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Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.

Kadungure T, Ucher AJ, Linehan EK, Schrader CE, Stavnezer J.

PLoS One. 2015 Aug 12;10(8):e0134397. doi: 10.1371/journal.pone.0134397. eCollection 2015.


Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.

Khair L, Baker RE, Linehan EK, Schrader CE, Stavnezer J.

PLoS Genet. 2015 Aug 11;11(8):e1005438. doi: 10.1371/journal.pgen.1005438. eCollection 2015 Aug.


Response to comment on "IgH chain class switch recombination: mechanism and regulation".

Stavnezer J, Schrader CE.

J Immunol. 2015 Mar 1;194(5):2040. doi: 10.4049/jimmunol.1500050. No abstract available.


IgH chain class switch recombination: mechanism and regulation.

Stavnezer J, Schrader CE.

J Immunol. 2014 Dec 1;193(11):5370-8. doi: 10.4049/jimmunol.1401849. Review.


Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.

Ucher AJ, Ranjit S, Kadungure T, Linehan EK, Khair L, Xie E, Limauro J, Rauch KS, Schrader CE, Stavnezer J.

J Immunol. 2014 Aug 1;193(3):1440-50. doi: 10.4049/jimmunol.1400365. Epub 2014 Jun 27.


Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.

Peng M, Xie J, Ucher A, Stavnezer J, Cantor SB.

EMBO J. 2014 Aug 1;33(15):1698-712. doi: 10.15252/embj.201387530. Epub 2014 Jun 25.


Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.

Stavnezer J, Linehan EK, Thompson MR, Habboub G, Ucher AJ, Kadungure T, Tsuchimoto D, Nakabeppu Y, Schrader CE.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9217-22. doi: 10.1073/pnas.1405590111. Epub 2014 Jun 9.


ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.

Khair L, Guikema JE, Linehan EK, Ucher AJ, Leus NG, Ogilvie C, Lou Z, Schrader CE, Stavnezer J.

J Immunol. 2014 May 15;192(10):4887-96. doi: 10.4049/jimmunol.1303481. Epub 2014 Apr 11.


A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J.

Nat Immunol. 2013 Nov;14(11):1183-1189. doi: 10.1038/ni.2732. Epub 2013 Oct 6.


DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J.

DNA Repair (Amst). 2013 Dec;12(12):1087-93. doi: 10.1016/j.dnarep.2013.09.002. Epub 2013 Sep 29.


Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.

Hasham MG, Snow KJ, Donghia NM, Branca JA, Lessard MD, Stavnezer J, Shopland LS, Mills KD.

J Immunol. 2012 Sep 1;189(5):2374-82. doi: 10.4049/jimmunol.1200414. Epub 2012 Jul 23.


The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.

Ucher AJ, Linehan EK, Teebor GW, Schrader CE, Stavnezer J.

PLoS One. 2012;7(4):e36061. doi: 10.1371/journal.pone.0036061. Epub 2012 Apr 20.


AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J.

J Immunol. 2011 Sep 1;187(5):2464-75. doi: 10.4049/jimmunol.1101406. Epub 2011 Jul 29. Erratum in: J Immunol. 2014 May 15;192(10):4934.


Editorial overview.

Lund F, Stavnezer J.

Curr Opin Immunol. 2011 Jun;23(3):307-9. doi: 10.1016/j.coi.2011.04.001. Epub 2011 Apr 21. No abstract available.


Complex regulation and function of activation-induced cytidine deaminase.

Stavnezer J.

Trends Immunol. 2011 May;32(5):194-201. doi: 10.1016/ Epub 2011 Apr 13. Review.


Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.

Staszewski O, Baker RE, Ucher AJ, Martier R, Stavnezer J, Guikema JE.

Mol Cell. 2011 Jan 21;41(2):232-42. doi: 10.1016/j.molcel.2011.01.007.


Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching.

Stavnezer J, Björkman A, Du L, Cagigi A, Pan-Hammarström Q.

Adv Immunol. 2010;108:45-109. doi: 10.1016/B978-0-12-380995-7.00003-3. Review.


p53 represses class switch recombination to IgG2a through its antioxidant function.

Guikema JE, Schrader CE, Brodsky MH, Linehan EK, Richards A, El Falaky N, Li DH, Sluss HK, Szomolanyi-Tsuda E, Stavnezer J.

J Immunol. 2010 Jun 1;184(11):6177-87. doi: 10.4049/jimmunol.0904085. Epub 2010 May 5. Erratum in: J Immunol. 2011 Nov 1;187(9):4920.


The role of Apex2 in class-switch recombination of immunoglobulin genes.

Guikema JE, Stavnezer J, Schrader CE.

Int Immunol. 2010 Mar;22(3):213; author reply 213-4. doi: 10.1093/intimm/dxq003. No abstract available.


Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.

Eccleston J, Schrader CE, Yuan K, Stavnezer J, Selsing E.

J Immunol. 2009 Jul 15;183(2):1222-8. doi: 10.4049/jimmunol.0900135. Epub 2009 Jun 24.


The surprising discovery that TGF beta specifically induces the IgA class switch.

Stavnezer J, Kang J.

J Immunol. 2009 Jan 1;182(1):5-7. No abstract available.


Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

Guikema JE, Schrader CE, Leus NG, Ucher A, Linehan EK, Werling U, Edelmann W, Stavnezer J.

J Immunol. 2008 Dec 15;181(12):8450-9.


The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch.

Schrader CE, Guikema JE, Wu X, Stavnezer J.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):645-52. doi: 10.1098/rstb.2008.0200. Review.


Mechanism and regulation of class switch recombination.

Stavnezer J, Guikema JE, Schrader CE.

Annu Rev Immunol. 2008;26:261-92. doi: 10.1146/annurev.immunol.26.021607.090248. Review.


APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE.

J Exp Med. 2007 Nov 26;204(12):3017-26. Epub 2007 Nov 19. Erratum in: J Exp Med. 2007 Dec 24;204(13):3295.


Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J.

J Immunol. 2007 Nov 1;179(9):6064-71. Erratum in: J Immunol. 2008 Jan 1;180(1):664.


Antibody class switching differs among SJL, C57BL/6 and 129 mice.

Kaminski DA, Stavnezer J.

Int Immunol. 2007 Apr;19(4):545-56. Epub 2007 Feb 27.


The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

Bradley SP, Kaminski DA, Peters AH, Jenuwein T, Stavnezer J.

J Immunol. 2006 Jul 15;177(2):1179-88.


Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination.

Stavnezer J, Schrader CE.

Trends Genet. 2006 Jan;22(1):23-8. Epub 2005 Nov 23.


Inducible DNA breaks in Ig S regions are dependent on AID and UNG.

Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J.

J Exp Med. 2005 Aug 15;202(4):561-8.


Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2.

Min IM, Rothlein LR, Schrader CE, Stavnezer J, Selsing E.

J Exp Med. 2005 Jun 20;201(12):1885-90. Epub 2005 Jun 13.


Evolution of isotype switching.

Stavnezer J, Amemiya CT.

Semin Immunol. 2004 Aug;16(4):257-75. Review.


Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.

Schrader CE, Vardo J, Linehan E, Twarog MZ, Niedernhofer LJ, Hoeijmakers JH, Stavnezer J.

J Exp Med. 2004 Aug 2;200(3):321-30. Epub 2004 Jul 26.


Antibody class switching: uncoupling S region accessibility from transcription.

Kaminski DA, Stavnezer J.

Trends Genet. 2004 Aug;20(8):337-40.


Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.

Schrader CE, Bradley SP, Vardo J, Mochegova SN, Flanagan E, Stavnezer J.

EMBO J. 2003 Nov 3;22(21):5893-903.


The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2.

Min IM, Schrader CE, Vardo J, Luby TM, D'Avirro N, Stavnezer J, Selsing E.

Immunity. 2003 Oct;19(4):515-24.


Mlh1 can function in antibody class switch recombination independently of Msh2.

Schrader CE, Vardo J, Stavnezer J.

J Exp Med. 2003 May 19;197(10):1377-83. Epub 2003 May 12.


Immunoglobulin genes: generating diversity with AID and UNG.

Storb U, Stavnezer J.

Curr Biol. 2002 Oct 29;12(21):R725-7. Review.


Does activation-induced deaminase initiate antibody diversification by DNA deamination?

Stavnezer J, Bradley SP.

Trends Genet. 2002 Nov;18(11):541-3. No abstract available.


The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.

Luby TM, Schrader CE, Stavnezer J, Selsing E.

J Exp Med. 2001 Jan 15;193(2):159-68.


Immunology. A touch of antibody class.

Stavnezer J.

Science. 2000 May 12;288(5468):984-5. No abstract available.


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