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Items: 9


PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription.

Steinbach N, Hasson D, Mathur D, Stratikopoulos EE, Sachidanandam R, Bernstein E, Parsons RE.

Nucleic Acids Res. 2019 Jun 20;47(11):5573-5586. doi: 10.1093/nar/gkz272.


p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes.

Pappas K, Xu J, Zairis S, Resnick-Silverman L, Abate F, Steinbach N, Ozturk S, Saal LH, Su T, Cheung P, Schmidt H, Aaronson S, Hibshoosh H, Manfredi J, Rabadan R, Parsons R.

Mol Cancer Res. 2017 Aug;15(8):1051-1062. doi: 10.1158/1541-7786.MCR-17-0089. Epub 2017 May 8.


PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.

Mathur D, Stratikopoulos E, Ozturk S, Steinbach N, Pegno S, Schoenfeld S, Yong R, Murty VV, Asara JM, Cantley LC, Parsons R.

Cancer Discov. 2017 Apr;7(4):380-390. doi: 10.1158/2159-8290.CD-16-0612. Epub 2017 Mar 2.


PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.

Mense SM, Barrows D, Hodakoski C, Steinbach N, Schoenfeld D, Su W, Hopkins BD, Su T, Fine B, Hibshoosh H, Parsons R.

Sci Signal. 2015 Mar 31;8(370):ra32. doi: 10.1126/scisignal.2005840.


A secreted PTEN phosphatase that enters cells to alter signaling and survival.

Hopkins BD, Fine B, Steinbach N, Dendy M, Rapp Z, Shaw J, Pappas K, Yu JS, Hodakoski C, Mense S, Klein J, Pegno S, Sulis ML, Goldstein H, Amendolara B, Lei L, Maurer M, Bruce J, Canoll P, Hibshoosh H, Parsons R.

Science. 2013 Jul 26;341(6144):399-402. doi: 10.1126/science.1234907. Epub 2013 Jun 6.


A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor.

Pellegrino M, Steinbach N, Stensmyr MC, Hansson BS, Vosshall LB.

Nature. 2011 Sep 21;478(7370):511-4. doi: 10.1038/nature10438.


Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice.

Outtz HH, Tattersall IW, Kofler NM, Steinbach N, Kitajewski J.

Blood. 2011 Sep 22;118(12):3436-9. doi: 10.1182/blood-2010-12-327015. Epub 2011 Jul 27.


Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites.

Kirchheiner J, Störmer E, Meisel C, Steinbach N, Roots I, Brockmöller J.

Pharmacogenetics. 2003 Aug;13(8):473-80.


Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans.

Kirchheiner J, Meineke I, Steinbach N, Meisel C, Roots I, Brockmöller J.

Br J Clin Pharmacol. 2003 Jan;55(1):51-61.

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