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Items: 1 to 50 of 130

1.

Beta1-Adrenergic Receptor Regulation Revisited.

Steinberg SF.

Circ Res. 2018 Nov 9;123(11):1199-1201. doi: 10.1161/CIRCRESAHA.118.313884. No abstract available.

PMID:
30571467
2.

Carvedilol Prevents Redox Inactivation of Cardiomyocyte Β1-Adrenergic Receptors.

Park M, Steinberg SF.

JACC Basic Transl Sci. 2018 Aug 28;3(4):521-532. doi: 10.1016/j.jacbts.2018.06.002. eCollection 2018 Aug.

3.

Post-translational modifications at the ATP-positioning G-loop that regulate protein kinase activity.

Steinberg SF.

Pharmacol Res. 2018 Sep;135:181-187. doi: 10.1016/j.phrs.2018.07.009. Epub 2018 Jul 23. Review.

4.

β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes.

Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF.

Sci Rep. 2017 Aug 11;7(1):7890. doi: 10.1038/s41598-017-06607-z.

5.

Cleavage Alters the Molecular Determinants of Protein Kinase C-δ Catalytic Activity.

Gong J, Park M, Steinberg SF.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00324-17. doi: 10.1128/MCB.00324-17. Print 2017 Oct 15.

6.

Phos-tag SDS-PAGE resolves agonist- and isoform-specific activation patterns for PKD2 and PKD3 in cardiomyocytes and cardiac fibroblasts.

Qiu W, Steinberg SF.

J Mol Cell Cardiol. 2016 Oct;99:14-22. doi: 10.1016/j.yjmcc.2016.08.005. Epub 2016 Aug 8.

7.

Protein kinase C mechanisms that contribute to cardiac remodelling.

Newton AC, Antal CE, Steinberg SF.

Clin Sci (Lond). 2016 Sep 1;130(17):1499-510. doi: 10.1042/CS20160036. Review.

8.

A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ.

Gong J, Holewinski RJ, Van Eyk JE, Steinberg SF.

Biochem J. 2016 Feb 1;473(3):311-20. doi: 10.1042/BJ20150812. Epub 2015 Nov 6.

9.

Mechanisms for redox-regulation of protein kinase C.

Steinberg SF.

Front Pharmacol. 2015 Jun 23;6:128. doi: 10.3389/fphar.2015.00128. eCollection 2015. Review.

10.

The C2 Domain and Altered ATP-Binding Loop Phosphorylation at Ser³⁵⁹ Mediate the Redox-Dependent Increase in Protein Kinase C-δ Activity.

Gong J, Yao Y, Zhang P, Udayasuryan B, Komissarova EV, Chen J, Sivaramakrishnan S, Van Eyk JE, Steinberg SF.

Mol Cell Biol. 2015 May;35(10):1727-40. doi: 10.1128/MCB.01436-14. Epub 2015 Mar 9.

11.

The protein kinase D1 COOH terminus: marker or regulator of enzyme activity?

Qiu W, Zhang F, Steinberg SF.

Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C606-10. doi: 10.1152/ajpcell.00155.2014. Epub 2014 Jul 30.

12.

S49G and R389G polymorphisms of the β₁-adrenergic receptor influence signaling via the cAMP-PKA and ERK pathways.

Zhang F, Steinberg SF.

Physiol Genomics. 2013 Dec 1;45(23):1186-92. doi: 10.1152/physiolgenomics.00087.2013. Epub 2013 Oct 22.

13.

Oxidative stress and sarcomeric proteins.

Steinberg SF.

Circ Res. 2013 Jan 18;112(2):393-405. doi: 10.1161/CIRCRESAHA.111.300496. Review.

14.

Cardiac actions of protein kinase C isoforms.

Steinberg SF.

Physiology (Bethesda). 2012 Jun;27(3):130-9. doi: 10.1152/physiol.00009.2012. Review.

15.

Regulatory domain determinants that control PKD1 activity.

Rybin VO, Guo J, Harleton E, Zhang F, Steinberg SF.

J Biol Chem. 2012 Jun 29;287(27):22609-15. doi: 10.1074/jbc.M112.379719. Epub 2012 May 11.

16.

Regulation of protein kinase D1 activity.

Steinberg SF.

Mol Pharmacol. 2012 Mar;81(3):284-91. doi: 10.1124/mol.111.075986. Epub 2011 Dec 21. Review.

17.

Redox signaling and cardiac sarcomeres.

Sumandea MP, Steinberg SF.

J Biol Chem. 2011 Mar 25;286(12):9921-7. doi: 10.1074/jbc.R110.175489. Epub 2011 Jan 21. Review.

18.

Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes.

Guo J, Gertsberg Z, Ozgen N, Sabri A, Steinberg SF.

J Biol Chem. 2011 Feb 25;286(8):6500-9. doi: 10.1074/jbc.M110.208058. Epub 2010 Dec 14.

19.

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.

Drosatos K, Bharadwaj KG, Lymperopoulos A, Ikeda S, Khan R, Hu Y, Agarwal R, Yu S, Jiang H, Steinberg SF, Blaner WS, Koch WJ, Goldberg IJ.

Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E489-99. doi: 10.1152/ajpendo.00569.2010. Epub 2010 Dec 7.

20.

Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes.

Guo J, Cong L, Rybin VO, Gertsberg Z, Steinberg SF.

Am J Physiol Cell Physiol. 2010 Oct;299(4):C770-8. doi: 10.1152/ajpcell.00170.2010. Epub 2010 Aug 4.

21.

Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation.

Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD, Kieffer TJ, Abrahani A, Rodrigues B.

Diabetes. 2009 Nov;58(11):2464-75. doi: 10.2337/db09-0681.

22.

Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation.

Ozgen N, Guo J, Gertsberg Z, Danilo P Jr, Rosen MR, Steinberg SF.

Mol Pharmacol. 2009 Oct;76(4):896-902. doi: 10.1124/mol.109.056473. Epub 2009 Jul 20.

23.

Raf-1: a novel cardiac troponin T kinase.

Pfleiderer P, Sumandea MP, Rybin VO, Wang C, Steinberg SF.

J Muscle Res Cell Motil. 2009;30(1-2):67-72. doi: 10.1007/s10974-009-9176-y. Epub 2009 Apr 21.

24.

Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295.

Rybin VO, Guo J, Harleton E, Feinmark SJ, Steinberg SF.

Biochemistry. 2009 Jun 2;48(21):4642-51. doi: 10.1021/bi802171c.

25.

p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.

Guo J, Gertsberg Z, Ozgen N, Steinberg SF.

Circ Res. 2009 Mar 13;104(5):660-9. doi: 10.1161/CIRCRESAHA.108.186288. Epub 2009 Jan 22.

26.

Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916.

Rybin VO, Guo J, Steinberg SF.

J Biol Chem. 2009 Jan 23;284(4):2332-43. doi: 10.1074/jbc.M806381200. Epub 2008 Nov 24.

27.

Structural basis of protein kinase C isoform function.

Steinberg SF.

Physiol Rev. 2008 Oct;88(4):1341-78. doi: 10.1152/physrev.00034.2007. Review.

28.

Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin.

Kryukova Y, Rybin VO, Qu J, Steinberg SF, Robinson RB.

Pflugers Arch. 2009 Feb;457(4):821-30. doi: 10.1007/s00424-008-0565-7. Epub 2008 Aug 12.

29.

Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.

Sumandea MP, Rybin VO, Hinken AC, Wang C, Kobayashi T, Harleton E, Sievert G, Balke CW, Feinmark SJ, Solaro RJ, Steinberg SF.

J Biol Chem. 2008 Aug 15;283(33):22680-9. doi: 10.1074/jbc.M802396200. Epub 2008 Jun 12.

30.

Scaffolding proteins in cardiac myocytes.

Chudasama NL, Marx SO, Steinberg SF.

Handb Exp Pharmacol. 2008;(186):301-25. doi: 10.1007/978-3-540-72843-6_13. Review.

PMID:
18491058
31.

Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae.

Rybin VO, Guo J, Gertsberg Z, Feinmark SJ, Steinberg SF.

J Biol Chem. 2008 Jun 27;283(26):17777-88. doi: 10.1074/jbc.M800333200. Epub 2008 Apr 3.

32.

Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart.

Ozgen N, Obreztchikova M, Guo J, Elouardighi H, Dorn GW 2nd, Wilson BA, Steinberg SF.

J Biol Chem. 2008 Jun 20;283(25):17009-19. doi: 10.1074/jbc.M709851200. Epub 2008 Mar 31.

33.

G protein betagamma dimer expression in cardiomyocytes: developmental acquisition of Gbeta3.

Rybin VO, Steinberg SF.

Biochem Biophys Res Commun. 2008 Apr 4;368(2):408-13. doi: 10.1016/j.bbrc.2008.01.100. Epub 2008 Jan 31.

34.

Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis.

Rafiq K, Hanscom M, Valerie K, Steinberg SF, Sabri A.

Circ Res. 2008 Jan 4;102(1):32-41. Epub 2007 Nov 1.

PMID:
17975113
35.

Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes.

Rybin VO, Guo J, Gertsberg Z, Elouardighi H, Steinberg SF.

J Biol Chem. 2007 Aug 10;282(32):23631-8. Epub 2007 Jun 14.

36.

Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes.

Guo J, Sabri A, Elouardighi H, Rybin V, Steinberg SF.

Circ Res. 2006 Dec 8;99(12):1367-75. Epub 2006 Nov 16.

PMID:
17110596
37.

Distinct signaling functions for Shc isoforms in the heart.

Obreztchikova M, Elouardighi H, Ho M, Wilson BA, Gertsberg Z, Steinberg SF.

J Biol Chem. 2006 Jul 21;281(29):20197-204. Epub 2006 May 12.

38.

Sustained augmentation of cardiac alpha1A-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes.

Chaulet H, Lin F, Guo J, Owens WA, Michalicek J, Kesteven SH, Guan Z, Prall OW, Mearns BM, Feneley MP, Steinberg SF, Graham RM.

J Mol Cell Cardiol. 2006 Apr;40(4):540-52. Epub 2006 Mar 6.

PMID:
16516910
39.

Immunoblotting PKC-delta: a cautionary note from the bench.

Rybin VO, Steinberg SF.

Am J Physiol Cell Physiol. 2006 Mar;290(3):C750-6. Epub 2005 Oct 19.

40.

Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost.

Steinberg SF, Sussman MA.

Circ Res. 2005 Apr 15;96(7):711-3. No abstract available.

PMID:
15831822
41.

Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms.

Yang L, Liu G, Zakharov SI, Morrow JP, Rybin VO, Steinberg SF, Marx SO.

J Biol Chem. 2005 Jan 7;280(1):207-14. Epub 2004 Oct 27.

42.

Distinctive activation mechanisms and functions for protein kinase Cdelta.

Steinberg SF.

Biochem J. 2004 Dec 15;384(Pt 3):449-59. Review.

43.

The cardiovascular actions of protease-activated receptors.

Steinberg SF.

Mol Pharmacol. 2005 Jan;67(1):2-11. Epub 2004 Sep 15. Review.

PMID:
15371558
44.

Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin.

Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA.

J Biol Chem. 2004 Dec 17;279(51):53516-23. Epub 2004 Aug 22.

45.

beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts.

Steinberg SF.

J Mol Cell Cardiol. 2004 Aug;37(2):407-15. Review.

PMID:
15276011
46.

Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes.

Rybin VO, Guo J, Sabri A, Elouardighi H, Schaefer E, Steinberg SF.

J Biol Chem. 2004 Apr 30;279(18):19350-61. Epub 2004 Feb 17.

47.

Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure.

Sabri A, Steinberg SF.

Mol Cell Biochem. 2003 Sep;251(1-2):97-101. Review.

PMID:
14575310
48.

Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L.

Protas L, Barbuti A, Qu J, Rybin VO, Palmiter RD, Steinberg SF, Robinson RB.

Circ Res. 2003 Nov 14;93(10):972-9. Epub 2003 Oct 2.

PMID:
14525809
49.

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM.

Circulation. 2003 Oct 28;108(17):2147-52. Epub 2003 Sep 8.

PMID:
12963636
50.

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