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Items: 5

1.

The Ewing family of tumors rely on BCL-2 and BCL-XL to escape PARP inhibitor toxicity.

Heisey DAR, Lochmann TL, Floros KV, Coon CM, Powell KM, Jacob S, Calbert ML, Ghotra MS, Stein GT, Kato Maves Y, Smith SC, Benes CH, Leverson JD, Souers AJ, Boikos SA, Faber AC.

Clin Cancer Res. 2018 Oct 22. pii: clincanres.0277.2018. doi: 10.1158/1078-0432.CCR-18-0277. [Epub ahead of print]

PMID:
30348635
2.

KRAS G12C NSCLC models are sensitive to direct targeting of KRAS in combination with PI3K inhibition.

Misale S, Fatherree JP, Cortez E, Li C, Bilton SJ, Timonina D, Lee D, Gomez-Caraballo M, Greenberg M, Nangia V, Greninger P, Egan RK, McClanaghan JD, Stein GT, Murchie E, Zarrinkar PP, Janes MR, Li LS, Liu Y, Hata AN, Benes CH.

Clin Cancer Res. 2018 Oct 16. pii: clincanres.0368.2018. doi: 10.1158/1078-0432.CCR-18-0368. [Epub ahead of print]

PMID:
30327306
3.

Potent and selective effect of the mir-10b inhibitor MN-anti-mir10b in human cancer cells of diverse primary disease origin.

Yoo B, Greninger P, Stein GT, Egan RK, McClanaghan J, Moore A, Benes CH, Medarova Z.

PLoS One. 2018 Jul 20;13(7):e0201046. doi: 10.1371/journal.pone.0201046. eCollection 2018.

4.

Differential Effector Engagement by Oncogenic KRAS.

Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Strathern LA, Powell K, Smith B, Waters AM, Drubin D, Thomson T, Liao R, Greninger P, Stein GT, Murchie E, Cortez E, Egan RK, Procter L, Bess M, Cheng KT, Lee CS, Lee LC, Fellmann C, Stephens R, Luo J, Lowe SW, Benes CH, McCormick F.

Cell Rep. 2018 Feb 13;22(7):1889-1902. doi: 10.1016/j.celrep.2018.01.051.

5.

Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Lochmann TL, Floros KV, Naseri M, Powell KM, Cook W, March RJ, Stein GT, Greninger P, Maves YK, Saunders LR, Dylla SJ, Costa C, Boikos SA, Leverson JD, Souers AJ, Krystal GW, Harada H, Benes CH, Faber AC.

Clin Cancer Res. 2018 Jan 15;24(2):360-369. doi: 10.1158/1078-0432.CCR-17-1606. Epub 2017 Nov 8.

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