Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 63

1.

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.

Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten CCFMJ.

Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019.

2.

Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics.

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG.

Haematologica. 2019 Jun 27. pii: haematol.2018.202010. doi: 10.3324/haematol.2018.202010. [Epub ahead of print]

3.

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice.

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G.

Int J Mol Sci. 2019 Apr 24;20(8). pii: E2019. doi: 10.3390/ijms20082019.

4.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.

PMID:
30936549
5.

Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells.

Mekala SR, Wörsdörfer P, Bauer J, Stoll O, Wagner N, Reeh L, Loew K, Eckner G, Kwok CK, Wischmeyer E, Dickinson ME, Schulze H, Stegner D, Benndorf RA, Edenhofer F, Pfeiffer V, Kuerten S, Frantz S, Ergün S.

Circ Res. 2018 Aug 31;123(6):686-699. doi: 10.1161/CIRCRESAHA.117.312526.

PMID:
30355234
6.

Optical Clearing of Murine Bones to Study Megakaryocytes in Intact Bone Marrow Using Light-Sheet Fluorescence Microscopy.

Gorelashvili MG, Heinze KG, Stegner D.

Methods Mol Biol. 2018;1812:233-253. doi: 10.1007/978-1-4939-8585-2_14.

PMID:
30171582
7.

Imaging platelet biogenesis in vivo.

Schulze H, Stegner D.

Res Pract Thromb Haemost. 2018 Jun 10;2(3):461-468. doi: 10.1002/rth2.12112. eCollection 2018 Jul. Review.

8.

ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M.

Blood. 2018 Aug 9;132(6):635-646. doi: 10.1182/blood-2018-01-829259. Epub 2018 Jun 27.

9.

CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis.

Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O.

Blood. 2017 Dec 21;130(25):2774-2785. doi: 10.1182/blood-2017-05-784413. Epub 2017 Sep 19.

10.

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.

Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T.

J Immunol. 2017 Oct 15;199(8):2948-2957. doi: 10.4049/jimmunol.1700556. Epub 2017 Sep 8.

11.

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B.

Blood. 2017 Nov 16;130(20):2224-2228. doi: 10.1182/blood-2017-03-771907. Epub 2017 Aug 23.

12.

Thrombopoiesis is spatially regulated by the bone marrow vasculature.

Stegner D, vanEeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG.

Nat Commun. 2017 Jul 25;8(1):127. doi: 10.1038/s41467-017-00201-7.

13.

Protein kinase Cι/λ is dispensable for platelet function in thrombosis and hemostasis in mice.

Beck S, Leitges M, Stegner D.

Cell Signal. 2017 Oct;38:223-229. doi: 10.1016/j.cellsig.2017.07.015. Epub 2017 Jul 21.

PMID:
28739484
14.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

15.

Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice.

Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G, Nieswandt B.

Blood. 2017 Mar 23;129(12):1702-1706. doi: 10.1182/blood-2016-12-750711. Epub 2017 Jan 11.

16.

GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.

Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K.

J Invest Dermatol. 2017 Mar;137(3):686-695. doi: 10.1016/j.jid.2016.09.036. Epub 2016 Nov 3.

17.

Congenital valvular defects associated with deleterious mutations in the PLD1 gene.

Ta-Shma A, Zhang K, Salimova E, Zernecke A, Sieiro-Mosti D, Stegner D, Furtado M, Shaag A, Perles Z, Nieswandt B, Rein AJ, Rosenthal N, Neiman AM, Elpeleg O.

J Med Genet. 2017 Apr;54(4):278-286. doi: 10.1136/jmedgenet-2016-104259. Epub 2016 Oct 31.

PMID:
27799408
18.

Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice.

Vorlova S, Koch M, Manthey HD, Cochain C, Busch M, Chaudhari SM, Stegner D, Yepes M, Lorenz K, Nolte MW, Nieswandt B, Zernecke A.

Thromb Haemost. 2017 Jan 5;117(1):176-187. doi: 10.1160/TH16-06-0466. Epub 2016 Oct 27.

PMID:
27786338
19.

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157. Epub 2016 Sep 15.

PMID:
27634832
20.

Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.

Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bösing H, Eckes B, Nieswandt B, Schulze H.

J Cell Sci. 2016 Sep 15;129(18):3473-84. doi: 10.1242/jcs.187971. Epub 2016 Aug 5.

21.

SePARating thrombosis and hemostasis?

Stegner D.

Thromb Res. 2016 Sep;145:140-2. doi: 10.1016/j.thromres.2016.07.011. Epub 2016 Jul 21. No abstract available.

PMID:
27470324
22.

Model systems for platelet receptor shedding.

Bender M, Stegner D, Nieswandt B.

Platelets. 2017 Jun;28(4):325-332. doi: 10.1080/09537104.2016.1195491. Epub 2016 Jun 23. Review.

PMID:
27337269
23.

Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight.

Trujillo Viera J, El-Merahbi R, Nieswandt B, Stegner D, Sumara G.

PLoS One. 2016 Jun 14;11(6):e0157607. doi: 10.1371/journal.pone.0157607. eCollection 2016.

24.

FcγRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice.

Stegner D, Popp M, Lorenz V, Wax JK, Gessner JE, Nieswandt B.

Blood. 2016 Aug 11;128(6):862-5. doi: 10.1182/blood-2016-05-714378. Epub 2016 Jun 13.

25.

Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction.

Chen W, Spitzl A, Mathes D, Nikolaev VO, Werner F, Weirather J, Špiranec K, Röck K, Fischer JW, Kämmerer U, Stegner D, Baba HA, Hofmann U, Frantz S, Kuhn M.

Circ Res. 2016 Jul 8;119(2):237-48. doi: 10.1161/CIRCRESAHA.115.307196. Epub 2016 May 3.

PMID:
27142162
26.

The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction.

van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1247-53. doi: 10.1161/ATVBAHA.115.306883. Epub 2016 Apr 21.

PMID:
27102960
27.

PLD1 participates in BDNF-induced signalling in cortical neurons.

Ammar MR, Thahouly T, Hanauer A, Stegner D, Nieswandt B, Vitale N.

Sci Rep. 2015 Oct 6;5:14778. doi: 10.1038/srep14778.

28.

Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation.

Sogkas G, Stegner D, Syed SN, Vögtle T, Rau E, Gewecke B, Schmidt RE, Nieswandt B, Gessner JE.

Immun Inflamm Dis. 2015 Sep;3(3):154-70. doi: 10.1002/iid3.56. Epub 2015 May 12.

29.

Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5).

Popp M, Thielmann I, Nieswandt B, Stegner D.

PLoS One. 2015 Jul 14;10(7):e0133429. doi: 10.1371/journal.pone.0133429. eCollection 2015.

30.

Orai1 controls C5a-induced neutrophil recruitment in inflammation.

Sogkas G, Vögtle T, Rau E, Gewecke B, Stegner D, Schmidt RE, Nieswandt B, Gessner JE.

Eur J Immunol. 2015 Jul;45(7):2143-53. doi: 10.1002/eji.201445337. Epub 2015 May 15.

31.

Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.

Lorenz V, Stegner D, Stritt S, Vögtle T, Kiefer F, Witke W, Schymeinsky J, Watson SP, Walzog B, Nieswandt B.

Blood. 2015 Jun 25;125(26):4069-77. doi: 10.1182/blood-2014-11-611905. Epub 2015 Mar 20.

32.

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T.

Oncotarget. 2015 Mar 10;6(7):5354-68.

33.

Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2015 Mar 6;6:6507. doi: 10.1038/ncomms7507. No abstract available.

34.

STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia.

Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R.

Glia. 2015 Apr;63(4):652-63. doi: 10.1002/glia.22775. Epub 2014 Dec 3.

PMID:
25471906
35.

Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration.

Teng S, Stegner D, Chen Q, Hongu T, Hasegawa H, Chen L, Kanaho Y, Nieswandt B, Frohman MA, Huang P.

Mol Biol Cell. 2015 Feb 1;26(3):506-17. doi: 10.1091/mbc.E14-03-0802. Epub 2014 Nov 26.

36.

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746. Erratum in: Nat Commun. 2015;6:6507. Heinze, Katrin [corrected to Heinze, Katrin G].

PMID:
25187265
37.

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation.

Shida Y, Rydz N, Stegner D, Brown C, Mewburn J, Sponagle K, Danisment O, Crawford B, Vidal B, Hegadorn CA, Pruss CM, Nieswandt B, Lillicrap D.

Blood. 2014 Sep 11;124(11):1799-807. doi: 10.1182/blood-2013-09-521484. Epub 2014 Jul 22.

38.

Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway.

Stegner D, Haining EJ, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1615-20. doi: 10.1161/ATVBAHA.114.303408. Epub 2014 Jun 12. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):e18.

PMID:
24925975
39.

Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytes.

Stritt S, Thielmann I, Dütting S, Stegner D, Nieswandt B.

J Thromb Haemost. 2014 Aug;12(8):1364-71. doi: 10.1111/jth.12623. Epub 2014 Jul 5.

40.

Mechanistic explanation for platelet contribution to cancer metastasis.

Stegner D, Dütting S, Nieswandt B.

Thromb Res. 2014 May;133 Suppl 2:S149-57. doi: 10.1016/S0049-3848(14)50025-4. Review.

PMID:
24862136
41.

Impaired brain development and reduced cognitive function in phospholipase D-deficient mice.

Burkhardt U, Stegner D, Hattingen E, Beyer S, Nieswandt B, Klein J.

Neurosci Lett. 2014 Jun 20;572:48-52. doi: 10.1016/j.neulet.2014.04.052. Epub 2014 May 9.

PMID:
24813107
42.

Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis.

Göbel K, Schuhmann MK, Pankratz S, Stegner D, Herrmann AM, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth SG.

Eur J Immunol. 2014 Aug;44(8):2295-305. doi: 10.1002/eji.201344107. Epub 2014 Jun 5.

43.

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation.

Suo J, Linke B, Meyer dos Santos S, Pierre S, Stegner D, Zhang DD, Denis CV, Geisslinger G, Nieswandt B, Scholich K.

J Leukoc Biol. 2014 Jul;96(1):133-42. doi: 10.1189/jlb.3A1213-628R. Epub 2014 Feb 20.

PMID:
24555986
44.

Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets.

Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A.

J Thromb Haemost. 2014 Apr;12(4):528-39. doi: 10.1111/jth.12525.

45.

Phospholipase D1 is involved in α1-adrenergic contraction of murine vascular smooth muscle.

Wegener JW, Loga F, Stegner D, Nieswandt B, Hofmann F.

FASEB J. 2014 Mar;28(3):1044-8. doi: 10.1096/fj.13-237925. Epub 2013 Nov 19.

PMID:
24253251
46.

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.

Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG.

Nat Med. 2013 Sep;19(9):1161-5. doi: 10.1038/nm.3303. Epub 2013 Aug 11.

PMID:
23933981
47.

Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.

Stegner D, Thielmann I, Kraft P, Frohman MA, Stoll G, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2212-7. doi: 10.1161/ATVBAHA.113.302030. Epub 2013 Jul 18.

PMID:
23868933
48.

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B.

J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

49.

Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke.

Stegner D, Deppermann C, Kraft P, Morowski M, Kleinschnitz C, Stoll G, Nieswandt B.

J Thromb Haemost. 2013 Jul;11(7):1430-3. doi: 10.1111/jth.12293. No abstract available.

50.

The Nbeal2(-/-) mouse as a model for the gray platelet syndrome.

Deppermann C, Nurden P, Nurden AT, Nieswandt B, Stegner D.

Rare Dis. 2013 Sep 26;1:e26561. doi: 10.4161/rdis.26561. eCollection 2013.

Supplemental Content

Loading ...
Support Center