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Items: 1 to 50 of 304

1.

Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide.

Galbraith AR, Seabloom DE, Wuertz BR, Antonides JD, Steele VE, Wattenberg LW, Ondrey FG.

Cancer Prev Res (Phila). 2019 Feb;12(2):69-78. doi: 10.1158/1940-6207.CAPR-17-0402. Epub 2019 Jan 3.

PMID:
30606719
2.

[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor MK2206 in mammary cancer models.

Lubet RA, Steele VE, Juliana MM, Bode A, Moeinpour F, Grubbs CJ.

Oncol Rep. 2019 Jan;41(1):718. doi: 10.3892/or.2018.6802. Epub 2018 Oct 17.

3.

Screening of Chemopreventive Agents in Animal Models: Results on Reproducibility, Agents of a Given Class, and Agents Tested During Tumor Progression.

Lubet RA, Steele VE, Shoemaker RH, Grubbs CJ.

Cancer Prev Res (Phila). 2018 Oct;11(10):595-606. doi: 10.1158/1940-6207.CAPR-18-0084. Epub 2018 Jul 25. Review.

4.

Release of MicroRNAs into Body Fluids from Ten Organs of Mice Exposed to Cigarette Smoke.

Izzotti A, Longobardi M, La Maestra S, Micale RT, Pulliero A, Camoirano A, Geretto M, D'Agostini F, Balansky R, Miller MS, Steele VE, De Flora S.

Theranostics. 2018 Mar 8;8(8):2147-2160. doi: 10.7150/thno.22726. eCollection 2018.

5.

Effects of talactoferrin alpha on lung adenoma prevention in A/J mice June 2, 2016.

Seabloom DE, Galbraith AR, Haynes AM, Fujita AS, Antonides JD, Wuertz BR, Steele VE, Ondrey FG, Wattenberg LW.

Am J Transl Res. 2018 Mar 15;10(3):875-880. eCollection 2018.

6.

Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models.

Lubet RA, Steele VE, Juliana MM, Bode A, Moeinpour F, Grubbs CJ.

Oncol Rep. 2018 Sep;40(3):1545-1553. doi: 10.3892/or.2018.6313. Epub 2018 Mar 14. Erratum in: Oncol Rep. 2019 Jan;41(1):718.

7.

Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer.

Mohammed A, Janakiram NB, Madka V, Pathuri G, Li Q, Ritchie R, Biddick L, Kutche H, Zhang Y, Singh A, Gali H, Lightfoot S, Steele VE, Suen CS, Rao CV.

Oncotarget. 2017 Oct 26;8(58):97822-97834. doi: 10.18632/oncotarget.22085. eCollection 2017 Nov 17.

8.

Early and late effects of aspirin and naproxen on microRNAs in the lung and blood of mice, either unexposed or exposed to cigarette smoke.

Izzotti A, Balansky R, Ganchev G, Iltcheva M, Longobardi M, Pulliero A, Camoirano A, D'Agostini F, Geretto M, Micale RT, La Maestra S, Miller MS, Steele VE, De Flora S.

Oncotarget. 2017 Aug 24;8(49):85716-85748. doi: 10.18632/oncotarget.20464. eCollection 2017 Oct 17.

9.

Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention.

Seabloom DE, Galbraith AR, Haynes AM, Antonides JD, Wuertz BR, Miller WA, Miller KA, Steele VE, Miller MS, Clapper ML, O'Sullivan MG, Ondrey FG.

Cancer Prev Res (Phila). 2017 Feb;10(2):116-123. doi: 10.1158/1940-6207.CAPR-16-0232. Epub 2017 Jan 4.

10.

Safety and Preclinical Efficacy of Aerosol Pioglitazone on Lung Adenoma Prevention in A/J Mice.

Seabloom DE, Galbraith AR, Haynes AM, Antonides JD, Wuertz BR, Miller WA, Miller KA, Steele VE, Suen CS, O'Sullivan MG, Ondrey FG.

Cancer Prev Res (Phila). 2017 Feb;10(2):124-132. doi: 10.1158/1940-6207.CAPR-16-0174. Epub 2016 Dec 19.

11.

Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer.

Janakiram NB, Mohammed A, Bryant T, Zhang Y, Brewer M, Duff A, Biddick L, Singh A, Lightfoot S, Steele VE, Rao CV.

Sci Rep. 2016 Nov 14;6:37046. doi: 10.1038/srep37046.

12.

Interactions between ethanol and cigarette smoke in a mouse lung carcinogenesis model.

Balansky R, Ganchev G, Iltcheva M, Nikolov M, La Maestra S, Micale RT, Steele VE, De Flora S.

Toxicology. 2016 Dec 12;373:54-62. doi: 10.1016/j.tox.2016.11.008. Epub 2016 Nov 10.

PMID:
27840117
13.

Blood and lung microRNAs as biomarkers of pulmonary tumorigenesis in cigarette smoke-exposed mice.

Izzotti A, Balansky R, Ganchev G, Iltcheva M, Longobardi M, Pulliero A, Geretto M, Micale RT, La Maestra S, Miller MS, Steele VE, De Flora S.

Oncotarget. 2016 Dec 20;7(51):84758-84774. doi: 10.18632/oncotarget.12475.

14.

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Miller MS, Allen P, Brentnall TA, Goggins M, Hruban RH, Petersen GM, Rao CV, Whitcomb DC, Brand RE, Chari ST, Klein AP, Lubman DM, Rhim AD, Simeone DM, Wolpin BM, Umar A, Srivastava S, Steele VE, Rinaudo JA.

Pancreas. 2016 Sep;45(8):1080-91. doi: 10.1097/MPA.0000000000000705.

15.

Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice.

Kumar G, Patlolla JM, Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Singh A, Gillaspy A, Lightfoot S, Steele VE, Kopelovich L, Rao CV.

Am J Cancer Res. 2016 May 1;6(5):894-909. eCollection 2016.

16.

5MeCDDO Blocks Metabolic Activation but not Progression of Breast, Intestine, and Tongue Cancers. Is Antioxidant Response Element a Prevention Target?

Lubet RA, Townsend R, Clapper ML, Juliana MM, Steele VE, McCormick DL, Grubbs CJ.

Cancer Prev Res (Phila). 2016 Jul;9(7):616-23. doi: 10.1158/1940-6207.CAPR-15-0294. Epub 2016 May 5.

17.

The National Cancer Institute's PREVENT Cancer Preclinical Drug Development Program: overview, current projects, animal models, agent development strategies, and molecular targets.

Shoemaker RH, Suen CS, Holmes CA, Fay JR, Steele VE.

Semin Oncol. 2016 Feb;43(1):189-197. doi: 10.1053/j.seminoncol.2015.09.008. Epub 2015 Sep 8. Review.

18.

Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.

Umar A, Steele VE, Menter DG, Hawk ET.

Semin Oncol. 2016 Feb;43(1):65-77. doi: 10.1053/j.seminoncol.2015.09.010. Epub 2015 Sep 10. Review.

PMID:
26970125
19.

Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence.

De Flora S, Ganchev G, Iltcheva M, La Maestra S, Micale RT, Steele VE, Balansky R.

Trends Pharmacol Sci. 2016 Feb;37(2):120-142. doi: 10.1016/j.tips.2015.11.003. Epub 2015 Dec 23. Review.

20.

Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo.

Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla JM, Lightfoot S, Towner RA, Wu XR, Steele VE, Kopelovich L, Rao CV.

Cancer Prev Res (Phila). 2016 Jan;9(1):53-62. doi: 10.1158/1940-6207.CAPR-15-0199. Epub 2015 Nov 17.

21.

Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor γ.

McCormick DL, Horn TL, Johnson WD, Peng X, Lubet RA, Steele VE.

PLoS One. 2015 Oct 30;10(10):e0141849. doi: 10.1371/journal.pone.0141849. eCollection 2015.

22.

Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth.

La Maestra S, D'Agostini F, Izzotti A, Micale RT, Mastracci L, Camoirano A, Balansky R, Trosko JE, Steele VE, De Flora S.

Carcinogenesis. 2015 Dec;36(12):1531-8. doi: 10.1093/carcin/bgv149. Epub 2015 Oct 13.

23.

Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma.

Rao CV, Janakiram NB, Madka V, Devarkonda V, Brewer M, Biddick L, Lightfoot S, Steele VE, Mohammed A.

Oncotarget. 2015 Oct 20;6(32):33290-305. doi: 10.18632/oncotarget.5396.

24.

Predictive Value Tools as an Aid in Chemopreventive Agent Development.

Dunn BK, Steele VE, Fagerstrom RM, Topp CF, Ransohoff D, Cunningham C, Lubet R, Ford LG, Kramer BS.

J Natl Cancer Inst. 2015 Sep 28;107(12):djv259. doi: 10.1093/jnci/djv259. Print 2015 Dec.

25.

Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice.

Balansky R, Ganchev G, Iltcheva M, Micale RT, La Maestra S, D'Oria C, Steele VE, De Flora S.

Arch Toxicol. 2016 May;90(5):1251-60. doi: 10.1007/s00204-015-1550-5. Epub 2015 Jun 24.

PMID:
26104855
26.

Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.

Mohammed A, Janakiram NB, Madka V, Brewer M, Ritchie RL, Lightfoot S, Kumar G, Sadeghi M, Patlolla JM, Yamada HY, Cruz-Monserrate Z, May R, Houchen CW, Steele VE, Rao CV.

Oncotarget. 2015 Jun 20;6(17):15524-39.

27.

Prevention of chemically induced urinary bladder cancers by naproxen: protocols to reduce gastric toxicity in humans do not alter preventive efficacy.

Lubet RA, Scheiman JM, Bode A, White J, Minasian L, Juliana MM, Boring DL, Steele VE, Grubbs CJ.

Cancer Prev Res (Phila). 2015 Apr;8(4):296-302. doi: 10.1158/1940-6207.CAPR-14-0347. Epub 2015 Mar 11.

28.

Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke.

Balansky R, Ganchev G, Iltcheva M, Nikolov M, La Maestra S, Micale RT, D'Agostini F, Steele VE, De Flora S.

Curr Cancer Drug Targets. 2015;15(3):188-95.

PMID:
25687474
29.

Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models.

Thompson MD, Grubbs CJ, Bode AM, Reid JM, McGovern R, Bernard PS, Stijleman IJ, Green JE, Bennett C, Juliana MM, Moeinpour F, Steele VE, Lubet RA.

Cancer Prev Res (Phila). 2015 Mar;8(3):231-9. doi: 10.1158/1940-6207.CAPR-14-0181-T. Epub 2015 Feb 13.

30.

Improved innate immune responses by Frondanol A5, a sea cucumber extract, prevent intestinal tumorigenesis.

Janakiram NB, Mohammed A, Bryant T, Lightfoot S, Collin PD, Steele VE, Rao CV.

Cancer Prev Res (Phila). 2015 Apr;8(4):327-37. doi: 10.1158/1940-6207.CAPR-14-0380. Epub 2015 Feb 5.

31.

Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling.

Mohammed A, Janakiram NB, Madka V, Ritchie RL, Brewer M, Biddick L, Patlolla JM, Sadeghi M, Lightfoot S, Steele VE, Rao CV.

Cancer Prev Res (Phila). 2014 Dec;7(12):1198-209. doi: 10.1158/1940-6207.CAPR-14-0176. Epub 2014 Sep 23.

32.

Assay of lapatinib in murine models of cigarette smoke carcinogenesis.

Balansky R, Izzotti A, D'Agostini F, Longobardi M, Micale RT, La Maestra S, Camoirano A, Ganchev G, Iltcheva M, Steele VE, De Flora S.

Carcinogenesis. 2014 Oct;35(10):2300-7. doi: 10.1093/carcin/bgu154. Epub 2014 Jul 22.

33.

Rationale and approaches to the prevention of smoking-related diseases: overview of recent studies on chemoprevention of smoking-induced tumors in rodent models.

De Flora S, Izzotti A, D'Agostini F, La Maestra S, Micale RT, Ceccaroli C, Steele VE, Balansky R.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32(2):105-20. doi: 10.1080/10590501.2014.907459. Review.

PMID:
24875440
34.

Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice.

Izzotti A, Balansky R, D'Agostini F, Longobardi M, Cartiglia C, Micale RT, La Maestra S, Camoirano A, Ganchev G, Iltcheva M, Steele VE, De Flora S.

Cancer Med. 2014 Jun;3(3):719-30. doi: 10.1002/cam4.234. Epub 2014 Mar 28.

35.

Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling.

Mohammed A, Janakiram NB, Brewer M, Ritchie RL, Marya A, Lightfoot S, Steele VE, Rao CV.

Transl Oncol. 2013 Dec 1;6(6):649-59. eCollection 2013 Dec 1.

36.

Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model.

Nicastro HL, Grubbs CJ, Margaret Juliana M, Bode AM, Kim MS, Lu Y, You M, Milne GL, Boring D, Steele VE, Lubet RA.

Cancer Prev Res (Phila). 2014 Feb;7(2):246-54. doi: 10.1158/1940-6207.CAPR-13-0164. Epub 2013 Dec 17.

37.

Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis.

Ravillah D, Mohammed A, Qian L, Brewer M, Zhang Y, Biddick L, Steele VE, Rao CV.

J Pharmacol Exp Ther. 2014 Jan;348(1):59-68. doi: 10.1124/jpet.113.208645. Epub 2013 Nov 11.

38.

Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats.

Janakiram NB, Mohammed A, Zhang Y, Brewer M, Bryant T, Lightfoot S, Steele VE, Rao CV.

Cancer Prev Res (Phila). 2013 Dec;6(12):1251-61. doi: 10.1158/1940-6207.CAPR-13-0249. Epub 2013 Sep 30.

39.

Relationships between pulmonary micro-RNA and proteome profiles, systemic cytogenetic damage and lung tumors in cigarette smoke-exposed mice treated with chemopreventive agents.

Izzotti A, Balansky R, D'Agostini F, Longobardi M, Cartiglia C, La Maestra S, Micale RT, Camoirano A, Ganchev G, Iltcheva M, Steele VE, De Flora S.

Carcinogenesis. 2013 Oct;34(10):2322-9. doi: 10.1093/carcin/bgt178. Epub 2013 May 24.

40.

Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil.

Rao CV, Patlolla JM, Cooma I, Kawamori T, Steele VE.

Nutr Cancer. 2013;65 Suppl 1:54-60. doi: 10.1080/01635581.2013.785009.

PMID:
23682783
41.

Multitargeted low-dose GLAD combination chemoprevention: a novel and promising approach to combat colon carcinogenesis.

Mohammed A, Janakiram NB, Brewer M, Vedala K, Steele VE, Rao CV.

Neoplasia. 2013 May;15(5):481-90.

42.

Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis.

Lubet RA, Szabo E, Iwata KK, Gill SC, Tucker C, Bode A, Steele VE, Juliana MM, Nicastro HL, Grubbs CJ.

Cancer Prev Res (Phila). 2013 May;6(5):448-54. doi: 10.1158/1940-6207.CAPR-12-0322. Epub 2013 Mar 26.

43.

Early-phase development of cancer prevention agents: challenges and opportunities.

Perloff M, Steele VE.

Cancer Prev Res (Phila). 2013 May;6(5):379-83. doi: 10.1158/1940-6207.CAPR-12-0463. Epub 2013 Mar 6.

44.

Oxidative stress in the lung of mice exposed to cigarette smoke either early in life or in adulthood.

Micale RT, La Maestra S, Di Pietro A, Visalli G, Baluce B, Balansky R, Steele VE, De Flora S.

Arch Toxicol. 2013 May;87(5):915-8. doi: 10.1007/s00204-012-0993-1. Epub 2013 Feb 20. Erratum in: Arch Toxicol. 2013 May;87(5):919. Maestra, Sebastiano La [corrected to La Maestra, Sebastiano]; Pietro, Angela Di [corrected to Di Pietro, Angela].

PMID:
23423711
45.

DNA damage in exfoliated cells and histopathological alterations in the urinary tract of mice exposed to cigarette smoke and treated with chemopreventive agents.

La Maestra S, Micale RT, De Flora S, D'Agostini F, Ganchev G, Iltcheva M, Petkov N, Steele VE, Balansky R.

Carcinogenesis. 2013 Jan;34(1):183-9. doi: 10.1093/carcin/bgs314. Epub 2012 Oct 5.

46.

Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice.

Rao CV, Mohammed A, Janakiram NB, Li Q, Ritchie RL, Lightfoot S, Vibhudutta A, Steele VE.

Neoplasia. 2012 Sep;14(9):778-87.

47.

Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents.

De Flora S, Balansky R, D'Agostini F, Cartiglia C, Longobardi M, Steele VE, Izzotti A.

Int J Cancer. 2012 Dec 15;131(12):2763-73. doi: 10.1002/ijc.27814. Epub 2012 Sep 26. Review.

48.

MicroRNAs as targets for dietary and pharmacological inhibitors of mutagenesis and carcinogenesis.

Izzotti A, Cartiglia C, Steele VE, De Flora S.

Mutat Res. 2012 Oct-Dec;751(2):287-303. doi: 10.1016/j.mrrev.2012.05.004. Epub 2012 Jun 7. Review.

49.

Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice.

Janakiram NB, Mohammed A, Qian L, Choi CI, Steele VE, Rao CV.

Neoplasia. 2012 Feb;14(2):159-68.

50.

Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke.

Balansky R, Ganchev G, Iltcheva M, Kratchanova M, Denev P, Kratchanov C, Polasa K, D'Agostini F, Steele VE, De Flora S.

Int J Cancer. 2012 Nov 1;131(9):1991-7. doi: 10.1002/ijc.27486. Epub 2012 Mar 27.

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