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A European initiative to unclog pipeline for new medicines.

Macleod M, Steckler T.

Nature. 2019 Apr;568(7753):458. doi: 10.1038/d41586-019-01293-5. No abstract available.


Impact of hydrocodone reclassification on analgesic prescribing in the Veterans Health Administration.

Steckler TJ, Mosher HJ, Desloover-Koch Y, Lund BC.

Am J Health Syst Pharm. 2019 Mar 15. pii: zxy090. doi: 10.1093/ajhp/zxy090. [Epub ahead of print]


Pharmacy informatics: A call to action for educators, administrators, and residency directors.

Steckler TJ, Brownlee MJ, Urick BY, Farley MJ.

Curr Pharm Teach Learn. 2017 Sep;9(5):746-749. doi: 10.1016/j.cptl.2017.05.003. Epub 2017 Jun 30.


Lacking quality in research: Is behavioral neuroscience affected more than other areas of biomedical science?

Bespalov A, Steckler T.

J Neurosci Methods. 2018 Apr 15;300:4-9. doi: 10.1016/j.jneumeth.2017.10.018. Epub 2017 Oct 28.


Evaluating aged mice in three touchscreen tests that differ in visual demands: Impaired cognitive function and impaired visual abilities.

Buscher N, van Dorsselaer P, Steckler T, Talpos JC.

Behav Brain Res. 2017 Aug 30;333:142-149. doi: 10.1016/j.bbr.2017.06.053. Epub 2017 Jul 6.


Using estrus detection patches to optimally time insemination improved pregnancy risk in suckled beef cows enrolled in a fixed-time artificial insemination program.

Hill SL, Grieger DM, Olson KC, Jaeger JR, Dahlen CR, Bridges GA, Dantas F, Larson JE, Muth-Spurlock AM, Ahola JK, Fischer MC, Perry GA, Larimore EL, Steckler TL, Whittier WD, Currin JF, Stevenson JS.

J Anim Sci. 2016 Sep;94(9):3703-3710. doi: 10.2527/jas.2016-0469.


Metabolomic biosignature differentiates melancholic depressive patients from healthy controls.

Liu Y, Yieh L, Yang T, Drinkenburg W, Peeters P, Steckler T, Narayan VA, Wittenberg G, Ye J.

BMC Genomics. 2016 Aug 23;17:669. doi: 10.1186/s12864-016-2953-2.


Do wholes become more than the sum of their parts in the rodent (Rattus Norvegicus) visual system? A test case with the configural superiority effect.

Talpos JC, de-Wit L, Olley J, Riordan J, Steckler T.

Eur J Neurosci. 2016 Oct;44(8):2593-2599. doi: 10.1111/ejn.13350. Epub 2016 Aug 22.


Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets.

Bespalov A, Steckler T, Altevogt B, Koustova E, Skolnick P, Deaver D, Millan MJ, Bastlund JF, Doller D, Witkin J, Moser P, O'Donnell P, Ebert U, Geyer MA, Prinssen E, Ballard T, Macleod M.

Nat Rev Drug Discov. 2016 Jul;15(7):516. doi: 10.1038/nrd.2016.88. Epub 2016 Jun 17. No abstract available.


Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.

Maher MP, Wu N, Ravula S, Ameriks MK, Savall BM, Liu C, Lord B, Wyatt RM, Matta JA, Dugovic C, Yun S, Ver Donck L, Steckler T, Wickenden AD, Carruthers NI, Lovenberg TW.

J Pharmacol Exp Ther. 2016 May;357(2):394-414. doi: 10.1124/jpet.115.231712. Epub 2016 Mar 17.


Editorial: Reporting guidelines for psychopharmacology.

Steckler T, Curran HV, de Wit H, Howes O, Hoyer D, Lucki I, Miczek KA, Morrow AL, Price LH, Robbins TW.

Psychopharmacology (Berl). 2016 Apr;233(7):1131-4. doi: 10.1007/s00213-016-4252-7. No abstract available.


Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

Conde-Ceide S, Alcázar J, Alonso de Diego SA, López S, Martín-Martín ML, Martínez-Viturro CM, Pena MA, Tong HM, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Lindsley CW, Bartolomé-Nebreda JM.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434. doi: 10.1016/j.bmcl.2015.11.098. Epub 2015 Nov 28.


Effects of administration of prostaglandin F at initiation of the seven-day CO-Synch+controlled internal drug release ovulation synchronization protocol for suckled beef cows and replacement beef heifers.

Mercadante VR, Kozicki LE, Ciriaco FM, Henry DD, Dahlen CR, Crosswhite MR, Larson JE, Voelz BE, Patterson DJ, Perry GA, Funston RN, Steckler TL, Hill SL, Stevenson JS, Lamb GC.

J Anim Sci. 2015 Nov;93(11):5204-13. doi: 10.2527/jas.2015-8967.


Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.

Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5115-20. doi: 10.1016/j.bmcl.2015.10.009. Epub 2015 Oct 9.


TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice.

De Vry J, Vanmierlo T, Martínez-Martínez P, Losen M, Temel Y, Boere J, Kenis G, Steckler T, Steinbusch HWM, Baets M, Prickaerts J.

Behav Brain Res. 2016 Jan 1;296:15-25. doi: 10.1016/j.bbr.2015.08.027. Epub 2015 Aug 24.


Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation.

Kumar G, Olley J, Steckler T, Talpos J.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3991-4003. doi: 10.1007/s00213-015-4008-9. Epub 2015 Jul 18.


Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound.

Zhou Y, Malosh C, Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3515-9. doi: 10.1016/j.bmcl.2015.06.096. Epub 2015 Jul 4.


Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.

Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Garcia-Barrantes PM, Lavreysen H, Mackie C, Vinson PN, Rook JM, Bridges TM, Daniels JS, Megens A, Langlois X, Drinkenburg WH, Ahnaou A, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW.

ACS Med Chem Lett. 2015 May 20;6(6):716-20. doi: 10.1021/acsmedchemlett.5b00181. eCollection 2015 Jun 11.


The preclinical data forum network: A new ECNP initiative to improve data quality and robustness for (preclinical) neuroscience.

Steckler T, Brose K, Haas M, Kas MJ, Koustova E, Bespalov A; ECNP Preclinical Data Forum Network.

Eur Neuropsychopharmacol. 2015 Oct;25(10):1803-7. doi: 10.1016/j.euroneuro.2015.05.011. Epub 2015 Jun 4.


The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia.

Janhunen SK, Svärd H, Talpos J, Kumar G, Steckler T, Plath N, Lerdrup L, Ruby T, Haman M, Wyler R, Ballard TM.

Psychopharmacology (Berl). 2015 Nov;232(21-22):4059-83. doi: 10.1007/s00213-015-3954-6. Epub 2015 Jun 14. Review.


Opposing effects of glutamatergic and GABAergic pharmacological manipulations on a visual perception task with relevance to schizophrenia.

Talpos JC, Riordan J, Olley J, Waddell J, Steckler T.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3967-76. doi: 10.1007/s00213-015-3964-4. Epub 2015 May 28.


Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.

Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ.

Neuron. 2015 May 20;86(4):1029-1040. doi: 10.1016/j.neuron.2015.03.063. Epub 2015 Apr 30.


MK-801 and amphetamine result in dissociable profiles of cognitive impairment in a rodent paired associates learning task with relevance for schizophrenia.

Talpos J, Aerts N, Waddell J, Steckler T.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3911-20. doi: 10.1007/s00213-015-3934-x. Epub 2015 Apr 23.


Strain-dependent effects on acquisition and reversal of visual and spatial tasks in a rat touchscreen battery of cognition.

Kumar G, Talpos J, Steckler T.

Physiol Behav. 2015 May 15;144:26-36. doi: 10.1016/j.physbeh.2015.03.001. Epub 2015 Mar 3.


Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Martín-Martín ML, Bartolomé-Nebreda JM, Conde-Ceide S, Alonso de Diego SA, López S, Martínez-Viturro CM, Tong HM, Lavreysen H, Macdonald GJ, Steckler T, Mackie C, Bridges TM, Daniels JS, Niswender CM, Noetzel MJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1310-7. doi: 10.1016/j.bmcl.2015.01.038. Epub 2015 Jan 28.


Editorial: preclinical data reproducibility for R&D - the challenge for neuroscience.

Steckler T.

Springerplus. 2015 Jan 13;4:1. doi: 10.1186/2193-1801-4-1. eCollection 2015. No abstract available.


Relevance of the metabotropic glutamate receptor (mGluR5) in the regulation of NREM-REM sleep cycle and homeostasis: evidence from mGluR5 (-/-) mice.

Ahnaou A, Raeymaekers L, Steckler T, Drinkenbrug WH.

Behav Brain Res. 2015 Apr 1;282:218-26. doi: 10.1016/j.bbr.2015.01.009. Epub 2015 Jan 13.


Preclinical data reproducibility for R&D--the challenge for neuroscience.

Steckler T.

Psychopharmacology (Berl). 2015 Jan;232(2):317-20. doi: 10.1007/s00213-014-3836-3. Epub 2015 Jan 14. No abstract available.


In the grey zone between epilepsy and schizophrenia: alterations in group II metabotropic glutamate receptors.

Dedeurwaerdere S, Boets S, Janssens P, Lavreysen H, Steckler T.

Acta Neurol Belg. 2015 Sep;115(3):221-32. doi: 10.1007/s13760-014-0407-7. Epub 2014 Dec 25. Review.


GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein.

Credle JJ, George JL, Wills J, Duka V, Shah K, Lee YC, Rodriguez O, Simkins T, Winter M, Moechars D, Steckler T, Goudreau J, Finkelstein DI, Sidhu A.

Cell Death Differ. 2015 May;22(5):838-51. doi: 10.1038/cdd.2014.179. Epub 2014 Nov 14.


Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats.

Ahnaou A, Langlois X, Steckler T, Bartolome-Nebreda JM, Drinkenburg WH.

Psychopharmacology (Berl). 2015 Mar;232(6):1107-22. doi: 10.1007/s00213-014-3746-4. Epub 2014 Oct 18.


Re-evaluating the PCP challenge as a pre-clinical model of impaired cognitive flexibility in schizophrenia.

Fellini L, Kumar G, Gibbs S, Steckler T, Talpos J.

Eur Neuropsychopharmacol. 2014 Nov;24(11):1836-49. doi: 10.1016/j.euroneuro.2014.08.012. Epub 2014 Aug 27.


Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.

Pollard M, Bartolome JM, Conn PJ, Steckler T, Shaban H.

J Psychopharmacol. 2014 Oct;28(10):935-46. doi: 10.1177/0269881114542856. Epub 2014 Jul 16.


Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.

Turlington M, Noetzel MJ, Bridges TM, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Tong HM, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3641-6. doi: 10.1016/j.bmcl.2014.04.087. Epub 2014 May 2.


Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

Turlington M, Malosh C, Jacobs J, Manka JT, Noetzel MJ, Vinson PN, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martín-Martín ML, Tong HM, López S, MacDonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.

J Med Chem. 2014 Jul 10;57(13):5620-37. doi: 10.1021/jm500259z. Epub 2014 Jun 25.


Developmental programing: impact of testosterone on placental differentiation.

Beckett EM, Astapova O, Steckler TL, Veiga-Lopez A, Padmanabhan V.

Reproduction. 2014 Aug;148(2):199-209. doi: 10.1530/REP-14-0055. Epub 2014 May 19.


Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment.

Millan MJ, Fone K, Steckler T, Horan WP.

Eur Neuropsychopharmacol. 2014 May;24(5):645-92. doi: 10.1016/j.euroneuro.2014.03.008. Epub 2014 Apr 4.


A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment.

Talpos JC, Aerts N, Fellini L, Steckler T.

Pharmacol Biochem Behav. 2014 Jul;122:97-106. doi: 10.1016/j.pbb.2014.03.014. Epub 2014 Mar 22.


Autism spectrum disorders--an emerging area in psychopharmacology.

Steckler T, Spooren W, Murphy D.

Psychopharmacology (Berl). 2014 Mar;231(6):977-8. doi: 10.1007/s00213-014-3460-2. No abstract available.


Very low band gap thiadiazoloquinoxaline donor-acceptor polymers as multi-tool conjugated polymers.

Steckler TT, Henriksson P, Mollinger S, Lundin A, Salleo A, Andersson MR.

J Am Chem Soc. 2014 Jan 29;136(4):1190-3. doi: 10.1021/ja410527n. Epub 2014 Jan 14.


Developmental programming: postnatal estradiol amplifies ovarian follicular defects induced by fetal exposure to excess testosterone and dihydrotestosterone in sheep.

Veiga-Lopez A, Wurst AK, Steckler TL, Ye W, Padmanabhan V.

Reprod Sci. 2014 Apr;21(4):444-55. doi: 10.1177/1933719113503412. Epub 2013 Sep 27.


Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives.

Kas MJ, Glennon JC, Buitelaar J, Ey E, Biemans B, Crawley J, Ring RH, Lajonchere C, Esclassan F, Talpos J, Noldus LP, Burbach JP, Steckler T.

Psychopharmacology (Berl). 2014 Mar;231(6):1125-46. doi: 10.1007/s00213-013-3268-5. Epub 2013 Sep 19. Review.


Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.

Blobaum AL, Bridges TM, Byers FW, Turlington ML, Mattmann ME, Morrison RD, Mackie C, Lavreysen H, Bartolomé JM, Macdonald GJ, Steckler T, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR, Daniels JS.

Drug Metab Dispos. 2013 Dec;41(12):2066-75. doi: 10.1124/dmd.113.052662. Epub 2013 Sep 3.


N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

Gregory KJ, Herman EJ, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Bridges TM, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolomé JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ, Jones CK.

J Pharmacol Exp Ther. 2013 Nov;347(2):438-57. doi: 10.1124/jpet.113.206623. Epub 2013 Aug 21.


Touching on translation.

Talpos J, Steckler T.

Cell Tissue Res. 2013 Oct;354(1):297-308. doi: 10.1007/s00441-013-1694-7. Epub 2013 Aug 16. Review.


Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.

Bartolomé-Nebreda JM, Conde-Ceide S, Delgado F, Iturrino L, Pastor J, Pena MÁ, Trabanco AA, Tresadern G, Wassvik CM, Stauffer SR, Jadhav S, Gogi K, Vinson PN, Noetzel MJ, Days E, Weaver CD, Lindsley CW, Niswender CM, Jones CK, Conn PJ, Rombouts F, Lavreysen H, Macdonald GJ, Mackie C, Steckler T.

J Med Chem. 2013 Sep 26;56(18):7243-59. doi: 10.1021/jm400650w. Epub 2013 Sep 4.


The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders.

Cocks G, Curran S, Gami P, Uwanogho D, Jeffries AR, Kathuria A, Lucchesi W, Wood V, Dixon R, Ogilvie C, Steckler T, Price J.

Psychopharmacology (Berl). 2014 Mar;231(6):1079-88. doi: 10.1007/s00213-013-3196-4. Epub 2013 Jul 10. Review.


Near-infrared polymer light-emitting diodes based on low-energy gap oligomers copolymerized into a high-gap polymer host.

Steckler TT, Fenwick O, Lockwood T, Andersson MR, Cacialli F.

Macromol Rapid Commun. 2013 Jun 25;34(12):990-6. doi: 10.1002/marc.201300240. Epub 2013 Apr 2.


Trialkyl phosphites and diaryliodonium salts as co-initiators in a system for radical-promoted visible-light-induced cationic polymerization.

Nalli TW, Stanek LG, Molenaar RH, Weidell KL, Meyer JP, Johnson BR, Steckler TT, Wackerly JW, Studler MJ, Vickerman KL, Klankowski SA.

J Org Chem. 2013 Apr 19;78(8):3561-9. doi: 10.1021/jo302830r. Epub 2013 Apr 2.


Developmental programming: impact of prenatal exposure to bisphenol-A and methoxychlor on steroid feedbacks in sheep.

Abi Salloum B, Steckler TL, Herkimer C, Lee JS, Padmanabhan V.

Toxicol Appl Pharmacol. 2013 May 1;268(3):300-8. doi: 10.1016/j.taap.2013.02.011. Epub 2013 Feb 27.

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