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Antibody-drug conjugates for cancer.

Chau CH, Steeg PS, Figg WD.

Lancet. 2019 Aug 31;394(10200):793-804. doi: 10.1016/S0140-6736(19)31774-X. Review.


Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.

Khan I, Gril B, Steeg PS.

Cancer Res. 2019 Sep 15;79(18):4689-4702. doi: 10.1158/0008-5472.CAN-19-0492. Epub 2019 Jul 16.


Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases.

Contreras-Zárate MJ, Day NL, Ormond DR, Borges VF, Tobet S, Gril B, Steeg PS, Cittelly DM.

Oncogene. 2019 Jun;38(24):4685-4699. doi: 10.1038/s41388-019-0756-z. Epub 2019 Feb 22.


MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer.

Greer YE, Gilbert SF, Gril B, Narwal R, Peacock Brooks DL, Tice DA, Steeg PS, Lipkowitz S.

Breast Cancer Res. 2019 Feb 18;21(1):27. doi: 10.1186/s13058-019-1116-1.


Brain metastases.

Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, Peters S, Arvold ND, Harsh GR, Steeg PS, Chang SD.

Nat Rev Dis Primers. 2019 Jan 17;5(1):5. doi: 10.1038/s41572-018-0055-y. Review.


A framework for the development of effective anti-metastatic agents.

Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D, Jones PS, Jones R, Marshall JF, Panico MB, Shaw JA, Steeg PS, Sullivan M, Tong W, Westwell AD, Ritchie JWA; Cancer Research UK and Cancer Therapeutics CRC Australia Metastasis Working Group.

Nat Rev Clin Oncol. 2019 Mar;16(3):185-204. doi: 10.1038/s41571-018-0134-8.


Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.

Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Pęksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS.

Nat Commun. 2018 Jul 13;9(1):2705. doi: 10.1038/s41467-018-05030-w.


Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.

Brooks D, Zimmer A, Wakefield L, Lyle LT, Difilippantonio S, Tucci FC, Illiano S, Annunziata CM, Steeg PS.

Oncotarget. 2018 May 4;9(34):23462-23481. doi: 10.18632/oncotarget.25231. eCollection 2018 May 4.


Retraction Notice to: FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM.

Cell. 2018 Apr 5;173(2):529. doi: 10.1016/j.cell.2018.03.058. No abstract available.


Analysis of breast cancer in young women in the Department of Defense (DOD) database.

Zimmer AS, Zhu K, Steeg PS, Wu A, Gatti-Mays ME, Soltani S, Perkins JG, Shao S, Brown D, Georg M, Hu H, Shriver CD, Lipkowitz S.

Breast Cancer Res Treat. 2018 Apr;168(2):501-511. doi: 10.1007/s10549-017-4615-8. Epub 2017 Dec 15.


Metastasis suppressors: functional pathways.

Khan I, Steeg PS.

Lab Invest. 2018 Feb;98(2):198-210. doi: 10.1038/labinvest.2017.104. Epub 2017 Oct 2. Review.


FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM.

Cell. 2016 Dec 1;167(6):1571-1585.e18. doi: 10.1016/j.cell.2016.10.023. Epub 2016 Nov 10. Retraction in: Cell. 2018 Apr 5;173(2):529.


Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer.

Samala R, Thorsheim HR, Goda S, Taskar K, Gril B, Steeg PS, Smith QR.

Pharm Res. 2016 Dec;33(12):2904-2919. Epub 2016 Aug 19.


Therapeutics for Brain Metastases, v3.

Steeg PS, Zimmer A, Gril B.

Clin Cancer Res. 2016 Dec 15;22(24):5953-5955. Epub 2016 Oct 10.


Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer.

Lyle LT, Lockman PR, Adkins CE, Mohammad AS, Sechrest E, Hua E, Palmieri D, Liewehr DJ, Steinberg SM, Kloc W, Izycka-Swieszewska E, Duchnowska R, Nayyar N, Brastianos PK, Steeg PS, Gril B.

Clin Cancer Res. 2016 Nov 1;22(21):5287-5299. Epub 2016 May 31.


Targeting metastasis.

Steeg PS.

Nat Rev Cancer. 2016 Apr;16(4):201-18. doi: 10.1038/nrc.2016.25. Review.


A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival.

Hernandez L, Kim MK, Noonan AM, Sagher E, Kohlhammer H, Wright G, Lyle LT, Steeg PS, Anver M, Bowtell DD; Australian Ovarian Cancer Study Group 57, Annunziata CM.

Cell Death Discov. 2015 Dec 14;1:15053. doi: 10.1038/cddiscovery.2015.53. eCollection 2015.


Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.

Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D.

Nature. 2015 Nov 5;527(7576):100-104. doi: 10.1038/nature15376. Epub 2015 Oct 19.


Estrogen promotes the brain metastatic colonization of triple negative breast cancer cells via an astrocyte-mediated paracrine mechanism.

Sartorius CA, Hanna CT, Gril B, Cruz H, Serkova NJ, Huber KM, Kabos P, Schedin TB, Borges VF, Steeg PS, Cittelly DM.

Oncogene. 2016 Jun 2;35(22):2881-92. doi: 10.1038/onc.2015.353. Epub 2015 Sep 28.


Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis.

Smart D, Garcia-Glaessner A, Palmieri D, Wong-Goodrich SJ, Kramp T, Gril B, Shukla S, Lyle T, Hua E, Cameron HA, Camphausen K, Steeg PS.

Clin Exp Metastasis. 2015 Oct;32(7):717-27. doi: 10.1007/s10585-015-9739-9. Epub 2015 Aug 30.


LAMC2 enhances the metastatic potential of lung adenocarcinoma.

Moon YW, Rao G, Kim JJ, Shim HS, Park KS, An SS, Kim B, Steeg PS, Sarfaraz S, Changwoo Lee L, Voeller D, Choi EY, Luo J, Palmieri D, Chung HC, Kim JH, Wang Y, Giaccone G.

Cell Death Differ. 2015 Aug;22(8):1341-52. doi: 10.1038/cdd.2014.228. Epub 2015 Jan 16.


Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.

Hsu T, Steeg PS, Zollo M, Wieland T; Steering Committee on Nme-related research and the organizers of the International Congresses of the NDP Kinase/Nm23/awd Gene Family.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb;388(2):109-17. doi: 10.1007/s00210-014-1079-9. Epub 2015 Jan 15. No abstract available.


Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients.

Duchnowska R, Jassem J, Goswami CP, Dundar M, Gökmen-Polar Y, Li L, Woditschka S, Biernat W, Sosińska-Mielcarek K, Czartoryska-Arłukowicz B, Radecka B, Tomasevic Z, Stępniak P, Wojdan K, Sledge GW Jr, Steeg PS, Badve S.

J Neurooncol. 2015 Mar;122(1):205-16. doi: 10.1007/s11060-014-1704-y. Epub 2015 Jan 6.


Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.

Zimmer AS, Steeg PS.

J Mol Med (Berl). 2015 Jan;93(1):13-29. doi: 10.1007/s00109-014-1226-2. Epub 2014 Nov 22. Review.


A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007.

Miller KD, Althouse SK, Nabell L, Rugo H, Carey L, Kimmick G, Jones DR, Merino MJ, Steeg PS.

Breast Cancer Res Treat. 2014 Nov;148(1):99-106. doi: 10.1007/s10549-014-3131-3. Epub 2014 Sep 26.


Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.

Marino N, Collins JW, Shen C, Caplen NJ, Merchant AS, Gökmen-Polar Y, Goswami CP, Hoshino T, Qian Y, Sledge GW Jr, Steeg PS.

Clin Exp Metastasis. 2014 Oct;31(7):771-86. doi: 10.1007/s10585-014-9667-0. Epub 2014 Aug 3.


Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study.

Morikawa A, Peereboom DM, Thorsheim HR, Samala R, Balyan R, Murphy CG, Lockman PR, Simmons A, Weil RJ, Tabar V, Steeg PS, Smith QR, Seidman AD.

Neuro Oncol. 2015 Feb;17(2):289-95. doi: 10.1093/neuonc/nou141. Epub 2014 Jul 11. Erratum in: Neuro Oncol. 2015 Oct;17(10):1423.


DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

Woditschka S, Evans L, Duchnowska R, Reed LT, Palmieri D, Qian Y, Badve S, Sledge G Jr, Gril B, Aladjem MI, Fu H, Flores NM, Gökmen-Polar Y, Biernat W, Szutowicz-Zielińska E, Mandat T, Trojanowski T, Och W, Czartoryska-Arlukowicz B, Jassem J, Mitchell JB, Steeg PS.

J Natl Cancer Inst. 2014 Jun 19;106(7). pii: dju145. doi: 10.1093/jnci/dju145. Print 2014 Jul.


Toward a drug development path that targets metastatic progression in osteosarcoma.

Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton PJ, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Meltzer P, Kirsch DG, Janeway KA, Weigel B, Randall L, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Smith M, Uren A, Patel SR, Trent J, Savage SA, Mirabello L, Reinke D, Barkaukas DA, Krailo M, Bernstein M.

Clin Cancer Res. 2014 Aug 15;20(16):4200-9. doi: 10.1158/1078-0432.CCR-13-2574. Epub 2014 May 6.


Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-dependent manner.

Palmieri D, Duchnowska R, Woditschka S, Hua E, Qian Y, Biernat W, Sosińska-Mielcarek K, Gril B, Stark AM, Hewitt SM, Liewehr DJ, Steinberg SM, Jassem J, Steeg PS.

Clin Cancer Res. 2014 May 15;20(10):2727-39. doi: 10.1158/1078-0432.CCR-13-2588. Epub 2014 Mar 14.


A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.

McMullin RP, Wittner BS, Yang C, Denton-Schneider BR, Hicks D, Singavarapu R, Moulis S, Lee J, Akbari MR, Narod SA, Aldape KD, Steeg PS, Ramaswamy S, Sgroi DC.

Breast Cancer Res. 2014 Mar 14;16(2):R25. doi: 10.1186/bcr3625.


CNS metastases in breast cancer: old challenge, new frontiers.

Lin NU, Amiri-Kordestani L, Palmieri D, Liewehr DJ, Steeg PS.

Clin Cancer Res. 2013 Dec 1;19(23):6404-18. doi: 10.1158/1078-0432.CCR-13-0790. Review.


Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma.

Wei JS, Johansson P, Chen L, Song YK, Tolman C, Li S, Hurd L, Patidar R, Wen X, Badgett TC, Cheuk AT, Marshall JC, Steeg PS, Vaqué Díez JP, Yu Y, Gutkind JS, Khan J.

PLoS One. 2013 Oct 16;8(10):e77731. doi: 10.1371/journal.pone.0077731. eCollection 2013.


Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.

Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC.

PLoS One. 2013 Sep 5;8(9):e73406. doi: 10.1371/journal.pone.0073406. eCollection 2013.


Roadblocks to translational advances on metastasis research.

Brabletz T, Lyden D, Steeg PS, Werb Z.

Nat Med. 2013 Sep;19(9):1104-9. doi: 10.1038/nm.3327.


Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model.

Mittapalli RK, Liu X, Adkins CE, Nounou MI, Bohn KA, Terrell TB, Qhattal HS, Geldenhuys WJ, Palmieri D, Steeg PS, Smith QR, Lockman PR.

Mol Cancer Ther. 2013 Nov;12(11):2389-99. doi: 10.1158/1535-7163.MCT-13-0132. Epub 2013 Sep 3.


Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis.

Marino N, Marshall JC, Collins JW, Zhou M, Qian Y, Veenstra T, Steeg PS.

Cancer Res. 2013 Oct 1;73(19):5949-62. doi: 10.1158/0008-5472.CAN-13-0368. Epub 2013 Aug 12.


SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases.

Zhang S, Huang WC, Zhang L, Zhang C, Lowery FJ, Ding Z, Guo H, Wang H, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D.

Cancer Res. 2013 Sep 15;73(18):5764-74. doi: 10.1158/0008-5472.CAN-12-1803. Epub 2013 Aug 1.


Breast cancer metastasis: issues for the personalization of its prevention and treatment.

Marino N, Woditschka S, Reed LT, Nakayama J, Mayer M, Wetzel M, Steeg PS.

Am J Pathol. 2013 Oct;183(4):1084-1095. doi: 10.1016/j.ajpath.2013.06.012. Epub 2013 Jul 26. Review.


Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells.

Gril B, Palmieri D, Qian Y, Anwar T, Liewehr DJ, Steinberg SM, Andreu Z, Masana D, Fernández P, Steeg PS, Vidal-Vanaclocha F.

Am J Pathol. 2013 Jun;182(6):2368-79. doi: 10.1016/j.ajpath.2013.02.043. Epub 2013 Apr 12.


A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice.

Peer CJ, Rao M, Spencer SD, Shahbazi S, Steeg PS, Schrump DS, Figg WD.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 15;927:142-6. doi: 10.1016/j.jchromb.2013.01.003. Epub 2013 Jan 9.


The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model.

Liu H, Kato Y, Erzinger SA, Kiriakova GM, Qian Y, Palmieri D, Steeg PS, Price JE.

BMC Cancer. 2012 Dec 7;12:583. doi: 10.1186/1471-2407-12-583.


AACR Cancer Progress Report 2012.

Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS.

Clin Cancer Res. 2012 Nov 1;18(21 Suppl):S1-100. doi: 10.1158/1078-0432.CCR-12-2891. Epub 2012 Sep 11. No abstract available.


Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer.

Marshall JC, Collins JW, Nakayama J, Horak CE, Liewehr DJ, Steinberg SM, Albaugh M, Vidal-Vanaclocha F, Palmieri D, Barbier M, Murone M, Steeg PS.

J Natl Cancer Inst. 2012 Sep 5;104(17):1306-19. doi: 10.1093/jnci/djs319. Epub 2012 Aug 21.


Dipyridamole prevents triple-negative breast-cancer progression.

Spano D, Marshall JC, Marino N, De Martino D, Romano A, Scoppettuolo MN, Bello AM, Di Dato V, Navas L, De Vita G, Medaglia C, Steeg PS, Zollo M.

Clin Exp Metastasis. 2013 Jan;30(1):47-68. doi: 10.1007/s10585-012-9506-0. Epub 2012 Jul 4.


Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene.

Marino N, Nakayama J, Collins JW, Steeg PS.

Cancer Metastasis Rev. 2012 Dec;31(3-4):593-603. doi: 10.1007/s10555-012-9374-8. Review.


Perspective: The right trials.

Steeg PS.

Nature. 2012 May 30;485(7400):S58-9. doi: 10.1038/485S58a. No abstract available.


TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells.

Fitzgerald DP, Emerson DL, Qian Y, Anwar T, Liewehr DJ, Steinberg SM, Silberman S, Palmieri D, Steeg PS.

Mol Cancer Ther. 2012 Sep;11(9):1959-67. doi: 10.1158/1535-7163.MCT-12-0061. Epub 2012 May 23. Erratum in: Mol Cancer Ther. 2013 Feb;12(2):241.


Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage.

Fitzgerald DP, Subramanian P, Deshpande M, Graves C, Gordon I, Qian Y, Snitkovsky Y, Liewehr DJ, Steinberg SM, Paltán-Ortiz JD, Herman MM, Camphausen K, Palmieri D, Becerra SP, Steeg PS.

Cancer Res. 2012 Jan 1;72(1):144-53. doi: 10.1158/0008-5472.CAN-11-1904.

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