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Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas.

Supsrisunjai C, Hsu CK, Michael M, Duval C, Lee JYW, Yang HS, Huang HY, Chaikul T, Onoufriadis A, Steiner RA, Ariëns RAS, Sarig O, Sprecher E, Schwartz-Eskin M, Samlaska C, Simpson MA, Calonje E, Parsons M, McGrath JA.

J Invest Dermatol. 2019 Sep 4. pii: S0022-202X(19)33212-9. doi: 10.1016/j.jid.2019.08.441. [Epub ahead of print]


Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.

Pernigo S, Chegkazi MS, Yip YY, Treacy C, Glorani G, Hansen K, Politis A, Bui S, Dodding MP, Steiner RA.

Elife. 2018 Oct 15;7. pii: e38362. doi: 10.7554/eLife.38362.


The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field.

Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Hwa-Yeo S, Padilla SL, Kauffman AS, Garcia J, Kelly MJ, Clarkson J, Radovick S, Babwah AV, Leon S, Tena-Sempere M, Comninos A, Seminara S, Dhillo WS, Levine J, Terasawa E, Negron A, Herbison AE.

J Neuroendocrinol. 2018 Apr 14:e12600. doi: 10.1111/jne.12600. [Epub ahead of print] Review.


A small-molecule activator of kinesin-1 drives remodeling of the microtubule network.

Randall TS, Yip YY, Wallock-Richards DJ, Pfisterer K, Sanger A, Ficek W, Steiner RA, Beavil AJ, Parsons M, Dodding MP.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13738-13743. doi: 10.1073/pnas.1715115115. Epub 2017 Dec 11.


Online Raman spectroscopy for structural biology on beamline ID29 of the ESRF.

von Stetten D, Giraud T, Bui S, Steiner RA, Fihman F, de Sanctis D, Royant A.

J Struct Biol. 2017 Nov;200(2):124-127. doi: 10.1016/j.jsb.2017.10.004. Epub 2017 Oct 16.


The Cannabinoid Receptor Interacting Proteins 1 of zebrafish are not required for morphological development, viability or fertility.

Fin L, Bergamin G, Steiner RA, Hughes SM.

Sci Rep. 2017 Jul 7;7(1):4858. doi: 10.1038/s41598-017-05017-5.


A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide.

Krull AA, Larsen SA, Clifton DK, Neal-Perry G, Steiner RA.

Endocrinology. 2017 Oct 1;158(10):3259-3268. doi: 10.1210/en.2017-00142.


SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain.

Sanger A, Yip YY, Randall TS, Pernigo S, Steiner RA, Dodding MP.

J Cell Sci. 2017 May 1;130(9):1637-1651. doi: 10.1242/jcs.198267. Epub 2017 Mar 16.


Synthesis and Speciation-Dependent Properties of a Multimetallic Model Complex of NiSOD That Exhibits Unique Hydrogen-Bonding.

Steiner RA, Dzul SP, Stemmler TL, Harrop TC.

Inorg Chem. 2017 Mar 6;56(5):2849-2862. doi: 10.1021/acs.inorgchem.6b02997. Epub 2017 Feb 17.


Keep it together: restraints in crystallographic refinement of macromolecule-ligand complexes.

Steiner RA, Tucker JA.

Acta Crystallogr D Struct Biol. 2017 Feb 1;73(Pt 2):93-102. doi: 10.1107/S2059798316017964. Epub 2017 Feb 1. Review.


Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.

Pernigo S, Fukuzawa A, Beedle AEM, Holt M, Round A, Pandini A, Garcia-Manyes S, Gautel M, Steiner RA.

Structure. 2017 Jan 3;25(1):107-120. doi: 10.1016/j.str.2016.11.015. Epub 2016 Dec 15.


New insight into cofactor-free oxygenation from combined experimental and computational approaches.

Bui S, Steiner RA.

Curr Opin Struct Biol. 2016 Dec;41:109-118. doi: 10.1016/ Epub 2016 Jul 6. Review.


The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1.

Twelvetrees AE, Pernigo S, Sanger A, Guedes-Dias P, Schiavo G, Steiner RA, Dodding MP, Holzbaur EL.

Neuron. 2016 Jun 1;90(5):1000-15. doi: 10.1016/j.neuron.2016.04.046. Epub 2016 May 19.


The light chains of kinesin-1 are autoinhibited.

Yip YY, Pernigo S, Sanger A, Xu M, Parsons M, Steiner RA, Dodding MP.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2418-23. doi: 10.1073/pnas.1520817113. Epub 2016 Feb 16.


Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.

Santos CX, Hafstad AD, Beretta M, Zhang M, Molenaar C, Kopec J, Fotinou D, Murray TV, Cobb AM, Martin D, Zeh Silva M, Anilkumar N, Schröder K, Shanahan CM, Brewer AC, Brandes RP, Blanc E, Parsons M, Belousov V, Cammack R, Hider RC, Steiner RA, Shah AM.

EMBO J. 2016 Feb 1;35(3):319-34. doi: 10.15252/embj.201592394. Epub 2016 Jan 7.


κ Agonists as a novel therapy for menopausal hot flashes.

Oakley AE, Steiner RA, Chavkin C, Clifton DK, Ferrara LK, Reed SD.

Menopause. 2015 Dec;22(12):1328-34. doi: 10.1097/GME.0000000000000476.


Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates.

Hernández-Ortega A, Quesne MG, Bui S, Heyes DJ, Steiner RA, Scrutton NS, de Visser SP.

J Am Chem Soc. 2015 Jun 17;137(23):7474-87. doi: 10.1021/jacs.5b03836. Epub 2015 Jun 4.


Fertility-regulating Kiss1 neurons arise from hypothalamic POMC-expressing progenitors.

Sanz E, Quintana A, Deem JD, Steiner RA, Palmiter RD, McKnight GS.

J Neurosci. 2015 Apr 8;35(14):5549-56. doi: 10.1523/JNEUROSCI.3614-14.2015.


Accessing Ni(III)-thiolate versus Ni(II)-thiyl bonding in a family of Ni-N2S2 synthetic models of NiSOD.

Broering EP, Dillon S, Gale EM, Steiner RA, Telser J, Brunold TC, Harrop TC.

Inorg Chem. 2015 Apr 20;54(8):3815-28. doi: 10.1021/ic503124f. Epub 2015 Apr 2.


TACkling NKB's role in puberty.

Angell AE, Steiner RA.

Endocrinology. 2015 Apr;156(4):1207-9. doi: 10.1210/en.2015-1158. No abstract available.


The crystal structure of the human titin:obscurin complex reveals a conserved yet specific muscle M-band zipper module.

Pernigo S, Fukuzawa A, Pandini A, Holt M, Kleinjung J, Gautel M, Steiner RA.

J Mol Biol. 2015 Feb 27;427(4):718-736. doi: 10.1016/j.jmb.2014.11.019. Epub 2014 Dec 6.


Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.

Bui S, von Stetten D, Jambrina PG, Prangé T, Colloc'h N, de Sanctis D, Royant A, Rosta E, Steiner RA.

Angew Chem Int Ed Engl. 2014 Dec 8;53(50):13710-4. doi: 10.1002/anie.201405485. Epub 2014 Oct 14.


Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons.

Koemeter-Cox AI, Sherwood TW, Green JA, Steiner RA, Berbari NF, Yoder BK, Kauffman AS, Monsma PC, Brown A, Askwith CC, Mykytyn K.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10335-40. doi: 10.1073/pnas.1403286111. Epub 2014 Jun 30.


Synthesis, characterization, crystal structures and biological activity of set of Cu(II) benzothiazole complexes: artificial nucleases with cytotoxic activities.

Steiner RA, Foreman D, Lin HX, Carney BK, Fox KM, Cassimeris L, Tanski JM, Tyler LA.

J Inorg Biochem. 2014 Aug;137:1-11. doi: 10.1016/j.jinorgbio.2014.04.002. Epub 2014 Apr 12.


Origin of the proton-transfer step in the cofactor-free (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase: effect of the basicity of an active site His residue.

Hernandez-Ortega A, Quesne MG, Bui S, Heuts DP, Steiner RA, Heyes DJ, de Visser SP, Scrutton NS.

J Biol Chem. 2014 Mar 21;289(12):8620-32. doi: 10.1074/jbc.M113.543033. Epub 2014 Jan 30.


Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area.

Zhang C, Tonsfeldt KJ, Qiu J, Bosch MA, Kobayashi K, Steiner RA, Kelly MJ, Rønnekleiv OK.

Am J Physiol Endocrinol Metab. 2013 Dec 1;305(11):E1384-97. doi: 10.1152/ajpendo.00406.2013. Epub 2013 Oct 8.


Redundancy in Kiss1 expression safeguards reproduction in the mouse.

Popa SM, Moriyama RM, Caligioni CS, Yang JJ, Cho CM, Concepcion TL, Oakley AE, Lee IH, Sanz E, Amieux PS, Caraty A, Palmiter RD, Navarro VM, Chan YM, Seminara SB, Clifton DK, Steiner RA.

Endocrinology. 2013 Aug;154(8):2784-94. doi: 10.1210/en.2013-1222. Epub 2013 Jun 4.


Kisspeptin: past, present, and prologue.

Steiner RA.

Adv Exp Med Biol. 2013;784:3-7. doi: 10.1007/978-1-4614-6199-9_1. Review.


Structural basis for kinesin-1:cargo recognition.

Pernigo S, Lamprecht A, Steiner RA, Dodding MP.

Science. 2013 Apr 19;340(6130):356-9. doi: 10.1126/science.1234264. Epub 2013 Mar 21.


Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1.

Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB.

Endocrinology. 2012 Oct;153(10):4883-93. Epub 2012 Aug 14.


Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids.

Ruiz-Pino F, Navarro VM, Bentsen AH, Garcia-Galiano D, Sanchez-Garrido MA, Ciofi P, Steiner RA, Mikkelsen JD, Pinilla L, Tena-Sempere M.

Endocrinology. 2012 Oct;153(10):4818-29. Epub 2012 Jul 20.


Model building, refinement and validation.

Steiner RA, Rupp B.

Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):325-7. doi: 10.1107/S0907444912002090. Epub 2012 Mar 16. No abstract available.


Tacking toward reconciliation on Tacr3/TACR3 mutations.

Steiner RA, Navarro VM.

Endocrinology. 2012 Apr;153(4):1578-81. doi: 10.1210/en.2012-1032. Epub 2012 Mar 9. No abstract available.


Role of neurokinin B in the control of female puberty and its modulation by metabolic status.

Navarro VM, Ruiz-Pino F, Sánchez-Garrido MA, García-Galiano D, Hobbs SJ, Manfredi-Lozano M, León S, Sangiao-Alvarellos S, Castellano JM, Clifton DK, Pinilla L, Steiner RA, Tena-Sempere M.

J Neurosci. 2012 Feb 15;32(7):2388-97. doi: 10.1523/JNEUROSCI.4288-11.2012.


Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse.

Gottsch ML, Popa SM, Lawhorn JK, Qiu J, Tonsfeldt KJ, Bosch MA, Kelly MJ, Rønnekleiv OK, Sanz E, McKnight GS, Clifton DK, Palmiter RD, Steiner RA.

Endocrinology. 2011 Nov;152(11):4298-309. doi: 10.1210/en.2011-1521. Epub 2011 Sep 20.


Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.

Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA.

Endocrinology. 2011 Nov;152(11):4265-75. doi: 10.1210/en.2011-1143. Epub 2011 Sep 13.


REFMAC5 for the refinement of macromolecular crystal structures.

Murshudov GN, Skubák P, Lebedev AA, Pannu NS, Steiner RA, Nicholls RA, Winn MD, Long F, Vagin AA.

Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67. doi: 10.1107/S0907444911001314. Epub 2011 Mar 18.


Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse.

Kim J, Semaan SJ, Clifton DK, Steiner RA, Dhamija S, Kauffman AS.

Endocrinology. 2011 May;152(5):2020-30. doi: 10.1210/en.2010-1498. Epub 2011 Mar 1.


Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.

Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, Pinilla L, Clifton DK, Tena-Sempere M, Steiner RA.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E202-10. doi: 10.1152/ajpendo.00517.2010. Epub 2010 Nov 2.


Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.

Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17951-6. doi: 10.1073/pnas.1008206107. Epub 2010 Sep 29.


Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat.

Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H.

J Neurosci. 2010 Feb 24;30(8):3124-32. doi: 10.1523/JNEUROSCI.5848-09.2010.


Cofactor-independent oxidases and oxygenases.

Fetzner S, Steiner RA.

Appl Microbiol Biotechnol. 2010 Apr;86(3):791-804. doi: 10.1007/s00253-010-2455-0. Epub 2010 Feb 16. Review.


Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.

Pernigo S, Fukuzawa A, Bertz M, Holt M, Rief M, Steiner RA, Gautel M.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2908-13. doi: 10.1073/pnas.0913736107. Epub 2010 Feb 1.


Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the alpha/beta-hydrolase fold.

Steiner RA, Janssen HJ, Roversi P, Oakley AJ, Fetzner S.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):657-62. doi: 10.1073/pnas.0909033107. Epub 2009 Dec 22.


Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse.

Dungan Lemko HM, Naderi R, Adjan V, Jennes LH, Navarro VM, Clifton DK, Steiner RA.

Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E80-8. doi: 10.1152/ajpendo.00380.2009. Epub 2009 Oct 27.


Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse.

Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA.

J Neurosci. 2009 Sep 23;29(38):11859-66. doi: 10.1523/JNEUROSCI.1569-09.2009.


Kisspeptin signaling in the brain.

Oakley AE, Clifton DK, Steiner RA.

Endocr Rev. 2009 Oct;30(6):713-43. doi: 10.1210/er.2009-0005. Epub 2009 Sep 21. Review.


Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty.

Kauffman AS, Navarro VM, Kim J, Clifton DK, Steiner RA.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1212-21. doi: 10.1152/ajpendo.00461.2009. Epub 2009 Sep 15.


Seasonal changes in androgen receptor mRNA in the brain of the white-crowned sparrow.

Fraley GS, Steiner RA, Lent KL, Brenowitz EA.

Gen Comp Endocrinol. 2010 Mar 1;166(1):66-71. doi: 10.1016/j.ygcen.2009.08.001. Epub 2009 Aug 15.


Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat.

Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI, Okamura H.

J Neuroendocrinol. 2009 Oct;21(10):813-21. doi: 10.1111/j.1365-2826.2009.01909.x. Epub 2009 Aug 12.


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