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The effect of spatiotemporal antibiotic inhomogeneities on the evolution of resistance.

Steel H, Papachristodoulou A.

J Theor Biol. 2019 Nov 9:110077. doi: 10.1016/j.jtbi.2019.110077. [Epub ahead of print]


Biofilm formation and induction of stress response genes is a common response of several serotypes of the pneumococcus to cigarette smoke condensate.

Cockeran R, Dix-Peek T, Dickens C, Steel HC, Anderson R, Feldman C.

J Infect. 2019 Oct 26. pii: S0163-4453(19)30326-3. doi: 10.1016/j.jinf.2019.10.014. [Epub ahead of print]


Low-Burden Biological Feedback Controllers for Near-Perfect Adaptation.

Steel H, Papachristodoulou A.

ACS Synth Biol. 2019 Oct 18;8(10):2212-2219. doi: 10.1021/acssynbio.9b00125. Epub 2019 Sep 13.


Interleukin-10 and interleukin-1 receptor antagonist distinguish between patients with sepsis and the systemic inflammatory response syndrome (SIRS).

Potjo M, Theron AJ, Cockeran R, Sipholi NN, Steel HC, Bale TV, Meyer PWA, Anderson R, Tintinger GR.

Cytokine. 2019 Aug;120:227-233. doi: 10.1016/j.cyto.2019.05.015. Epub 2019 May 21.


Plasma Biomarkers of Human Immunodeficiency Virus-Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral Therapy.

Kroeze S, Wit FW, Rossouw TM, Steel HC, Kityo CM, Siwale M, Akanmu S, Mandaliya K, de Jager M, Ondoa P, Reiss P, Rinke de Wit TF, Kootstra N, Hamers RL.

J Infect Dis. 2019 Aug 9;220(6):1029-1033. doi: 10.1093/infdis/jiz252.


Development of Aspirin-Inducible Biosensors in Escherichia coli and SimCells.

Chen JX, Steel H, Wu YH, Wang Y, Xu J, Rampley CPN, Thompson IP, Papachristodoulou A, Huang WE.

Appl Environ Microbiol. 2019 Mar 6;85(6). pii: e02959-18. doi: 10.1128/AEM.02959-18. Print 2019 Mar 15.


Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants.

Steel HC, Venter WDF, Theron AJ, Anderson R, Feldman C, Kwofie L, Cronjé T, Arullapan N, Rossouw TM.

Mediators Inflamm. 2018 Dec 9;2018:8357109. doi: 10.1155/2018/8357109. eCollection 2018.


Strategies for screening cord blood for a public cord blood bank in high HIV prevalence regions.

Meissner-Roloff M, Gaggia L, Vermeulen M, Mazanderani AFH, du Plessis NM, Steel HC, Pepper MS.

Glob Health Epidemiol Genom. 2018 May 15;3:e9. doi: 10.1017/gheg.2018.6. eCollection 2018. Review.


Synthetic negative feedback circuits using engineered small RNAs.

Kelly CL, Harris AWK, Steel H, Hancock EJ, Heap JT, Papachristodoulou A.

Nucleic Acids Res. 2018 Oct 12;46(18):9875-9889. doi: 10.1093/nar/gky828.


Probing Intercell Variability Using Bulk Measurements.

Steel H, Papachristodoulou A.

ACS Synth Biol. 2018 Jun 15;7(6):1528-1537. doi: 10.1021/acssynbio.8b00014. Epub 2018 Jun 7.


HIV as a Cause of Immune Activation and Immunosenescence.

Sokoya T, Steel HC, Nieuwoudt M, Rossouw TM.

Mediators Inflamm. 2017;2017:6825493. doi: 10.1155/2017/6825493. Epub 2017 Oct 25. Review.


The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders.

Theron AJ, Anderson R, Rossouw TM, Steel HC.

Front Immunol. 2017 Nov 2;8:1461. doi: 10.3389/fimmu.2017.01461. eCollection 2017. Review.


Facial appearance reveals immunity in African men.

Phalane KG, Tribe C, Steel HC, Cholo MC, Coetzee V.

Sci Rep. 2017 Aug 7;7(1):7443. doi: 10.1038/s41598-017-08015-9.


Investigation of the Mechanism of Anti-Inflammatory Action and Cytotoxicity of a Semipurified Fraction and Isolated Compounds From the Leaf of Peltophorum africanum (Fabaceae).

Adebayo SA, Steel HC, Shai LJ, Eloff JN.

J Evid Based Complementary Altern Med. 2017 Oct;22(4):840-845. doi: 10.1177/2156587217717417. Epub 2017 Jul 6.


Ribo-attenuators: novel elements for reliable and modular riboswitch engineering.

Folliard T, Mertins B, Steel H, Prescott TP, Newport T, Jones CW, Wadhams G, Bayer T, Armitage JP, Papachristodoulou A, Rothschild LJ.

Sci Rep. 2017 Jul 4;7(1):4599. doi: 10.1038/s41598-017-04093-x.


A Synthetic Recombinase-Based Feedback Loop Results in Robust Expression.

Folliard T, Steel H, Prescott TP, Wadhams G, Rothschild LJ, Papachristodoulou A.

ACS Synth Biol. 2017 Sep 15;6(9):1663-1671. doi: 10.1021/acssynbio.7b00131. Epub 2017 Jun 21.


Formoterol is more effective than salmeterol in suppressing neutrophil reactivity.

Tintinger GR, Theron AJ, Steel HC, Feldman C, Anderson R.

ERJ Open Res. 2015 Sep 14;1(1). pii: 00014-2015. eCollection 2015 May.


Nematodes enhance plant growth and nutrient uptake under C and N-rich conditions.

Gebremikael MT, Steel H, Buchan D, Bert W, De Neve S.

Sci Rep. 2016 Sep 8;6:32862. doi: 10.1038/srep32862.


Quality of life among South African patients receiving antiretroviral therapy in the Western Cape Province.

Kagee A, Coetzee B, Steel H.

S Afr J Psychol. 2016 Sep;46(3):376-389. doi: 10.1177/0081246315623237. Epub 2016 Jan 11.


Phenotypic and genotypic analysis of influenza viruses isolated from adult subjects during a phase II study of intravenous zanamivir in hospitalised subjects.

Yates PJ, Raimonde DS, Zhao HH, Man CY, Steel HM, Mehta N, Peppercorn AF.

Antiviral Res. 2016 Oct;134:144-152. doi: 10.1016/j.antiviral.2016.08.023. Epub 2016 Aug 26.


Symptoms of posttraumatic stress, depression, and anxiety as predictors of suicidal ideation among South African university students.

Bantjes JR, Kagee A, McGowan T, Steel H.

J Am Coll Health. 2016 Aug-Sep;64(6):429-37. doi: 10.1080/07448481.2016.1178120. Epub 2016 Apr 18.


Systemic Immune Activation Profiles of HIV-1 Subtype C-Infected Children and Their Mothers.

Makhubele TG, Steel HC, Anderson R, van Dyk G, Theron AJ, Rossouw TM.

Mediators Inflamm. 2016;2016:9026573. doi: 10.1155/2016/9026573. Epub 2016 Feb 25.


The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance.

Kostyanev T, Bonten MJ, O'Brien S, Steel H, Ross S, François B, Tacconelli E, Winterhalter M, Stavenger RA, Karlén A, Harbarth S, Hackett J, Jafri HS, Vuong C, MacGowan A, Witschi A, Angyalosi G, Elborn JS, deWinter R, Goossens H.

J Antimicrob Chemother. 2016 Feb;71(2):290-5. doi: 10.1093/jac/dkv339. Epub 2015 Nov 15. Review.


Quantifying the Contribution of Entire Free-Living Nematode Communities to Carbon Mineralization under Contrasting C and N Availability.

Gebremikael MT, Steel H, Bert W, Maenhout P, Sleutel S, De Neve S.

PLoS One. 2015 Sep 22;10(9):e0136244. doi: 10.1371/journal.pone.0136244. eCollection 2015.


Platinum trimethyl bipyridyl thiolates--new, tunable, red- to near IR emitting luminophores for bioimaging applications.

Steel HL, Allinson SL, Andre J, Coogan MP, Platts JA.

Chem Commun (Camb). 2015 Jul 21;51(57):11441-4. doi: 10.1039/c5cc04003e.


Constituting a public umbilical cord blood bank in South Africa.

Mellet J, Alessandrini M, Steel HC, Pepper MS.

Bone Marrow Transplant. 2015 Apr;50(4):615-6. doi: 10.1038/bmt.2014.329. Epub 2015 Jan 26. No abstract available.


Expression of soluble triggering receptor expressed on myeloid cells-1 in childhood CF and non-CF bronchiectasis.

Masekela R, Anderson R, de Boeck K, Vreys M, Steel HC, Olurunju S, Green RJ.

Pediatr Pulmonol. 2015 Apr;50(4):333-9. doi: 10.1002/ppul.23121. Epub 2014 Oct 27.


Investigation of biofilm formation on a charged intravenous catheter relative to that on a similar but uncharged catheter.

Richards GA, Brink AJ, McIntosh R, Steel HC, Cockeran R.

Med Devices (Auckl). 2014 Jun 20;7:219-24. doi: 10.2147/MDER.S63449. eCollection 2014.


Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function.

Theron AJ, Steel HC, Tintinger GR, Gravett CM, Anderson R, Feldman C.

J Immunol Res. 2014;2014:608930. doi: 10.1155/2014/608930. Epub 2014 May 25. Review.


Nematodes from terrestrial, freshwater and brackish water habitats in Belgium: an updated list with special emphasis on compost nematodes.

Steel H, Coomans A, Decraemer W, Moens T, Bert W.

Zootaxa. 2014 Feb 17;3765:143-60. doi: 10.11646/zootaxa.3765.2.3.


Circulating biomarkers of immune activation distinguish viral suppression from nonsuppression in HAART-treated patients with advanced HIV-1 subtype C infection.

Malherbe G, Steel HC, Cassol S, de Oliveira T, Seebregts CJ, Anderson R, Cassol E, Rossouw TM.

Mediators Inflamm. 2014;2014:198413. doi: 10.1155/2014/198413. Epub 2014 Apr 6.


Oxidative induction of pro-inflammatory cytokine formation by human monocyte-derived macrophages following exposure to manganese in vitro.

Mokgobu MI, Cholo MC, Anderson R, Steel HC, Motheo MP, Hlatshwayo TN, Tintinger GR, Theron AJ.

J Immunotoxicol. 2015 Jan-Mar;12(1):98-103. doi: 10.3109/1547691X.2014.902877. Epub 2014 May 7.


The beta-2-adrenoreceptor agonists, formoterol and indacaterol, but not salbutamol, effectively suppress the reactivity of human neutrophils in vitro.

Anderson R, Theron AJ, Steel HC, Durandt C, Tintinger GR, Feldman C.

Mediators Inflamm. 2014;2014:105420. doi: 10.1155/2014/105420. Epub 2014 Mar 6.


The internal-external respiratory motion correlation is unaffected by audiovisual biofeedback.

Steel H, Pollock S, Lee D, Keall P, Kim T.

Australas Phys Eng Sci Med. 2014 Mar;37(1):97-102. doi: 10.1007/s13246-014-0247-z. Epub 2014 Feb 8.


Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease.

Steel HC, Cockeran R, Anderson R, Feldman C.

Mediators Inflamm. 2013;2013:490346. doi: 10.1155/2013/490346. Epub 2013 Dec 25. Review.


Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?

Theron AJ, Steel HC, Tintinger GR, Feldman C, Anderson R.

Drug Des Devel Ther. 2013 Nov 22;7:1387-98. doi: 10.2147/DDDT.S50995. eCollection 2013. Review.


Dynamic patterns and their interactions in networks of excitable elements.

Gong P, Steel H, Robinson P, Qi Y.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Oct;88(4):042821. Epub 2013 Oct 30.


The prevalence of smoking and the knowledge of smoking hazards and smoking cessation strategies among HIV- positive patients in Johannesburg, South Africa.

Waweru P, Anderson R, Steel H, Venter WD, Murdoch D, Feldman C.

S Afr Med J. 2013 Sep 30;103(11):858-60. doi: 10.7196/samj.7388.


Truncated robust distance for clinical laboratory safety data monitoring and assessment.

Lin X, Parks D, Zhu L, Curtis L, Steel H, Rut A, Mooser V, Cardon L, Menius A, Lee K.

J Biopharm Stat. 2012;22(6):1174-92. doi: 10.1080/10543406.2011.580483.


Manganese promotes increased formation of hydrogen peroxide by activated human macrophages and neutrophils in vitro.

Mokgobu MI, Anderson R, Steel HC, Cholo MC, Tintinger GR, Theron AJ.

Inhal Toxicol. 2012 Aug;24(10):634-44. doi: 10.3109/08958378.2012.706657.


Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics.

Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C.

Mediators Inflamm. 2012;2012:584262. doi: 10.1155/2012/584262. Epub 2012 Jun 21. Review.


Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin.

Mutepe ND, Cockeran R, Steel HC, Theron AJ, Mitchell TJ, Feldman C, Anderson R.

Eur Respir J. 2013 Feb;41(2):392-5. doi: 10.1183/09031936.00213211. Epub 2012 Jun 27.


Clofazimine: current status and future prospects.

Cholo MC, Steel HC, Fourie PB, Germishuizen WA, Anderson R.

J Antimicrob Chemother. 2012 Feb;67(2):290-8. doi: 10.1093/jac/dkr444. Epub 2011 Oct 20. Review.


Calcium-dependent potentiation of the pro-inflammatory functions of human neutrophils by tigecycline in vitro.

Cockeran R, Mutepe ND, Theron AJ, Tintinger GR, Steel HC, Stivaktas PI, Richards GA, Feldman C, Anderson R.

J Antimicrob Chemother. 2012 Jan;67(1):130-7. doi: 10.1093/jac/dkr441. Epub 2011 Oct 18.


Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro.

Cockeran R, Steel HC, Theron AJ, Mitchell TJ, Feldman C, Anderson R.

Vaccine. 2011 Nov 8;29(48):8780-2. doi: 10.1016/j.vaccine.2011.09.080. Epub 2011 Oct 1.


Fatal respiratory events caused by zanamivir nebulization.

Steel HM, Peppercorn AF.

Clin Infect Dis. 2010 Jul 1;51(1):121. doi: 10.1086/653450. No abstract available.


Interactive inhibitory effects of formoterol and montelukast on activated human neutrophils.

Gravett CM, Theron AJ, Steel HC, Tintinger GR, Cockeran R, Feldman C, Anderson R.

Eur Respir J. 2010 Dec;36(6):1417-24. doi: 10.1183/09031936.00157409. Epub 2010 Apr 22.


Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C.

Tintinger GR, Theron AJ, Steel HC, Cockeran R, Pretorius L, Anderson R.

J Inflamm (Lond). 2009 Oct 30;6:29. doi: 10.1186/1476-9255-6-29.


Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation.

Steel HC, Theron AJ, Tintinger GR, Anderson R.

J Antimicrob Chemother. 2009 Nov;64(5):1008-12. doi: 10.1093/jac/dkp329. Epub 2009 Sep 10.


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