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Items: 50

1.

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.

Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, Nadkarni GN, Steger DJ, Loos RJF, Hu C, Jia W, Soccio RE, Lazar MA.

Cell Stem Cell. 2019 Feb 7;24(2):299-308.e6. doi: 10.1016/j.stem.2018.11.018. Epub 2019 Jan 10.

PMID:
30639037
2.

Shared nucleotide flanks confer transcriptional competency to bZip core motifs.

Cohen DM, Lim HW, Won KJ, Steger DJ.

Nucleic Acids Res. 2018 Sep 19;46(16):8371-8384. doi: 10.1093/nar/gky681.

3.

PPARγ is dispensable for clear cell renal cell carcinoma progression.

Sanchez DJ, Steger DJ, Skuli N, Bansal A, Simon MC.

Mol Metab. 2018 Aug;14:139-149. doi: 10.1016/j.molmet.2018.05.013. Epub 2018 May 21.

4.

Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription.

Kim YH, Marhon SA, Zhang Y, Steger DJ, Won KJ, Lazar MA.

Science. 2018 Mar 16;359(6381):1274-1277. doi: 10.1126/science.aao6891. Epub 2018 Feb 8.

5.

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.

Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA.

Nature. 2017 Jun 22;546(7659):544-548. doi: 10.1038/nature22819. Epub 2017 Jun 14.

6.

Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor.

Cohen DM, Steger DJ.

Trends Endocrinol Metab. 2017 Jul;28(7):531-540. doi: 10.1016/j.tem.2017.04.001. Epub 2017 May 8. Review.

7.

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice.

Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, Damle M, Lim HW, Won KJ, Seale P, Steger DJ, Lazar MA.

J Clin Invest. 2017 Apr 3;127(4):1451-1462. doi: 10.1172/JCI91211. Epub 2017 Feb 27.

8.

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.

Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.

J Biol Chem. 2016 May 13;291(20):10867-75. doi: 10.1074/jbc.M116.719120. Epub 2016 Mar 21.

9.

Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα.

Bauer RC, Sasaki M, Cohen DM, Cui J, Smith MA, Yenilmez BO, Steger DJ, Rader DJ.

J Clin Invest. 2015 Oct 1;125(10):3809-18. doi: 10.1172/JCI77095. Epub 2015 Sep 8.

10.

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo.

Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, Voight BF, Lazar MA.

Cell. 2015 Jul 2;162(1):33-44. doi: 10.1016/j.cell.2015.06.025.

11.

ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis.

Cohen DM, Won KJ, Nguyen N, Lazar MA, Chen CS, Steger DJ.

Elife. 2015 Jun 25;4:e06821. doi: 10.7554/eLife.06821.

12.

GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock.

Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA.

Science. 2015 Jun 26;348(6242):1488-92. doi: 10.1126/science.aab3021. Epub 2015 Jun 4.

13.

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.

Lim HW, Uhlenhaut NH, Rauch A, Weiner J, Hübner S, Hübner N, Won KJ, Lazar MA, Tuckermann J, Steger DJ.

Genome Res. 2015 Jun;25(6):836-44. doi: 10.1101/gr.188581.114. Epub 2015 May 8.

14.

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.

Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P.

Genes Dev. 2015 Feb 1;29(3):298-307. doi: 10.1101/gad.252734.114.

15.

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers.

Step SE, Lim HW, Marinis JM, Prokesch A, Steger DJ, You SH, Won KJ, Lazar MA.

Genes Dev. 2014 May 1;28(9):1018-28. doi: 10.1101/gad.237628.114.

16.

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver.

Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH.

BMC Genomics. 2013 May 17;14:337. doi: 10.1186/1471-2164-14-337.

17.

An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.

Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P.

Mol Cell Biol. 2012 Jun;32(12):2289-99. doi: 10.1128/MCB.06529-11. Epub 2012 Apr 2.

18.

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.

Mullican SE, Gaddis CA, Alenghat T, Nair MG, Giacomin PR, Everett LJ, Feng D, Steger DJ, Schug J, Artis D, Lazar MA.

Genes Dev. 2011 Dec 1;25(23):2480-8. doi: 10.1101/gad.175950.111.

19.

Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.

Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16271-6. doi: 10.1073/pnas.1109409108. Epub 2011 Sep 13.

20.

Adipogenic hotspots: where the action is.

Steger DJ, Lazar MA.

EMBO J. 2011 Apr 20;30(8):1418-9. doi: 10.1038/emboj.2011.80. No abstract available.

21.

Propagation of adipogenic signals through an epigenomic transition state.

Steger DJ, Grant GR, Schupp M, Tomaru T, Lefterova MI, Schug J, Manduchi E, Stoeckert CJ Jr, Lazar MA.

Genes Dev. 2010 May 15;24(10):1035-44. doi: 10.1101/gad.1907110.

22.

Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages.

Lefterova MI, Steger DJ, Zhuo D, Qatanani M, Mullican SE, Tuteja G, Manduchi E, Grant GR, Lazar MA.

Mol Cell Biol. 2010 May;30(9):2078-89. doi: 10.1128/MCB.01651-09. Epub 2010 Feb 22.

23.

Retinol saturase promotes adipogenesis and is downregulated in obesity.

Schupp M, Lefterova MI, Janke J, Leitner K, Cristancho AG, Mullican SE, Qatanani M, Szwergold N, Steger DJ, Curtin JC, Kim RJ, Suh MJ, Albert MR, Engeli S, Gudas LJ, Lazar MA.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1105-10. doi: 10.1073/pnas.0812065106. Epub 2009 Jan 12. Erratum in: Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4571. Suh, Moojin [corrected to Suh, Moo-Jin].

24.

Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.

Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA.

J Biol Chem. 2009 Apr 3;284(14):9458-64. doi: 10.1074/jbc.M809498200. Epub 2009 Jan 9.

25.

Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins.

Tomaru T, Steger DJ, Lefterova MI, Schupp M, Lazar MA.

J Biol Chem. 2009 Mar 6;284(10):6116-25. doi: 10.1074/jbc.M808407200. Epub 2009 Jan 5.

26.

PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.

Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert CJ Jr, Liu XS, Lazar MA.

Genes Dev. 2008 Nov 1;22(21):2941-52. doi: 10.1101/gad.1709008.

27.

Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment.

Phelan CA, Weaver JM, Steger DJ, Joshi S, Maslany JT, Collins JL, Zuercher WJ, Willson TM, Walker M, Jaye M, Lazar MA.

Mol Endocrinol. 2008 Oct;22(10):2241-9. doi: 10.1210/me.2008-0041. Epub 2008 Jul 31.

28.

Chromatin decouples promoter threshold from dynamic range.

Lam FH, Steger DJ, O'Shea EK.

Nature. 2008 May 8;453(7192):246-50. doi: 10.1038/nature06867. Epub 2008 Apr 16.

29.

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR.

Mol Cell Biol. 2008 Apr;28(8):2825-39. doi: 10.1128/MCB.02076-07. Epub 2008 Feb 19.

30.

Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.

Shearer BG, Steger DJ, Way JM, Stanley TB, Lobe DC, Grillot DA, Iannone MA, Lazar MA, Willson TM, Billin AN.

Mol Endocrinol. 2008 Feb;22(2):523-9. Epub 2007 Nov 1.

31.
32.

Regulation of chromatin remodeling by inositol polyphosphates.

Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK.

Science. 2003 Jan 3;299(5603):114-6. Epub 2002 Nov 14.

33.

Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes.

Vignali M, Steger DJ, Neely KE, Workman JL.

EMBO J. 2000 Jun 1;19(11):2629-40.

34.

The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor.

Tran HG, Steger DJ, Iyer VR, Johnson AD.

EMBO J. 2000 May 15;19(10):2323-31.

35.

Analysis of nucleosome disruption by ATP-driven chromatin remodeling complexes.

Owen-Hughes T, Utley RT, Steger DJ, West JM, John S, Côté J, Havas KM, Workman JL.

Methods Mol Biol. 1999;119:319-31. Review. No abstract available.

PMID:
10804522
36.

AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin.

LiCalsi C, Christophe S, Steger DJ, Buescher M, Fischer W, Mellon PL.

Nucleic Acids Res. 2000 Feb 15;28(4):1036-43.

37.

Transcriptional analysis of purified histone acetyltransferase complexes.

Steger DJ, Workman JL.

Methods. 1999 Nov;19(3):410-6. Review.

PMID:
10579936
38.

Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays.

Neely KE, Hassan AH, Wallberg AE, Steger DJ, Cairns BR, Wright AP, Workman JL.

Mol Cell. 1999 Oct;4(4):649-55.

39.

Regulation of transcription by multisubunit complexes that alter nucleosome structure.

Steger DJ, Utley RT, Grant PA, John S, Eberharter A, Côté J, Owen-Hughes T, Ikeda K, Workman JL.

Cold Spring Harb Symp Quant Biol. 1998;63:483-91. Review. No abstract available.

PMID:
10384312
40.

A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila.

Ohba R, Steger DJ, Brownell JE, Mizzen CA, Cook RG, Côté J, Workman JL, Allis CD.

Mol Cell Biol. 1999 Mar;19(3):2061-8.

41.

Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes.

Ikeda K, Steger DJ, Eberharter A, Workman JL.

Mol Cell Biol. 1999 Jan;19(1):855-63.

42.

Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays.

Steger DJ, Eberharter A, John S, Grant PA, Workman JL.

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12924-9.

43.

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.

Utley RT, Ikeda K, Grant PA, Côté J, Steger DJ, Eberharter A, John S, Workman JL.

Nature. 1998 Jul 30;394(6692):498-502.

PMID:
9697775
44.

A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.

Grant PA, Schieltz D, Pray-Grant MG, Steger DJ, Reese JC, Yates JR 3rd, Workman JL.

Cell. 1998 Jul 10;94(1):45-53.

45.

Analysis of transcription factor-mediated remodeling of nucleosomal arrays in a purified system.

Steger DJ, Owen-Hughes T, John S, Workman JL.

Methods. 1997 Jul;12(3):276-85.

PMID:
9237171
46.
47.

Remodeling chromatin structures for transcription: what happens to the histones?

Steger DJ, Workman JL.

Bioessays. 1996 Nov;18(11):875-84. Review.

PMID:
8939065
48.
49.
50.

Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin alpha-subunit genes.

Steger DJ, Altschmied J, Büscher M, Mellon PL.

Mol Endocrinol. 1991 Feb;5(2):243-55.

PMID:
1710031

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