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Items: 30

1.

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H.

JCI Insight. 2019 Dec 5;4(23). pii: 135306. doi: 10.1172/jci.insight.135306. No abstract available.

2.

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H.

JCI Insight. 2019 Nov 1;4(21). pii: 130416. doi: 10.1172/jci.insight.130416. Erratum in: JCI Insight. 2019 Dec 5;4(23):.

3.

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H.

Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18.

PMID:
31227230
4.

A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation.

Steentoft C, Yang Z, Wang S, Ju T, Vester-Christensen MB, Festari MF, King SL, Moremen K, Larsen ISB, Goth CK, Schjoldager KT, Hansen L, Bennett EP, Mandel U, Narimatsu Y.

Glycobiology. 2019 Aug 20;29(9):645-656. doi: 10.1093/glycob/cwz041.

PMID:
31172184
5.

Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics.

Narimatsu Y, Joshi HJ, Schjoldager KT, Hintze J, Halim A, Steentoft C, Nason R, Mandel U, Bennett EP, Clausen H, Vakhrushev SY.

Mol Cell Proteomics. 2019 Jul;18(7):1396-1409. doi: 10.1074/mcp.RA118.001121. Epub 2019 Apr 30.

PMID:
31040225
6.

A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.

Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen TD, Campos D, Halim A, Vakhrushev SY, Joshi HJ, Schreiber H, Mandel U, Narimatsu Y.

Glycobiology. 2019 Apr 1;29(4):307-319. doi: 10.1093/glycob/cwz004.

PMID:
30726901
7.

The GAGOme: a cell-based library of displayed glycosaminoglycans.

Chen YH, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP, Mao Y, Clausen H, Yang Z.

Nat Methods. 2018 Nov;15(11):881-888. doi: 10.1038/s41592-018-0086-z. Epub 2018 Aug 13.

PMID:
30104636
8.

Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours.

Coelho R, Marcos-Silva L, Mendes N, Pereira D, Brito C, Jacob F, Steentoft C, Mandel U, Clausen H, David L, Ricardo S.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2045. doi: 10.3390/ijms19072045.

9.

Glycan-directed CAR-T cells.

Steentoft C, Migliorini D, King TR, Mandel U, June CH, Posey AD Jr.

Glycobiology. 2018 Sep 1;28(9):656-669. doi: 10.1093/glycob/cwy008. Review.

PMID:
29370379
10.

GlycoDomainViewer: a bioinformatics tool for contextual exploration of glycoproteomes.

Joshi HJ, Jørgensen A, Schjoldager KT, Halim A, Dworkin LA, Steentoft C, Wandall HH, Clausen H, Vakhrushev SY.

Glycobiology. 2018 Mar 1;28(3):131-136. doi: 10.1093/glycob/cwx104.

PMID:
29267884
11.

Glycosylation Engineering.

Clausen H, Wandall HH, Steentoft C, Stanley P, Schnaar RL.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 56.
2017.

12.

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH.

Immunity. 2016 Jun 21;44(6):1444-54. doi: 10.1016/j.immuni.2016.05.014.

13.

Fucosylation and protein glycosylation create functional receptors for cholera toxin.

Wands AM, Fujita A, McCombs JE, Cervin J, Dedic B, Rodriguez AC, Nischan N, Bond MR, Mettlen M, Trudgian DC, Lemoff A, Quiding-Järbrink M, Gustavsson B, Steentoft C, Clausen H, Mirzaei H, Teneberg S, Yrlid U, Kohler JJ.

Elife. 2015 Oct 29;4:e09545. doi: 10.7554/eLife.09545.

14.

Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.

Campos D, Freitas D, Gomes J, Magalhães A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA.

Mol Cell Proteomics. 2015 Jun;14(6):1616-29. doi: 10.1074/mcp.M114.046862. Epub 2015 Mar 26.

15.

Fast and sensitive detection of indels induced by precise gene targeting.

Yang Z, Steentoft C, Hauge C, Hansen L, Thomsen AL, Niola F, Vester-Christensen MB, Frödin M, Clausen H, Wandall HH, Bennett EP.

Nucleic Acids Res. 2015 May 19;43(9):e59. doi: 10.1093/nar/gkv126. Epub 2015 Mar 9.

16.

Advances in mass spectrometry driven O-glycoproteomics.

Levery SB, Steentoft C, Halim A, Narimatsu Y, Clausen H, Vakhrushev SY.

Biochim Biophys Acta. 2015 Jan;1850(1):33-42. doi: 10.1016/j.bbagen.2014.09.026. Epub 2014 Oct 2. Review.

PMID:
25284204
17.

Immature truncated O-glycophenotype of cancer directly induces oncogenic features.

Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12.

18.

The GalNAc-type O-Glycoproteome of CHO cells characterized by the SimpleCell strategy.

Yang Z, Halim A, Narimatsu Y, Jitendra Joshi H, Steentoft C, Schjoldager KT, Alder Schulz M, Sealover NR, Kayser KJ, Paul Bennett E, Levery SB, Vakhrushev SY, Clausen H.

Mol Cell Proteomics. 2014 Dec;13(12):3224-35. doi: 10.1074/mcp.M114.041541. Epub 2014 Aug 4.

19.

Precision genome editing: a small revolution for glycobiology.

Steentoft C, Bennett EP, Schjoldager KT, Vakhrushev SY, Wandall HH, Clausen H.

Glycobiology. 2014 Aug;24(8):663-80. doi: 10.1093/glycob/cwu046. Epub 2014 May 26. Review.

PMID:
24861053
20.

Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.

Vester-Christensen MB, Halim A, Joshi HJ, Steentoft C, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21018-23. doi: 10.1073/pnas.1313446110. Epub 2013 Oct 7.

21.

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Madsen CB, Lavrsen K, Steentoft C, Vester-Christensen MB, Clausen H, Wandall HH, Pedersen AE.

PLoS One. 2013 Sep 6;8(9):e72413. doi: 10.1371/journal.pone.0072413. eCollection 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/81b54c99-e47f-4128-8aeb-b6b3e8c02562.

22.

Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness.

Gill DJ, Tham KM, Chia J, Wang SC, Steentoft C, Clausen H, Bard-Chapeau EA, Bard FA.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3152-61. doi: 10.1073/pnas.1305269110. Epub 2013 Aug 2.

24.

Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.

Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12.

25.

Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells.

Vakhrushev SY, Steentoft C, Vester-Christensen MB, Bennett EP, Clausen H, Levery SB.

Mol Cell Proteomics. 2013 Apr;12(4):932-44. doi: 10.1074/mcp.O112.021972. Epub 2013 Feb 11.

26.

Microarray Glycoprofiling of CA125 improves differential diagnosis of ovarian cancer.

Chen K, Gentry-Maharaj A, Burnell M, Steentoft C, Marcos-Silva L, Mandel U, Jacobs I, Dawnay A, Menon U, Blixt O.

J Proteome Res. 2013 Mar 1;12(3):1408-18. doi: 10.1021/pr3010474. Epub 2013 Feb 19.

PMID:
23360124
27.

Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

Schjoldager KT, Vakhrushev SY, Kong Y, Steentoft C, Nudelman AS, Pedersen NB, Wandall HH, Mandel U, Bennett EP, Levery SB, Clausen H.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9893-8. doi: 10.1073/pnas.1203563109. Epub 2012 May 7.

28.

Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.

Steentoft C, Vakhrushev SY, Vester-Christensen MB, Schjoldager KT, Kong Y, Bennett EP, Mandel U, Wandall H, Levery SB, Clausen H.

Nat Methods. 2011 Oct 9;8(11):977-82. doi: 10.1038/nmeth.1731.

PMID:
21983924
29.

Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8).

Steentoft C, Schjoldager KT, Cló E, Mandel U, Levery SB, Pedersen JW, Jensen K, Blixt O, Clausen H.

Glycoconj J. 2010 Aug;27(6):571-82. doi: 10.1007/s10719-010-9301-6. Epub 2010 Aug 19.

PMID:
20721622
30.

Glyco-scan: varying glycosylation in the sequence of the peptide hormone PYY3-36 and its effect on receptor selectivity.

Pedersen SL, Steentoft C, Vrang N, Jensen KJ.

Chembiochem. 2010 Feb 15;11(3):366-74. doi: 10.1002/cbic.200900661.

PMID:
20049760

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