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Items: 1 to 50 of 160

1.

Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ.

Mol Microbiol. 2019 Jul;112(1):62-80. doi: 10.1111/mmi.14254. Epub 2019 Apr 15.

PMID:
30927289
2.

Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).

Spees LP, Martin PL, Kurtzberg J, Stokhuyzen A, McGill L, Prasad VK, Driscoll TA, Parikh SH, Page KM, Vinesett R, Severyn C, Sung AD, Proia AD, Jenkins K, Arshad M, Steinbach WJ, Seed PC, Kelly MS.

Biol Blood Marrow Transplant. 2019 Apr;25(4):756-763. doi: 10.1016/j.bbmt.2018.11.018. Epub 2018 Nov 24.

PMID:
30481599
3.

Funding Pediatric Subspecialty Training: Are T32 Grants the Future?

Steinbach WJ, Benjamin DK Jr, Sleasman JW.

J Pediatr. 2018 Nov;202:4-7.e1. doi: 10.1016/j.jpeds.2018.08.035. No abstract available.

PMID:
30360878
4.

Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.

Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ.

Biochem Biophys Res Commun. 2018 Nov 2;505(3):740-746. doi: 10.1016/j.bbrc.2018.09.186. Epub 2018 Oct 4.

PMID:
30292408
5.

A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection.

Danziger-Isakov L, Steinbach WJ, Paulsen G, Munoz FM, Sweet LR, Green M, Michaels MG, Englund JA, Murray A, Halasa N, Dulek DE, Madan RP, Herold BC, Fisher BT.

J Pediatric Infect Dis Soc. 2018 Mar 10. doi: 10.1093/jpids/piy024. [Epub ahead of print]

PMID:
29538674
6.

Special Issue "Aspergillus fumigatus: From Diagnosis to Therapy".

Steinbach WJ.

J Fungi (Basel). 2016 Dec 8;2(4). pii: E31. doi: 10.3390/jof2040031.

7.

Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.

Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ.

J Proteome Res. 2018 Feb 2;17(2):780-793. doi: 10.1021/acs.jproteome.7b00499. Epub 2017 Dec 29.

8.

The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.

Renshaw H, Vargas-Muñiz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ.

J Cell Sci. 2018 Feb 7;131(3). pii: jcs205955. doi: 10.1242/jcs.205955.

9.

A Multicenter Consortium to Define the Epidemiology and Outcomes of Inpatient Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients.

Fisher BT, Danziger-Isakov L, Sweet LR, Munoz FM, Maron G, Tuomanen E, Murray A, Englund JA, Dulek D, Halasa N, Green M, Michaels MG, Madan RP, Herold BC, Steinbach WJ.

J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):275-282. doi: 10.1093/jpids/pix051.

PMID:
29106589
10.

Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ.

FEBS Lett. 2017 Nov;591(22):3730-3744. doi: 10.1002/1873-3468.12886. Epub 2017 Nov 9.

11.

Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children.

Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ.

J Pediatric Infect Dis Soc. 2017 Sep 1;6(suppl_1):S32-S44. doi: 10.1093/jpids/pix054. Review.

12.

Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.

King J, Pana ZD, Lehrnbecher T, Steinbach WJ, Warris A.

J Pediatric Infect Dis Soc. 2017 Sep 1;6(suppl_1):S12-S21. doi: 10.1093/jpids/pix053. Review.

13.

International Collaborative on Contemporary Epidemiology and Diagnosis of Invasive Fungal Disease in Children.

Steinbach WJ, Fisher BT.

J Pediatric Infect Dis Soc. 2017 Sep 1;6(suppl_1):S1-S2. doi: 10.1093/jpids/pix039. No abstract available.

PMID:
28927199
14.

Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization.

Moseley MA, Hughes CJ, Juvvadi PR, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Steinbach WJ, Geromanos SJ, Wildgoose J, Langridge JI, Richardson K, Vissers JPC.

J Proteome Res. 2018 Feb 2;17(2):770-779. doi: 10.1021/acs.jproteome.7b00464. Epub 2017 Dec 29.

PMID:
28901143
15.

Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization.

Moreno-Velásquez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00710-17. doi: 10.1128/AAC.00710-17. Print 2017 Oct.

16.

Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population.

Wong SSW, Rasid O, Laskaris P, Fekkar A, Cavaillon JM, Steinbach WJ, Ibrahim-Granet O.

Virulence. 2017 Nov 17;8(8):1744-1752. doi: 10.1080/21505594.2017.1339007. Epub 2017 Jul 6.

17.

Risk Factors for Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review.

Fisher BT, Robinson PD, Lehrnbecher T, Steinbach WJ, Zaoutis TE, Phillips B, Sung L.

J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):191-198. doi: 10.1093/jpids/pix030. Review.

18.

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update.

Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L.

J Clin Oncol. 2017 Jun 20;35(18):2082-2094. doi: 10.1200/JCO.2016.71.7017. Epub 2017 May 1. Review.

PMID:
28459614
19.

Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus.

Vargas-Muñiz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ.

Biochem Biophys Res Commun. 2017 Apr 1;485(2):221-226. doi: 10.1016/j.bbrc.2017.02.116. Epub 2017 Feb 24.

20.

A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.

Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ.

MBio. 2017 Feb 7;8(1). pii: e02319-16. doi: 10.1128/mBio.02319-16.

21.

Galactomannan, β-D-Glucan, and Polymerase Chain Reaction-Based Assays for the Diagnosis of Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Lehrnbecher T, Robinson PD, Fisher BT, Castagnola E, Groll AH, Steinbach WJ, Zaoutis TE, Negeri ZF, Beyene J, Phillips B, Sung L.

Clin Infect Dis. 2016 Nov 15;63(10):1340-1348. Epub 2016 Aug 27. Review.

22.

Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.

Vargas-Muñiz JM, Juvvadi PR, Steinbach WJ.

Microbiology. 2016 Sep;162(9):1527-1534. doi: 10.1099/mic.0.000359. Epub 2016 Aug 23. Review.

23.

Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.

Patterson TF, Thompson GR 3rd, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE.

Clin Infect Dis. 2016 Aug 15;63(4):433-42. doi: 10.1093/cid/ciw444.

24.

Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus.

Vargas-Muñiz JM, Renshaw H, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Asfaw Y, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2016 Jun 22;7:997. doi: 10.3389/fmicb.2016.00997. eCollection 2016.

25.

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.

Patterson TF, Thompson GR 3rd, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE.

Clin Infect Dis. 2016 Aug 15;63(4):e1-e60. doi: 10.1093/cid/ciw326. Epub 2016 Jun 29.

26.

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Juvvadi PR, Lee SC, Heitman J, Steinbach WJ.

Virulence. 2017 Feb 17;8(2):186-197. doi: 10.1080/21505594.2016.1201250. Epub 2016 Jun 20. Review.

27.

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA.

MBio. 2016 Apr 26;7(2):e00492-16. doi: 10.1128/mBio.00492-16.

28.

Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis.

Renshaw H, Vargas-Muñiz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ.

Infect Immun. 2016 Apr 22;84(5):1556-64. doi: 10.1128/IAI.01190-15. Print 2016 May.

29.

Editorial: Advances in Aspergillus fumigatus Pathobiology.

Lamoth F, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2016 Feb 3;7:43. doi: 10.3389/fmicb.2016.00043. eCollection 2016. No abstract available.

30.

Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.

Juvvadi PR, Pemble CW 4th, Ma Y, Steinbach WJ.

FEBS Lett. 2016 Feb;590(4):501-8. doi: 10.1002/1873-3468.12075. Epub 2016 Feb 15.

31.

Pediatric Invasive Candidiasis: Epidemiology and Diagnosis in Children.

Steinbach WJ.

J Fungi (Basel). 2016 Jan 8;2(1). pii: E5. doi: 10.3390/jof2010005. Review.

32.

Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?

Juvvadi PR, Steinbach WJ.

Pathogens. 2015 Dec 16;4(4):883-93. doi: 10.3390/pathogens4040883. Review.

33.

A Prospective, International Cohort Study of Invasive Mold Infections in Children.

Wattier RL, Dvorak CC, Hoffman JA, Brozovich AA, Bin-Hussain I, Groll AH, Castagnola E, Knapp KM, Zaoutis TE, Gustafsson B, Sung L, Berman D, Halasa NB, Abzug MJ, Velegraki A, Sharma TS, Fisher BT, Steinbach WJ.

J Pediatric Infect Dis Soc. 2015 Dec;4(4):313-22. doi: 10.1093/jpids/piu074. Epub 2014 Jul 16.

34.

Potential Microbiological Effects of Higher Dosing of Echinocandins.

Steinbach WJ, Lamoth F, Juvvadi PR.

Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S669-77. doi: 10.1093/cid/civ725.

PMID:
26567286
35.

Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia.

Fisher BT, Ross RK, Roilides E, Palazzi DL, Abzug MJ, Hoffman JA, Berman DM, Prasad PA, Localio AR, Steinbach WJ, Vogiatzi L, Dutta A, Zaoutis TE.

J Pediatric Infect Dis Soc. 2016 Dec;5(4):458-461. Epub 2015 Apr 29.

PMID:
26407259
36.

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.

Falloon K, Juvvadi PR, Richards AD, Vargas-Muñiz JM, Renshaw H, Steinbach WJ.

PLoS One. 2015 Sep 14;10(9):e0137869. doi: 10.1371/journal.pone.0137869. eCollection 2015.

37.

Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients.

Steinbach WJ.

Pediatr Infect Dis J. 2015 Sep;34(9):1020-2. doi: 10.1097/INF.0000000000000797. Review. No abstract available.

PMID:
26083591
38.

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.

Juvvadi PR, Muñoz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4946-55. doi: 10.1128/AAC.00263-15. Epub 2015 Jun 8.

39.

The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.

Vargas-Muñiz JM, Renshaw H, Richards AD, Lamoth F, Soderblom EJ, Moseley MA, Juvvadi PR, Steinbach WJ.

Fungal Genet Biol. 2015 Aug;81:41-51. doi: 10.1016/j.fgb.2015.05.014. Epub 2015 Jun 5.

40.

Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Steinbach WJ.

Antimicrob Agents Chemother. 2015 Aug;59(8):4727-33. doi: 10.1128/AAC.00946-15. Epub 2015 May 26.

41.

Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus.

Juvvadi PR, Ma Y, Richards AD, Soderblom EJ, Moseley MA, Lamoth F, Steinbach WJ.

Front Microbiol. 2015 Mar 13;6:175. doi: 10.3389/fmicb.2015.00175. eCollection 2015.

42.

Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis.

Lamoth F, Juvvadi PR, Steinbach WJ.

Front Microbiol. 2015 Feb 16;6:96. doi: 10.3389/fmicb.2015.00096. eCollection 2015.

43.

Bronchoalveolar lavage and lung biopsy in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review and meta-analysis.

Chellapandian D, Lehrnbecher T, Phillips B, Fisher BT, Zaoutis TE, Steinbach WJ, Beyene J, Sung L.

J Clin Oncol. 2015 Feb 10;33(5):501-9. doi: 10.1200/JCO.2014.58.0480. Epub 2015 Jan 5. Review.

PMID:
25559816
44.

Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species.

Lamoth F, Alexander BD, Juvvadi PR, Steinbach WJ.

J Antimicrob Chemother. 2015 May;70(5):1408-11. doi: 10.1093/jac/dku549. Epub 2015 Jan 3.

PMID:
25558076
46.

Aspergillus fumigatus and related species.

Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latgé JP, Steinbach WJ.

Cold Spring Harb Perspect Med. 2014 Nov 6;5(2):a019786. doi: 10.1101/cshperspect.a019786. Review.

47.

Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Steinbach WJ.

Crit Rev Microbiol. 2016;42(2):310-21. doi: 10.3109/1040841X.2014.947239. Epub 2014 Sep 22. Review.

PMID:
25243616
48.

Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.

Juvvadi PR, Lamoth F, Steinbach WJ.

Mycopathologia. 2014 Dec;178(5-6):341-8. doi: 10.1007/s11046-014-9794-9. Epub 2014 Aug 15. Review.

49.

Candida speciation, antifungal treatment and adverse events in pediatric invasive candidiasis: results from 441 infections in a prospective, multi-national study.

Palazzi DL, Arrieta A, Castagnola E, Halasa N, Hubbard S, Brozovich AA, Fisher BT, Steinbach WJ.

Pediatr Infect Dis J. 2014 Dec;33(12):1294-6. doi: 10.1097/INF.0000000000000431.

PMID:
24892850
50.

Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ.

Antimicrob Agents Chemother. 2014;58(4):1889-96. doi: 10.1128/AAC.02286-13. Epub 2014 Jan 6.

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