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Items: 20


XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity.

Horton JK, Stefanick DF, Çağlayan M, Zhao ML, Janoshazi AK, Prasad R, Gassman NR, Wilson SH.

DNA Repair (Amst). 2018 Apr;64:26-33. doi: 10.1016/j.dnarep.2018.02.004. Epub 2018 Feb 15.


DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria.

Prasad R, Çağlayan M, Dai DP, Nadalutti CA, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH.

DNA Repair (Amst). 2017 Dec;60:77-88. doi: 10.1016/j.dnarep.2017.10.011. Epub 2017 Oct 28.


XRCC1-mediated repair of strand breaks independent of PNKP binding.

Horton JK, Stefanick DF, Zhao ML, Janoshazi AK, Gassman NR, Seddon HJ, Wilson SH.

DNA Repair (Amst). 2017 Dec;60:52-63. doi: 10.1016/j.dnarep.2017.10.007. Epub 2017 Oct 19.


Role of the oxidized form of XRCC1 in protection against extreme oxidative stress.

Horton JK, Seddon HJ, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Wilson SH.

Free Radic Biol Med. 2017 Jun;107:292-300. doi: 10.1016/j.freeradbiomed.2017.02.005. Epub 2017 Feb 4.


Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.

Çağlayan M, Horton JK, Dai DP, Stefanick DF, Wilson SH.

Nat Commun. 2017 Jan 9;8:14045. doi: 10.1038/ncomms14045.


Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.

Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH.

PLoS One. 2015 Feb 18;10(2):e0118819. doi: 10.1371/journal.pone.0118819. eCollection 2015.


DNA polymerase β-dependent cell survival independent of XRCC1 expression.

Horton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH.

DNA Repair (Amst). 2015 Feb;26:23-9. doi: 10.1016/j.dnarep.2014.11.008. Epub 2014 Dec 3.


Base excision repair defects invoke hypersensitivity to PARP inhibition.

Horton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH.

Mol Cancer Res. 2014 Aug;12(8):1128-39. doi: 10.1158/1541-7786.MCR-13-0502. Epub 2014 Apr 25.


Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH.

DNA Repair (Amst). 2013 Sep;12(9):774-85. doi: 10.1016/j.dnarep.2013.06.004. Epub 2013 Jul 18.


Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.

Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH.

PLoS One. 2012;7(11):e49301. doi: 10.1371/journal.pone.0049301. Epub 2012 Nov 7.


Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts.

Kedar PS, Stefanick DF, Horton JK, Wilson SH.

Mol Cancer Res. 2012 Mar;10(3):360-8. doi: 10.1158/1541-7786.MCR-11-0477. Epub 2012 Jan 13.


Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.

Horton JK, Stefanick DF, Zeng JY, Carrozza MJ, Wilson SH.

DNA Repair (Amst). 2011 Feb 7;10(2):225-34. doi: 10.1016/j.dnarep.2010.11.003. Epub 2010 Dec 3.


Base excision repair and design of small molecule inhibitors of human DNA polymerase β.

Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA, Prasad R, Hou EW, Liu Y, Asagoshi K, Horton JK, Stefanick DF, Kedar PS, Carrozza MJ, Masaoka A, Heacock ML.

Cell Mol Life Sci. 2010 Nov;67(21):3633-47. doi: 10.1007/s00018-010-0489-1. Epub 2010 Sep 16. Review.


Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.

Heacock ML, Stefanick DF, Horton JK, Wilson SH.

DNA Repair (Amst). 2010 Aug 5;9(8):929-36. doi: 10.1016/j.dnarep.2010.05.007. Epub 2010 Jun 22.


PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.

Carrozza MJ, Stefanick DF, Horton JK, Kedar PS, Wilson SH.

DNA Repair (Amst). 2009 Nov 2;8(11):1264-72. doi: 10.1016/j.dnarep.2009.07.010. Epub 2009 Aug 31.


Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition.

Kedar PS, Stefanick DF, Horton JK, Wilson SH.

DNA Repair (Amst). 2008 Nov 1;7(11):1787-98. doi: 10.1016/j.dnarep.2008.07.006. Epub 2008 Aug 22.


XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.

Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA, Wilson SH.

Cell Res. 2008 Jan;18(1):48-63. doi: 10.1038/cr.2008.7. Review.


ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.

Horton JK, Stefanick DF, Kedar PS, Wilson SH.

DNA Repair (Amst). 2007 Jun 1;6(6):742-50. Epub 2007 Feb 9.


Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.

Horton JK, Stefanick DF, Wilson SH.

DNA Repair (Amst). 2005 Sep 28;4(10):1111-20.


Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.

Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH.

J Biol Chem. 2005 Apr 22;280(16):15773-85. Epub 2005 Feb 7.

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