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Items: 1 to 50 of 210

1.

Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function.

Lille-Langøy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksøyr A.

Toxicol Sci. 2018 Oct 29. doi: 10.1093/toxsci/kfy269. [Epub ahead of print]

PMID:
30371853
2.

Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ.

Aquat Toxicol. 2017 Nov;192:105-115. doi: 10.1016/j.aquatox.2017.09.002. Epub 2017 Sep 4.

3.

Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus.

Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees JF, Hahn ME, Stegeman JJ.

Biochim Biophys Acta Proteins Proteom. 2018 Jan;1866(1):155-165. doi: 10.1016/j.bbapap.2017.06.026. Epub 2017 Jul 8.

4.

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo.

Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy A.

Redox Biol. 2017 Oct;13:207-218. doi: 10.1016/j.redox.2017.05.023. Epub 2017 May 30.

5.

The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families.

Parente TE, Moreira DA, Magalhães MGP, de Andrade PCC, Furtado C, Haas BJ, Stegeman JJ, Hahn ME.

Mar Pollut Bull. 2017 Feb 15;115(1-2):352-361. doi: 10.1016/j.marpolbul.2016.12.012. Epub 2017 Jan 4.

6.

Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities.

Tokunaga S, Woodin BR, Stegeman JJ.

Food Chem Toxicol. 2016 Oct;96:160-6. doi: 10.1016/j.fct.2016.07.012. Epub 2016 Jul 15.

PMID:
27427306
7.

Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.

Wincent E, Kubota A, Timme-Laragy A, Jönsson ME, Hahn ME, Stegeman JJ.

Biochem Pharmacol. 2016 Jun 15;110-111:117-29. doi: 10.1016/j.bcp.2016.04.012. Epub 2016 Apr 22.

8.

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.

Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ.

Toxicol Appl Pharmacol. 2016 Apr 1;296:73-84. doi: 10.1016/j.taap.2016.02.001. Epub 2016 Feb 4.

9.

Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution.

Goldstone JV, Sundaramoorthy M, Zhao B, Waterman MR, Stegeman JJ, Lamb DC.

Mol Phylogenet Evol. 2016 Jan;94(Pt B):676-687. doi: 10.1016/j.ympev.2015.09.012. Epub 2015 Oct 3.

10.

Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast.

Stegeman JJ, Behrendt L, Woodin BR, Kubota A, Lemaire B, Pompon D, Goldstone JV, Urban P.

Biochim Biophys Acta. 2015 Nov;1850(11):2340-52. doi: 10.1016/j.bbagen.2015.07.010. Epub 2015 Jul 29.

11.

Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio).

Hahn ME, Timme-Laragy AR, Karchner SI, Stegeman JJ.

Free Radic Biol Med. 2015 Nov;88(Pt B):275-289. doi: 10.1016/j.freeradbiomed.2015.06.022. Epub 2015 Jun 28. Review.

12.

Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.

Wincent E, Stegeman JJ, Jönsson ME.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):163-79. doi: 10.1016/j.taap.2015.02.014. Epub 2015 Feb 21. Erratum in: Toxicol Appl Pharmacol. 2015 Oct 15;288(2):280.

13.

Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.

Lille-Langøy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksøyr A.

Toxicol Appl Pharmacol. 2015 Apr 1;284(1):54-64. doi: 10.1016/j.taap.2015.02.001. Epub 2015 Feb 10.

14.

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor.

Gräns J, Wassmur B, Fernández-Santoscoy M, Zanette J, Woodin BR, Karchner SI, Nacci DE, Champlin D, Jayaraman S, Hahn ME, Stegeman JJ, Celander MC.

Aquat Toxicol. 2015 Feb;159:198-207. doi: 10.1016/j.aquatox.2014.12.010. Epub 2014 Dec 18.

15.

Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA.

Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN.

Aquat Toxicol. 2015 Feb;159:156-66. doi: 10.1016/j.aquatox.2014.12.017. Epub 2014 Dec 19.

16.

Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.

Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ.

Toxicol Sci. 2015 Feb;143(2):398-407. doi: 10.1093/toxsci/kfu240. Epub 2014 Nov 25.

17.

The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney E.

PLoS One. 2014 Nov 17;9(11):e113158. doi: 10.1371/journal.pone.0113158. eCollection 2014.

18.

Elimination of nonspecific bands in non-radioactive electrophoretic mobility shift assays using the digoxigenin system.

Tokunaga S, Stegeman JJ.

Anal Biochem. 2014 Nov 15;465:70-2. doi: 10.1016/j.ab.2014.06.020. Epub 2014 Jul 5.

19.

Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish.

Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A.

Aquat Toxicol. 2014 Sep;154:19-26. doi: 10.1016/j.aquatox.2014.04.025. Epub 2014 May 2.

20.

Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase.

Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ.

Biochim Biophys Acta. 2014 Jun;1840(6):1825-36. doi: 10.1016/j.bbagen.2013.12.009. Epub 2013 Dec 19.

21.

Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio.

Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME.

PLoS One. 2013 Oct 24;8(10):e79574. doi: 10.1371/journal.pone.0079574. eCollection 2013.

22.

Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio).

Bainy AC, Kubota A, Goldstone JV, Lille-Langøy R, Karchner SI, Celander MC, Hahn ME, Goksøyr A, Stegeman JJ.

Aquat Toxicol. 2013 Oct 15;142-143:447-57. doi: 10.1016/j.aquatox.2013.09.014. Epub 2013 Sep 20.

23.

Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo.

Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM.

Free Radic Biol Med. 2013 Dec;65:89-101. doi: 10.1016/j.freeradbiomed.2013.06.011. Epub 2013 Jun 13.

24.

The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers.

Kubota A, Bainy AC, Woodin BR, Goldstone JV, Stegeman JJ.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):172-9. doi: 10.1016/j.taap.2013.05.017. Epub 2013 May 29.

25.

The African coelacanth genome provides insights into tetrapod evolution.

Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SM, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K.

Nature. 2013 Apr 18;496(7445):311-6. doi: 10.1038/nature12027.

26.

The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s.

Nelson DR, Goldstone JV, Stegeman JJ.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 6;368(1612):20120474. doi: 10.1098/rstb.2012.0474. Print 2013 Feb 19.

27.

Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis.

Zanette J, Jenny MJ, Goldstone JV, Parente T, Woodin BR, Bainy AC, Stegeman JJ.

Aquat Toxicol. 2013 Mar 15;128-129:101-12. doi: 10.1016/j.aquatox.2012.11.017. Epub 2012 Nov 29.

28.

Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish.

Jönsson ME, Kubota A, Timme-Laragy AR, Woodin B, Stegeman JJ.

Toxicol Appl Pharmacol. 2012 Dec 1;265(2):166-74. doi: 10.1016/j.taap.2012.09.023. Epub 2012 Oct 2.

29.

Basal and 3-methylcholanthrene-induced expression of cytochrome P450 1A, 1B and 1C genes in the Brazilian guppy, Poecilia vivipara.

Dorrington T, Zanette J, Zacchi FL, Stegeman JJ, Bainy AC.

Aquat Toxicol. 2012 Nov 15;124-125:106-13. doi: 10.1016/j.aquatox.2012.08.006. Epub 2012 Aug 14.

30.

Methodological approaches to cytochrome P450 profiling in embryos.

Goldstone JV, Stegeman JJ.

Methods Mol Biol. 2012;889:265-75. doi: 10.1007/978-1-61779-867-2_16.

31.

EZR1: a novel family of highly expressed retroelements induced by TCDD and regulated by a NF-κB-like factor in embryos of zebrafish (Danio rerio).

Goldstone HM, Tokunaga S, Schlezinger JJ, Goldstone JV, Stegeman JJ.

Zebrafish. 2012 Mar;9(1):15-25. doi: 10.1089/zeb.2011.0722. Epub 2012 Feb 22.

32.

Cytochrome p450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos.

Jönsson ME, Woodin BR, Stegeman JJ, Brunström B.

PLoS One. 2011;6(12):e28257. doi: 10.1371/journal.pone.0028257. Epub 2011 Dec 2.

33.

Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp.

Parente TE, Rebelo MF, da-Silva ML, Woodin BR, Goldstone JV, Bisch PM, Paumgartten FJ, Stegeman JJ.

Gene. 2011 Dec 10;489(2):111-8. doi: 10.1016/j.gene.2011.07.023. Epub 2011 Aug 5.

34.

Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties.

Tarrant AM, Behrendt L, Stegeman JJ, Verslycke T.

Gen Comp Endocrinol. 2011 Sep 1;173(2):346-55. doi: 10.1016/j.ygcen.2011.06.010. Epub 2011 Jun 22.

PMID:
21722641
35.

Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2.

Kubota A, Stegeman JJ, Woodin BR, Iwanaga T, Harano R, Peterson RE, Hiraga T, Teraoka H.

Toxicol Appl Pharmacol. 2011 Jun 15;253(3):244-52. doi: 10.1016/j.taap.2011.03.025. Epub 2011 Apr 12.

36.

Pacific Ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in sperm whale skin biopsies.

Godard-Codding CA, Clark R, Fossi MC, Marsili L, Maltese S, West AG, Valenzuela L, Rowntree V, Polyak I, Cannon JC, Pinkerton K, Rubio-Cisneros N, Mesnick SL, Cox SB, Kerr I, Payne R, Stegeman JJ.

Environ Health Perspect. 2011 Mar;119(3):337-43. doi: 10.1289/ehp.0901809. Epub 2010 Dec 6.

37.

Cytochrome P4501A biomarker indication of the timeline of chronic exposure of Barrow's goldeneyes to residual Exxon Valdez oil.

Esler D, Ballachey BE, Trust KA, Iverson SA, Reed JA, Miles AK, Henderson JD, Woodin BR, Stegeman JJ, McAdie M, Mulcahy DM, Wilson BW.

Mar Pollut Bull. 2011 Mar;62(3):609-14. doi: 10.1016/j.marpolbul.2010.11.015. Epub 2010 Dec 4.

PMID:
21131011
38.

Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression.

Kubota A, Stegeman JJ, Goldstone JV, Nelson DR, Kim EY, Tanabe S, Iwata H.

Comp Biochem Physiol C Toxicol Pharmacol. 2011 Apr;153(3):280-9. doi: 10.1016/j.cbpc.2010.11.006. Epub 2010 Dec 3.

39.

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.

Goldstone JV, McArthur AG, Kubota A, Zanette J, Parente T, Jönsson ME, Nelson DR, Stegeman JJ.

BMC Genomics. 2010 Nov 18;11:643. doi: 10.1186/1471-2164-11-643.

40.

New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development.

Jönsson ME, Berg C, Goldstone JV, Stegeman JJ.

Toxicol Appl Pharmacol. 2011 Jan 15;250(2):170-83. doi: 10.1016/j.taap.2010.10.010. Epub 2010 Oct 18.

41.

Cytochrome P4501A biomarker indication of oil exposure in harlequin ducks up to 20 years after the Exxon Valdez oil spill.

Esler D, Trust KA, Ballachey BE, Iverson SA, Lewis TL, Rizzolo DJ, Mulcahy DM, Miles AK, Woodin BR, Stegeman JJ, Henderson JD, Wilson BW.

Environ Toxicol Chem. 2010 May;29(5):1138-45. doi: 10.1002/etc.129.

PMID:
20821550
42.

Altered gene expression associated with epizootic shell disease in the American lobster, Homarus americanus.

Tarrant AM, Stegeman JJ, Verslycke T.

Fish Shellfish Immunol. 2010 Dec;29(6):1003-9. doi: 10.1016/j.fsi.2010.08.008. Epub 2010 Aug 20.

PMID:
20728539
43.

Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish.

Teraoka H, Ogawa A, Kubota A, Stegeman JJ, Peterson RE, Hiraga T.

Aquat Toxicol. 2010 Aug 15;99(2):241-7. doi: 10.1016/j.aquatox.2010.05.003. Epub 2010 May 7.

44.

Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation.

Behrendt L, Jönsson ME, Goldstone JV, Stegeman JJ.

Aquat Toxicol. 2010 Jun 1;98(1):74-82. doi: 10.1016/j.aquatox.2010.01.008. Epub 2010 Feb 4.

45.

Catalytic and immunochemical detection of hepatic and extrahepatic microsomal cytochrome P450 1A1 (CYP1A1) in white-sided dolphin (Lagenorhynchus acutus).

Wilson JY, Moore MJ, Stegeman JJ.

Aquat Toxicol. 2010 Feb 18;96(3):216-24. doi: 10.1016/j.aquatox.2009.10.021. Epub 2009 Nov 4.

46.

Identification of CYP genes in Mytilus (mussel) and Crassostrea (oyster) species: first approach to the full complement of cytochrome P450 genes in bivalves.

Zanette J, Goldstone JV, Bainy AC, Stegeman JJ.

Mar Environ Res. 2010;69 Suppl:S1-3. doi: 10.1016/j.marenvres.2009.10.013. Epub 2009 Nov 18.

47.

The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish.

Jönsson ME, Franks DG, Woodin BR, Jenny MJ, Garrick RA, Behrendt L, Hahn ME, Stegeman JJ.

Chem Biol Interact. 2009 Oct 30;181(3):447-54. doi: 10.1016/j.cbi.2009.07.003. Epub 2009 Jul 15.

48.

New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126.

Zanette J, Jenny MJ, Goldstone JV, Woodin BR, Watka LA, Bainy AC, Stegeman JJ.

Aquat Toxicol. 2009 Jul 26;93(4):234-43. doi: 10.1016/j.aquatox.2009.05.008. Epub 2009 May 15.

49.

Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Jenny MJ, Karchner SI, Franks DG, Woodin BR, Stegeman JJ, Hahn ME.

Toxicol Sci. 2009 Aug;110(2):426-41. doi: 10.1093/toxsci/kfp116. Epub 2009 Jun 3.

50.

Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD.

Goldstone JV, Jönsson ME, Behrendt L, Woodin BR, Jenny MJ, Nelson DR, Stegeman JJ.

Arch Biochem Biophys. 2009 Feb;482(1-2):7-16. doi: 10.1016/j.abb.2008.12.002. Epub 2008 Dec 10.

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