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Cell-Extrinsic Stressors from the Aging Bone Marrow (BM) Microenvironment Promote Dnmt3a-Mutant Clonal Hematopoiesis.

SanMiguel JM, Loberg M, Heuer S, Stearns T, Young K, Trowbridge J.

Blood. 2019 Nov 13;134(Supplement_1):5. doi: 10.1182/blood-2019-124511.


Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data.

Bogue MA, Philip VM, Walton DO, Grubb SC, Dunn MH, Kolishovski G, Emerson J, Mukherjee G, Stearns T, He H, Sinha V, Kadakkuzha B, Kunde-Ramamoorthy G, Chesler EJ.

Nucleic Acids Res. 2019 Nov 7. pii: gkz1032. doi: 10.1093/nar/gkz1032. [Epub ahead of print]


Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity.

Sundberg JP, Pratt CH, Silva KA, Kennedy VE, Qin W, Stearns TM, Frost J, Sundberg BA, Bowcock AM.

Exp Mol Pathol. 2019 Oct;110:104286. doi: 10.1016/j.yexmp.2019.104286. Epub 2019 Jul 16.


Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.

Mirvis M, Siemers KA, Nelson WJ, Stearns TP.

PLoS Biol. 2019 Jul 17;17(7):e3000381. doi: 10.1371/journal.pbio.3000381. eCollection 2019 Jul.


Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans.

Zeiss CJ, Gatti DM, Toro-Salazar O, Davis C, Lutz CM, Spinale F, Stearns T, Furtado MB, Churchill GA.

G3 (Bethesda). 2019 Aug 8;9(8):2637-2646. doi: 10.1534/g3.119.400232.


Quantitative Trait Locus and Integrative Genomics Revealed Candidate Modifier Genes for Ectopic Mineralization in Mouse Models of Pseudoxanthoma Elasticum.

Li Q, Philip VM, Stearns TM, Bubier JA, King BL, Low BE, Wiles MV, Saeidian AH, Sundberg BA, Uitto J, Sundberg JP.

J Invest Dermatol. 2019 Dec;139(12):2447-2457.e7. doi: 10.1016/j.jid.2019.04.023. Epub 2019 Jun 15.


Regulation of cilia abundance in multiciliated cells.

Nanjundappa R, Kong D, Shim K, Stearns T, Brody SL, Loncarek J, Mahjoub MR.

Elife. 2019 Apr 26;8. pii: e44039. doi: 10.7554/eLife.44039.


Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX).

Malcolm JE, Stearns TM, Airhart SD, Graber JH, Bult CJ.

PeerJ. 2019 Mar 28;7:e6586. doi: 10.7717/peerj.6586. eCollection 2019.


Glycine supplementation extends lifespan of male and female mice.

Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R.

Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27.


Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site.

Lo YC, Cormier O, Liu T, Nettles KW, Katzenellenbogen JA, Stearns T, Altman RB.

Nat Commun. 2019 Mar 4;10(1):1033. doi: 10.1038/s41467-019-08965-w.


Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol.

Weiss LE, Milenkovic L, Yoon J, Stearns T, Moerner WE.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5550-5557. doi: 10.1073/pnas.1816747116. Epub 2019 Feb 28.


Acarbose improves health and lifespan in aging HET3 mice.

Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA.

Aging Cell. 2019 Apr;18(2):e12898. doi: 10.1111/acel.12898. Epub 2019 Jan 27.


Revealing Nanoscale Morphology of the Primary Cilium Using Super-Resolution Fluorescence Microscopy.

Yoon J, Comerci CJ, Weiss LE, Milenkovic L, Stearns T, Moerner WE.

Biophys J. 2019 Jan 22;116(2):319-329. doi: 10.1016/j.bpj.2018.11.3136. Epub 2018 Dec 7.


Glabellar Botulinum Toxin Injections in Major Depressive Disorder: A Critical Review.

Stearns TP, Shad MU, Guzman GC.

Prim Care Companion CNS Disord. 2018 Oct 4;20(5). pii: 18r02298. doi: 10.4088/PCC.18r02298. Review.


Cyclin-dependent kinase control of motile ciliogenesis.

Vladar EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD.

Elife. 2018 Aug 28;7. pii: e36375. doi: 10.7554/eLife.36375.


A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.

Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV.

J Immunol. 2018 Oct 1;201(7):1907-1917. doi: 10.4049/jimmunol.1800465. Epub 2018 Aug 20.


Cilium structure, assembly, and disassembly regulated by the cytoskeleton.

Mirvis M, Stearns T, James Nelson W.

Biochem J. 2018 Jul 31;475(14):2329-2353. doi: 10.1042/BCJ20170453. Review.


The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules.

Wang JT, Stearns T.

Cold Spring Harb Symp Quant Biol. 2017;82:145-155. doi: 10.1101/sqb.2017.82.034496. Epub 2018 Mar 14.


Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation.

Stratton M, Stearns T.

Dev Cell. 2017 Nov 20;43(4):385-386. doi: 10.1016/j.devcel.2017.11.001.


Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice.

Bogue MA, Grubb SC, Walton DO, Philip VM, Kolishovski G, Stearns T, Dunn MH, Skelly DA, Kadakkuzha B, TeHennepe G, Kunde-Ramamoorthy G, Chesler EJ.

Nucleic Acids Res. 2018 Jan 4;46(D1):D843-D850. doi: 10.1093/nar/gkx1082.


Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.

Wang JT, Kong D, Hoerner CR, Loncarek J, Stearns T.

Elife. 2017 Sep 14;6. pii: e29061. doi: 10.7554/eLife.29061.


Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.

Hosur V, Burzenski LM, Stearns TM, Farley ML, Sundberg JP, Wiles MV, Shultz LD.

Exp Mol Pathol. 2017 Apr;102(2):337-346. doi: 10.1016/j.yexmp.2017.03.003. Epub 2017 Mar 6.


Loss of FAS/FASL signalling does not reduce apoptosis in Sharpin null mice.

Potter CS, Silva KA, Kennedy VE, Stearns TM, HogenEsch H, Sundberg JP.

Exp Dermatol. 2017 Sep;26(9):820-822. doi: 10.1111/exd.13289. Epub 2017 May 3.


Using yeast to determine the functional consequences of mutations in the human p53 tumor suppressor gene: An introductory course-based undergraduate research experience in molecular and cell biology.

Hekmat-Scafe DS, Brownell SE, Seawell PC, Malladi S, Imam JF, Singla V, Bradon N, Cyert MS, Stearns T.

Biochem Mol Biol Educ. 2017 Mar 4;45(2):161-178. doi: 10.1002/bmb.21024. Epub 2016 Nov 22.


Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis.

HogenEsch H, Sola M, Stearns TM, Silva KA, Kennedy VE, Sundberg JP.

Exp Mol Pathol. 2016 Dec;101(3):303-307. doi: 10.1016/j.yexmp.2016.05.015. Epub 2016 Oct 26.


Global gene profiling of aging lungs in Atp8b1 mutant mice.

Soundararajan R, Stearns TM, Czachor A, Fukumoto J, Turn C, Westermann-Clark E, Breitzig M, Tan L, Lockey RF, King BL, Kolliputi N.

Aging (Albany NY). 2016 Sep 29;8(9):2232-2252. doi: 10.18632/aging.101056.


Dermal lymphatic dilation in a mouse model of alopecia areata.

Sundberg JP, Pratt CH, Silva KA, Kennedy VE, Stearns TM, Sundberg BA, King LE, HogenEsch H.

Exp Mol Pathol. 2016 Apr;100(2):332-6. doi: 10.1016/j.yexmp.2016.03.001. Epub 2016 Mar 6.


Sperm Centrosomes: Kiss Your Asterless Goodbye, for Fertility's Sake.

Schatten G, Stearns T.

Curr Biol. 2015 Dec 21;25(24):R1178-81. doi: 10.1016/j.cub.2015.11.015.


Detection of canonical A-to-G editing events at 3' UTRs and microRNA target sites in human lungs using next-generation sequencing.

Soundararajan R, Stearns TM, Griswold AL, Mehta A, Czachor A, Fukumoto J, Lockey RF, King BL, Kolliputi N.

Oncotarget. 2015 Nov 3;6(34):35726-36. doi: 10.18632/oncotarget.6132.


MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.

Van de Mark D, Kong D, Loncarek J, Stearns T.

Mol Biol Cell. 2015 Nov 1;26(21):3788-802. doi: 10.1091/mbc.E15-04-0235. Epub 2015 Sep 2.



Smith JE, Stearns TH, Musgrove J.

Med Econ. 2015 Feb 25;92(4):48, 50. No abstract available.


Zeta-Tubulin Is a Member of a Conserved Tubulin Module and Is a Component of the Centriolar Basal Foot in Multiciliated Cells.

Turk E, Wills AA, Kwon T, Sedzinski J, Wallingford JB, Stearns T.

Curr Biol. 2015 Aug 17;25(16):2177-83. doi: 10.1016/j.cub.2015.06.063. Epub 2015 Jul 30.


Probing mammalian centrosome structure using BioID proximity-dependent biotinylation.

Firat-Karalar EN, Stearns T.

Methods Cell Biol. 2015;129:153-170. doi: 10.1016/bs.mcb.2015.03.016. Epub 2015 May 27.


Cell biology. Centrioles, in absentia.

Stearns T.

Science. 2015 Jun 5;348(6239):1091-2. doi: 10.1126/science.aac4860. No abstract available.


A high-enrollment course-based undergraduate research experience improves student conceptions of scientific thinking and ability to interpret data.

Brownell SE, Hekmat-Scafe DS, Singla V, Chandler Seawell P, Conklin Imam JF, Eddy SL, Stearns T, Cyert MS.

CBE Life Sci Educ. 2015 Summer;14(2):14:ar21. doi: 10.1187/cbe.14-05-0092. Epub 2015 Jun 1.


Observing planar cell polarity in multiciliated mouse airway epithelial cells.

Vladar EK, Lee YL, Stearns T, Axelrod JD.

Methods Cell Biol. 2015;127:37-54. doi: 10.1016/bs.mcb.2015.01.016. Epub 2015 Mar 7.


Development and validation of the JAX Cancer Treatment Profile™ for detection of clinically actionable mutations in solid tumors.

Ananda G, Mockus S, Lundquist M, Spotlow V, Simons A, Mitchell T, Stafford G, Philip V, Stearns T, Srivastava A, Barter M, Rowe L, Malcolm J, Bult C, Karuturi RK, Rasmussen K, Hinerfeld D.

Exp Mol Pathol. 2015 Feb;98(1):106-12. doi: 10.1016/j.yexmp.2014.12.009. Epub 2015 Jan 3.


Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas.

Sundberg JP, Stearns TM, Joh J, Proctor M, Ingle A, Silva KA, Dadras SS, Jenson AB, Ghim SJ.

PLoS One. 2014 Dec 4;9(12):e113582. doi: 10.1371/journal.pone.0113582. eCollection 2014.


Crisp1 and alopecia areata in C3H/HeJ mice.

Sundberg JP, Awgulewitsch A, Pruett ND, Potter CS, Silva KA, Stearns TM, Sundberg BA, Muñoz MW, Cuasnicu PS, King LE Jr, Rice RH.

Exp Mol Pathol. 2014 Dec;97(3):525-8. doi: 10.1016/j.yexmp.2014.10.010. Epub 2014 Oct 29.


Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs.

Soundararajan R, Won J, Stearns TM, Charette JR, Hicks WL, Collin GB, Naggert JK, Krebs MP, Nishina PM.

PLoS One. 2014 Oct 30;9(10):e110299. doi: 10.1371/journal.pone.0110299. eCollection 2014.


Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function.

Lee YL, Santé J, Comerci CJ, Cyge B, Menezes LF, Li FQ, Germino GG, Moerner WE, Takemaru K, Stearns T.

Mol Biol Cell. 2014 Oct 1;25(19):2919-33. doi: 10.1091/mbc.E14-02-0735. Epub 2014 Aug 7.


Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.

Firat-Karalar EN, Sante J, Elliott S, Stearns T.

J Cell Sci. 2014 Oct 1;127(Pt 19):4128-33. doi: 10.1242/jcs.157008. Epub 2014 Jul 29.


The centriole duplication cycle.

Fırat-Karalar EN, Stearns T.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130460. doi: 10.1098/rstb.2013.0460. Review.


3-Dimensional histological reconstruction and imaging of the murine pancreas.

Ciciotte SL, Lessard M, Akeson EC, Cameron E, Stearns TM, Denegre JM, Ruberte J, Svenson KL.

Mamm Genome. 2014 Oct;25(9-10):539-48. doi: 10.1007/s00335-014-9522-2. Epub 2014 May 18.


Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.

Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2200-9. doi: 10.1073/pnas.1323908111. Epub 2014 May 13.


Journey to the center of the centrosome.

Stearns T.

Dev Cell. 2014 Mar 31;28(6):603-4. doi: 10.1016/j.devcel.2014.03.011.


Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.

Lee JY, Hong WJ, Majeti R, Stearns T.

PLoS One. 2014 Mar 21;9(3):e92641. doi: 10.1371/journal.pone.0092641. eCollection 2014.


Effects of housing density in five inbred strains of mice.

Morgan JL, Svenson KL, Lake JP, Zhang W, Stearns TM, Marion MA, Peters LL, Paigen B, Donahue LR.

PLoS One. 2014 Mar 21;9(3):e90012. doi: 10.1371/journal.pone.0090012. eCollection 2014.


Proximity interactions among centrosome components identify regulators of centriole duplication.

Firat-Karalar EN, Rauniyar N, Yates JR 3rd, Stearns T.

Curr Biol. 2014 Mar 17;24(6):664-70. doi: 10.1016/j.cub.2014.01.067. Epub 2014 Mar 6.


The effect of culling on health and physiology of mouse litters.

Paigen B, Marion MA, Stearns TM, Harper JM, Svenson KL.

Lab Anim. 2014 Jul;48(3):207-215. Epub 2014 Feb 14.

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