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TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung.

Bhattacharyya S, Wang W, Qin W, Cheng K, Coulup S, Chavez S, Jiang S, Raparia K, De Almeida LMV, Stehlik C, Tamaki Z, Yin H, Varga J.

JCI Insight. 2018 Jul 12;3(13). pii: 98850. doi: 10.1172/jci.insight.98850.


Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.

Viaud M, Ivanov S, Vujic N, Duta-Mare M, Aira LE, Barouillet T, Garcia E, Orange F, Dugail I, Hainault I, Stehlik C, Marchetti S, Boyer L, Guinamard R, Foufelle F, Bochem A, Hovingh KG, Thorp EB, Gautier EL, Kratky D, Dasilva-Jardine P, Yvan-Charvet L.

Circ Res. 2018 May 11;122(10):1369-1384. doi: 10.1161/CIRCRESAHA.117.312333. Epub 2018 Mar 9.


The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C.

Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3.


Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H.

J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7.


COPs and POPs Patrol Inflammasome Activation.

Indramohan M, Stehlik C, Dorfleutner A.

J Mol Biol. 2018 Jan 19;430(2):153-173. doi: 10.1016/j.jmb.2017.10.004. Epub 2017 Oct 10. Review.


In vivo Analysis of Neutrophil Infiltration during LPS-induced Peritonitis.

de Almeida L, Dorfleutner A, Stehlik C.

Bio Protoc. 2016 Oct 5;6(19). pii: e1945. doi: 10.21769/BioProtoc.1945.


The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C.

Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556.


ASC-particle-induced Peritonitis.

de Almeida L, Dorfleutner A, Stehlik C.

Bio Protoc. 2016 Oct 5;6(19). pii: e1944. doi: 10.21769/BioProtoc.1944.


SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.

Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM.

Autophagy. 2017 Feb;13(2):285-301. doi: 10.1080/15548627.2016.1261238. Epub 2016 Dec 8.


The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C.

Cell Mol Immunol. 2017 Jan;14(1):127-142. doi: 10.1038/cmi.2016.35. Epub 2016 Aug 15.


A dRAStic RHOAdblock of Pyrin inflammasome activation.

Dorfleutner A, Stehlik C.

Nat Immunol. 2016 Jul 19;17(8):900-2. doi: 10.1038/ni.3511. No abstract available.


Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking.

Khare S, Radian AD, Dorfleutner A, Stehlik C.

Methods Mol Biol. 2016;1417:131-43. doi: 10.1007/978-1-4939-3566-6_8.


Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H.

Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z.


The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.


ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides.

Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C.

Mol Immunol. 2015 Oct;67(2 Pt B):294-302. doi: 10.1016/j.molimm.2015.06.013. Epub 2015 Jul 2.


Inhibiting the inflammasome: one domain at a time.

Dorfleutner A, Chu L, Stehlik C.

Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review.


Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype.

Queen J, Agarwal S, Dolores JS, Stehlik C, Satchell KJ.

Infect Immun. 2015 Jun;83(6):2496-506. doi: 10.1128/IAI.02461-14. Epub 2015 Apr 6.


T-cell exhaustion in allograft rejection and tolerance.

Thorp EB, Stehlik C, Ansari MJ.

Curr Opin Organ Transplant. 2015 Feb;20(1):37-42. doi: 10.1097/MOT.0000000000000153. Review.


An updated view on the structure and function of PYRIN domains.

Chu LH, Gangopadhyay A, Dorfleutner A, Stehlik C.

Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1.


Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H.

J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7.


S-nitrosylation of FLICE inhibitory protein determines its interaction with RIP1 and activation of NF-κB.

Talbott SJ, Luanpitpong S, Stehlik C, Azad N, Iyer AK, Wang L, Rojanasakul Y.

Cell Cycle. 2014;13(12):1948-57. doi: 10.4161/cc.28898. Epub 2014 Apr 24.


The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.

Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.


An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology.

Ratsimandresy RA, Dorfleutner A, Stehlik C.

Front Immunol. 2013 Dec 9;4:440. doi: 10.3389/fimmu.2013.00440. Review.


NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.

Radian AD, de Almeida L, Dorfleutner A, Stehlik C.

Microbes Infect. 2013 Jul-Aug;15(8-9):630-9. doi: 10.1016/j.micinf.2013.04.001. Epub 2013 Apr 22. Review.


Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells.

Luanpitpong S, Chanvorachote P, Stehlik C, Tse W, Callery PS, Wang L, Rojanasakul Y.

Mol Biol Cell. 2013 Mar;24(6):858-69. doi: 10.1091/mbc.E12-10-0747. Epub 2013 Jan 30.


Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis.

Huang QQ, Koessler RE, Birkett R, Dorfleutner A, Perlman H, Haines GK 3rd, Stehlik C, Nicchitta CV, Pope RM.

Arthritis Rheum. 2012 Nov;64(11):3638-48. doi: 10.1002/art.34610.


SNAPIN: an endogenous Toll-like receptor ligand in rheumatoid arthritis.

Shi B, Huang Q, Tak PP, Vervoordeldonk MJ, Huang CC, Dorfleutner A, Stehlik C, Pope RM.

Ann Rheum Dis. 2012 Aug;71(8):1411-7. doi: 10.1136/annrheumdis-2011-200899. Epub 2012 Apr 20.


Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination.

Luanpitpong S, Chanvorachote P, Nimmannit U, Leonard SS, Stehlik C, Wang L, Rojanasakul Y.

Biochem Pharmacol. 2012 Jun 15;83(12):1643-54. doi: 10.1016/j.bcp.2012.03.010. Epub 2012 Mar 24.


An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages.

Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C.

Immunity. 2012 Mar 23;36(3):464-76. doi: 10.1016/j.immuni.2012.02.001. Epub 2012 Feb 21.


An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome.

Kung VL, Khare S, Stehlik C, Bacon EM, Hughes AJ, Hauser AR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1275-80. doi: 10.1073/pnas.1109285109. Epub 2012 Jan 9.


Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner.

Iyer AK, Azad N, Talbot S, Stehlik C, Lu B, Wang L, Rojanasakul Y.

J Immunol. 2011 Sep 15;187(6):3256-66. doi: 10.4049/jimmunol.1002915. Epub 2011 Aug 19.


Inflammasomes and their activation.

Khare S, Luc N, Dorfleutner A, Stehlik C.

Crit Rev Immunol. 2010;30(5):463-87. Review.


Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation.

Azad N, Iyer A, Vallyathan V, Wang L, Castranova V, Stehlik C, Rojanasakul Y.

Ann N Y Acad Sci. 2010 Aug;1203:1-6. doi: 10.1111/j.1749-6632.2010.05608.x. Review.


Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes.

Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C.

J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23.


Multiple interleukin-1beta-converting enzymes contribute to inflammatory arthritis.

Stehlik C.

Arthritis Rheum. 2009 Dec;60(12):3524-30. doi: 10.1002/art.24961. No abstract available.


Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain.

Bryan NB, Dorfleutner A, Rojanasakul Y, Stehlik C.

J Immunol. 2009 Mar 1;182(5):3173-82. doi: 10.4049/jimmunol.0802367.


Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.

Dorfleutner A, Cho Y, Vincent D, Cunnick J, Lin H, Weed SA, Stehlik C, Flynn DC.

J Cell Sci. 2008 Jul 15;121(Pt 14):2394-405. doi: 10.1242/jcs.026187. Epub 2008 Jun 24.


COPs and POPs: modulators of inflammasome activity.

Stehlik C, Dorfleutner A.

J Immunol. 2007 Dec 15;179(12):7993-8. Review.


Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells.

Wang L, Chanvorachote P, Toledo D, Stehlik C, Mercer RR, Castranova V, Rojanasakul Y.

Mol Pharmacol. 2008 Jan;73(1):119-27. Epub 2007 Oct 2.


A Shope Fibroma virus PYRIN-only protein modulates the host immune response.

Dorfleutner A, Talbott SJ, Bryan NB, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C.

Virus Genes. 2007 Dec;35(3):685-94. Epub 2007 Aug 4.


The PYRIN domain in signal transduction.

Stehlik C.

Curr Protein Pept Sci. 2007 Jun;8(3):293-310. Review.


AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.

Dorfleutner A, Stehlik C, Zhang J, Gallick GE, Flynn DC.

J Cell Physiol. 2007 Dec;213(3):740-9.


Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.

Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C.

Infect Immun. 2007 Mar;75(3):1484-92. Epub 2006 Dec 18.


S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis.

Azad N, Vallyathan V, Wang L, Tantishaiyakul V, Stehlik C, Leonard SS, Rojanasakul Y.

J Biol Chem. 2006 Nov 10;281(45):34124-34. Epub 2006 Sep 15.


Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination.

Chanvorachote P, Nimmannit U, Stehlik C, Wang L, Jiang BH, Ongpipatanakul B, Rojanasakul Y.

Cancer Res. 2006 Jun 15;66(12):6353-60.


Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells.

Lu B, Wang L, Stehlik C, Medan D, Huang C, Hu S, Chen F, Shi X, Rojanasakul Y.

J Immunol. 2006 Jun 1;176(11):6785-93.


Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of FLICE inhibitory protein.

Chanvorachote P, Nimmannit U, Wang L, Stehlik C, Lu B, Azad N, Rojanasakul Y.

J Biol Chem. 2005 Dec 23;280(51):42044-50. Epub 2005 Oct 24.


PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

Bruey JM, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed JC.

J Biol Chem. 2004 Dec 10;279(50):51897-907. Epub 2004 Sep 28.


Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages.

Medan D, Wang L, Toledo D, Lu B, Stehlik C, Jiang BH, Shi X, Rojanasakul Y.

J Cell Physiol. 2005 Apr;203(1):78-84.


The PYRIN connection: novel players in innate immunity and inflammation.

Stehlik C, Reed JC.

J Exp Med. 2004 Sep 6;200(5):551-8.

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