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DNA Methylation Near the INS Gene is Associated with INS Genetic Variation (rs689) and Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY).

Carry PM, Vanderlinden LA, Johnson RK, Dong F, Steck AK, Frohnert BI, Rewers M, Yang IV, Kechris K, Norris JM.

Pediatr Diabetes. 2020 Feb 14. doi: 10.1111/pedi.12995. [Epub ahead of print]


Réflexions sur cerveau et psyché.

Steck A, Steck B.

Rev Med Suisse. 2020 Jan 29;16(679):241-245. French. No abstract available.


Lessons From Continuous Glucose Monitoring in Youth With Pre-Type 1 Diabetes, Obesity, and Cystic Fibrosis.

Chan CL, Steck AK, Severn C, Pyle L, Rewers M, Zeitler PS.

Diabetes Care. 2020 Jan 14. pii: dc191690. doi: 10.2337/dc19-1690. [Epub ahead of print] No abstract available.


Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources.

Frohnert BI, Webb-Robertson BJ, Bramer LM, Reehl SM, Waugh K, Steck AK, Norris JM, Rewers M.

Diabetes. 2020 Feb;69(2):238-248. doi: 10.2337/db18-1263. Epub 2019 Nov 18.


Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes.

Simmons KM, Fouts A, Pyle L, Clark P, Dong F, Yu L, Usmani-Brown S, Gottlieb P, Herold KC, Steck AK; Type 1 Diabetes TrialNet Study Group.

Int J Mol Sci. 2019 Aug 8;20(16). pii: E3857. doi: 10.3390/ijms20163857.


The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.

Redondo MJ, Evans-Molina C, Steck AK, Atkinson MA, Sosenko J.

Diabetes Care. 2019 Aug;42(8):1357-1364. doi: 10.2337/dc19-0102. Epub 2019 Jun 4.


Retrospective Review of a Novel Approach to Buprenorphine Induction in the Emergency Department.

Dunkley CA, Carpenter JE, Murray BP, Sizemore E, Wheatley M, Morgan BW, Moran TP, Steck A.

J Emerg Med. 2019 Aug;57(2):181-186. doi: 10.1016/j.jemermed.2019.03.029. Epub 2019 May 3.


Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children.

Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3337-3344. doi: 10.1210/jc.2018-02196.


In reply to: "Early administration of fab antivenom resulted in faster limb recovery in copperhead snake envenomation patients" by Anderson et al., CLIN TOXICOL 2018, ahead of print.

Carpenter J, Murray BP, Rothstein LS, Steck A.

Clin Toxicol (Phila). 2019 Jul;57(7):673-674. doi: 10.1080/15563650.2018.1541180. Epub 2019 Feb 14. No abstract available.


Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.

Onengut-Gumuscu S, Chen WM, Robertson CC, Bonnie JK, Farber E, Zhu Z, Oksenberg JR, Brant SR, Bridges SL Jr, Edberg JC, Kimberly RP, Gregersen PK, Rewers MJ, Steck AK, Black MH, Dabelea D, Pihoker C, Atkinson MA, Wagenknecht LE, Divers J, Bell RA; SEARCH for Diabetes in Youth; Type 1 Diabetes Genetics Consortium, Erlich HA, Concannon P, Rich SS.

Diabetes Care. 2019 Mar;42(3):406-415. doi: 10.2337/dc18-1727. Epub 2019 Jan 18.


Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group; Teddy Study Group.

Diabetes. 2019 Apr;68(4):847-857. doi: 10.2337/db18-0882. Epub 2019 Jan 17.


Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Jacobsen LM, Larsson HE, Tamura RN, Vehik K, Clasen J, Sosenko J, Hagopian WA, She JX, Steck AK, Rewers M, Simell O, Toppari J, Veijola R, Ziegler AG, Krischer JP, Akolkar B, Haller MJ; TEDDY Study Group.

Pediatr Diabetes. 2019 May;20(3):263-270. doi: 10.1111/pedi.12812. Epub 2019 Jan 29.


Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG; TEDDY Study Group.

J Med Genet. 2019 Sep;56(9):602-605. doi: 10.1136/jmedgenet-2018-105532. Epub 2018 Oct 4.


Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.

Redondo MJ, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth JM, Atkinson MA, Pugliese A, Geyer S; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Dec;41(12):2480-2486. doi: 10.2337/dc18-0861. Epub 2018 Oct 1.


β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis.

Evans-Molina C, Sims EK, DiMeglio LA, Ismail HM, Steck AK, Palmer JP, Krischer JP, Geyer S, Xu P, Sosenko JM; Type 1 Diabetes TrialNet Study Group.

JCI Insight. 2018 Aug 9;3(15). pii: 120877. doi: 10.1172/jci.insight.120877. eCollection 2018 Aug 9.


Identification and Analysis of Islet Antigen-Specific CD8+ T Cells with T Cell Libraries.

Ogura H, Preston-Hurlburt P, Perdigoto AL, Amodio M, Krishnaswamy S, Clark P, Yu H, Egli D, Fouts A, Steck AK, Herold KC.

J Immunol. 2018 Sep 15;201(6):1662-1670. doi: 10.4049/jimmunol.1800267. Epub 2018 Aug 6.


Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.

Triolo TM, Fouts A, Pyle L, Yu L, Gottlieb PA, Steck AK; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2019 Feb;42(2):192-199. doi: 10.2337/dc18-0288. Epub 2018 Jul 30.


A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.

Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Sep;41(9):1887-1894. doi: 10.2337/dc18-0087. Epub 2018 Jul 12.


Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG; TEDDY Study Group.

PLoS Med. 2018 Apr 3;15(4):e1002548. doi: 10.1371/journal.pmed.1002548. eCollection 2018 Apr.


Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?

Smith LB, Liu X, Johnson SB, Tamura R, Elding Larsson H, Ahmed S, Veijola R, Haller MJ, Akolkar B, Hagopian WA, Rewers MJ, Krischer J, Steck AK; TEDDY study group.

Pediatr Diabetes. 2018 Aug;19(5):1025-1033. doi: 10.1111/pedi.12674. Epub 2018 May 2.


Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study.

Long AE, Wilson IV, Becker DJ, Libman IM, Arena VC, Wong FS, Steck AK, Rewers MJ, Yu L, Achenbach P, Casas R, Ludvigsson J, Williams AJK, Gillespie KM.

Diabetologia. 2018 Jun;61(6):1484-1490. doi: 10.1007/s00125-018-4591-5. Epub 2018 Mar 12.


Predicting progression to diabetes in islet autoantibody positive children.

Steck AK, Dong F, Frohnert BI, Waugh K, Hoffman M, Norris JM, Rewers MJ.

J Autoimmun. 2018 Jun;90:59-63. doi: 10.1016/j.jaut.2018.01.006. Epub 2018 Feb 1.


Can Biomarkers Help Target Maturity-Onset Diabetes of the Young Genetic Testing in Antibody-Negative Diabetes?

Majidi S, Fouts A, Pyle L, Chambers C, Armstrong T, Wang Z, Batish SD, Klingensmith G, Steck AK.

Diabetes Technol Ther. 2018 Feb;20(2):106-112. doi: 10.1089/dia.2017.0317.


Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.

Sharma A, Liu X, Hadley D, Hagopian W, Chen WM, Onengut-Gumuscu S, Törn C, Steck AK, Frohnert BI, Rewers M, Ziegler AG, Lernmark Å, Toppari J, Krischer JP, Akolkar B, Rich SS, She JX; TEDDY Study Group.

J Autoimmun. 2018 May;89:90-100. doi: 10.1016/j.jaut.2017.12.008. Epub 2018 Jan 5.


Description of a Mass Poisoning in a Rural District in Mozambique: The First Documented Bongkrekic Acid Poisoning in Africa.

Gudo ES, Cook K, Kasper AM, Vergara A, Salomão C, Oliveira F, Ismael H, Saeze C, Mosse C, Fernandes Q, Viegas SO, Baltazar CS, Doyle TJ, Yard E, Steck A, Serret M, Falconer TM, Kern SE, Brzezinski JL, Turner JA, Boyd BL, Jani IV; Chitima Investigation Group.

Clin Infect Dis. 2018 Apr 17;66(9):1400-1406. doi: 10.1093/cid/cix1005.


Genetics of type 1 diabetes.

Redondo MJ, Steck AK, Pugliese A.

Pediatr Diabetes. 2018 May;19(3):346-353. doi: 10.1111/pedi.12597. Epub 2017 Nov 2. Review.


Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis.

Redondo MJ, Oram RA, Steck AK.

Curr Diab Rep. 2017 Oct 28;17(12):129. doi: 10.1007/s11892-017-0961-5. Review.


Anti-MAG antibodies in 202 patients: clinicopathological and therapeutic features.

Svahn J, Petiot P, Antoine JC, Vial C, Delmont E, Viala K, Steck AJ, Magot A, Cauquil C, Zarea A, Echaniz-Laguna A, Iancu Ferfoglia R, Gueguen A, Magy L, Léger JM, Kuntzer T, Ferraud K, Lacour A, Camdessanché JP; Francophone anti-MAG cohort Group.

J Neurol Neurosurg Psychiatry. 2018 May;89(5):499-505. doi: 10.1136/jnnp-2017-316715. Epub 2017 Oct 25.


TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.

Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2018 Feb;41(2):311-317. doi: 10.2337/dc17-0961. Epub 2017 Oct 12.


Opportunity for Collaboration Between Radiation Injury Treatment Network Centers and Medical Toxicology Specialists.

Davlantes E, Shartar S, Venero J, Steck A, Langston A, Kazzi ZN.

South Med J. 2017 Aug;110(8):497-501. doi: 10.14423/SMJ.0000000000000677.


Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young.

Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK.

Pediatr Diabetes. 2018 Mar;19(2):277-283. doi: 10.1111/pedi.12543. Epub 2017 Jul 11.


Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives.

Bosi E, Boulware DC, Becker DJ, Buckner JH, Geyer S, Gottlieb PA, Henderson C, Kinderman A, Sosenko JM, Steck AK, Bingley PJ; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2881-2886. doi: 10.1210/jc.2017-00569.


Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?

Steck AK, Xu P, Geyer S, Redondo MJ, Antinozzi P, Wentworth JM, Sosenko J, Onengut-Gumuscu S, Chen WM, Rich SS, Pugliese A; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2873-2880. doi: 10.1210/jc.2016-4003.


T1D Autoantibodies: room for improvement?

Yu L, Zhao Z, Steck AK.

Curr Opin Endocrinol Diabetes Obes. 2017 Aug;24(4):285-291. doi: 10.1097/MED.0000000000000348. Review.


Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy.

Herrendorff R, Hänggi P, Pfister H, Yang F, Demeestere D, Hunziker F, Frey S, Schaeren-Wiemers N, Steck AJ, Ernst B.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3689-E3698. doi: 10.1073/pnas.1619386114. Epub 2017 Apr 17.


Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY).

Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M.

PLoS One. 2017 Apr 5;12(4):e0174840. doi: 10.1371/journal.pone.0174840. eCollection 2017.


Low dose ketamine in the age of opioids.

Sobel RM, Steck AR.

Am J Emerg Med. 2017 Jun;35(6):917-918. doi: 10.1016/j.ajem.2017.03.062. Epub 2017 Mar 23. No abstract available.


Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY).

Frohnert BI, Ide L, Dong F, Barón AE, Steck AK, Norris JM, Rewers MJ.

Diabetologia. 2017 Jun;60(6):998-1006. doi: 10.1007/s00125-017-4256-9. Epub 2017 Mar 17.


Use of self-collected capillary blood samples for islet autoantibody screening in relatives: a feasibility and acceptability study.

Liu Y, Rafkin LE, Matheson D, Henderson C, Boulware D, Besser REJ, Ferrara C, Yu L, Steck AK, Bingley PJ; Type 1 Diabetes TrialNet Study Group.

Diabet Med. 2017 Jul;34(7):934-937. doi: 10.1111/dme.13338. Epub 2017 Mar 8.


The Use of Electrochemiluminescence Assays to Predict Autoantibody and Glycemic Progression Toward Type 1 Diabetes in Individuals with Single Autoantibodies.

Sosenko JM, Yu L, Skyler JS, Krischer JP, Gottlieb PA, Boulware D, Miao D, Palmer JP, Steck AK.

Diabetes Technol Ther. 2017 Mar;19(3):183-187. doi: 10.1089/dia.2016.0243. Epub 2017 Feb 8.


Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls.

Steck AK, Larsson HE, Liu X, Veijola R, Toppari J, Hagopian WA, Haller MJ, Ahmed S, Akolkar B, Lernmark Å, Rewers MJ, Krischer JP; and the TEDDY Study Group.

Pediatr Diabetes. 2017 Dec;18(8):794-802. doi: 10.1111/pedi.12485. Epub 2017 Jan 27.


Bongkrekic Acid-a Review of a Lesser-Known Mitochondrial Toxin.

Anwar M, Kasper A, Steck AR, Schier JG.

J Med Toxicol. 2017 Jun;13(2):173-179. doi: 10.1007/s13181-016-0577-1. Epub 2017 Jan 19. Review.


Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.

Paul DS, Teschendorff AE, Dang MA, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S, Fouts AR, Ramelius A, Burden F, Farrow S, Rowlston S, Rehnstrom K, Frontini M, Downes K, Busche S, Cheung WA, Ge B, Simon MM, Bujold D, Kwan T, Bourque G, Datta A, Lowy E, Clarke L, Flicek P, Libertini E, Heath S, Gut M, Gut IG, Ouwehand WH, Pastinen T, Soranzo N, Hofer SE, Karges B, Meissner T, Boehm BO, Cilio C, Elding Larsson H, Lernmark Å, Steck AK, Rakyan VK, Beck S, Leslie RD.

Nat Commun. 2016 Nov 29;7:13555. doi: 10.1038/ncomms13555.


Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects?

Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2016 Oct;39(10):1738-44. doi: 10.2337/dc16-0302. Epub 2016 Jul 25.


Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.

Wilson AJ, Sarfo-Kantanka K, Barrack T, Steck A, Saskowski J, Crispens MA, Khabele D.

Gynecol Oncol. 2016 Oct;143(1):143-151. doi: 10.1016/j.ygyno.2016.07.088. Epub 2016 Jul 19.


Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children.

Poppy A, Retamal-Munoz C, Cree-Green M, Wood C, Davis S, Clements SA, Majidi S, Steck AK, Alonso GT, Chambers C, Rewers A.

Pediatrics. 2016 Jul;138(1). pii: e20151404. doi: 10.1542/peds.2015-1404. Epub 2016 Jun 17.


Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study.

Törn C, Liu X, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J; TEDDY Study Group.

Sci Rep. 2016 Jun 16;6:27887. doi: 10.1038/srep27887.


Intravenous Immunoglobulins Lower Inflammatory Gene Expression in Skin Biopsies of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients.

Tsouni P, Panaite PA, Puttini S, Kuntzer T, Steck AJ.

Eur Neurol. 2016;75(5-6):290-1. doi: 10.1159/000447127. Epub 2016 Jun 11. No abstract available.


Predictors of slow progression to diabetes in children with multiple islet autoantibodies.

Steck AK, Dong F, Waugh K, Frohnert BI, Yu L, Norris JM, Rewers MJ.

J Autoimmun. 2016 Aug;72:113-7. doi: 10.1016/j.jaut.2016.05.010. Epub 2016 May 30.


Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Faucard R, Madeira A, Gehin N, Authier FJ, Panaite PA, Lesage C, Burgelin I, Bertel M, Bernard C, Curtin F, Lang AB, Steck AJ, Perron H, Kuntzer T, Créange A.

EBioMedicine. 2016 Apr;6:190-198. doi: 10.1016/j.ebiom.2016.03.001. Epub 2016 Mar 10.

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