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Items: 1 to 50 of 160

1.

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, Anagnostopoulos AE, Wang A, Broadfield LA, Ford RJ, Foster RA, Bates J, Sun H, Wang T, Liu H, Ray AS, Saha AK, Greenwood J, Bhat S, Harriman G, Miao W, Rocnik JL, Westlin WF, Muti P, Tsakiridis T, Harwood HJ Jr, Kapeller R, Hoshida Y, Tanabe KK, Steinberg GR, Fuchs BC.

Cell Metab. 2018 Sep 19. pii: S1550-4131(18)30521-7. doi: 10.1016/j.cmet.2018.08.020. [Epub ahead of print]

PMID:
30244972
2.

Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes.

Desjardins EM, Steinberg GR.

Curr Diab Rep. 2018 Aug 17;18(10):80. doi: 10.1007/s11892-018-1049-6. Review.

PMID:
30120579
3.

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23.

PMID:
30038219
4.

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

Lepropre S, Kautbally S, Octave M, Ginion A, Onselaer MB, Steinberg GR, Kemp BE, Hego A, Wéra O, Brouns S, Swieringa F, Giera M, Darley-Usmar VM, Ambroise J, Guigas B, Heemskerk J, Bertrand L, Oury C, Beauloye C, Horman S.

Blood. 2018 Sep 13;132(11):1180-1192. doi: 10.1182/blood-2018-02-831503. Epub 2018 Jul 17.

PMID:
30018077
5.

The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.

Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE.

EMBO Mol Med. 2018 Jul;10(7). pii: e8307. doi: 10.15252/emmm.201708307.

6.

Recent advances in the detection of brown adipose tissue in adult humans: a review.

Ong FJ, Ahmed BA, Oreskovich SM, Blondin DP, Haq T, Konyer NB, Noseworthy MD, Haman F, Carpentier AC, Morrison KM, Steinberg GR.

Clin Sci (Lond). 2018 May 25;132(10):1039-1054. doi: 10.1042/CS20170276. Print 2018 May 31. Review.

PMID:
29802209
7.

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.

Esquejo RM, Salatto CT, Delmore J, Albuquerque B, Reyes A, Shi Y, Moccia R, Cokorinos E, Peloquin M, Monetti M, Barricklow J, Bollinger E, Smith BK, Day EA, Nguyen C, Geoghegan KF, Kreeger JM, Opsahl A, Ward J, Kalgutkar AS, Tess D, Butler L, Shirai N, Osborne TF, Steinberg GR, Birnbaum MJ, Cameron KO, Miller RA.

EBioMedicine. 2018 May;31:122-132. doi: 10.1016/j.ebiom.2018.04.009. Epub 2018 Apr 8.

8.

Association of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis.

Tang GH, Satkunam M, Pond GR, Steinberg GR, Blandino G, Schünemann HJ, Muti P.

Cancer Epidemiol Biomarkers Prev. 2018 Jun;27(6):627-635. doi: 10.1158/1055-9965.EPI-17-0936. Epub 2018 Apr 4.

PMID:
29618465
9.

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.

Galic S, Loh K, Murray-Segal L, Steinberg GR, Andrews ZB, Kemp BE.

Elife. 2018 Feb 13;7. pii: e32656. doi: 10.7554/eLife.32656.

10.

The role of AMP-activated protein kinase in the expression of the dystrophin-associated protein complex in skeletal muscle.

Dial AG, Rooprai P, Lally JS, Bujak AL, Steinberg GR, Ljubicic V.

FASEB J. 2018 Jun;32(6):2950-2965. doi: 10.1096/fj.201700868RRR. Epub 2018 Jan 11.

PMID:
29401588
11.
12.

High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women.

Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, Gibala MJ, Ashkar AA.

J Cancer Prev. 2017 Dec;22(4):260-266. doi: 10.15430/JCP.2017.22.4.260. Epub 2017 Dec 30.

13.

Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.

Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE.

Mol Metab. 2017 Nov;6(11):1503-1516. doi: 10.1016/j.molmet.2017.08.012. Epub 2017 Sep 1.

14.

Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults.

McGlory C, von Allmen MT, Stokes T, Morton RW, Hector AJ, Lago BA, Raphenya AR, Smith BK, McArthur AG, Steinberg GR, Baker SK, Phillips SM.

J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1070-1077. doi: 10.1093/gerona/glx203.

PMID:
29095970
15.

Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.

Pinkosky SL, Groot PHE, Lalwani ND, Steinberg GR.

Trends Mol Med. 2017 Nov;23(11):1047-1063. doi: 10.1016/j.molmed.2017.09.001. Epub 2017 Oct 6. Review.

PMID:
28993031
16.

Optimizing the methodology for measuring supraclavicular skin temperature using infrared thermography; implications for measuring brown adipose tissue activity in humans.

Haq T, Crane JD, Kanji S, Gunn E, Tarnopolsky MA, Gerstein HC, Steinberg GR, Morrison KM.

Sci Rep. 2017 Sep 20;7(1):11934. doi: 10.1038/s41598-017-11537-x.

17.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS.

Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y.

18.

Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.

Troncone M, Cargnelli SM, Villani LA, Isfahanian N, Broadfield LA, Zychla L, Wright J, Pond G, Steinberg GR, Tsakiridis T.

Oncotarget. 2017 Apr 27;8(34):57733-57754. doi: 10.18632/oncotarget.17496. eCollection 2017 Aug 22. Review.

19.

Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.

Whitfield J, Paglialunga S, Smith BK, Miotto PM, Simnett G, Robson HL, Jain SS, Herbst EAF, Desjardins EM, Dyck DJ, Spriet LL, Steinberg GR, Holloway GP.

J Biol Chem. 2017 Oct 6;292(40):16653-16664. doi: 10.1074/jbc.M117.806786. Epub 2017 Aug 14.

20.

A short term high-fat high-sucrose diet in mice impairs optic nerve recovery after injury and this is not reversed by exercise.

Chrysostomou V, van Wijngaarden P, Steinberg GR, Crowston JG.

Exp Eye Res. 2017 Sep;162:104-109. doi: 10.1016/j.exer.2017.07.015. Epub 2017 Jul 27.

PMID:
28757158
21.

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.

Pulito C, Mori F, Sacconi A, Goeman F, Ferraiuolo M, Pasanisi P, Campagnoli C, Berrino F, Fanciulli M, Ford RJ, Levrero M, Pediconi N, Ciuffreda L, Milella M, Steinberg GR, Cioce M, Muti P, Strano S, Blandino G.

Cell Discov. 2017 Jul 4;3:17022. doi: 10.1038/celldisc.2017.22. eCollection 2017.

22.

AMPK as a Therapeutic Target for Treating Metabolic Diseases.

Day EA, Ford RJ, Steinberg GR.

Trends Endocrinol Metab. 2017 Aug;28(8):545-560. doi: 10.1016/j.tem.2017.05.004. Epub 2017 Jun 21. Review.

PMID:
28647324
23.

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.

Mottillo EP, Desjardins EM, Fritzen AM, Zou VZ, Crane JD, Yabut JM, Kiens B, Erion DM, Lanba A, Granneman JG, Talukdar S, Steinberg GR.

Mol Metab. 2017 Apr 5;6(6):471-481. doi: 10.1016/j.molmet.2017.04.001. eCollection 2017 Jun.

24.

AMPK β1 reduces tumor progression and improves survival in p53 null mice.

Houde VP, Donzelli S, Sacconi A, Galic S, Hammill JA, Bramson JL, Foster RA, Tsakiridis T, Kemp BE, Grasso G, Blandino G, Muti P, Steinberg GR.

Mol Oncol. 2017 Sep;11(9):1143-1155. doi: 10.1002/1878-0261.12079. Epub 2017 Jun 28.

25.

Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

Ford RJ, Desjardins EM, Steinberg GR.

EBioMedicine. 2017 May;19:16-17. doi: 10.1016/j.ebiom.2017.04.027. Epub 2017 Apr 20. No abstract available.

26.

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

Cavallari JF, Fullerton MD, Duggan BM, Foley KP, Denou E, Smith BK, Desjardins EM, Henriksbo BD, Kim KJ, Tuinema BR, Stearns JC, Prescott D, Rosenstiel P, Coombes BK, Steinberg GR, Schertzer JD.

Cell Metab. 2017 May 2;25(5):1063-1074.e3. doi: 10.1016/j.cmet.2017.03.021. Epub 2017 Apr 20.

27.

Rac1 and AMPK Account for the Majority of Muscle Glucose Uptake Stimulated by Ex Vivo Contraction but Not In Vivo Exercise.

Sylow L, Møller LLV, Kleinert M, D'Hulst G, De Groote E, Schjerling P, Steinberg GR, Jensen TE, Richter EA.

Diabetes. 2017 Jun;66(6):1548-1559. doi: 10.2337/db16-1138. Epub 2017 Apr 7.

28.

AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity.

Smith BK, Steinberg GR.

Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):248-253. doi: 10.1097/MCO.0000000000000380. Review.

PMID:
28375880
29.

Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice.

Gaur V, Connor T, Venardos K, Henstridge DC, Martin SD, Swinton C, Morrison S, Aston-Mourney K, Gehrig SM, van Ewijk R, Lynch GS, Febbraio MA, Steinberg GR, Hargreaves M, Walder KR, McGee SL.

Diabetes Obes Metab. 2017 Jul;19(7):936-943. doi: 10.1111/dom.12896. Epub 2017 Mar 3.

PMID:
28155245
30.

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin.

Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators.

Diabetes Care. 2017 Feb;40(2):280-283. doi: 10.2337/dc16-1682. Epub 2016 Dec 14.

PMID:
27974345
31.

Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.

Miotto PM, Steinberg GR, Holloway GP.

Biochem J. 2017 Feb 15;474(4):557-569. doi: 10.1042/BCJ20160913. Epub 2016 Dec 8.

PMID:
27941154
32.

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.

Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith BK, Filippov S, Groot PH, Steinberg GR, Lalwani ND.

Nat Commun. 2016 Nov 28;7:13457. doi: 10.1038/ncomms13457.

33.

The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration.

Villani LA, Smith BK, Marcinko K, Ford RJ, Broadfield LA, Green AE, Houde VP, Muti P, Tsakiridis T, Steinberg GR.

Mol Metab. 2016 Aug 26;5(10):1048-1056. doi: 10.1016/j.molmet.2016.08.014. eCollection 2016 Oct.

34.

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway.

Chrysostomou V, Galic S, van Wijngaarden P, Trounce IA, Steinberg GR, Crowston JG.

Aging Cell. 2016 Dec;15(6):1082-1091. doi: 10.1111/acel.12512. Epub 2016 Sep 9.

35.

Treatment of nonalcoholic fatty liver disease: role of AMPK.

Smith BK, Marcinko K, Desjardins EM, Lally JS, Ford RJ, Steinberg GR.

Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E730-E740. doi: 10.1152/ajpendo.00225.2016. Epub 2016 Aug 30. Review.

36.

An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice.

Rohm M, Schäfer M, Laurent V, Üstünel BE, Niopek K, Algire C, Hautzinger O, Sijmonsma TP, Zota A, Medrikova D, Pellegata NS, Ryden M, Kulyte A, Dahlman I, Arner P, Petrovic N, Cannon B, Amri EZ, Kemp BE, Steinberg GR, Janovska P, Kopecky J, Wolfrum C, Blüher M, Berriel Diaz M, Herzig S.

Nat Med. 2016 Oct;22(10):1120-1130. doi: 10.1038/nm.4171. Epub 2016 Aug 29.

PMID:
27571348
37.

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1.

Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Mottillo EP, Perry CG, Kemp BE, Tarnopolsky MA, Steinberg GR.

Diabetes. 2016 Nov;65(11):3352-3361. Epub 2016 Aug 23.

38.

Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth.

Lhoták Š, Gyulay G, Cutz JC, Al-Hashimi A, Trigatti BL, Richards CD, Igdoura SA, Steinberg GR, Bramson J, Ask K, Austin RC.

J Am Heart Assoc. 2016 Aug 15;5(8). pii: e003945. doi: 10.1161/JAHA.116.003945.

39.

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

Mottillo EP, Desjardins EM, Crane JD, Smith BK, Green AE, Ducommun S, Henriksen TI, Rebalka IA, Razi A, Sakamoto K, Scheele C, Kemp BE, Hawke TJ, Ortega J, Granneman JG, Steinberg GR.

Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.

40.

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG.

Diabetes. 2016 Sep;65(9):2784-94. doi: 10.2337/db16-0058. Epub 2016 Jul 5.

41.

High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity.

Denou E, Marcinko K, Surette MG, Steinberg GR, Schertzer JD.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E982-93. doi: 10.1152/ajpendo.00537.2015. Epub 2016 Apr 26.

42.

High intensity interval training improves liver and adipose tissue insulin sensitivity.

Marcinko K, Sikkema SR, Samaan MC, Kemp BE, Fullerton MD, Steinberg GR.

Mol Metab. 2015 Oct 9;4(12):903-15. doi: 10.1016/j.molmet.2015.09.006. eCollection 2015 Dec.

43.

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ.

J Clin Invest. 2015 Oct 26;125(12):4334-48. doi: 10.1172/JCI81676.

44.

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.

Marcinko K, Bujak AL, Lally JS, Ford RJ, Wong TH, Smith BK, Kemp BE, Jenkins Y, Li W, Kinsella TM, Hitoshi Y, Steinberg GR.

Mol Metab. 2015 Jun 15;4(9):643-51. doi: 10.1016/j.molmet.2015.06.002. eCollection 2015 Sep.

45.

Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice.

Van Sinderen ML, Steinberg GR, Jørgensen SB, Honeyman J, Chow JD, Herridge KA, Winship AL, Dimitriadis E, Jones ME, Simpson ER, Boon WC.

PLoS One. 2015 Aug 28;10(8):e0136143. doi: 10.1371/journal.pone.0136143. eCollection 2015.

46.

Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise.

O'Neill HM, Lally JS, Galic S, Pulinilkunnil T, Ford RJ, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR.

Physiol Rep. 2015 Jul;3(7). pii: e12444. doi: 10.14814/phy2.12444.

47.

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS.

Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011.

48.

AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.

Bujak AL, Crane JD, Lally JS, Ford RJ, Kang SJ, Rebalka IA, Green AE, Kemp BE, Hawke TJ, Schertzer JD, Steinberg GR.

Cell Metab. 2015 Jun 2;21(6):883-90. doi: 10.1016/j.cmet.2015.05.016.

49.

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.

Sung MM, Zordoky BN, Bujak AL, Lally JS, Fung D, Young ME, Horman S, Miller EJ, Light PE, Kemp BE, Steinberg GR, Dyck JR.

Cardiovasc Res. 2015 Jul 15;107(2):235-45. doi: 10.1093/cvr/cvv166. Epub 2015 May 28.

50.

Leukemia inhibitory factor increases glucose uptake in mouse skeletal muscle.

Brandt N, O'Neill HM, Kleinert M, Schjerling P, Vernet E, Steinberg GR, Richter EA, Jørgensen SB.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E142-53. doi: 10.1152/ajpendo.00313.2014. Epub 2015 May 12.

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