

McNamara A, Steinfeld T, Pulido-Rios MT, Stangeland E, Hegde SS, Mammen M, Martin WJ.

Pulm Pharmacol Ther. 2012 Oct;25(5):357-63. doi: 10.1016/j.pupt.2012.06.007. Epub 2012 Jul 2.

PMID:
22766316
8.

Multivalent dual pharmacology muscarinic antagonist and β₂ agonist (MABA) molecules for the treatment of COPD.

Hughes AD, McNamara A, Steinfeld T.

Prog Med Chem. 2012;51:71-95. doi: 10.1016/B978-0-12-396493-9.00003-0. Review. No abstract available.

PMID:
22520472
9.

Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation.

Witte LP, de Haas N, Mammen M, Stangeland EL, Steinfeld T, Aiyar J, Michel MC.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):555-63. doi: 10.1007/s00210-011-0689-8. Epub 2011 Sep 24.

10.

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.

Hughes AD, Chin KH, Dunham SL, Jasper JR, King KE, Lee TW, Mammen M, Martin J, Steinfeld T.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1354-8. doi: 10.1016/j.bmcl.2011.01.043. Epub 2011 Jan 18.

PMID:
21310610
11.

THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner.

Steinfeld T, Hughes AD, Klein U, Smith JA, Mammen M.

Mol Pharmacol. 2011 Mar;79(3):389-99. doi: 10.1124/mol.110.069120. Epub 2010 Dec 7.

PMID:
21139051
12.

In vitro isolated tissue functional muscarinic receptor assays.

Pulido-Rios MT, Steinfeld T, Armstrong S, Watson N, Choppin A, Eglen R, Hegde SS.

Curr Protoc Pharmacol. 2010 Mar;Chapter 4:Unit 4.15. doi: 10.1002/0471141755.ph0415s48.

PMID:
22294371
13.

In vivo pharmacodynamic assays for M2 and M3 muscarinic receptors.

Armstrong S, Steinfeld T, Pulido-Rios MT, Hegde SS.

Curr Protoc Pharmacol. 2010 Mar;Chapter 12:Unit 12.13. doi: 10.1002/0471141755.ph1213s48.

PMID:
22294364
14.

In vitro muscarinic receptor radioligand-binding assays.

Steinfeld T, Pulido-Rios MT, Armstrong S, Hegde SS.

Curr Protoc Pharmacol. 2010 Mar;Chapter 1:Unit 1.33. doi: 10.1002/0471141755.ph0133s48.

PMID:
22294363
15.

Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist.

McNamara A, Pulido-Rios MT, Sweazey S, Obedencio GP, Thibodeaux H, Renner T, Armstrong SR, Steinfeld T, Hughes AD, Wilson RD, Jasper JR, Mammen M, Hegde SS.

Eur J Pharmacol. 2009 Mar 1;605(1-3):145-52. doi: 10.1016/j.ejphar.2008.12.043. Epub 2009 Jan 10.

PMID:
19168050
16.

A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor.

Steinfeld T, Mammen M, Smith JA, Wilson RD, Jasper JR.

Mol Pharmacol. 2007 Aug;72(2):291-302. Epub 2007 May 3.

PMID:
17478612
17.

Telemetric monitoring of tracheal pressure after tracheal occlusion for treatment of severe congenital diaphragmatic hernia.

Hellmeyer L, Exner C, Folz B, Hiller M, Sierra F, Lukasewitz P, Steinfeld T, Werner JA, Heldmaier G, Schmidt S.

Arch Gynecol Obstet. 2007 Apr;275(4):245-8. Epub 2006 Sep 20.

PMID:
17021771
18.

[Postoperative nausea and vomiting (PONV) - meaning and multimodal treatment].

Maybauer DM, Eberhart LH, Kranke P, Steinfeld T, Putzke C.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2005 Sep;40(9):555-9. Review. German. No abstract available.

PMID:
16145646

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