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DNA Methylation Near the INS Gene is Associated with INS Genetic Variation (rs689) and Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY).

Carry PM, Vanderlinden LA, Johnson RK, Dong F, Steck AK, Frohnert BI, Rewers M, Yang IV, Kechris K, Norris JM.

Pediatr Diabetes. 2020 Feb 14. doi: 10.1111/pedi.12995. [Epub ahead of print]


Lessons From Continuous Glucose Monitoring in Youth With Pre-Type 1 Diabetes, Obesity, and Cystic Fibrosis.

Chan CL, Steck AK, Severn C, Pyle L, Rewers M, Zeitler PS.

Diabetes Care. 2020 Jan 14. pii: dc191690. doi: 10.2337/dc19-1690. [Epub ahead of print] No abstract available.


Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources.

Frohnert BI, Webb-Robertson BJ, Bramer LM, Reehl SM, Waugh K, Steck AK, Norris JM, Rewers M.

Diabetes. 2020 Feb;69(2):238-248. doi: 10.2337/db18-1263. Epub 2019 Nov 18.


Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes.

Simmons KM, Fouts A, Pyle L, Clark P, Dong F, Yu L, Usmani-Brown S, Gottlieb P, Herold KC, Steck AK; Type 1 Diabetes TrialNet Study Group.

Int J Mol Sci. 2019 Aug 8;20(16). pii: E3857. doi: 10.3390/ijms20163857.


The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.

Redondo MJ, Evans-Molina C, Steck AK, Atkinson MA, Sosenko J.

Diabetes Care. 2019 Aug;42(8):1357-1364. doi: 10.2337/dc19-0102. Epub 2019 Jun 4.


Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children.

Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3337-3344. doi: 10.1210/jc.2018-02196.


Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.

Onengut-Gumuscu S, Chen WM, Robertson CC, Bonnie JK, Farber E, Zhu Z, Oksenberg JR, Brant SR, Bridges SL Jr, Edberg JC, Kimberly RP, Gregersen PK, Rewers MJ, Steck AK, Black MH, Dabelea D, Pihoker C, Atkinson MA, Wagenknecht LE, Divers J, Bell RA; SEARCH for Diabetes in Youth; Type 1 Diabetes Genetics Consortium, Erlich HA, Concannon P, Rich SS.

Diabetes Care. 2019 Mar;42(3):406-415. doi: 10.2337/dc18-1727. Epub 2019 Jan 18.


Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group; Teddy Study Group.

Diabetes. 2019 Apr;68(4):847-857. doi: 10.2337/db18-0882. Epub 2019 Jan 17.


Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Jacobsen LM, Larsson HE, Tamura RN, Vehik K, Clasen J, Sosenko J, Hagopian WA, She JX, Steck AK, Rewers M, Simell O, Toppari J, Veijola R, Ziegler AG, Krischer JP, Akolkar B, Haller MJ; TEDDY Study Group.

Pediatr Diabetes. 2019 May;20(3):263-270. doi: 10.1111/pedi.12812. Epub 2019 Jan 29.


Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG; TEDDY Study Group.

J Med Genet. 2019 Sep;56(9):602-605. doi: 10.1136/jmedgenet-2018-105532. Epub 2018 Oct 4.


Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.

Redondo MJ, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth JM, Atkinson MA, Pugliese A, Geyer S; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Dec;41(12):2480-2486. doi: 10.2337/dc18-0861. Epub 2018 Oct 1.


β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis.

Evans-Molina C, Sims EK, DiMeglio LA, Ismail HM, Steck AK, Palmer JP, Krischer JP, Geyer S, Xu P, Sosenko JM; Type 1 Diabetes TrialNet Study Group.

JCI Insight. 2018 Aug 9;3(15). pii: 120877. doi: 10.1172/jci.insight.120877. eCollection 2018 Aug 9.


Identification and Analysis of Islet Antigen-Specific CD8+ T Cells with T Cell Libraries.

Ogura H, Preston-Hurlburt P, Perdigoto AL, Amodio M, Krishnaswamy S, Clark P, Yu H, Egli D, Fouts A, Steck AK, Herold KC.

J Immunol. 2018 Sep 15;201(6):1662-1670. doi: 10.4049/jimmunol.1800267. Epub 2018 Aug 6.


Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.

Triolo TM, Fouts A, Pyle L, Yu L, Gottlieb PA, Steck AK; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2019 Feb;42(2):192-199. doi: 10.2337/dc18-0288. Epub 2018 Jul 30.


A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.

Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Sep;41(9):1887-1894. doi: 10.2337/dc18-0087. Epub 2018 Jul 12.


Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG; TEDDY Study Group.

PLoS Med. 2018 Apr 3;15(4):e1002548. doi: 10.1371/journal.pmed.1002548. eCollection 2018 Apr.


Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?

Smith LB, Liu X, Johnson SB, Tamura R, Elding Larsson H, Ahmed S, Veijola R, Haller MJ, Akolkar B, Hagopian WA, Rewers MJ, Krischer J, Steck AK; TEDDY study group.

Pediatr Diabetes. 2018 Aug;19(5):1025-1033. doi: 10.1111/pedi.12674. Epub 2018 May 2.


Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study.

Long AE, Wilson IV, Becker DJ, Libman IM, Arena VC, Wong FS, Steck AK, Rewers MJ, Yu L, Achenbach P, Casas R, Ludvigsson J, Williams AJK, Gillespie KM.

Diabetologia. 2018 Jun;61(6):1484-1490. doi: 10.1007/s00125-018-4591-5. Epub 2018 Mar 12.


Predicting progression to diabetes in islet autoantibody positive children.

Steck AK, Dong F, Frohnert BI, Waugh K, Hoffman M, Norris JM, Rewers MJ.

J Autoimmun. 2018 Jun;90:59-63. doi: 10.1016/j.jaut.2018.01.006. Epub 2018 Feb 1.


Can Biomarkers Help Target Maturity-Onset Diabetes of the Young Genetic Testing in Antibody-Negative Diabetes?

Majidi S, Fouts A, Pyle L, Chambers C, Armstrong T, Wang Z, Batish SD, Klingensmith G, Steck AK.

Diabetes Technol Ther. 2018 Feb;20(2):106-112. doi: 10.1089/dia.2017.0317.


Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.

Sharma A, Liu X, Hadley D, Hagopian W, Chen WM, Onengut-Gumuscu S, Törn C, Steck AK, Frohnert BI, Rewers M, Ziegler AG, Lernmark Å, Toppari J, Krischer JP, Akolkar B, Rich SS, She JX; TEDDY Study Group.

J Autoimmun. 2018 May;89:90-100. doi: 10.1016/j.jaut.2017.12.008. Epub 2018 Jan 5.


Genetics of type 1 diabetes.

Redondo MJ, Steck AK, Pugliese A.

Pediatr Diabetes. 2018 May;19(3):346-353. doi: 10.1111/pedi.12597. Epub 2017 Nov 2. Review.


Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis.

Redondo MJ, Oram RA, Steck AK.

Curr Diab Rep. 2017 Oct 28;17(12):129. doi: 10.1007/s11892-017-0961-5. Review.


TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.

Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Feb;41(2):311-317. doi: 10.2337/dc17-0961. Epub 2017 Oct 12.


Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young.

Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK.

Pediatr Diabetes. 2018 Mar;19(2):277-283. doi: 10.1111/pedi.12543. Epub 2017 Jul 11.


Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives.

Bosi E, Boulware DC, Becker DJ, Buckner JH, Geyer S, Gottlieb PA, Henderson C, Kinderman A, Sosenko JM, Steck AK, Bingley PJ; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2881-2886. doi: 10.1210/jc.2017-00569.


Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?

Steck AK, Xu P, Geyer S, Redondo MJ, Antinozzi P, Wentworth JM, Sosenko J, Onengut-Gumuscu S, Chen WM, Rich SS, Pugliese A; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2873-2880. doi: 10.1210/jc.2016-4003.


T1D Autoantibodies: room for improvement?

Yu L, Zhao Z, Steck AK.

Curr Opin Endocrinol Diabetes Obes. 2017 Aug;24(4):285-291. doi: 10.1097/MED.0000000000000348. Review.


Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY).

Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M.

PLoS One. 2017 Apr 5;12(4):e0174840. doi: 10.1371/journal.pone.0174840. eCollection 2017.


Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY).

Frohnert BI, Ide L, Dong F, Barón AE, Steck AK, Norris JM, Rewers MJ.

Diabetologia. 2017 Jun;60(6):998-1006. doi: 10.1007/s00125-017-4256-9. Epub 2017 Mar 17.


Use of self-collected capillary blood samples for islet autoantibody screening in relatives: a feasibility and acceptability study.

Liu Y, Rafkin LE, Matheson D, Henderson C, Boulware D, Besser REJ, Ferrara C, Yu L, Steck AK, Bingley PJ; Type 1 Diabetes TrialNet Study Group.

Diabet Med. 2017 Jul;34(7):934-937. doi: 10.1111/dme.13338. Epub 2017 Mar 8.


The Use of Electrochemiluminescence Assays to Predict Autoantibody and Glycemic Progression Toward Type 1 Diabetes in Individuals with Single Autoantibodies.

Sosenko JM, Yu L, Skyler JS, Krischer JP, Gottlieb PA, Boulware D, Miao D, Palmer JP, Steck AK.

Diabetes Technol Ther. 2017 Mar;19(3):183-187. doi: 10.1089/dia.2016.0243. Epub 2017 Feb 8.


Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls.

Steck AK, Larsson HE, Liu X, Veijola R, Toppari J, Hagopian WA, Haller MJ, Ahmed S, Akolkar B, Lernmark Å, Rewers MJ, Krischer JP; and the TEDDY Study Group.

Pediatr Diabetes. 2017 Dec;18(8):794-802. doi: 10.1111/pedi.12485. Epub 2017 Jan 27.


Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.

Paul DS, Teschendorff AE, Dang MA, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S, Fouts AR, Ramelius A, Burden F, Farrow S, Rowlston S, Rehnstrom K, Frontini M, Downes K, Busche S, Cheung WA, Ge B, Simon MM, Bujold D, Kwan T, Bourque G, Datta A, Lowy E, Clarke L, Flicek P, Libertini E, Heath S, Gut M, Gut IG, Ouwehand WH, Pastinen T, Soranzo N, Hofer SE, Karges B, Meissner T, Boehm BO, Cilio C, Elding Larsson H, Lernmark Å, Steck AK, Rakyan VK, Beck S, Leslie RD.

Nat Commun. 2016 Nov 29;7:13555. doi: 10.1038/ncomms13555.


Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects?

Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2016 Oct;39(10):1738-44. doi: 10.2337/dc16-0302. Epub 2016 Jul 25.


Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children.

Poppy A, Retamal-Munoz C, Cree-Green M, Wood C, Davis S, Clements SA, Majidi S, Steck AK, Alonso GT, Chambers C, Rewers A.

Pediatrics. 2016 Jul;138(1). pii: e20151404. doi: 10.1542/peds.2015-1404. Epub 2016 Jun 17.


Predictors of slow progression to diabetes in children with multiple islet autoantibodies.

Steck AK, Dong F, Waugh K, Frohnert BI, Yu L, Norris JM, Rewers MJ.

J Autoimmun. 2016 Aug;72:113-7. doi: 10.1016/j.jaut.2016.05.010. Epub 2016 May 30.


ECL-IAA and ECL-GADA Can Identify High-Risk Single Autoantibody-Positive Relatives in the TrialNet Pathway to Prevention Study.

Steck AK, Fouts A, Miao D, Zhao Z, Dong F, Sosenko J, Gottlieb P, Rewers MJ, Yu L; TrialNet Study Group.

Diabetes Technol Ther. 2016 Jul;18(7):410-4. doi: 10.1089/dia.2015.0316. Epub 2016 Mar 18.


HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.

Pugliese A, Boulware D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molina C, Harrison LC, Schatz D, Palmer JP, Greenbaum C, Eisenbarth GS, Sosenko JM; Type 1 Diabetes TrialNet Study Group.

Diabetes. 2016 Apr;65(4):1109-19. doi: 10.2337/db15-1105. Epub 2016 Jan 28.


Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.

Elboudwarej E, Cole M, Briggs FB, Fouts A, Fain PR, Quach H, Quach D, Sinclair E, Criswell LA, Lane JA, Steck AK, Barcellos LF, Noble JA.

J Autoimmun. 2016 Apr;68:23-9. doi: 10.1016/j.jaut.2015.12.003. Epub 2016 Jan 9.


Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study.

Bingley PJ, Rafkin LE, Matheson D, Steck AK, Yu L, Henderson C, Beam CA, Boulware DC; TrialNet Study Group.

Diabetes Technol Ther. 2015 Dec;17(12):867-71. doi: 10.1089/dia.2015.0133. Epub 2015 Sep 16.


Comparison of Metabolic Outcomes in Children Diagnosed with Type 1 Diabetes Through Research Screening (Diabetes Autoimmunity Study in the Young [DAISY]) Versus in the Community.

Chan CL, Taki I, Dong F, Hoffman M, Norris JM, Klingensmith G, Rewers MJ, Steck AK.

Diabetes Technol Ther. 2015 Sep;17(9):649-56. doi: 10.1089/dia.2015.0029. Epub 2015 Jun 3.


Heritability of thyroid peroxidase autoantibody levels in type 1 diabetes: evidence from discordant twin pairs.

Wang B, Hawa MI, Rijsdijk FV, Fain PR, Paschou SA, Boehm BO, Steck AK, Snieder H, Leslie RD.

Diabetologia. 2015 Sep;58(9):2079-86. doi: 10.1007/s00125-015-3664-y. Epub 2015 Jun 13.


Characteristics of maturity onset diabetes of the young in a large diabetes center.

Chambers C, Fouts A, Dong F, Colclough K, Wang Z, Batish SD, Jaremko M, Ellard S, Hattersley AT, Klingensmith G, Steck AK.

Pediatr Diabetes. 2016 Aug;17(5):360-7. doi: 10.1111/pedi.12289. Epub 2015 Jun 8.


Response to comment on Steck et al. Early hyperglycemia detected by continuous glucose monitoring in children at risk for type 1 diabetes. Diabetes care 2014;37:2031-2033.

Steck AK, Dong F, Taki I, Hoffman M, Klingensmith GJ, Rewers MJ.

Diabetes Care. 2015 Mar;38(3):e48. doi: 10.2337/dc14-2876. No abstract available.


Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).

Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ; TEDDY Study Group.

Diabetes Care. 2015 May;38(5):808-13. doi: 10.2337/dc14-2426. Epub 2015 Feb 9.


Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk.

Miao D, Steck AK, Zhang L, Guyer KM, Jiang L, Armstrong T, Muller SM, Krischer J, Rewers M, Yu L; Type 1 Diabetes TrialNet Study Group.

Diabetes Technol Ther. 2015 Feb;17(2):119-27. doi: 10.1089/dia.2014.0186. Epub 2015 Jan 6.


Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.

Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J; TEDDY Study Group.

Diabetes. 2015 May;64(5):1818-29. doi: 10.2337/db14-1497. Epub 2014 Nov 24.


Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.

Steck AK, Dong F, Wong R, Fouts A, Liu E, Romanos J, Wijmenga C, Norris JM, Rewers MJ.

Pediatr Diabetes. 2014 Aug;15(5):355-62. Epub 2013 Nov 8.


Analysis of β-cell death in type 1 diabetes by droplet digital PCR.

Usmani-Brown S, Lebastchi J, Steck AK, Beam C, Herold KC, Ledizet M.

Endocrinology. 2014 Sep;155(9):3694-8. doi: 10.1210/en.2014-1150. Epub 2014 Jul 8.

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