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Precision medicine, agriculture, and genome editing: science and ethics.

Moscoso CG, Potz KR, Tan S, Jacobson PA, Berger KM, Steer CJ.

Ann N Y Acad Sci. 2019 Nov 13. doi: 10.1111/nyas.14266. [Epub ahead of print]


"Let my liver rather heat with wine" - a review of hepatic fibrosis pathophysiology and emerging therapeutics.

Moscoso CG, Steer CJ.

Hepat Med. 2019 Sep 2;11:109-129. doi: 10.2147/HMER.S213397. eCollection 2019.


Ursodeoxycholic acid: A promising therapeutic target for inflammatory bowel diseases?

Keely SJ, Steer CJ, Lajczak-McGinley NK.

Am J Physiol Gastrointest Liver Physiol. 2019 Sep 11. doi: 10.1152/ajpgi.00163.2019. [Epub ahead of print]


Interspecies Organogenesis for Human Transplantation.

Crane AT, Aravalli RN, Asakura A, Grande AW, Krishna VD, Carlson DF, Cheeran MC, Danczyk G, Dutton JR, Hackett PB, Hu WS, Li L, Lu WC, Miller ZD, O'Brien TD, Panoskaltsis-Mortari A, Parr AM, Pearce C, Ruiz-Estevez M, Shiao M, Sipe CJ, Toman NG, Voth J, Xie H, Steer CJ, Low WC.

Cell Transplant. 2019 Sep-Oct;28(9-10):1091-1105. doi: 10.1177/0963689719845351. Epub 2019 Aug 19.


Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells.

Desir S, Wong P, Turbyville T, Chen, Shetty M, Clark C, Zhai E, Romin Y, Manova-Todorova K, Starr TK, Nissley DV, Steer CJ, Subramanian S, Lou E.

Cancers (Basel). 2019 Jun 26;11(7). pii: E892. doi: 10.3390/cancers11070892.


Special Issue: MicroRNA Regulation in Health and Disease.

Subramanian S, Steer CJ.

Genes (Basel). 2019 Jun 15;10(6). pii: E457. doi: 10.3390/genes10060457.


A new era of genetic engineering for autoimmune and inflammatory diseases.

Ewart D, Peterson EJ, Steer CJ.

Semin Arthritis Rheum. 2019 Aug;49(1):e1-e7. doi: 10.1016/j.semarthrit.2019.05.004. Epub 2019 May 16. Review.


Host⁻MicroRNA⁻Microbiota Interactions in Colorectal Cancer.

Yuan C, Steer CJ, Subramanian S.

Genes (Basel). 2019 Apr 2;10(4). pii: E270. doi: 10.3390/genes10040270. Review.


A new era of gene editing for the treatment of human diseases.

Kc M, Steer CJ.

Swiss Med Wkly. 2019 Jan 27;149:w20021. doi: 10.4414/smw.2019.20021. eCollection 2019 Jan 14. Review.


Early career biomedical grantsmanship self-efficacy: validation of an abbreviated self-assessment tool.

Harwood EM, Jones AR, Erickson D, Buchwald D, Johnson-Hemming J, Jones HP, Manson S, McGee R, Smith A, Steer CJ, Vishwanatha JK, Weber-Main AM, Okuyemi KS.

Ann N Y Acad Sci. 2019 Jun;1445(1):17-26. doi: 10.1111/nyas.13995. Epub 2018 Dec 5.


Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes.

Lou E, Zhai E, Sarkari A, Desir S, Wong P, Iizuka Y, Yang J, Subramanian S, McCarthy J, Bazzaro M, Steer CJ.

Front Cell Dev Biol. 2018 Oct 2;6:95. doi: 10.3389/fcell.2018.00095. eCollection 2018.


LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression.

Zhang T, Duan J, Zhang L, Li Z, Steer CJ, Yan G, Song G.

Hepatology. 2019 Apr;69(4):1488-1503. doi: 10.1002/hep.30301. Epub 2019 Jan 7.


MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-κB-TNFα pathway.

Zhang T, Hu J, Wang X, Zhao X, Li Z, Niu J, Steer CJ, Zheng G, Song G.

J Hepatol. 2019 Jan;70(1):87-96. doi: 10.1016/j.jhep.2018.08.026. Epub 2018 Sep 13.


Gene editing for inflammatory disorders.

Ewart DT, Peterson EJ, Steer CJ.

Ann Rheum Dis. 2019 Jan;78(1):6-15. doi: 10.1136/annrheumdis-2018-213454. Epub 2018 Aug 4. Review.


Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer.

Desir S, O'Hare P, Vogel RI, Sperduto W, Sarkari A, Dickson EL, Wong P, Nelson AC, Fong Y, Steer CJ, Subramanian S, Lou E.

Sci Rep. 2018 Jun 21;8(1):9484. doi: 10.1038/s41598-018-27649-x.


Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.

Belcher JD, Chen C, Nguyen J, Abdulla F, Zhang P, Nguyen H, Nguyen P, Killeen T, Miescher SM, Brinkman N, Nath KA, Steer CJ, Vercellotti GM.

PLoS One. 2018 Apr 25;13(4):e0196455. doi: 10.1371/journal.pone.0196455. eCollection 2018.


A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet.

Zhang T, Zhao X, Steer CJ, Yan G, Song G.

Metabolism. 2018 Aug;85:183-191. doi: 10.1016/j.metabol.2018.03.023. Epub 2018 Apr 3.


Liver Regeneration in the Acute Liver Failure Patient.

Wirth KM, Kizy S, Steer CJ.

Clin Liver Dis. 2018 May;22(2):269-287. doi: 10.1016/j.cld.2018.01.004. Review.


CRISPR/Cas9 therapeutics for liver diseases.

Aravalli RN, Steer CJ.

J Cell Biochem. 2018 Jun;119(6):4265-4278. doi: 10.1002/jcb.26627. Epub 2018 Feb 22. Review.


A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication.

Thayanithy V, O'Hare P, Wong P, Zhao X, Steer CJ, Subramanian S, Lou E.

Cell Commun Signal. 2017 Nov 13;15(1):46. doi: 10.1186/s12964-017-0201-2.


Team science and the physician-scientist in the age of grand health challenges.

Steer CJ, Jackson PR, Hornbeak H, McKay CK, Sriramarao P, Murtaugh MP.

Ann N Y Acad Sci. 2017 Sep;1404(1):3-16. doi: 10.1111/nyas.13498. Review.


Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors.

Lou E, Gholami S, Romin Y, Thayanithy V, Fujisawa S, Desir S, Steer CJ, Subramanian S, Fong Y, Manova-Todorova K, Moore MAS.

Trends Cancer. 2017 Oct;3(10):678-685. doi: 10.1016/j.trecan.2017.08.001. Epub 2017 Sep 14. Review.


A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.


MicroRNA-206 prevents the pathogenesis of hepatocellular carcinoma by modulating expression of met proto-oncogene and cyclin-dependent kinase 6 in mice.

Wu H, Tao J, Li X, Zhang T, Zhao L, Wang Y, Zhang L, Xiong J, Zeng Z, Zhan N, Steer CJ, Che L, Dong M, Wang X, Niu J, Li Z, Yan G, Chen X, Song G.

Hepatology. 2017 Dec;66(6):1952-1967. doi: 10.1002/hep.29374. Epub 2017 Oct 30.


The science behind One Health: at the interface of humans, animals, and the environment.

Murtaugh MP, Steer CJ, Sreevatsan S, Patterson N, Kennedy S, Sriramarao P.

Ann N Y Acad Sci. 2017 May;1395(1):12-32. doi: 10.1111/nyas.13355.


Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination.

Stoltz KL, Erickson R, Staley C, Weingarden AR, Romens E, Steer CJ, Khoruts A, Sadowsky MJ, Dosa PI.

J Med Chem. 2017 Apr 27;60(8):3451-3471. doi: 10.1021/acs.jmedchem.7b00295. Epub 2017 Apr 12.


Immune-Mediated Therapies for Liver Cancer.

Aravalli RN, Steer CJ.

Genes (Basel). 2017 Feb 17;8(2). pii: E76. doi: 10.3390/genes8020076. Review.


MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis.

Wu H, Zhang T, Pan F, Steer CJ, Li Z, Chen X, Song G.

J Hepatol. 2017 Apr;66(4):816-824. doi: 10.1016/j.jhep.2016.12.016. Epub 2016 Dec 23.


Sp1-mediated transcriptional activation of miR-205 promotes radioresistance in esophageal squamous cell carcinoma.

Pan F, Mao H, Bu F, Tong X, Li J, Zhang S, Liu X, Wang L, Wu L, Chen R, Wei H, Li B, Li C, Yang Y, Steer CJ, Zhao J, Guo Y.

Oncotarget. 2017 Jan 24;8(4):5735-5752. doi: 10.18632/oncotarget.13902.


Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments.

Lou E, O'Hare P, Subramanian S, Steer CJ.

FEBS J. 2017 Mar;284(5):699-707. doi: 10.1111/febs.13946. Epub 2016 Nov 30. Review.


Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease.

Vercellotti GM, Zhang P, Nguyen J, Abdulla F, Chen C, Nguyen P, Nowotny C, Steer CJ, Smith A, Belcher JD.

Mol Med. 2016 Sep;22:437-451. doi: 10.2119/molmed.2016.00063. Epub 2016 Jul 19.


Detection of Sleeping Beauty transposition in the genome of host cells by non-radioactive Southern blot analysis.

Aravalli RN, Park CW, Steer CJ.

Biochem Biophys Res Commun. 2016 Aug 26;477(3):317-21. doi: 10.1016/j.bbrc.2016.06.094. Epub 2016 Jun 18.


Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells.

Desir S, Dickson EL, Vogel RI, Thayanithy V, Wong P, Teoh D, Geller MA, Steer CJ, Subramanian S, Lou E.

Oncotarget. 2016 Jul 12;7(28):43150-43161. doi: 10.18632/oncotarget.9504.


MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases.

Mahgoub A, Steer CJ.

J Clin Med. 2016 May 10;5(5). pii: E52. doi: 10.3390/jcm5050052. Review.


Gene editing technology as an approach to the treatment of liver diseases.

Aravalli RN, Steer CJ.

Expert Opin Biol Ther. 2016;16(5):595-608. doi: 10.1517/14712598.2016.1158808. Epub 2016 Mar 21. Review.


Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma.

Shu J, Li L, Sarver AE, Pope EA, Varshney J, Thayanithy V, Spector L, Largaespada DA, Steer CJ, Subramanian S.

Oncotarget. 2016 Apr 19;7(16):21298-314. doi: 10.18632/oncotarget.6965.


Changes in Colonic Bile Acid Composition following Fecal Microbiota Transplantation Are Sufficient to Control Clostridium difficile Germination and Growth.

Weingarden AR, Dosa PI, DeWinter E, Steer CJ, Shaughnessy MK, Johnson JR, Khoruts A, Sadowsky MJ.

PLoS One. 2016 Jan 20;11(1):e0147210. doi: 10.1371/journal.pone.0147210. eCollection 2016.


A common variant in MTHFR influences response to chemoradiotherapy and recurrence of rectal cancer.

Nikas JB, Lee JT, Maring ED, Washechek-Aletto J, Felmlee-Devine D, Johnson RA, Smyrk TC, Tawadros PS, Boardman LA, Steer CJ.

Am J Cancer Res. 2015 Sep 15;5(10):3231-40. eCollection 2015.


microRNAs in Mitochondria: An Unexplored Niche.

Borralho PM, Rodrigues CM, Steer CJ.

Adv Exp Med Biol. 2015;887:31-51. doi: 10.1007/978-3-319-22380-3_3.


Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.

Weingarden AR, Chen C, Zhang N, Graiziger CT, Dosa PI, Steer CJ, Shaughnessy MK, Johnson JR, Sadowsky MJ, Khoruts A.

J Clin Gastroenterol. 2016 Sep;50(8):624-30. doi: 10.1097/MCG.0000000000000427.


Advancing One Health Policy and Implementation Through the Concept of One Medicine One Science.

Cardona C, Travis DA, Berger K, Coat G, Kennedy S, Steer CJ, Murtaugh MP, Sriramarao P.

Glob Adv Health Med. 2015 Sep;4(5):50-4. doi: 10.7453/gahmj.2015.053. Epub 2015 Sep 1.


MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway.

Wu H, Ng R, Chen X, Steer CJ, Song G.

Gut. 2016 Nov;65(11):1850-1860. doi: 10.1136/gutjnl-2014-308430. Epub 2015 Aug 17.


High-resolution melting analysis of single nucleotide polymorphisms.

Bruzzone CM, Steer CJ.

Methods Mol Biol. 2015;1310:5-27. doi: 10.1007/978-1-4939-2690-9_2.


Circulating microRNAs: novel biomarkers for early detection of colorectal cancer.

Aravalli RN, Steer CJ.

Transl Res. 2015 Sep;166(3):219-24. doi: 10.1016/j.trsl.2015.04.007. Epub 2015 Apr 15. No abstract available.


Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation.

Simões AE, Pereira DM, Gomes SE, Brito H, Carvalho T, French A, Castro RE, Steer CJ, Thibodeau SN, Rodrigues CM, Borralho PM.

Cell Death Dis. 2015 Apr 9;6:e1718. doi: 10.1038/cddis.2015.83.


Liver-targeted gene therapy: Approaches and challenges.

Aravalli RN, Belcher JD, Steer CJ.

Liver Transpl. 2015 Jun;21(6):718-37. doi: 10.1002/lt.24122. Review.


Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing.

Aravalli RN, Talbot NC, Steer CJ.

World J Gastroenterol. 2015 Feb 21;21(7):2011-29. doi: 10.3748/wjg.v21.i7.2011.


One Medicine One Science and policy.

Sriramarao P, Murtaugh MP, Berger K, Travis D, Kennedy S, Steer CJ, Cardona C.

Science. 2015 Jan 16;347(6219):242. doi: 10.1126/science.347.6219.242-a. No abstract available.


One Medicine One Science: a framework for exploring challenges at the intersection of animals, humans, and the environment.

Travis DA, Sriramarao P, Cardona C, Steer CJ, Kennedy S, Sreevatsan S, Murtaugh MP.

Ann N Y Acad Sci. 2014 Dec;1334:26-44. doi: 10.1111/nyas.12601. Epub 2014 Dec 4.

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