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Items: 1 to 50 of 89

1.

Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity.

Gnocchi D, Ellis ECS, Johansson H, Eriksson M, Bruscalupi G, Steffensen KR, Parini P.

Mol Cell Endocrinol. 2019 Sep 30;499:110604. doi: 10.1016/j.mce.2019.110604. [Epub ahead of print]

PMID:
31580898
2.

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.

Wouters E, de Wit NM, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA, de Vries HE.

Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. eCollection 2019.

3.

Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors.

Fontana R, Raccosta L, Rovati L, Steffensen KR, Paniccia A, Jakobsson T, Melloni G, Bandiera A, Mangili G, Bergamini A, Maggioni D, Doglioni C, Crocchiolo R, Cella M, Mattioli M, Battaglia C, Colonna M, Russo V.

Oncoimmunology. 2018 Dec 13;8(3):1554967. doi: 10.1080/2162402X.2018.1554967. eCollection 2019.

PMID:
30723587
4.

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.

Becares N, Gage MC, Voisin M, Shrestha E, Martin-Gutierrez L, Liang N, Louie R, Pourcet B, Pello OM, Luong TV, Goñi S, Pichardo-Almarza C, Røberg-Larsen H, Diaz-Zuccarini V, Steffensen KR, O'Brien A, Garabedian MJ, Rombouts K, Treuter E, Pineda-Torra I.

Cell Rep. 2019 Jan 22;26(4):984-995.e6. doi: 10.1016/j.celrep.2018.12.094.

5.

Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice.

Ahmed O, Pramfalk C, Pedrelli M, Olin M, Steffensen KR, Eriksson M, Parini P.

Dig Liver Dis. 2019 Jul;51(7):1016-1022. doi: 10.1016/j.dld.2018.12.007. Epub 2018 Dec 23.

PMID:
30630736
6.

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice.

Smet M, Van Hoecke L, De Beuckelaer A, Vander Beken S, Naessens T, Vergote K, Willart M, Lambrecht BN, Gustafsson JÅ, Steffensen KR, Grooten J.

Immun Inflamm Dis. 2016 Aug 2;4(3):350-61. doi: 10.1002/iid3.118. eCollection 2016 Sep.

7.

The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms.

Pourcet B, Gage MC, León TE, Waddington KE, Pello OM, Steffensen KR, Castrillo A, Valledor AF, Pineda-Torra I.

Sci Rep. 2016 May 6;6:25481. doi: 10.1038/srep25481.

8.

The emerging roles of liver X receptors and their ligands in cancer.

Lin CY, Vedin LL, Steffensen KR.

Expert Opin Ther Targets. 2016;20(1):61-71. doi: 10.1517/14728222.2015.1081169. Epub 2015 Aug 26. Review.

PMID:
26788589
9.

Emerging role of thyroid hormone metabolites.

Gnocchi D, Steffensen KR, Bruscalupi G, Parini P.

Acta Physiol (Oxf). 2016 Jul;217(3):184-216. doi: 10.1111/apha.12648. Epub 2016 Jan 24. Review.

PMID:
26748938
10.

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes.

Cannon MV, Silljé HH, Sijbesma JW, Khan MA, Steffensen KR, van Gilst WH, de Boer RA.

Diabetologia. 2016 Mar;59(3):634-43. doi: 10.1007/s00125-015-3827-x. Epub 2015 Dec 18.

11.

Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling.

Matsushita K, Morello F, Zhang Z, Masuda T, Iwanaga S, Steffensen KR, Gustafsson JÅ, Pratt RE, Dzau VJ.

Lab Invest. 2016 Feb;96(2):230-8. doi: 10.1038/labinvest.2015.141. Epub 2015 Nov 23.

12.

Are Synthetic Compounds that Silence the Liver-X-Receptor the Next Generation of Anti-cancer Drugs?

Steffensen KR.

Cancer Cell. 2015 Jul 13;28(1):3-4. doi: 10.1016/j.ccell.2015.06.013.

13.

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity.

Bindesbøll C, Fan Q, Nørgaard RC, MacPherson L, Ruan HB, Wu J, Pedersen TÅ, Steffensen KR, Yang X, Matthews J, Mandrup S, Nebb HI, Grønning-Wang LM.

J Lipid Res. 2015 Apr;56(4):771-85. doi: 10.1194/jlr.M049130. Epub 2015 Feb 27.

14.

Cholestenoic acids regulate motor neuron survival via liver X receptors.

Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, Honda A, Mizuochi T, Kimura A, Nittono H, De Michele G, Carbone R, Criscuolo C, Yau JL, Seckl JR, Schüle R, Schöls L, Sailer AW, Kuhle J, Fraidakis MJ, Gustafsson JÅ, Steffensen KR, Björkhem I, Ernfors P, Sjövall J, Arenas E, Wang Y.

J Clin Invest. 2014 Nov;124(11):4829-42. doi: 10.1172/JCI68506. Epub 2014 Oct 1.

15.

Liver X receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status.

Ghaddab-Zroud R, Seugnet I, Steffensen KR, Demeneix BA, Clerget-Froidevaux MS.

PLoS One. 2014 Sep 17;9(9):e106983. doi: 10.1371/journal.pone.0106983. eCollection 2014.

16.

Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.

Candelaria NR, Addanki S, Zheng J, Nguyen-Vu T, Karaboga H, Dey P, Gabbi C, Vedin LL, Liu K, Wu W, Jonsson PK, Lin JZ, Su F, Bollu LR, Hodges SE, McElhany AL, Issazadeh MA, Fisher WE, Ittmann MM, Steffensen KR, Gustafsson JÅ, Lin CY.

PLoS One. 2014 Sep 3;9(9):e106289. doi: 10.1371/journal.pone.0106289. eCollection 2014.

17.

The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice.

Jakobsson T, Vedin LL, Hassan T, Venteclef N, Greco D, D'Amato M, Treuter E, Gustafsson JÅ, Steffensen KR.

Mucosal Immunol. 2014 Nov;7(6):1416-28. doi: 10.1038/mi.2014.31. Epub 2014 May 7.

PMID:
24803164
18.

LXR-dependent and -independent effects of oxysterols on immunity and tumor growth.

Traversari C, Sozzani S, Steffensen KR, Russo V.

Eur J Immunol. 2014 Jul;44(7):1896-903. doi: 10.1002/eji.201344292. Epub 2014 May 22. Review.

19.

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

Pedrelli M, Davoodpour P, Degirolamo C, Gomaraschi M, Graham M, Ossoli A, Larsson L, Calabresi L, Gustafsson JÅ, Steffensen KR, Eriksson M, Parini P.

PLoS One. 2014 Apr 2;9(4):e93552. doi: 10.1371/journal.pone.0093552. eCollection 2014.

20.

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis.

Archer A, Laurencikiene J, Ahmed O, Steffensen KR, Parini P, Gustafsson JÅ, Korach-André M.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E494-502. doi: 10.1152/ajpendo.00410.2013. Epub 2013 Dec 24.

21.

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice.

Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J.

Hepatology. 2014 May;59(5):1791-802. doi: 10.1002/hep.26951. Epub 2014 Mar 27.

PMID:
24277692
22.

LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

Kannisto K, Gåfvels M, Jiang ZY, Slätis K, Hu X, Jorns C, Steffensen KR, Eggertsen G.

Lipids. 2014 Jan;49(1):71-83. doi: 10.1007/s11745-013-3853-8. Epub 2013 Oct 27.

PMID:
24163219
23.

The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.

Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V.

J Exp Med. 2013 Aug 26;210(9):1711-28. doi: 10.1084/jem.20130440. Epub 2013 Jul 29.

24.

Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

Nguyen-Vu T, Vedin LL, Liu K, Jonsson P, Lin JZ, Candelaria NR, Candelaria LP, Addanki S, Williams C, Gustafsson JÅ, Steffensen KR, Lin CY.

Breast Cancer Res. 2013 Jun 20;15(3):R51. doi: 10.1186/bcr3443.

25.

Targeting liver X receptors in inflammation.

Steffensen KR, Jakobsson T, Gustafsson JÅ.

Expert Opin Ther Targets. 2013 Aug;17(8):977-90. doi: 10.1517/14728222.2013.806490. Epub 2013 Jun 6. Review.

PMID:
23738533
26.

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ-induced inflammatory responses and LXR-dependent gene expression.

Pascual-García M, Rué L, León T, Julve J, Carbó JM, Matalonga J, Auer H, Celada A, Escolà-Gil JC, Steffensen KR, Pérez-Navarro E, Valledor AF.

J Immunol. 2013 Jun 15;190(12):6520-32. doi: 10.4049/jimmunol.1201393. Epub 2013 May 17.

27.

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.

Theofilopoulos S, Wang Y, Kitambi SS, Sacchetti P, Sousa KM, Bodin K, Kirk J, Saltó C, Gustafsson M, Toledo EM, Karu K, Gustafsson JÅ, Steffensen KR, Ernfors P, Sjövall J, Griffiths WJ, Arenas E.

Nat Chem Biol. 2013 Feb;9(2):126-33. doi: 10.1038/nchembio.1156. Epub 2012 Dec 23.

PMID:
23292650
28.

Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

Bogie JF, Timmermans S, Huynh-Thu VA, Irrthum A, Smeets HJ, Gustafsson JÅ, Steffensen KR, Mulder M, Stinissen P, Hellings N, Hendriks JJ.

PLoS One. 2012;7(9):e44998. doi: 10.1371/journal.pone.0044998. Epub 2012 Sep 12.

29.

Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice.

González-Granillo M, Steffensen KR, Granados O, Torres N, Korach-André M, Ortíz V, Aguilar-Salinas C, Jakobsson T, Díaz-Villaseñor A, Loza-Valdes A, Hernandez-Pando R, Gustafsson JÅ, Tovar AR.

Diabetologia. 2012 Sep;55(9):2469-78. doi: 10.1007/s00125-012-2599-9. Epub 2012 Jun 29.

PMID:
22739758
30.

Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content.

Bentinger M, Tekle M, Dallner G, Brismar K, Gustafsson JÅ, Steffensen KR, Catrina SB.

Mol Membr Biol. 2012 Nov;29(7):299-308. doi: 10.3109/09687688.2012.694484. Epub 2012 Jun 14.

PMID:
22694168
31.

The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.

Vedin LL, Gustafsson JÅ, Steffensen KR.

Mol Carcinog. 2013 Nov;52(11):835-44. doi: 10.1002/mc.21924. Epub 2012 May 18.

PMID:
22610535
32.

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities.

Jakobsson T, Treuter E, Gustafsson JÅ, Steffensen KR.

Trends Pharmacol Sci. 2012 Jul;33(7):394-404. doi: 10.1016/j.tips.2012.03.013. Epub 2012 Apr 27. Review.

PMID:
22541735
33.

LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.

Hu X, Steffensen KR, Jiang ZY, Parini P, Gustafsson JÅ, Gåfvels M, Eggertsen G.

J Intern Med. 2012 Nov;272(5):452-64. doi: 10.1111/j.1365-2796.2012.02529.x. Epub 2012 Mar 26.

34.

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

Pehkonen P, Welter-Stahl L, Diwo J, Ryynänen J, Wienecke-Baldacchino A, Heikkinen S, Treuter E, Steffensen KR, Carlberg C.

BMC Genomics. 2012 Jan 31;13:50. doi: 10.1186/1471-2164-13-50.

35.

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites.

Boergesen M, Pedersen TÅ, Gross B, van Heeringen SJ, Hagenbeek D, Bindesbøll C, Caron S, Lalloyer F, Steffensen KR, Nebb HI, Gustafsson JÅ, Stunnenberg HG, Staels B, Mandrup S.

Mol Cell Biol. 2012 Feb;32(4):852-67. doi: 10.1128/MCB.06175-11. Epub 2011 Dec 12.

36.

Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture.

Wang YY, Ryg U, Dahle MK, Steffensen KR, Thiemermann C, Chaudry IH, Reinholt FP, Collins JL, Nebb HI, Aasen AO, Gustafsson JÅ, Wang JE.

Surg Infect (Larchmt). 2011 Aug;12(4):283-9. doi: 10.1089/sur.2010.066. Epub 2011 Aug 4.

PMID:
21815813
37.

Metabolic nuclear receptor signaling and the inflammatory acute phase response.

Venteclef N, Jakobsson T, Steffensen KR, Treuter E.

Trends Endocrinol Metab. 2011 Aug;22(8):333-43. doi: 10.1016/j.tem.2011.04.004. Epub 2011 Jun 7. Review.

PMID:
21646028
38.

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT.

J Neurosci. 2011 May 11;31(19):7049-59. doi: 10.1523/JNEUROSCI.6546-10.2011.

39.

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice.

Korach-André M, Archer A, Gabbi C, Barros RP, Pedrelli M, Steffensen KR, Pettersson AT, Laurencikiene J, Parini P, Gustafsson JÅ.

Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E210-22. doi: 10.1152/ajpendo.00541.2010. Epub 2011 Apr 26.

40.

Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease.

Bigini P, Steffensen KR, Ferrario A, Diomede L, Ferrara G, Barbera S, Salzano S, Fumagalli E, Ghezzi P, Mennini T, Gustafsson JA.

J Neuropathol Exp Neurol. 2010 Jun;69(6):593-605. doi: 10.1097/NEN.0b013e3181df20e1.

PMID:
20467332
41.

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, Nilsson LM, Parini P, Jänne OA, Gustafsson JA, Steffensen KR, Treuter E.

Genes Dev. 2010 Feb 15;24(4):381-95. doi: 10.1101/gad.545110.

42.

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.

Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V.

Nat Med. 2010 Jan;16(1):98-105. doi: 10.1038/nm.2074. Epub 2009 Dec 27.

PMID:
20037595
43.

ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes.

Hao Q, Hansen JB, Petersen RK, Hallenborg P, Jørgensen C, Cinti S, Larsen PJ, Steffensen KR, Wang H, Collins S, Wang J, Gustafsson JA, Madsen L, Kristiansen K.

Biochim Biophys Acta. 2010 Apr;1801(4):421-9. doi: 10.1016/j.bbalip.2009.11.008. Epub 2009 Dec 2.

PMID:
19962449
44.

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.

Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E.

Cell Stem Cell. 2009 Oct 2;5(4):409-19. doi: 10.1016/j.stem.2009.08.019.

45.

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.

Hellemans KH, Hannaert JC, Denys B, Steffensen KR, Raemdonck C, Martens GA, Van Veldhoven PP, Gustafsson JA, Pipeleers D.

PLoS One. 2009 Sep 29;4(9):e7266. doi: 10.1371/journal.pone.0007266.

46.

Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice.

Korach-André M, Parini P, Larsson L, Arner A, Steffensen KR, Gustafsson JA.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E167-78. doi: 10.1152/ajpendo.00184.2009. Epub 2009 Aug 18.

47.

Activation of liver X receptor regulates substrate oxidation in white adipocytes.

Stenson BM, Rydén M, Steffensen KR, Wåhlén K, Pettersson AT, Jocken JW, Arner P, Laurencikiene J.

Endocrinology. 2009 Sep;150(9):4104-13. doi: 10.1210/en.2009-0676. Epub 2009 Jun 25.

PMID:
19556420
48.

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E.

Mol Cell. 2009 May 14;34(4):510-8. doi: 10.1016/j.molcel.2009.05.006.

49.

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice.

Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K.

J Clin Invest. 2009 Jun;119(6):1626-37. doi: 10.1172/JCI35288. Epub 2009 May 11.

50.

Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages.

Wang YY, Dahle MK, Steffensen KR, Reinholt FP, Collins JL, Thiemermann C, Aasen AO, Gustafsson JA, Wang JE.

Shock. 2009 Nov;32(5):548-53. doi: 10.1097/SHK.0b013e3181a47f85.

PMID:
19295476

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