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Items: 1 to 50 of 61

1.

KinCon: Cell-based recording of full-length kinase conformations.

Enzler F, Tschaikner P, Schneider R, Stefan E.

IUBMB Life. 2020 Feb 6. doi: 10.1002/iub.2241. [Epub ahead of print]

PMID:
32027084
2.

Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium.

Tschaikner P, Enzler F, Torres-Quesada O, Aanstad P, Stefan E.

Cells. 2020 Jan 3;9(1). pii: E118. doi: 10.3390/cells9010118. Review.

3.

RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells.

Ortner NJ, Pinggera A, Hofer NT, Siller A, Brandt N, Raffeiner A, Vilusic K, Lang I, Blum K, Obermair GJ, Stefan E, Engel J, Striessnig J.

Pflugers Arch. 2020 Jan;472(1):3-25. doi: 10.1007/s00424-019-02338-4. Epub 2019 Dec 17.

4.

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E.

Sci Adv. 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463. eCollection 2019 Aug.

5.

Conformation space of a heterodimeric ABC exporter under turnover conditions.

Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, Moeller A.

Nature. 2019 Jul;571(7766):580-583. doi: 10.1038/s41586-019-1391-0. Epub 2019 Jul 17.

PMID:
31316210
6.

Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.

Rinaldi L, Delle Donne R, Catalanotti B, Torres-Quesada O, Enzler F, Moraca F, Nisticò R, Chiuso F, Piccinin S, Bachmann V, Lindner HH, Garbi C, Scorziello A, Russo NA, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A.

Nat Commun. 2019 Jun 12;10(1):2572. doi: 10.1038/s41467-019-10037-y.

7.

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.

Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, Curtin BH, Tseng H, Frombach KR, Butty VL, Levine SS, Feau C, Elmiligy S, Hong JA, Lewis TA, Vetere A, Clemons PA, Malstrom SE, Ebert BL, Lin CY, Felsher DW, Koehler AN.

Cell Chem Biol. 2019 May 16;26(5):711-723.e14. doi: 10.1016/j.chembiol.2019.02.009. Epub 2019 Mar 14.

PMID:
30880155
8.

Association of cytokine gene polymorphisms with osteoarthritis susceptibility.

Rogoveanu OC, Calina D, Cucu MG, Burada F, Docea AO, Sosoi S, Stefan E, Ioana M, Burada E.

Exp Ther Med. 2018 Sep;16(3):2659-2664. doi: 10.3892/etm.2018.6477. Epub 2018 Jul 18.

9.

Counterregulation of cAMP-directed kinase activities controls ciliogenesis.

Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres-Quesada O, Intartaglia D, Garbi C, Insabato L, Santoriello M, Bachmann VA, Synofzik M, Lindner HH, Conte I, Stefan E, Feliciello A.

Nat Commun. 2018 Mar 26;9(1):1224. doi: 10.1038/s41467-018-03643-9.

10.

Targeting the Architecture of Deregulated Protein Complexes in Cancer.

Stefan E, Troppmair J, Bister K.

Adv Protein Chem Struct Biol. 2018;111:101-132. doi: 10.1016/bs.apcsb.2017.07.001. Epub 2017 Aug 18. Review.

PMID:
29459029
11.

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells.

Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS.

J Biol Chem. 2018 Mar 23;293(12):4411-4421. doi: 10.1074/jbc.M117.809988. Epub 2018 Jan 29.

12.

The many faces of compartmentalized PKA signalosomes.

Torres-Quesada O, Mayrhofer JE, Stefan E.

Cell Signal. 2017 Sep;37:1-11. doi: 10.1016/j.cellsig.2017.05.012. Epub 2017 May 18. Review.

13.

MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.

Stefan E, Bister K.

Curr Top Microbiol Immunol. 2017;407:117-151. doi: 10.1007/82_2017_4. Review.

14.

Systematic Quantification of GPCR/cAMP-Controlled Protein Kinase A Interactions.

Torres-Quesada O, Röck R, Stefan E.

Horm Metab Res. 2017 Apr;49(4):240-249. doi: 10.1055/s-0042-110791. Epub 2016 Aug 2.

PMID:
28427097
15.

Calcium-dependent binding of Myc to calmodulin.

Raffeiner P, Schraffl A, Schwarz T, Röck R, Ledolter K, Hartl M, Konrat R, Stefan E, Bister K.

Oncotarget. 2017 Jan 10;8(2):3327-3343. doi: 10.18632/oncotarget.13759.

16.

Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation.

Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor SS.

J Mol Biol. 2016 Dec 4;428(24 Pt B):4890-4904. doi: 10.1016/j.jmb.2016.10.033. Epub 2016 Nov 5.

17.

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.

Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91. doi: 10.1073/pnas.1608061113. Epub 2016 Jun 28.

18.

praja2 regulates KSR1 stability and mitogenic signaling.

Rinaldi L, Delle Donne R, Sepe M, Porpora M, Garbi C, Chiuso F, Gallo A, Parisi S, Russo L, Bachmann V, Huber RG, Stefan E, Russo T, Feliciello A.

Cell Death Dis. 2016 May 19;7:e2230. doi: 10.1038/cddis.2016.109.

19.

Highlights from Faraday Discussion 182: Solid Oxide Electrolysis: Fuels and Feedstocks from Water and Air, York, UK, July 2015.

Stefan E, Norby T.

Chem Commun (Camb). 2016 Jan 31;52(9):1759-67. doi: 10.1039/c6cc90030e.

PMID:
26758816
20.

Corrigendum: Impact of kinase activating and inactivating patient mutations on binary PKA interactions.

Röck R, Mayrhofer JE, Bachmann V, Stefan E.

Front Pharmacol. 2015 Sep 24;6:214. doi: 10.3389/fphar.2015.00214. eCollection 2015.

21.

Impact of kinase activating and inactivating patient mutations on binary PKA interactions.

Röck R, Mayrhofer JE, Bachmann V, Stefan E.

Front Pharmacol. 2015 Aug 18;6:170. doi: 10.3389/fphar.2015.00170. eCollection 2015. Erratum in: Front Pharmacol. 2015;6:214.

22.

Stopping MYC in its tracks.

Stefan E, Hart JR, Bister K.

Aging (Albany NY). 2015 Jul;7(7):463-4. No abstract available.

23.

Total Synthesis and Structural Reassignment of Lyngbyaloside C Highlighted by Intermolecular Ketene Esterification.

Chang CF, Stefan E, Taylor RE.

Chemistry. 2015 Jul 20;21(30):10681-6. doi: 10.1002/chem.201502132. Epub 2015 Jun 23.

24.

In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs.

Röck R, Bachmann V, Bhang HE, Malleshaiah M, Raffeiner P, Mayrhofer JE, Tschaikner PM, Bister K, Aanstad P, Pomper MG, Michnick SW, Stefan E.

Sci Rep. 2015 Jun 23;5:11133. doi: 10.1038/srep11133.

25.

Systematic identification of signal integration by protein kinase A.

Filteau M, Diss G, Torres-Quiroz F, Dubé AK, Schraffl A, Bachmann VA, Gagnon-Arsenault I, Chrétien AÈ, Steunou AL, Dionne U, Côté J, Bisson N, Stefan E, Landry CR.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4501-6. doi: 10.1073/pnas.1409938112. Epub 2015 Mar 23.

26.

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.

Raffeiner P, Röck R, Schraffl A, Hartl M, Hart JR, Janda KD, Vogt PK, Stefan E, Bister K.

Oncotarget. 2014 Oct 15;5(19):8869-78.

27.

Inhibitor of MYC identified in a Kröhnke pyridine library.

Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, Rhee JK, Baksh MM, Stefan E, Hartl M, Bister K, Vogt PK, Janda KD.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61. doi: 10.1073/pnas.1319488111. Epub 2014 Aug 11.

28.

Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.

Bachmann VA, Bister K, Stefan E.

Small GTPases. 2013 Oct-Dec;4(4):247-51. doi: 10.4161/sgtp.27281. Epub 2013 Dec 10. Review.

29.

Concise enantioselective synthesis of diospongins A and B.

Stefan E, Nalin AP, Taylor RE.

Tetrahedron. 2013 Sep 9;69(36):7706-7712.

30.

Reciprocal regulation of PKA and Rac signaling.

Bachmann VA, Riml A, Huber RG, Baillie GS, Liedl KR, Valovka T, Stefan E.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8531-6. doi: 10.1073/pnas.1215902110. Epub 2013 May 8.

31.

Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.

Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L'Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A.

Nat Commun. 2013;4:1822. doi: 10.1038/ncomms2791.

32.

Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling.

Stückemann T, Wegleiter T, Stefan E, Nägele O, Tarbashevich K, Böck G, Raz E, Aanstad P.

Development. 2012 Aug;139(15):2711-20. doi: 10.1242/dev.074930.

33.

Stereoselective synthesis of the C9-C19 fragment of lyngbyaloside B and C via ether transfer.

Stefan E, Taylor RE.

Org Lett. 2012 Jul 6;14(13):3490-3. doi: 10.1021/ol301455p. Epub 2012 Jun 20.

34.

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

Stefan E, Malleshaiah MK, Breton B, Ear PH, Bachmann V, Beyermann M, Bouvier M, Michnick SW.

Nat Commun. 2011 Dec 20;2:598. doi: 10.1038/ncomms1605.

35.

Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs.

Haddach M, Pierre F, Regan CF, Borsan C, Michaux J, Stefan E, Kerdoncuff P, Schwaebe MK, Chua PC, Siddiqui-Jain A, Macalino D, Drygin D, O'Brien SE, Rice WG, Ryckman DM.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):45-8. doi: 10.1016/j.bmcl.2011.11.087. Epub 2011 Nov 30.

PMID:
22169261
36.

Occurrence of selected estrogens in mangrove sediments.

Froehner S, Machado KS, Stefan E, Bleninger T, da Rosa EC, de Castro Martins C.

Mar Pollut Bull. 2012 Jan;64(1):75-79. doi: 10.1016/j.marpolbul.2011.10.021. Epub 2011 Nov 16.

PMID:
22093257
37.

7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.

Pierre F, Stefan E, Nédellec AS, Chevrel MC, Regan CF, Siddiqui-Jain A, Macalino D, Streiner N, Drygin D, Haddach M, O'Brien SE, Anderes K, Ryckman DM.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. doi: 10.1016/j.bmcl.2011.09.059. Epub 2011 Sep 22.

PMID:
21982499
38.

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer.

Pierre F, Chua PC, O'Brien SE, Siddiqui-Jain A, Bourbon P, Haddach M, Michaux J, Nagasawa J, Schwaebe MK, Stefan E, Vialettes A, Whitten JP, Chen TK, Darjania L, Stansfield R, Bliesath J, Drygin D, Ho C, Omori M, Proffitt C, Streiner N, Rice WG, Ryckman DM, Anderes K.

Mol Cell Biochem. 2011 Oct;356(1-2):37-43. doi: 10.1007/s11010-011-0956-5. Epub 2011 Jul 14.

PMID:
21755459
39.

Alterations in expression of cartilage-specific genes for aggrecan and collagen type II in osteoarthritis.

Jalbă BA, Jalbă CS, Vlădoi AD, Gherghina F, Stefan E, Cruce M.

Rom J Morphol Embryol. 2011;52(2):587-91.

40.

Control of PKA stability and signalling by the RING ligase praja2.

Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A.

Nat Cell Biol. 2011 Apr;13(4):412-22. doi: 10.1038/ncb2209. Epub 2011 Mar 20.

PMID:
21423175
41.

Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties.

Pierre F, O'Brien SE, Haddach M, Bourbon P, Schwaebe MK, Stefan E, Darjania L, Stansfield R, Ho C, Siddiqui-Jain A, Streiner N, Rice WG, Anderes K, Ryckman DM.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1687-91. doi: 10.1016/j.bmcl.2011.01.091. Epub 2011 Jan 26.

PMID:
21316963
42.

Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.

Pierre F, Chua PC, O'Brien SE, Siddiqui-Jain A, Bourbon P, Haddach M, Michaux J, Nagasawa J, Schwaebe MK, Stefan E, Vialettes A, Whitten JP, Chen TK, Darjania L, Stansfield R, Anderes K, Bliesath J, Drygin D, Ho C, Omori M, Proffitt C, Streiner N, Trent K, Rice WG, Ryckman DM.

J Med Chem. 2011 Jan 27;54(2):635-54. doi: 10.1021/jm101251q. Epub 2010 Dec 21.

PMID:
21174434
43.

Ultrasound enhanced endocytotic activity of human fibroblasts.

Hauser J, Ellisman M, Steinau HU, Stefan E, Dudda M, Hauser M.

Ultrasound Med Biol. 2009 Dec;35(12):2084-92. doi: 10.1016/j.ultrasmedbio.2009.06.1090. Epub 2009 Oct 13.

PMID:
19828232
44.

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.

Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92. doi: 10.1016/j.bmcl.2009.01.057. Epub 2009 Jan 23.

45.

Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin.

Nyfeler B, Reiterer V, Wendeler MW, Stefan E, Zhang B, Michnick SW, Hauri HP.

J Cell Biol. 2008 Feb 25;180(4):705-12. doi: 10.1083/jcb.200709100. Epub 2008 Feb 18.

46.

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo.

Stefan E, Aquin S, Berger N, Landry CR, Nyfeler B, Bouvier M, Michnick SW.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16916-21. Epub 2007 Oct 17.

47.

Universal strategies in research and drug discovery based on protein-fragment complementation assays.

Michnick SW, Ear PH, Manderson EN, Remy I, Stefan E.

Nat Rev Drug Discov. 2007 Jul;6(7):569-82. Review.

PMID:
17599086
48.

A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.

Nedvetsky PI, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, Hammer JA 3rd, Nielsen S, Goldenring JR, Rosenthal W, Klussmann E.

Traffic. 2007 Feb;8(2):110-23. Epub 2006 Dec 6.

49.

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.

Stefan E, Wiesner B, Baillie GS, Mollajew R, Henn V, Lorenz D, Furkert J, Santamaria K, Nedvetsky P, Hundsrucker C, Beyermann M, Krause E, Pohl P, Gall I, MacIntyre AN, Bachmann S, Houslay MD, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2007 Jan;18(1):199-212. Epub 2006 Nov 29.

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