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Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs.

Dreier C, Resa-Infante P, Thiele S, Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Preuss A, Müller Z, Klenk HD, Stech J, Gabriel G.

Emerg Microbes Infect. 2019;8(1):1324-1336. doi: 10.1080/22221751.2019.1663131.


Double-attenuated influenza virus elicits broad protection against challenge viruses with different serotypes in swine.

Mamerow S, Scheffter R, Röhrs S, Stech O, Blohm U, Schwaiger T, Schröder C, Ulrich R, Schinköthe J, Beer M, Mettenleiter TC, Stech J.

Vet Microbiol. 2019 Apr;231:160-168. doi: 10.1016/j.vetmic.2019.03.013. Epub 2019 Mar 12.


A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle.

Martin S, Chiramel AI, Schmidt ML, Chen YC, Whitt N, Watt A, Dunham EC, Shifflett K, Traeger S, Leske A, Buehler E, Martellaro C, Brandt J, Wendt L, Müller A, Peitsch S, Best SM, Stech J, Finke S, Römer-Oberdörfer A, Groseth A, Feldmann H, Hoenen T.

Genome Med. 2018 Aug 7;10(1):58. doi: 10.1186/s13073-018-0570-1.


A Dual Motif in the Hemagglutinin of H5N1 Goose/Guangdong-Like Highly Pathogenic Avian Influenza Virus Strains Is Conserved from Their Early Evolution and Increases both Membrane Fusion pH and Virulence.

Wessels U, Abdelwhab EM, Veits J, Hoffmann D, Mamerow S, Stech O, Hellert J, Beer M, Mettenleiter TC, Stech J.

J Virol. 2018 Aug 16;92(17). pii: e00778-18. doi: 10.1128/JVI.00778-18. Print 2018 Sep 1.


Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells.

Yang W, Lambertz RLO, Punyadarsaniya D, Leist SR, Stech J, Schughart K, Herrler G, Wu NH, Meng F.

Vet Microbiol. 2017 Nov;211:129-134. doi: 10.1016/j.vetmic.2017.10.015. Epub 2017 Oct 16.


Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.

Yang W, Punyadarsaniya D, Lambertz RLO, Lee DCC, Liang CH, Höper D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F, Herrler G.

J Virol. 2017 Mar 29;91(8). pii: e02125-16. doi: 10.1128/JVI.02125-16. Print 2017 Apr 15.


Progressive glycosylation of the haemagglutinin of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission without significant impact on antigenic drift.

Abdelwhab EM, Veits J, Tauscher K, Ziller M, Grund C, Hassan MK, Shaheen M, Harder TC, Teifke J, Stech J, Mettenleiter TC.

J Gen Virol. 2016 Dec;97(12):3193-3204. doi: 10.1099/jgv.0.000648. Epub 2016 Oct 28.


Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens.

Abdelwhab el-SM, Veits J, Breithaupt A, Gohrbandt S, Ziller M, Teifke JP, Stech J, Mettenleiter TC.

Virulence. 2016 Jul 3;7(5):546-57. doi: 10.1080/21505594.2016.1159367. Epub 2016 Mar 16.


Carbon dioxide emissions from Tucuruí reservoir (Amazon biome): New findings based on three-dimensional ecological model simulations.

Curtarelli MP, Ogashawara I, de Araújo CA, Lorenzzetti JA, Leão JA, Alcântara E, Stech JL.

Sci Total Environ. 2016 May 1;551-552:676-94. doi: 10.1016/j.scitotenv.2016.02.001. Epub 2016 Feb 22.


A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens.

Abdelwhab el-SM, Veits J, Tauscher K, Ziller M, Teifke JP, Stech J, Mettenleiter TC.

J Virol. 2015 Oct 21;90(1):400-11. doi: 10.1128/JVI.02082-15. Print 2016 Jan 1.


Pathogenicity evaluation of neuraminidase-negative H5 and H7 viruses in day-old chicks and adult chicken.

Hoffmann D, Röhrs S, Rahn J, Stech J, Beer M.

Vaccine. 2015 Dec 8;33(49):6997-7001. doi: 10.1016/j.vaccine.2015.09.106. Epub 2015 Oct 21.


Improved universal cloning of influenza A virus genes by LacZα-mediated blue/white selection.

Wessels U, Stech O, Abdelwhab el-SM, Judel A, Mettenleiter TC, Stech J.

J Virol Methods. 2015 Dec 1;225:87-9. doi: 10.1016/j.jviromet.2015.09.009. Epub 2015 Sep 25.


The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken.

Stech O, Veits J, Abdelwhab EM, Wessels U, Mettenleiter TC, Stech J.

Sci Rep. 2015 Aug 26;5:13493. doi: 10.1038/srep13493.


Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

Sauer AK, Liang CH, Stech J, Peeters B, Quéré P, Schwegmann-Wessels C, Wu CY, Wong CH, Herrler G.

PLoS One. 2014 Feb 21;9(2):e89529. doi: 10.1371/journal.pone.0089529. eCollection 2014.


Avian influenza virus h3 hemagglutinin may enable high fitness of novel human virus reassortants.

Kreibich A, Stech O, Hundt J, Ziller M, Mettenleiter TC, Stech J.

PLoS One. 2013 Nov 12;8(11):e79165. doi: 10.1371/journal.pone.0079165. eCollection 2013.


Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses.

Kalthoff D, Röhrs S, Höper D, Hoffmann B, Bogs J, Stech J, Beer M.

J Virol. 2013 Dec;87(24):13556-68. doi: 10.1128/JVI.02244-13. Epub 2013 Oct 9.


Can high-pathogenic avian influenza viruses with novel hemagglutinin serotypes other than H5 or H7 emerge?

Stech J, Mettenleiter TC.

Virulence. 2012 Jul 1;3(4):418-9. doi: 10.4161/viru.20974. Epub 2012 Jun 22. No abstract available.


Diversifying evolution of highly pathogenic H5N1 avian influenza virus in Egypt from 2006 to 2011.

Abdelwhab EM, Arafa AS, Stech J, Grund C, Stech O, Graeber-Gerberding M, Beer M, Hassan MK, Aly MM, Harder TC, Hafez HM.

Virus Genes. 2012 Aug;45(1):14-23. doi: 10.1007/s11262-012-0758-1. Epub 2012 Jun 5.


Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells.

Ocaña-Macchi M, Ricklin ME, Python S, Monika GA, Stech J, Stech O, Summerfield A.

Virology. 2012 May 25;427(1):1-9. doi: 10.1016/j.virol.2012.01.037. Epub 2012 Feb 23.


Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype.

Veits J, Weber S, Stech O, Breithaupt A, Gräber M, Gohrbandt S, Bogs J, Hundt J, Teifke JP, Mettenleiter TC, Stech J.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2579-84. doi: 10.1073/pnas.1109397109. Epub 2012 Jan 30.


Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine.

Stech J, Garn H, Herwig A, Stech O, Dauber B, Wolff T, Mettenleiter TC, Klenk HD.

J Infect Dis. 2011 Nov 15;204(10):1483-90. doi: 10.1093/infdis/jir613. Epub 2011 Sep 14.


Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein.

Bogs J, Kalthoff D, Veits J, Pavlova S, Schwemmle M, Mänz B, Mettenleiter TC, Stech J.

J Virol. 2011 Oct;85(20):10691-8. doi: 10.1128/JVI.00786-11. Epub 2011 Aug 17.


Highly pathogenic avian influenza viruses do not inhibit interferon synthesis in infected chickens but can override the interferon-induced antiviral state.

Penski N, Härtle S, Rubbenstroth D, Krohmann C, Ruggli N, Schusser B, Pfann M, Reuter A, Gohrbandt S, Hundt J, Veits J, Breithaupt A, Kochs G, Stech J, Summerfield A, Vahlenkamp T, Kaspers B, Staeheli P.

J Virol. 2011 Aug;85(15):7730-41. doi: 10.1128/JVI.00063-11. Epub 2011 May 25.


H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chicken.

Gohrbandt S, Veits J, Breithaupt A, Hundt J, Teifke JP, Stech O, Mettenleiter TC, Stech J.

J Gen Virol. 2011 Aug;92(Pt 8):1843-53. doi: 10.1099/vir.0.031591-0. Epub 2011 Apr 27.


Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza A virus.

Mänz B, Götz V, Wunderlich K, Eisel J, Kirchmair J, Stech J, Stech O, Chase G, Frank R, Schwemmle M.

J Biol Chem. 2011 Mar 11;286(10):8414-24. doi: 10.1074/jbc.M110.205534. Epub 2010 Dec 23.


[The pandemic influenza virus H1N1/2009: a review of the molecular biology, phylogeny, history of reassortments, and parameters of host switching].

Stech J, Beer M, Vahlenkamp T, Harder T.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010 Dec;53(12):1231-7. doi: 10.1007/s00103-010-1166-0. Review. German.


Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5.

Gohrbandt S, Veits J, Hundt J, Bogs J, Breithaupt A, Teifke JP, Weber S, Mettenleiter TC, Stech J.

J Gen Virol. 2011 Jan;92(Pt 1):51-9. doi: 10.1099/vir.0.023887-0. Epub 2010 Sep 29.


Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site.

Bogs J, Veits J, Gohrbandt S, Hundt J, Stech O, Breithaupt A, Teifke JP, Mettenleiter TC, Stech J.

PLoS One. 2010 Jul 27;5(7):e11826. doi: 10.1371/journal.pone.0011826.


Influenza receptors, polymerase and host range.

Matrosovich M, Stech J, Klenk HD.

Rev Sci Tech. 2009 Apr;28(1):203-17. Review.


Simultaneous one-tube full-length amplification of the NA, NP, M, and NS genes of influenza A viruses for reverse genetics.

Kreibich A, Stech J, Mettenleiter TC, Stech O.

J Virol Methods. 2009 Aug;159(2):308-10. doi: 10.1016/j.jviromet.2009.04.020. Epub 2009 May 3.


Acquisition of a polybasic hemagglutinin cleavage site by a low-pathogenic avian influenza virus is not sufficient for immediate transformation into a highly pathogenic strain.

Stech O, Veits J, Weber S, Deckers D, Schröer D, Vahlenkamp TW, Breithaupt A, Teifke J, Mettenleiter TC, Stech J.

J Virol. 2009 Jun;83(11):5864-8. doi: 10.1128/JVI.02649-08. Epub 2009 Mar 18.


High prevalence of amantadine resistance among circulating European porcine influenza A viruses.

Krumbholz A, Schmidtke M, Bergmann S, Motzke S, Bauer K, Stech J, Dürrwald R, Wutzler P, Zell R.

J Gen Virol. 2009 Apr;90(Pt 4):900-8. doi: 10.1099/vir.2008.007260-0. Epub 2009 Feb 17.


A stochastic model for estimation of mutation rates in multiple-replication proliferation processes.

Xiong X, Boyett JM, Webster RG, Stech J.

J Math Biol. 2009 Aug;59(2):175-91. doi: 10.1007/s00285-008-0225-8. Epub 2008 Oct 10.


Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification.

Stech J, Stech O, Herwig A, Altmeppen H, Hundt J, Gohrbandt S, Kreibich A, Weber S, Klenk HD, Mettenleiter TC.

Nucleic Acids Res. 2008 Dec;36(21):e139. doi: 10.1093/nar/gkn646. Epub 2008 Oct 2.


Attenuated influenza A viruses with modified cleavage sites in hemagglutinin as live vaccines.

Stech J.

Expert Rev Vaccines. 2008 Aug;7(6):739-43. doi: 10.1586/14760584.7.6.739. Review.


The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine.

Gabriel G, Garn H, Wegmann M, Renz H, Herwig A, Klenk HD, Stech J.

Vaccine. 2008 Feb 13;26(7):956-65. doi: 10.1016/j.vaccine.2007.11.052. Epub 2007 Dec 10.


Differential polymerase activity in avian and mammalian cells determines host range of influenza virus.

Gabriel G, Abram M, Keiner B, Wagner R, Klenk HD, Stech J.

J Virol. 2007 Sep;81(17):9601-4. Epub 2007 Jun 13.


Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens.

Kochs G, Koerner I, Thiel L, Kothlow S, Kaspers B, Ruggli N, Summerfield A, Pavlovic J, Stech J, Staeheli P.

J Gen Virol. 2007 May;88(Pt 5):1403-9.


A new approach to an influenza life vaccine: haemagglutinin cleavage site mutants generated by reverse genetics.

Stech J, Klenk HD.

Berl Munch Tierarztl Wochenschr. 2006 Mar-Apr;119(3-4):186-91. Review.


The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.

Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, Stech J.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18590-5. Epub 2005 Dec 8.


A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin.

Stech J, Garn H, Wegmann M, Wagner R, Klenk HD.

Nat Med. 2005 Jun;11(6):683-9. Epub 2005 May 29.


Universal primer set for the full-length amplification of all influenza A viruses.

Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR.

Arch Virol. 2001 Dec;146(12):2275-89.


Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1?

Hoffmann E, Stech J, Leneva I, Krauss S, Scholtissek C, Chin PS, Peiris M, Shortridge KF, Webster RG.

J Virol. 2000 Jul;74(14):6309-15.


Protection against a lethal avian influenza A virus in a mammalian system.

Riberdy JM, Flynn KJ, Stech J, Webster RG, Altman JD, Doherty PC.

J Virol. 1999 Feb;73(2):1453-9.


[Demonstration of intrathecal antibody formation against Borrelia burgdorferi in Lyme neuroborreliosis].

Zbinden R, Stech J, Bürgi W, Meier T.

Schweiz Med Wochenschr. 1993 Dec 4;123(48):2293-8. German.


[New technical and therapeutic equipment for emergency prehospital transportation].

Stĕch J.

Cesk Zdrav. 1991 Jan;39(1):9-10. Czech. No abstract available.


Pericardial angiosarcoma simulating pericardial effusion by echocardiography.

Lin TK, Stech JM, Eckert WG, Lin JJ, Farha SJ, Hagan CT.

Chest. 1978 Jun;73(6):881-3.


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